2022
Associations between moderate alcohol consumption, brain iron, and cognition in UK Biobank participants: Observational and mendelian randomization analyses
Topiwala A, Wang C, Ebmeier KP, Burgess S, Bell S, Levey DF, Zhou H, McCracken C, Roca-Fernández A, Petersen SE, Raman B, Husain M, Gelernter J, Miller KL, Smith SM, Nichols TE. Associations between moderate alcohol consumption, brain iron, and cognition in UK Biobank participants: Observational and mendelian randomization analyses. PLOS Medicine 2022, 19: e1004039. PMID: 35834561, PMCID: PMC9282660, DOI: 10.1371/journal.pmed.1004039.Peer-Reviewed Original ResearchConceptsAlcohol use disorderHigh brain ironModerate alcohol consumptionBrain ironAlcohol consumptionAlcohol intakeUse disordersSubstantia nigraAlcohol-related cognitive declineIron depositionBrain regionsSusceptibility-weighted magnetic resonanceIron accumulationIron levelsBrain iron depositionBrain iron levelsSystemic iron levelsSystemic iron storesAlcohol-related cognitive deficitsBasal ganglia ironElevated liver ironMendelian randomizationWeekly alcohol consumptionUK Biobank participantsExecutive functionPopulation-level risks of alcohol consumption by amount, geography, age, sex, and year: a systematic analysis for the Global Burden of Disease Study 2020
Collaborators G, Bryazka D, Reitsma M, Griswold M, Abate K, Abbafati C, Abbasi-Kangevari M, Abbasi-Kangevari Z, Abdoli A, Abdollahi M, Abdullah A, Abhilash E, Abu-Gharbieh E, Acuna J, Addolorato G, Adebayo O, Adekanmbi V, Adhikari K, Adhikari S, Adnani Q, Afzal S, Agegnehu W, Aggarwal M, Ahinkorah B, Ahmad A, Ahmad S, Ahmad T, Ahmadi A, Ahmadi S, Ahmed H, Rashid T, Akunna C, Al Hamad H, Alam Z, Alem D, Alene K, Alimohamadi Y, Alizadeh A, Allel K, Alonso J, Alvand S, Alvis-Guzman N, Amare F, Ameyaw E, Amiri S, Ancuceanu R, Anderson J, Andrei C, Andrei T, Arabloo J, Arshad M, Artamonov A, Aryan Z, Asaad M, Asemahagn M, Astell-Burt T, Athari S, Atnafu D, Atorkey, Atreya A, Ausloos F, Ausloos M, Ayano G, Ayanore M, Ayinde O, Ayuso-Mateos J, Azadnajafabad S, Azanaw M, Azangou-Khyavy M, Jafari A, Azzam A, Badiye A, Bagheri N, Bagherieh S, Bairwa M, Bakkannavar S, Bakshi R, Balchut/Bilchut A, Bärnighausen T, Barra F, Barrow A, Baskaran P, Belo L, Bennett D, Benseñor I, Bhagavathula A, Bhala N, Bhalla A, Bhardwaj N, Bhardwaj P, Bhaskar S, Bhattacharyya K, Bhojaraja V, Bintoro B, Blokhina E, Bodicha B, Boloor A, Bosetti C, Braithwaite D, Brenner H, Briko N, Brunoni A, Butt Z, Cao C, Cao Y, Cárdenas R, Carvalho A, Carvalho M, Castaldelli-Maia J, Castelpietra G, Castro-de-Araujo L, Cattaruzza M, Chakraborty P, Charan J, Chattu V, Chaurasia A, Cherbuin N, Chu D, Chudal N, Chung S, Churko C, Ciobanu L, Cirillo M, Claro R, Costanzo S, Cowden R, Criqui M, Cruz-Martins N, Culbreth G, Dachew B, Dadras O, Dai X, Damiani G, Dandona L, Dandona R, Daniel B, Danielewicz A, Gela J, Davletov K, de Araujo J, de Sá-Junior A, Debela S, Dehghan A, Demetriades A, Molla M, Desai R, Desta A, da Silva D, Diaz D, Digesa L, Diress M, Dodangeh M, Dongarwar D, Dorostkar F, Dsouza H, Duko B, Duncan B, Edvardsson K, Ekholuenetale