2025
Understanding the characteristics and comorbidities of primary care patients with risky opioid use: Baseline data from the multi-site “Subthreshold Opioid Use Disorder Prevention” (STOP) Trial
Rostam-Abadi Y, Liebschutz J, Subramaniam G, Stone R, Appleton N, Mazel S, Alexander K, Brill S, Case A, Gelberg L, Gordon A, Hong H, Incze M, Kawasaki S, Kim T, Kline M, Lovejoy T, McCormack J, Zhang S, McNeely J. Understanding the characteristics and comorbidities of primary care patients with risky opioid use: Baseline data from the multi-site “Subthreshold Opioid Use Disorder Prevention” (STOP) Trial. Journal Of General Internal Medicine 2025, 1-10. PMID: 40457116, DOI: 10.1007/s11606-025-09613-4.Peer-Reviewed Original ResearchOpioid use disorderMental health symptomsHigh-risk useOpioid useHealth symptomsConsequences of opioid useSymptoms of opioid use disorderBaseline characteristics of participantsCollaborative care interventionRates of polysubstance usePrimary care patientsPrimary care sitesOpioid use disorder preventionPrimary care settingSelf-reported demographic characteristicsModerate-severe painSevere opioid use disorderCharacteristics of participantsModerate-severe anxietyPrimary careCare interventionsCare sitesCare settingsOpioid medicationsNon-HispanicCare Models to Improve Pain and Reduce Opioids Among Patients Prescribed Long-Term Opioid Therapy
Krebs E, Becker W, Nelson D, DeRonne B, Jensen A, Kats A, Morasco B, Frank J, Makris U, Allen K, Naylor J, Mixon A, Bohnert A, Reznik T, Painter J, Hudson T, Hagedorn H, Manuel J, Borsari B, Purcell N, Hammett P, Amundson E, Kerns R, Barbosa M, Garvey C, Jones E, Noh M, Okere J, Bhushan S, Pinsonnault J, Williams B, Herbst E, Lagisetty P, Librodo S, Mapara P, Son E, Tat C, Marraffa R, Seys R, Baxley C, Seal K, Abelleira A, Adams M, Anicich A, Ankawi B, Arnold S, Aryal A, Atkins D, Atkinson T, Backe K, Bair M, Bajpai S, Baller K, Bangerter A, Barnett S, Bartlett S, Bartnik M, Baskin J, Blehm R, Bloechl P, Boening N, Boesch N, Bolander S, Bolf M, Bonchak J, Booth K, Bordanea M, Borowa D, Bowden M, Britnell S, Broderick D, Bronars C, Brooks K, Brown C, Brudvik E, Buchanan K, Buesgens C, Buonora M, Burch R, Burton C, Butler C, Byerly S, Byrd C, Byrd G, Campbell E, Cariveau D, Carmody S, Carr M, Carr T, Cervone D, Chandler M, Clarke K, Clay M, Coy W, Craine M, Culver D, Cutting A, Dadabayev A, Daly D, Degerstrom R, Denietolis A, DePesa N, Desmet P, Devlin A, Dike D, Diokpa C, Dogra M, Drexler K, Drum-Oden A, Duvall T, Eads F, Edmond S, Eichelsdoerfer E, Ellifritz C, Ellison J, Erwin K, Escobedo C, Feighner L, Feuchs A, Fike A, Finetti T, Franchina L, Freeman J, Frontera R, Galvan R, Gayle S, Givens C, Glenn R, Godwin K, Goldstein M, Gosselin K, Graham S, Grimm K, Gumidyala A, Hagerman C, Hale A, Hall L, Harden J, Hawkins J, Hepton S, Herynk A, Heuermann B, Hidalgo N, Hoffmann J, Holland-deguire C, Hope K, Horowitz D, Huang A, Huffman K, Hunt N, Hyde S, Jacobson K, Johnson E, Kaiser B, Kauzlarich K, Kavathekar R, Knutson R, Kross T, LaHaie E, Lahidji S, Le G, Lelovic M, Lewis M, Linden E, Lindsay D, Lively-Brindley L, Lorenzo J, Luciani L, Lusk C, Mahal-Lichty J, Maloy P, Marcolivio K, Marcy B, Marek L, Mason B, McCamish N, McKissack M, Miller E, Moon J, Morris H, Mundt J, Nazario M, Nelson A, Nichols A, Njau E, Nolan C, Nolan P, Nugent S, Oakley J, Ofstad H, Olney R, Olson J, Ortolan V, Osborne J, Osler B, Packard-Milam M, Palyo S, Patel A, Wiener C, Peter D, Philippe M, Reddy S, Reed J, Rettmann N, Rezaei D, Roberti A, Robinson V, Roca H, Romano E, Rosema T, Rouse R, Rozzero P, Rutks I, Sabet R, Sacra E, Sadowski N, Salameh H, Sandbrink F, Sauve