2024
Gray Matter Atrophy in a 6-OHDA-induced Model of Parkinson’s Disease
Kumari S, Rana B, Kumaran S, Chaudhary S, Jain S, Srivastava A, Rajan R. Gray Matter Atrophy in a 6-OHDA-induced Model of Parkinson’s Disease. Neuroscience 2024, 551: 217-228. PMID: 38843989, DOI: 10.1016/j.neuroscience.2024.05.029.Peer-Reviewed Original ResearchVolume-based morphometryGray matter volumeMachine learningMagnetic resonance imagingClassification accuracyGray matter atrophySham controlsSupport vector machine (SVM)-based algorithmContralateral rotational behaviorUnilateral 6-hydroxydopamineIncrease classification accuracyAssociated with progressionMatter volumeModel of Parkinson's diseaseParkinson's diseaseBrain regionsBasal ganglia-thalamocortical circuitsPD modelSubcortical brain regionsGMV changesGray matter volume atrophyBrain morphometric changesInternal capsuleStudy of alterationsSubstantia nigraCross-Modal Synthesis of Structural MRI and Functional Connectivity Networks via Conditional ViT-GANs
Bi Y, Abrol A, Sui J, Calhoun V. Cross-Modal Synthesis of Structural MRI and Functional Connectivity Networks via Conditional ViT-GANs. 2024, 00: 1756-1760. DOI: 10.1109/icassp48485.2024.10446450.Peer-Reviewed Original ResearchFunctional network connectivityStructural magnetic resonance imagingCross-modality synthesisFunctional network connectivity matricesGenerative adversarial networkFunctional connectivity networksAdversarial networkSubcortical brain regionsMedical imagesNetwork connectivityFusion of MRIConnectivity networks
2023
Association between perceived stress and brain structure volumes in older adults without late-life depression: a key role for the thalamus?
Anam A, Wang L, Pearlson G. Association between perceived stress and brain structure volumes in older adults without late-life depression: a key role for the thalamus? American Journal Of Geriatric Psychiatry 2023, 31: s61-s62. DOI: 10.1016/j.jagp.2022.12.221.Peer-Reviewed Original ResearchLate-life depressionThalamus volumeEarly life stressHC groupLLD groupPrefrontal cortexOlder adultsAnterior cingulateBrain volumeControl groupDuke Depression Evaluation ScheduleMontgomery-Asberg Depression Rating ScaleSimilar findingsHealthy control subjectsDepression Rating ScaleIntracranial brain volumeSignificant differencesSignificant correlationConnecticut Health CenterDorsal anterior cingulateSubcortical brain regionsStandardized acquisition protocolBrain structure volumesVentral anterior cingulateInstitutional review boardVolume of subcortical brain regions in social anxiety disorder: mega-analytic results from 37 samples in the ENIGMA-Anxiety Working Group
Groenewold N, Bas-Hoogendam J, Amod A, Laansma M, Van Velzen L, Aghajani M, Hilbert K, Oh H, Salas R, Jackowski A, Pan P, Salum G, Blair J, Blair K, Hirsch J, Pantazatos S, Schneier F, Talati A, Roelofs K, Volman I, Blanco-Hinojo L, Cardoner N, Pujol J, Beesdo-Baum K, Ching C, Thomopoulos S, Jansen A, Kircher T, Krug A, Nenadić I, Stein F, Dannlowski U, Grotegerd D, Lemke H, Meinert S, Winter A, Erb M, Kreifelts B, Gong Q, Lui S, Zhu F, Mwangi B, Soares J, Wu M, Bayram A, Canli M, Tükel R, Westenberg P, Heeren A, Cremers H, Hofmann D, Straube T, Doruyter A, Lochner C, Peterburs J, Van Tol M, Gur R, Kaczkurkin A, Larsen B, Satterthwaite T, Filippi C, Gold A, Harrewijn A, Zugman A, Bülow R, Grabe H, Völzke H, Wittfeld K, Böhnlein J, Dohm K, Kugel H, Schrammen E, Zwanzger P, Leehr E, Sindermann L, Ball T, Fonzo G, Paulus M, Simmons A, Stein M, Klumpp H, Phan K, Furmark T, Månsson K, Manzouri A, Avery S, Blackford J, Clauss J, Feola B, Harper J, Sylvester C, Lueken U, Veltman D, Winkler A, Jahanshad N, Pine D, Thompson P, Stein D, Van der Wee N. Volume of subcortical brain regions in social anxiety disorder: mega-analytic results from 37 samples in the ENIGMA-Anxiety Working Group. Molecular Psychiatry 2023, 28: 1079-1089. PMID: 36653677, PMCID: PMC10804423, DOI: 10.1038/s41380-022-01933-9.Peer-Reviewed Original ResearchConceptsSocial anxiety disorderSubcortical brain regionsAnxiety disordersSAD patientsBilateral putamen volumesSubcortical regionsBrain regionsLinear mixed effects analysisComorbid anxiety disordersSubcortical volumesFamily-wise errorPutamen volumeSAD onsetVolumetric differencesPallidum volumeMixed effects analysisD effect sizesInconsistent findingsLeft putamenEffect sizeFull samplePrevious findingsInternational sampleSignificant interactionLimited convergence
2022
Neuroimaging Studies of Brain Structure in Older Adults with Bipolar Disorder: A Review
