2025
P-912. A 10-Year Retrospective, Single-Center Analysis of Nocardiosis in Immunocompetent and Immunocompromised Hosts: Clinical and Microbiological Features, Treatment Outcomes, and Determinants of Central Nervous System Involvement
Roman F, Grubman A, Azar M, Farhadian S. P-912. A 10-Year Retrospective, Single-Center Analysis of Nocardiosis in Immunocompetent and Immunocompromised Hosts: Clinical and Microbiological Features, Treatment Outcomes, and Determinants of Central Nervous System Involvement. Open Forum Infectious Diseases 2025, 12: ofae631.1103. PMCID: PMC11778850, DOI: 10.1093/ofid/ofae631.1103.Peer-Reviewed Original ResearchCentral nervous system involvementCentral nervous systemCNS involvementHost immune statusImmune statusImmunocompromised hostsUnivariate analysisAssociated with CNS involvementCentral nervous system nocardiosisRecipients of solid organ transplantsRisk of CNS involvementNet state of immunosuppressionAssociated with central nervous systemIdentification of Nocardia sppMultivariate logistic regression analysisSingle-center analysisStem cell transplantationState of immunosuppressionAssociated with increased riskCNS diseaseIndependent risk factorSolid organ transplantationNervous system involvementIsolates of NocardiaLogistic regression analysis
2024
7418 Xanthoma Disseminatum - A Rare cause of Diabetes Insipidus
Balasubramanian P, Cohen J, Corbin Z, Panse G, Inzucchi S. 7418 Xanthoma Disseminatum - A Rare cause of Diabetes Insipidus. Journal Of The Endocrine Society 2024, 8: bvae163.1380. PMCID: PMC11454384, DOI: 10.1210/jendso/bvae163.1380.Peer-Reviewed Original ResearchCentral diabetes insipidusDiabetes insipidusSystem involvementXanthoma disseminatumOvernight water deprivation testPartial central diabetes insipidusCentral nervous system involvementPituitary stalk involvementDegree of hypopituitarismNon-Langerhans cell histiocytosisVariable degrees of hypopituitarismAnterior pituitary functionResolution of symptomsWater deprivation testNervous system involvementSymptoms of polyuriaMRI pituitaryStalk involvementPituitary involvementHypogonadotropic hypogonadismIV contrastSpontaneous regressionPituitary functionPituitary stalkSerum sodiumNeurological complications of medical therapies in haematological malignancies
Baehring J, Soussain C. Neurological complications of medical therapies in haematological malignancies. 2024, 109-122. DOI: 10.1093/med/9780198884903.003.0008.Peer-Reviewed Original ResearchChimeric antigen receptorStem cell transplantationHaematological malignanciesCell transplantationMedical therapyNeurological complicationsAssociated with posterior reversible encephalopathy syndromeAllogeneic stem cell transplantationGraft-versus-host diseasePosterior reversible encephalopathy syndromeRisk of opportunistic infectionsCerebrospinal fluidHaematopoietic stem cell transplantationCentral nervous system involvementComplications of medical therapySpectrum of neurological complicationsT-cell therapyGraft-versus-hostTumor lysis syndromeReversible encephalopathy syndromeDural sinus thrombosisNervous system involvementBispecific monoclonal antibodyAdaptive immune systemSpecific to patients
2023
Recurrent petit mal seizures in Erdheim-Chester disease mimicking an intra-axial brain tumor: illustrative case