M, Elgar F, Elhadi M, Elmonem M, Endries A, Eskandarieh S, Etemadimanesh A, Fagbamigbe A, Fakhradiyev I, Farahmand F, Farinha C, Faro A, Farzadfar F, Fatehizadeh A, Fauk N, Feigin V, Feldman R, Feng X, Fentaw Z, Ferrero S, Desideri L, Filip I, Fischer F, Francis J, Franklin R, Gaal P, Gad M, Gallus S, Galvano F, Ganesan B, Garg T, Gebrehiwot M, Gebremeskel T, Gebremichael M, Gemechu T, Getacher L, Getachew M, Obsa A, Getie A, Ghaderi A, Ghafourifard M, Ghajar A, Ghamari S, Ghandour L, Nour M, Ghashghaee A, Ghozy S, Glozah F, Glushkova E, Godos J, Goel A, Goharinezhad S, Golechha M, Goleij P, Golitaleb M, Greaves F, Grivna M, Grosso G, Gudayu T, Gupta B, Gupta R, Gupta S, Gupta V, Gupta V, Hafezi-Nejad N, Haj-Mirzaian A, Hall B, Halwani R, Handiso T, Hankey G, Hariri S, Haro J, Hasaballah A, Hassanian-Moghaddam H, Hay S, Hayat K, Heidari G, Heidari M, Hendrie D, Herteliu C, Heyi D, Hezam K, Hlongwa M, Holla R, Hossain M, Hossain S, Hosseini S, hosseinzadeh M, Hostiuc M, Hostiuc S, Hu G, Huang J, Hussain S, Ibitoye S, Ilic I, Ilic M, Immurana M, Irham L, Islam M, Islam R, Islam M, Iso H, Itumalla R, Iwagami M, Jabbarinejad R, Jacob L, Jakovljevic M, Jamalpoor Z, Jamshidi E, Jayapal S, Jayarajah U, Jayawardena R, Jebai R, Jeddi S, Jema A, Jha R, Jindal H, Jonas J, Joo T, Joseph N, Joukar F, Jozwiak J, Jürisson M, Kabir A, Kabthymer R, Kamble B, Kandel H, Kanno G, Kapoor N, Karaye I, Karimi S, Kassa B, Kaur R, Kayode G, Keykhaei M, Khajuria H, Khalilov R, Khan I, Khan M, Kim H, Kim J, Kim M, Kimokoti R, Kivimäki M, Klymchuk V, Knudsen A, Kolahi A, Korshunov V, Koyanagi A, Krishan K, Krishnamoorthy Y, Kumar G, Kumar N, Kumar N, Lacey B, Lallukka T, Lasrado S, Lau J, Lee S, Lee W, Lee Y, Lim L, Lim S, Lobo S, Lopukhov P, Lorkowski S, Lozano R, Lucchetti G, Madadizadeh F, Madureira-Carvalho Á, Mahjoub S, Mahmoodpoor A, Mahumud R, Makki A, Malekpour M, Manjunatha N, Mansouri B, Mansournia M, Martinez-Raga J, Martinez-Villa F, Matzopoulos R, Maulik P, Mayeli M, McGrath J, Meena J, Nasab E, Menezes R, Mensink G, Mentis A, Meretoja A, Merga B, Mestrovic T, Jonasson J, Miazgowski B, de Sá A, Miller T, Mini G, Mirica A, Mirijello A, Mirmoeeni S, Mirrakhimov E, Misra S, Moazen B, Mobarakabadi M, Moccia M, Mohammad Y, Mohammadi E, Mohammadian-Hafshejani A, Mohammed T, Moka N, Mokdad A, Momtazmanesh S, Moradi Y, Mostafavi E, Mubarik S, Mullany E, Mulugeta B, Murillo-Zamora E, Murray C, Mwita J, Naghavi M, Naimzada M, Nangia V, Nayak B, Negoi I, Negoi R, Nejadghaderi S, Nepal S, Neupane S, Kandel S, Nigatu Y, Nowroozi A, Nuruzzaman K, Nzoputam C, Obamiro K, Ogbo F, Oguntade A, Okati-Aliabad H, Olakunde B, Oliveira G, Bali A, Omer E, Ortega-Altamirano D, Otoiu A, Otstavnov S, Oumer B, Mahesh P, Padron-Monedero A, Palladino R, Pana A, Panda-Jonas S, Pandey A, Pandey A, Pardhan S, Parekh T, Park E, Parry C, Kan F, Patel J, Pati S, Patton G, Paudel U, Pawar S, Peden A, Petcu I, Phillips M, Pinheiro M, Plotnikov E, Pradhan P, Prashant A, Quan J, Radfar A, Rafiei A, Raghav P, Rahimi-Movaghar V, Rahman A, Rahman M, Rahman M, Rahmani A, Rahmani S, Ranabhat C, Ranasinghe P, Rao C, Rasali D, Rashidi