Rajashekar N, Blumberg HP, Villa LM. Neuroimaging Studies of Brain Structure in Older Adults with Bipolar Disorder: A Review. Journal Of Psychiatry And Brain Science 2022, 7: e220006. PMID: 36092855, PMCID: PMC9453888, DOI: 10.20900/jpbs.20220006.Peer-Reviewed Original ResearchBipolar disorderWhite matterBrain regionsBrain differencesDiffusion-weighted magnetic resonance imaging studiesOlder adultsMagnetic resonance imaging studyMood-stabilizing medicationsWhite matter findingsGray matter reductionsLater lifeCommon mood disorderYounger age groupsResonance imaging studyStructural brain differencesSubcortical brain regionsAdverse outcomesCognitive dysfunctionBrain changesClinical dataMood disordersProtective effectElevated riskHigh riskCognitive symptoms
2020
O2.6. DELUSIONS ASSOCIATED WITH ABNORMAL FRONTOSTRIATAL EFFECTIVE CONNECTIVITY IN A SPECTRAL DCM ANALYSIS OF RESTING STATE FMRI
Okuneye V, Clementz B, Gershon E, Keshavan M, McDowell J, Pearlson G, Tamminga C, Sweeney J, Keedy S. O2.6. DELUSIONS ASSOCIATED WITH ABNORMAL FRONTOSTRIATAL EFFECTIVE CONNECTIVITY IN A SPECTRAL DCM ANALYSIS OF RESTING STATE FMRI. Schizophrenia Bulletin 2020, 46: s5-s5. PMCID: PMC7234244, DOI: 10.1093/schbul/sbaa028.011.Peer-Reviewed Original ResearchR-DLPFCEffective connectivityState effective connectivityDelusional severityPrefrontal cortexState fMRIRight dorsolateral prefrontal cortexVentrolateral prefrontal cortexDynamic causal modelingDorsolateral prefrontal cortexSignificant effective connectivityEffective connectivity resultsEffective connectivity differencesSpectral dynamic causal modelingResting-state fMRISubcortical brain regionsIntermediate Phenotypes (B-SNIP) studyNeurocognitive processesFMRI studyFrontostriatal connectivityPrediction errorVLPFCFalse beliefsDelusion severityDLPFCSpecialized medial prefrontal–amygdala coordination in other-regarding decision preference
Dal Monte O, Chu CCJ, Fagan NA, Chang SWC. Specialized medial prefrontal–amygdala coordination in other-regarding decision preference. Nature Neuroscience 2020, 23: 565-574. PMID: 32094970, PMCID: PMC7131896, DOI: 10.1038/s41593-020-0593-y.Peer-Reviewed Original ResearchConceptsMultiple cognitive operationsRostral anterior cingulate gyrusMedial prefrontal cortexSubcortical brain regionsAnterior cingulate gyrusCognitive operationsGamma frequency bandSocial decisionsSpecialized coordinationPrefrontal cortexNegative ORPSocial behaviorNeural populationsCingulate gyrusBrain regionsBasolateral amygdalaNetwork interactDecision preferencesSpecific directionalityNeuronal interactionsRewardGyrusAmygdalaPreferencesCortex
2017
Altered Functional Connectivity in Sickle Cell Disease Exists at Rest and During Acute Pain Challenge
Zempsky W, Stevens M, Santanelli J, Gaynor A, Khadka S. Altered Functional Connectivity in Sickle Cell Disease Exists at Rest and During Acute Pain Challenge. The Clinical Journal Of Pain 2017, 33: 1060-1070. PMID: 28272117, DOI: 10.1097/ajp.0000000000000492.Peer-Reviewed Original ResearchConceptsSickle cell diseaseChronic pain disordersPain challengePain disordersCell diseaseSomatosensory networkBrain regionsAltered functional connectivityFunctional connectivity abnormalitiesSubcortical brain regionsLower functional integrationDefault mode networkCentral sensitizationRed blood cellsNociceptive informationPain sensitizationChronic painPain responseParietal lobe regionsPressure algometerPainful stimuliNeurodevelopmental abnormalitiesSCD controlsConnectivity abnormalitiesSalience network
2014
Prenatal Cocaine Exposure and Adolescent Neural Responses to Appetitive and Stressful Stimuli
Yip SW, Potenza EB, Balodis IM, Lacadie CM, Sinha R, Mayes LC, Potenza MN. Prenatal Cocaine Exposure and Adolescent Neural Responses to Appetitive and Stressful Stimuli. Neuropsychopharmacology 2014, 39: 2824-2834. PMID: 24903650, PMCID: PMC4200493, DOI: 10.1038/npp.2014.133.Peer-Reviewed Original ResearchConceptsPrenatal cocaine exposureFavorite-food cuesFunctional magnetic resonance imagingPCE adolescentsPrefrontal cortexVentral striatumNeural responsesBrain regionsAdolescents' neural responsesSubjective food cravingsDorsolateral PFC activationSubjective anxiety ratingsDorsolateral prefrontal cortexCocaine exposureSubcortical brain regionsDevelopment of addictionPFC activationEmotional regulationHuman adolescentsSubstance use disordersAppetitive processingMotivational controlAddiction vulnerabilityHippocampus activityFood cravings
2002
Brain mitochondrial uncoupling protein 2 (UCP2): a protective stress signal in neuronal injury
Bechmann I, Diano S, Warden CH, Bartfai T, Nitsch R, Horvath TL. Brain mitochondrial uncoupling protein 2 (UCP2): a protective stress signal in neuronal injury. Biochemical Pharmacology 2002, 64: 363-367. PMID: 12147286, DOI: 10.1016/s0006-2952(02)01166-8.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedBrain InjuriesDisease Models, AnimalEntorhinal CortexGene Transfer TechniquesImmunohistochemistryIon ChannelsLearningMaleMembrane Transport ProteinsMemoryMiceMice, Inbred C57BLMitochondriaMitochondrial ProteinsNerve DegenerationNeuronsProtective AgentsProteinsRatsRats, WistarSignal TransductionStress, PhysiologicalUncoupling Protein 2
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