2025
RNA sensing at the crossroads of autoimmunity and autoinflammation
Williams S, Sim S, Wolin S. RNA sensing at the crossroads of autoimmunity and autoinflammation. RNA 2025, 31: rna.080304.124. PMID: 39779213, PMCID: PMC11874990, DOI: 10.1261/rna.080304.124.Peer-Reviewed Original ResearchConceptsRNA sensorsInnate immune system's abilityImmune systemAutoinflammatory diseasesHost defense systemRNA homeostasisForeign RNAHost RNAType I interferon-stimulated genesPathogen recognitionInnate immune systemI interferon-stimulated genesRNA sensingImmune-mediated diseasesImmune system's abilityRNAAdaptive immune systemHuman immune systemTumor surveillanceViral counterpartsSenescent cellsGenesHomeostatic processesViral infectionPathogens
2024
Understanding and overcoming resistance to immunotherapy in genitourinary cancers
Evans S, Jani Y, Jansen C, Yildirim A, Kalemoglu E, Bilen M. Understanding and overcoming resistance to immunotherapy in genitourinary cancers. Cancer Biology & Therapy 2024, 25: 2342599. PMID: 38629578, PMCID: PMC11028033, DOI: 10.1080/15384047.2024.2342599.Peer-Reviewed Original ResearchConceptsImmune checkpoint inhibitorsResistance to immunotherapyImmunotherapy resistanceTargeted therapyGenitourinary (GU) cancersCombined immune checkpoint inhibitorsIntroduction of novel immunotherapiesMechanisms of immunotherapy resistanceOvercome resistance to immunotherapyCancer cellsHost immune profileResponse to immunotherapyNovel Targeted TherapiesImmune system's rolePredictors of responseAttack cancer cellsImmune system's abilityStandard of careCheckpoint inhibitorsSequential therapyNovel immunotherapiesCombination therapyTreatment failureGU cancersTreatment landscape
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