M, Ratan Z, Rawaf D, Rawaf S, Rawal L, Renzaho A, Rezaei N, Rezaei S, Rezaeian M, Riahi S, Romero-Rodríguez E, Roth G, Rwegerera G, Saddik B, Sadeghi E, Sadeghian R, Saeed U, Saeedi F, Sagar R, Sahebkar A, Sahoo H, Sahraian M, Saif-Ur-Rahman K, Salahi S, Salimzadeh H, Samy A, Sanmarchi F, Santric-Milicevic M, Sarikhani Y, Sathian B, Saya G, Sayyah M, Schmidt M, Schutte A, Schwarzinger M, Schwebel D, Seidu A, Kumar N, SeyedAlinaghi S, Seylani A, Sha F, Shahin S, Shahraki-Sanavi F, Shahrokhi S, Shaikh M, Shaker E, Shakhmardanov M, Shams-Beyranvand M, Sheikhbahaei S, Sheikhi R, Shetty A, Shetty J, Shiferaw D, Shigematsu M, Shiri R, Shirkoohi R, Shivakumar K, Shivarov V, Shobeiri P, Shrestha R, Sidemo N, Sigfusdottir I, Silva D, da Silva N, Singh J, Singh S, Skryabin V, Skryabina A, Sleet D, Solmi M, SOLOMON Y, Song S, Song Y, Sorensen R, Soshnikov S, Soyiri I, Stein D, Subba S, Szócska M, Tabarés-Seisdedos R, Tabuchi T, Taheri M, Tan K, Tareke M, Tarkang E, Temesgen G, Temesgen W, Temsah M, Thankappan K, Thapar R, Thomas N, Tiruneh C, Todorovic J, Torrado M, Touvier M, Tovani-Palone M, Tran M, Trias-Llimós S, Tripathy J, Vakilian A, Valizadeh R, Varmaghani M, Varthya S, Vasankari T, Vos T, Wagaye B, Waheed Y, Walde M, Wang C, Wang Y, Wang Y, Westerman R, Wickramasinghe N, Wubetu A, Xu S, Yamagishi K, Yang L, Yesera G, Yigit A, Yiğit V, Yimaw A, Yon D, Yonemoto N, Yu C, Zadey S, Zahir M, Zare I, Zastrozhin M, Zastrozhina A, Zhang Z, Zhong C, Zmaili M, Zuniga Y, Gakidou E. Population-level risks of alcohol consumption by amount, geography, age, sex, and year: a systematic analysis for the Global Burden of Disease Study 2020. The Lancet 2022, 400: 185-235. PMID: 35843246, PMCID: PMC9289789, DOI: 10.1016/s0140-6736(22)00847-9.Peer-Reviewed Original ResearchConceptsTheoretical minimum risk exposure levelStandard drinksAlcohol consumptionGlobal burdenHealth outcomesDisease ratesModerate alcohol consumptionRelative risk curveHealth risksPopulation-level riskAge groupsRisk curvesOverall riskRisk exposure levelAlcohol useHarmful amountsMelinda Gates FoundationHealth lossYoung individualsExposure levelsAgeRiskSexDrinksDays
2020
The Moderate Alcohol and Cardiovascular Health Trial (MACH15): Design and methods for a randomized trial of moderate alcohol consumption and cardiometabolic risk
Spiegelman D, Lovato LC, Khudyakov P, Wilkens TL, Adebamowo CA, Adebamowo SN, Appel LJ, Beulens JW, Coughlin JW, Dragsted LO, Edenberg HJ, Eriksen JN, Estruch R, Grobbee DE, Gulayin PE, Irazola V, Krystal JH, Lazo M, Murray MM, Rimm EB, Schrieks IC, Williamson JD, Mukamal KJ. The Moderate Alcohol and Cardiovascular Health Trial (MACH15): Design and methods for a randomized trial of moderate alcohol consumption and cardiometabolic risk. European Journal Of Preventive Cardiology 2020, 27: 1967-1982. PMID: 32250171, PMCID: PMC7541556, DOI: 10.1177/2047487320912376.Peer-Reviewed Original ResearchConceptsModerate alcohol consumptionCardiovascular Health TrialAlcohol consumptionHealth trialsCardiovascular diseaseModerate alcoholNon-fatal ischemic strokeNon-fatal myocardial infarctionPrimary composite endpointCongestive heart failureCoronary heart diseaseModerate alcohol consumersAdults 50 yearsPublic health guidelinesAlcohol use disorderPreferred alcoholic beverageCardiometabolic effectsCardiometabolic riskCarotid revascularizationIschemic strokeSecondary outcomesComposite endpointHeart failurePrimary outcomeMyocardial infarction