Stuebe C, Jenson A, Lines T, Holloman A, Cykowski M, Fung S, Fisher R, McClain K, Baskin D. Recurrent petit mal seizures in Erdheim-Chester disease mimicking an intra-axial brain tumor: illustrative case. Journal Of Neurosurgery Case Lessons 2023, 6: case23248. PMID: 37870750, PMCID: PMC10584085, DOI: 10.3171/case23248.Peer-Reviewed Original ResearchErdheim-Chester diseaseMagnetic resonance imagingPetit mal seizuresLeft temporal lesionCell histiocytosisTemporal lesionsBiopsy-proven Erdheim-Chester diseaseRepeat magnetic resonance imagingCentral nervous system involvementIntra-axial brain tumorsSerial magnetic resonance imagingNon-Langerhans cell histiocytosisMesial temporal lobe lesionsNervous system involvementTemporal lobe tumorsWide differential diagnosisTouton giant cellsLangerhans cell histiocytosisBackground of fibrosisTemporal lobe lesionsBRAF V600E mutationBone painSingular symptomsSeizure controlSeizure frequencyBridging Radiotherapy Prior to Chimeric Antigen Receptor T-Cell Therapy for B-Cell Lymphomas: An ILROG Multi-Institutional Study
Yegya-Raman N, Wright C, Ladbury C, Chew J, Zhang S, Sun S, Burke S, Baron J, Sim A, LaRiviere M, Yang J, Robinson T, Tseng Y, Terezakis S, Braunstein S, Dandapani S, Schuster S, Chong E, Plastaras J, Figura N. Bridging Radiotherapy Prior to Chimeric Antigen Receptor T-Cell Therapy for B-Cell Lymphomas: An ILROG Multi-Institutional Study. International Journal Of Radiation Oncology • Biology • Physics 2023, 117: s50-s51. DOI: 10.1016/j.ijrobp.2023.06.333.Peer-Reviewed Original ResearchImmune effector cell-associated neurotoxicity syndromeProgression-free survivalCytokine release syndromeB-cell lymphomaChimeric antigen receptor T-cell therapySuperior progression-free survivalLarge B-cell lymphomaCAR-T infusionT-cell therapyMulti-institutional studyOverall survivalCTCAE v5.0T infusionTisa-celCAR TRefractory aggressive B-cell lymphomasStage III/IV diseaseT-cell/histiocyte-rich large B-cell lymphomaFavorable progression-free survivalCentral nervous system involvementDiffuse large B-cell lymphomaAggressive B-cell lymphomasPrimary mediastinal B-cell lymphomaMediastinal B-cell lymphomaNervous system involvement
2022
Correction to: Clinical features and high-risk indicators of central nervous system involvement in primary Sjögren’s syndrome
Fan W, Par-Young J, Li K, Zhang Y, Xiao P, Hua L, Leng L, Chen X, Bucala R. Correction to: Clinical features and high-risk indicators of central nervous system involvement in primary Sjögren’s syndrome. Clinical Rheumatology 2022, 42: 643-643. PMID: 36565380, PMCID: PMC9873696, DOI: 10.1007/s10067-022-06488-2.Peer-Reviewed Original ResearchClinical features and high-risk indicators of central nervous system involvement in primary Sjögren’s syndrome
Fan W, Par-Young J, Li K, Zhang Y, Xiao P, Hua L, Leng L, Chen X, Bucala R. Clinical features and high-risk indicators of central nervous system involvement in primary Sjögren’s syndrome. Clinical Rheumatology 2022, 42: 443-451. PMID: 36401063, PMCID: PMC9873757, DOI: 10.1007/s10067-022-06448-w.Peer-Reviewed Original ResearchConceptsCentral nervous system involvementNervous system involvementPotential risk factorsPrimary Sjögren's syndrome patientsHigh-dose glucocorticoidsSjögren's syndrome patientsCNS involvementSystem involvementHigh-risk indicatorsImmunosuppressive therapyLung involvementSyndrome patientsC3 levelsRisk factorsPulmonary involvementPS patientsHigh-dose glucocorticoid administrationMultivariate logistic regression analysisAnti-SSA positivityHigh titer ANAAnti-SSA antibodiesLow C3 levelsPrimary Sjögren's syndromeComplement 4 levelsLogistic regression analysisHigh-Grade B-Cell Lymphoma, Not Otherwise Specified (HGBL, NOS): Central Nervous System (CNS) Involvement, Prophylaxis, and Recurrence Risk in a Multi-Institutional Series
Epperla N, Zayac A, Landsburg D, Hughes M, Bock A, Nowakowski G, Ayers E, Girton M, Hu M, Beckman A, Li S, Medeiros L, Chang J, Stepanovic A, Kurt H, Sandoval-Sus J, Ansari-Lari M, Kothari S, Kress A, Xu M, Torka P, Sundaram S, Smith S, Naresh K, Karimi Y, Bond D, Farooq U, Saad M, Evens A, Pandya K, Naik S, Kamdar M, Haverkos B, Karmali R, Oh T, Vose J, Nutsch H, Rubinstein P, Chaudhry A, Olszewski A. High-Grade B-Cell Lymphoma, Not Otherwise Specified (HGBL, NOS): Central Nervous System (CNS) Involvement, Prophylaxis, and Recurrence Risk in a Multi-Institutional Series. Blood 2022, 140: 3839-3841. DOI: 10.1182/blood-2022-157105.Peer-Reviewed Original Research
