2024
Insights into the evolution, virulence and speciation of Babesia MO1 and Babesia divergens through multiomics analyses
Singh P, Vydyam P, Fang T, Estrada K, Gonzalez L, Grande R, Kumar M, Chakravarty S, Berry V, Ranwez V, Carcy B, Depoix D, Sánchez S, Cornillot E, Abel S, Ciampossin L, Lenz T, Harb O, Sanchez-Flores A, Montero E, Le Roch K, Lonardi S, Mamoun C. Insights into the evolution, virulence and speciation of Babesia MO1 and Babesia divergens through multiomics analyses. Emerging Microbes & Infections 2024, 13: 2386136. PMID: 39148308, PMCID: PMC11370697, DOI: 10.1080/22221751.2024.2386136.Peer-Reviewed Original ResearchLeveraging genomic informationHuman babesiosisTick-borne diseasesDiseases of significanceCases of human babesiosisGenomic divergenceGenome sequenceGenomic informationMultigene familyGene functionBabesia divergensMammalian hostsAnimal healthMultiomics analysisZoonotic pathogensBabesiosisProtozoan parasitesVirulent strainsPathogensVertebrate hostsEnvironmental changesVirulenceReplication rateAntiparasitic drugsParasitesIn vitro efficacy of next-generation dihydrotriazines and biguanides against babesiosis and malaria parasites
Vydyam P, Chand M, Gihaz S, Renard I, Heffernan G, Jacobus L, Jacobus D, Saionz K, Shah R, Shieh H, Terpinski J, Zhao W, Cornillot E, Mamoun C. In vitro efficacy of next-generation dihydrotriazines and biguanides against babesiosis and malaria parasites. Antimicrobial Agents And Chemotherapy 2024, 68: e00423-24. PMID: 39136469, PMCID: PMC11373198, DOI: 10.1128/aac.00423-24.Peer-Reviewed Original ResearchTherapeutic indexPlasmodium falciparum</i>Effective therapeutic strategyCausative agent of babesiosisIn vitro efficacyAntiparasitic drugsProtozoan parasitesMalaria parasitesIntraerythrocytic protozoan parasiteTherapeutic strategiesFolate pathwayBroad-spectrum antiparasitic drugStrain HB3Babesia divergensMalariaBabesia duncaniAnimal healthAntifolatesDrugWidespread resistanceCausative agentBiguanideBabesiaBabesiosisBiosynthesis of purines
2010
One Health approach to identify research needs in bovine and human babesioses: workshop report
Pérez de León AA, Strickman DA, Knowles DP, Fish D, Thacker E, de la Fuente J, Krause PJ, Wikel SK, Miller RS, Wagner GG, Almazán C, Hillman R, Messenger MT, Ugstad PO, Duhaime RA, Teel PD, Ortega-Santos A, Hewitt DG, Bowers EJ, Bent SJ, Cochran MH, McElwain TF, Scoles GA, Suarez CE, Davey R, Howell Freeman JM, Lohmeyer K, Li AY, Guerrero FD, Kammlah DM, Phillips P, Pound JM, the Group for Emerging Babesioses and One Health Research and Development in the U.S.. One Health approach to identify research needs in bovine and human babesioses: workshop report. Parasites & Vectors 2010, 3: 36. PMID: 20377902, PMCID: PMC2859369, DOI: 10.1186/1756-3305-3-36.Peer-Reviewed Original Research
2000
Babesiosis
Homer M, Aguilar-Delfin I, Telford S, Krause P, Persing D. Babesiosis. Clinical Microbiology Reviews 2000, 13: 451-469. PMID: 10885987, PMCID: PMC88943, DOI: 10.1128/cmr.13.3.451-469.2000.Peer-Reviewed Original ResearchConceptsSpecies of BabesiaMalaria-like diseaseWidespread blood parasitesPear-shaped formsPossible pathogenic mechanismsAppropriate patient managementInfected red blood cellsHematotropic parasitesVeterinary impactBabesia speciesGenus BabesiaIxodid ticksBabesial parasitesZoonotic diseaseRed blood cellsBabesia divergensSilent infectionAnimal hostsEpidemiological descriptionDisease manifestationsPatient managementImmunological responseSevere hemolysisB. microtiTransmission cycle
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