2016
Moderate Alcohol Consumption and Chronic Disease: The Case for a Long‐Term Trial
Mukamal KJ, Clowry CM, Murray MM, Hendriks HF, Rimm EB, Sink KM, Adebamowo CA, Dragsted LO, Lapinski PS, Lazo M, Krystal JH. Moderate Alcohol Consumption and Chronic Disease: The Case for a Long‐Term Trial. Alcohol Clinical And Experimental Research 2016, 40: 2283-2291. PMID: 27688006, PMCID: PMC5073014, DOI: 10.1111/acer.13231.Peer-Reviewed Original ResearchConceptsModerate alcohol consumptionChronic diseasesAlcohol consumptionRandomized trialsLong-term clinical trialsCoronary heart diseaseMajor chronic diseasesStrong epidemiological associationLong-term trialsGold standard evidenceNutritional interventionHeart diseaseClinical trialsBreast cancerEpidemiological associationModerate drinkingYears durationClinical investigatorsBiological mediatorsAvailable evidenceDiseaseObserved associationsTrialsStandard evidenceVariety of settings
2015
Risk factors for anthracycline-associated cardiotoxicity
Reinbolt R, Patel R, Pan X, Timmers C, Pilarski R, Shapiro C, Lustberg M. Risk factors for anthracycline-associated cardiotoxicity. Supportive Care In Cancer 2015, 24: 2173-2180. PMID: 26563179, PMCID: PMC4874738, DOI: 10.1007/s00520-015-3008-y.Peer-Reviewed Original ResearchConceptsSingle nucleotide polymorphismsAnthracycline cardiotoxicityRisk factorsAlcoholic drinks/weekFemale breast cancer patientsHigher cardiotoxicity riskDrinks/weekModerate alcohol consumptionAnthracycline-associated cardiotoxicityBreast cancer patientsCases of cardiotoxicityMajor alleleEjection fractionPediatric patientsCancer patientsCardiotoxicity riskLower riskTherapeutic strategiesAlcohol consumptionCardiotoxicityMultivariate analysisLogistic regressionPatientsGenomic predictorsSignificant correlationHigh Blood Pressure and Related Factors Among Individuals at High Risk for HIV/Sexually Transmitted Infections
Nam S, Whittemore R, Jeon S, Davey-Rothwell MA, Latkin C. High Blood Pressure and Related Factors Among Individuals at High Risk for HIV/Sexually Transmitted Infections. Journal Of Clinical Hypertension 2015, 18: 572-580. PMID: 26514661, PMCID: PMC4851924, DOI: 10.1111/jch.12714.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusBlood pressureHigh riskHigher SBPSystolic/diastolic blood pressureCardiovascular disease risk factorsPoor self-reported healthInfection prevention studiesDiastolic blood pressureDisease risk factorsHigh blood pressureHIV/STIModerate alcohol consumptionHIV/STIsCardiovascular disease programsSelf-reported healthHIV/Older patientsImmunodeficiency virusHigher DBPAlcohol drinkingPrevention StudyRisk factorsGeneral healthDepressive symptomsAcute alcohol consumption elevates serum bilirubin: An endogenous antioxidant