C, Schopmeyer K, Schroeder A, Sculley M, Sellinger J, Sewell K, Shah Barman M, Sharpe P, Sides T, Silver K, Siver M, Sloan J, Smith C, Stevens S, Stoll J, Stoll S, Stoner T, Strand M, Sumner J, Surginer B, Svabek K, Swanson G, Tappainer C, Taylor B, Theis A, Thomas L, Thomas G, Tiene K, Udouj R, Ugbo E, Varughese S, Venkatraman S, Viera K, Walker J, Walker J, Wang G, Watson K, Watson E, Westmoreland W, Wilbur E, Wolfman A, Woloszyn M, Zanga J, Zuniga S. Care Models to Improve Pain and Reduce Opioids Among Patients Prescribed Long-Term Opioid Therapy. JAMA Internal Medicine 2025, 185: 208-220. PMID: 39652356, PMCID: PMC11791716, DOI: 10.1001/jamainternmed.2024.6683.Peer-Reviewed Original ResearchIntegrated Pain TeamLong-term opioid therapyPatients prescribed long-term opioid therapyVeterans Affairs primary care clinicsOpioid therapyPrescribed long-term opioid therapyRandomized comparative effectiveness trialPharmacist care managementCollaborative care interventionPain care planPrimary care clinicsPoor quality of lifeMental health cliniciansOpioid dosageComparative effectiveness trialPain responseDaily dosageModerate to severe chronic painQuality of lifePain careCare modelCare planningCare interventionsCare clinicsOpioid dose reductionAdapting and Implementing a Blended Collaborative Care Intervention for Older Adults with Multimorbidity: Quantitative and Qualitative Results from the ESCAPE Pilot Study
Schulze J, Lühmann D, Nagel J, Regner C, Zelenak C, Bersch K, Herrmann-Lingen C, Burg M, Herbeck-Belnap B. Adapting and Implementing a Blended Collaborative Care Intervention for Older Adults with Multimorbidity: Quantitative and Qualitative Results from the ESCAPE Pilot Study. Behavioral Sciences 2025, 15: 79. PMID: 39851883, PMCID: PMC11762138, DOI: 10.3390/bs15010079.Peer-Reviewed Original ResearchPrimary care providersCare managementHealthcare systemPrimary care provider involvementImprove intervention deliveryPhysical-mental multimorbidityCollaborative care interventionPatient's health goalsEuropean healthcare systemsPilot studyRandomised-controlled trialsSemi-structured interviewsEvaluate goal attainmentCollaborative careFragmented careIntervention deliveryIntervention fidelityCare interventionsCare providersPsychosocial supportCare complexityHealth goalsOlder adultsParticipant satisfactionLifestyle changes
2018
Testing implementation facilitation of a primary care-based collaborative care clinical program using a hybrid type III interrupted time series design: a study protocol
Midboe AM, Martino S, Krein SL, Frank JW, Painter JT, Chandler M, Schroeder A, Fenton BT, Troszak L, Erhardt T, Kerns RD, Becker WC. Testing implementation facilitation of a primary care-based collaborative care clinical program using a hybrid type III interrupted time series design: a study protocol. Implementation Science 2018, 13: 145. PMID: 30486877, PMCID: PMC6262952, DOI: 10.1186/s13012-018-0838-2.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesics, OpioidCooperative BehaviorEvidence-Based PracticeHumansImplementation ScienceInservice TrainingInterrupted Time Series AnalysisPain ManagementPractice Patterns, Physicians'Primary Health CareProgram EvaluationResearch DesignUnited StatesUnited States Department of Veterans AffairsWork EngagementConceptsCollaborative care interventionVeterans Health AdministrationImplementation facilitationPrimary careCare interventionsHigh-dose opioid therapyMorphine equivalent daily doseVHA health care systemClinical programsImplementation facilitation strategyOutpatient opioid prescriptionsOpioid prescribing practicesPain management servicesCollaborative care programEquivalent daily dosePrimary care clinicsPrimary care providersRE-AIM frameworkInterrupted time seriesOpioid overdose crisisHealth care systemInterrupted time series designEligible patientsMedication taperingOpioid therapy