O’Malley S, Gueorguieva R, Wu R, Jatlow PI. Acute alcohol consumption elevates serum bilirubin: An endogenous antioxidant. Drug And Alcohol Dependence 2015, 149: 87-92. PMID: 25707709, PMCID: PMC4540054, DOI: 10.1016/j.drugalcdep.2015.01.023.Peer-Reviewed Original ResearchConceptsSerum bilirubinAlcohol consumptionBilirubin concentrationReduced riskTotal serum bilirubin concentrationModerate alcohol consumptionFavorable effectSerum bilirubin concentrationIndirect bilirubin concentrationsFuture longitudinal studiesMixed effects regression modelsCause mortalityBlood concentrationsCardiovascular diseaseAlcohol abstinenceHealthy individualsEndogenous antioxidantsBilirubinRandom orderNext morningEffects regression modelsLongitudinal studyNonsmokersAntioxidant propertiesBaselineChapter 1 Introduction Research Misconduct in Biomedical Research Institutions
Snyder P, Mayes L, Smith W. Chapter 1 Introduction Research Misconduct in Biomedical Research Institutions. 2015, 1-12. DOI: 10.1016/b978-0-12-405198-0.00001-1.Peer-Reviewed Original ResearchCardiac healthModerate alcohol consumptionSimple lifestyle changesCertain health benefitsPositive health effectsAlcohol ingestionLifestyle changesAge-related memory declineAlcohol consumptionAlzheimer's diseaseClinical investigatorsProtective factorsHealth effectsHealth benefitsDiseaseMemory declineNumerous reportsAlcoholic beveragesHealthRiskCancerProgressionIngestion
2012
Tobacco Quitlines Need to Assess and Intervene with Callers' Hazardous Drinking
Toll BA, Cummings KM, O'Malley SS, Carlin‐Menter S, McKee SA, Hyland A, Wu R, Hopkins J, Celestino P. Tobacco Quitlines Need to Assess and Intervene with Callers' Hazardous Drinking. Alcohol Clinical And Experimental Research 2012, 36: 1653-1658. PMID: 22703028, PMCID: PMC3436938, DOI: 10.1111/j.1530-0277.2012.01767.x.Peer-Reviewed Original ResearchConceptsSmoking cessation ratesCessation ratesBrief alcohol interventionHazardous drinkingHigh-risk drinkersQuitline callersTobacco quitlineCessation outcomesNIAAA guidelinesAlcohol interventionsLower smoking cessation ratesModerate alcohol consumptionShort-term followQuarter of smokersHazardous drinking patternsHigh rateSmoking cessationDaily smokersModerate drinkersSmoking relapseHazardous drinkersAlcohol consumptionSmokersDrinking patternsQuitline
2009
Alcohol and Tobacco Use Prediagnosis and Postdiagnosis, and Survival in a Cohort of Patients with Early Stage Cancers of the Oral Cavity, Pharynx, and Larynx
Mayne ST, Cartmel B, Kirsh V, Goodwin WJ. Alcohol and Tobacco Use Prediagnosis and Postdiagnosis, and Survival in a Cohort of Patients with Early Stage Cancers of the Oral Cavity, Pharynx, and Larynx. Cancer Epidemiology Biomarkers & Prevention 2009, 18: 3368-3374. PMID: 19959684, PMCID: PMC2789339, DOI: 10.1158/1055-9965.epi-09-0944.Peer-Reviewed Original ResearchConceptsNeck cancerAlcohol historySurvivors of headCohort of patientsModerate alcohol consumptionDrinks/dEarly-stage headUse of tobaccoEarly-stage cancerFirst cancerSurvivorship careInitial diagnosisCessation effortsPoor survivalMortality riskStage cancerHigh riskOral cavityStage headRecent survivorsAlcohol consumptionContinued drinkingPatientsCancerLiquor consumption
2006
Light to Moderate Alcohol Consumption Is Associated With Better Cognitive Function Among Older Male Veterans Receiving Primary Care
Reid MC, Van Ness PH, Hawkins KA, Towle V, Concato J, Guo Z. Light to Moderate Alcohol Consumption Is Associated With Better Cognitive Function Among Older Male Veterans Receiving Primary Care. Journal Of Geriatric Psychiatry And Neurology 2006, 19: 98-105. PMID: 16690995, DOI: 10.1177/0891988706286513.Peer-Reviewed Original ResearchConceptsModerate alcohol consumptionOlder male veteransBetter cognitive functionCognitive functionFormer drinkersPrimary careMale veteransModerate drinkingAlcohol consumptionBetter cognitive performanceOlder personsVeterans Administration primary care clinicCognitive performancePrimary care clinicsHopkins Verbal Learning TestCare clinicsVerbal Learning TestMean ageCurrent drinkersMedical statusOlder menReference groupLifetime useLearning TestDrinkers
2005
Low-to-Moderate Alcohol Intake and Health Status in Heart Failure Patients
Salisbury AC, House JA, Conard MW, Krumholz HM, Spertus JA. Low-to-Moderate Alcohol Intake and Health Status in Heart Failure Patients. Journal Of Cardiac Failure 2005, 11: 323-328. PMID: 15948080, DOI: 10.1016/j.cardfail.2004.11.009.Peer-Reviewed Original ResearchConceptsKansas City Cardiomyopathy QuestionnaireModerate alcohol intakeHealth statusHF hospitalizationAlcohol intakeAlcohol abstinenceBaseline Kansas City Cardiomyopathy QuestionnaireShort Form-12 scoresComplete alcohol abstinenceHeart failure guidelinesMulticenter observational studyHeart failure patientsModerate alcohol consumptionSF-12 scoresKCCQ scoresHF outpatientsHF patientsFailure patientsMultivariable analysisBaseline differencesObservational studyModerate drinkersAlcohol consumptionSimilar outcomesAlcohol useAlcohol consumption and high-density lipoprotein levels: the effect of ADH1C genotype, gender and menopausal status
Hines LM, Hunter DJ, Stampfer MJ, Spiegelman D, Chu NF, Rifai N, Hankinson SE, Rimm EB. Alcohol consumption and high-density lipoprotein levels: the effect of ADH1C genotype, gender and menopausal status. Atherosclerosis 2005, 182: 293-300. PMID: 16051248, DOI: 10.1016/j.atherosclerosis.2005.02.005.Peer-Reviewed Original ResearchConceptsHigh-density lipoprotein levelsPostmenopausal hormonesPostmenopausal womenModerate alcohol consumptionHDL levelsOlder-aged menPremenopausal womenAlcohol consumptionADH1C genotypeLipoprotein levelsAged menCoronary heart diseaseMenopausal statusExogenous estrogenMyocardial infarctionHeart diseaseModerate drinkersOlder menFunctional polymorphismsWomenType 1CMenVaried exposureAssociationHigh levels
2003
A Cross-Sectional Study of Alcohol Consumption Patterns and Biologic Markers of Glycemic Control Among 459 Women