2017
Implementing and Sustaining Team-Based Telecare for Bipolar Disorder: Lessons Learned from a Model-Guided, Mixed Methods Analysis
Bauer MS, Krawczyk L, Tuozzo K, Frigand C, Holmes S, Miller CJ, Abel E, Osser DN, Franz A, Brandt C, Rooney M, Fleming J, Smith E, Godleski L. Implementing and Sustaining Team-Based Telecare for Bipolar Disorder: Lessons Learned from a Model-Guided, Mixed Methods Analysis. Telemedicine Journal And E-Health 2017, 24: 45-53. PMID: 28665773, DOI: 10.1089/tmj.2017.0017.Peer-Reviewed Original ResearchConceptsBipolar disorderHealth Services implementation frameworkComplex mental health conditionsCollaborative care interventionCollaborative care modelIntegrated Promoting ActionTelemental health interventionsMental health conditionsMixed-methods program evaluationElectronic health recordsSite-based analysisClinical trialsCare interventionsCare modelClinical conditionsPromoting ActionHealth interventionsVeterans AffairsHealth conditionsHealth recordsInterventionConsultsFirst yearKey facilitatorsDisorders
2015
Predictors of anxiety recurrence in the Coordinated Anxiety Learning and Management (CALM) trial
Taylor JH, Jakubovski E, Bloch MH. Predictors of anxiety recurrence in the Coordinated Anxiety Learning and Management (CALM) trial. Journal Of Psychiatric Research 2015, 65: 154-165. PMID: 25896121, PMCID: PMC4492801, DOI: 10.1016/j.jpsychires.2015.03.020.Peer-Reviewed Original ResearchConceptsCoordinated Anxiety LearningAnxiety recurrenceAnxiety LearningAnxiety Sensitivity Index scoreUsual careCognitive behavioral therapyRelapse prevention programAnxiety remissionBehavioral therapyAnxiety disordersMultivariable logistic regression modelResidual anxietyCollaborative care interventionPrimary care clinicsPrimary care settingRisk of recurrenceComorbid depressionManagement trialsReceiver Operating CharacteristicLogistic regression modelsMonth 6Care clinicsPrevention programsPrognostic subgroupsCare interventions
2014
Prognostic subgroups for remission and response in the Coordinated Anxiety Learning and Management (CALM) trial.
Kelly JM, Jakubovski E, Bloch MH. Prognostic subgroups for remission and response in the Coordinated Anxiety Learning and Management (CALM) trial. The Journal Of Clinical Psychiatry 2014, 76: 267-78. PMID: 25562579, PMCID: PMC4930076, DOI: 10.4088/jcp.13m08922.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdrenergic Uptake InhibitorsAdultAgedAnti-Anxiety AgentsAnxiety DisordersBenzodiazepinesCognitive Behavioral TherapyCombined Modality TherapyDepressive Disorder, MajorFemaleHumansMaleMiddle AgedOutcome Assessment, Health CarePanic DisorderPhobic DisordersPrognosisRemission InductionSelective Serotonin Reuptake InhibitorsSeverity of Illness IndexSex FactorsSocial ClassSocial SupportStress Disorders, Post-TraumaticYoung AdultConceptsLow socioeconomic statusCoordinated Anxiety LearningUsual careGeneralized anxiety disorderPosttraumatic stress disorderAnxiety disordersBaseline characteristicsPatient characteristicsPrognostic subgroupsAnxiety LearningSocioeconomic statusBaseline patient characteristicsCollaborative care interventionPrimary care settingPoor treatment outcomesCommunity treatment centersDSM-IV criteriaManagement trialsCognitive behavioral therapyLimited social supportExploratory moderator analysesMost patientsRemission criteriaComorbid depressionPrognostic outcomes
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