Kroenke CH, Chu NF, Rifai N, Spiegelman D, Hankinson SE, Manson JE, Rimm EB. A Cross-Sectional Study of Alcohol Consumption Patterns and Biologic Markers of Glycemic Control Among 459 Women. Diabetes Care 2003, 26: 1971-1978. PMID: 12832298, DOI: 10.2337/diacare.26.7.1971.Peer-Reviewed Original ResearchConceptsHealth Study IIGlycemic controlAlcohol intakeBiologic markersNurses' Health Study IIBeneficial glycemic effectsAverage alcohol intakeModerate alcohol consumptionMain outcome measuresCross-sectional studyYears of ageAlcohol consumption patternsOverweight womenGlycemic effectsInsulin levelsLifestyle factorsInsulin resistanceDietary factorsInverse associationC-peptideAverage daily consumptionOutcome measuresPhysical activityBlood samplesAlcohol consumptionAlcohol Consumption Patterns and HbA1c, C-Peptide and Insulin Concentrations in Men
Meyer KA, Conigrave KM, Chu NF, Rifai N, Spiegelman D, Stampfer MJ, Rimm EB. Alcohol Consumption Patterns and HbA1c, C-Peptide and Insulin Concentrations in Men. Journal Of The American Nutrition Association 2003, 22: 185-194. PMID: 12805244, DOI: 10.1080/07315724.2003.10719292.Peer-Reviewed Original ResearchConceptsC-peptideInsulin concentrationsAverage alcohol consumptionAlcohol consumptionAlcohol consumption patternsBlood samplesStudy participantsDrinking patternsDisease-free menC-peptide concentrationsModerate alcohol consumptionCross-sectional studyYears of ageFrequent alcohol consumptionFrequency of consumptionEffects of alcoholInsulin levelsBiologic markersInsulin sensitivityInverse associationAverage daily consumptionIrregular drinkersObservational studyAnalysis of insulinHealth professionals
2002
A patient with autoimmune hepatitis type I, Addison's disease, atrophic thyroiditis, atrophic gastritis, exocrine pancreatic insufficiency, and heterozygous α1-antitrypsin deficiency
Bergwitz C, Trautwein C, Brabant G, Manns MP. A patient with autoimmune hepatitis type I, Addison's disease, atrophic thyroiditis, atrophic gastritis, exocrine pancreatic insufficiency, and heterozygous α1-antitrypsin deficiency. The American Journal Of Gastroenterology 2002, 97: 1050. PMID: 12003388, DOI: 10.1111/j.1572-0241.2002.05628.x.Peer-Reviewed Original ResearchConceptsModerate alcohol consumptionAtrophic gastritisAutoimmune hepatitisAddison's diseaseAlcohol consumptionAssociation of autoimmune hepatitisAutoimmune hepatitis type IHeterozygous alpha1-antitrypsin deficiencyHeterozygous α1-Antitrypsin DeficiencyHistory of Addison's diseaseSerum alpha1-antitrypsin levelsDiagnosis of autoimmune hepatitisDecompensated liver cirrhosisDevelopment of cirrhosisSevere atrophic gastritisAdditional risk factorsAlpha1-antitrypsin deficiencyAlpha1-antitrypsin levelsΑ1-antitrypsin deficiencyAlpha1-antitrypsin geneExocrine pancreatic insufficiencyAtrophic thyroiditisHydrocortisone therapyAdrenal insufficiencyLiver biopsy
2001
Moderate Alcohol Consumption and Risk of Heart Failure Among Older Persons
Abramson JL, Williams SA, Krumholz HM, Vaccarino V. Moderate Alcohol Consumption and Risk of Heart Failure Among Older Persons. JAMA 2001, 285: 1971-1977. PMID: 11308433, DOI: 10.1001/jama.285.15.1971.Peer-Reviewed Original ResearchConceptsModerate alcohol consumptionHeart failureHeart failure ratesMyocardial infarctionAlcohol consumptionOlder personsNonfatal heart failure eventsHistory of MIHeart failure eventsProspective cohort studyHeart failure riskBody mass indexPopulation-based sampleCohort studyCurrent smokingMass indexMI riskPulse pressureFailure rateRelative riskAmount of alcoholMAIN OUTCOMELower riskElderly personsBaseline
2000
Prospective Study of Alcohol Consumption and the Risk of Age-Related Macular Degeneration
Cho E, Hankinson SE, Willett WC, Stampfer MJ, Spiegelman D, Speizer FE, Rimm EB, Seddon JM. Prospective Study of Alcohol Consumption and the Risk of Age-Related Macular Degeneration. JAMA Ophthalmology 2000, 118: 681-688. PMID: 10815161, DOI: 10.1001/archopht.118.5.681.Peer-Reviewed Original ResearchConceptsAge-related macular degenerationRisk of AMDProspective studyMacular degenerationAlcohol consumptionRelative riskDiagnosis of AMDSemiquantitative food frequency questionnaireMale health professionalsPooled relative riskFood frequency questionnaireModerate alcohol consumptionVisual acuity lossConfidence intervalsRisk of AgeRelationship of alcoholYears of ageAlcohol intakeAcuity lossRisk factorsPooled estimatesFemale nursesHealth professionalsAdditional subjectsWomen
1999
Alcohol consumption in relation to breast cancer risk in a cohort of United States women 25-42 years of age.
Garland M, Hunter DJ, Colditz GA, Spiegelman DL, Manson JE, Stampfer MJ, Willett WC. Alcohol consumption in relation to breast cancer risk in a cohort of United States women 25-42 years of age. Cancer Epidemiology Biomarkers & Prevention 1999, 8: 1017-21. PMID: 10566558.Peer-Reviewed Original ResearchConceptsBreast cancer riskMultivariate relative riskAlcohol consumptionCancer riskRelative riskBreast cancerDrinks/weekInvasive breast cancerModerate alcohol consumptionMore drinks/weekAverage lifetime alcohol consumptionLifetime alcohol consumptionWomen age 25Past alcohol consumptionYears of agePostmenopausal womenPremenopausal womenWomen 25Age 25Young womenHeavy drinkingAge 23Drinking levelsWomenFurther studies
1997
Low-to-moderate gestational alcohol use and intrauterine growth retardation, low birthweight, and preterm delivery
Lundsberg L, Bracken M, Saftlas A. Low-to-moderate gestational alcohol use and intrauterine growth retardation, low birthweight, and preterm delivery. Annals Of Epidemiology 1997, 7: 498-508. PMID: 9349918, DOI: 10.1016/s1047-2797(97)00081-1.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcohol DrinkingCohort StudiesConfounding Factors, EpidemiologicConnecticutFemaleFetal Growth RetardationGestational AgeHumansInfant, Low Birth WeightInfant, NewbornLogistic ModelsMaternal-Fetal ExchangeMultivariate AnalysisObstetric Labor, PrematurePregnancyPregnancy ComplicationsPregnancy OutcomeProspective StudiesRisk FactorsSmokingConceptsIntrauterine growth retardationPreterm deliveryLow birthweightGrowth retardationMild drinkingProtective effectAlcohol useYale-New Haven HospitalGestational alcohol useAdverse perinatal outcomesModerate alcohol consumptionSingleton live birthsObserved protective effectFetal alcohol syndromeNeonatal outcomesPerinatal outcomesAbsolute alcoholMonth 7Alcohol drinkingProspective InvestigationRisk factorsMonths 1Live birthsLight drinkingAlcohol syndrome
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