2021
High-Grade B-Cell Lymphoma, Not Otherwise Specified (HGBL, NOS): Characteristics, Treatment, and Outcomes from 17 Academic US Centers
Zayac A, Landsburg D, Hughes M, Ayers E, Girton M, Hu M, Beckman A, Li S, Medeiros L, Kurt H, Sandoval-Sus J, Ansari-Lari M, Kothari S, Kress A, Xu M, Torka P, Sundaram S, Smith S, Naresh K, Karimi Y, Epperla N, Bond D, Evens A, Pandya K, Naik S, Kamdar M, Haverkos B, Karmali R, Oh T, Vose J, Nutsch H, Rubinstein P, Chaudhry A, Olszewski A. High-Grade B-Cell Lymphoma, Not Otherwise Specified (HGBL, NOS): Characteristics, Treatment, and Outcomes from 17 Academic US Centers. Blood 2021, 138: 455. DOI: 10.1182/blood-2021-144308.Peer-Reviewed Original ResearchInternational Prognostic IndexDA-EPOCHOverall survivalComplete responseB-cell lymphomaWorld Health OrganizationSpeakers bureauADC therapeuticsLactate dehydrogenaseCommon first-line regimensHigh serum lactate dehydrogenaseAdvisory board membersChimeric antigen receptor T cellsCentral nervous system involvementAntigen receptor T cellsGrade B-cell lymphomaAdvisory CommitteeAggressive B-cell lymphomasMYC extra copiesPoor performance statusOutcomes of patientsDe novo tumorsFirst-line regimensNervous system involvementGerminal center B-cell phenotypeLymphoplasmacytic lymphoma manifesting as a cervical spine mass with Parkinson-like symptoms treated with ibrutinib
Tan E, Tran N, Peguero E, Robinson T, Gaballa S. Lymphoplasmacytic lymphoma manifesting as a cervical spine mass with Parkinson-like symptoms treated with ibrutinib. Current Problems In Cancer Case Reports 2021, 3: 100046. DOI: 10.1016/j.cpccr.2020.100046.Peer-Reviewed Original ResearchParkinson-like symptomsCentral nervous system involvementNervous system involvementEfficacy of ibrutinibIgM monoclonal gammopathyRare B-cell malignancyB-cell malignanciesLymphoma involvementPatient's symptomsRare presentationLumbar punctureDiagnostic workupSystem involvementMonoclonal gammopathyLymphoplasmacytic lymphomaPatient historyLow doseBone marrowSymptomsIbrutinibLPLInvolvementBiopsyPatientsGammopathyA Rare Case of Steroid-Resistant Neurosarcoidosis of the Cavernous Sinus With Optic Neuropathy: A Case Report
Barforoshi S, Patel N, Singh A, Li T, Mba B. A Rare Case of Steroid-Resistant Neurosarcoidosis of the Cavernous Sinus With Optic Neuropathy: A Case Report. The Neurohospitalist 2021, 11: 356-359. PMID: 34567398, PMCID: PMC8442148, DOI: 10.1177/1941874421993644.Peer-Reviewed Original ResearchCase of neurosarcoidosisCavernous sinusOptic neuropathyProbable neurosarcoidosisMycophenolate mofetilCombination therapyCentral nervous system inflammationRight-sided vision lossTreatment of neurosarcoidosisAnti-TNF agentsNervous system inflammationNervous system involvementRight cavernous sinusRight optic nervePast medical historySystemic granulomatous diseaseAcute exacerbationAcute relapseRenal sarcoidosisBilateral hilarProgressive headacheSystem inflammationAggressive treatmentMediastinal lymphadenopathyPathological confirmation
2020
Endogenous Endophthalmitis Heralding Central Nervous System Involvement by Nocardia Farcinica
Aguirre L, Zamora Gonzalez R, Barreto-Coelho P, Yannuzzi N, Taldone S. Endogenous Endophthalmitis Heralding Central Nervous System Involvement by Nocardia Farcinica. Cureus 2020, 12: e9896. PMID: 32968562, PMCID: PMC7505538, DOI: 10.7759/cureus.9896.Peer-Reviewed Original ResearchFocal neurological deficitsNeurological deficitsCentral nervous system involvementGenus NocardiaChronic immunosuppressive therapyNervous system involvementPotential pathogensGram-positiveEndogenous endophthalmitisImmunosuppressive therapyImmunosuppressed patientsImmunocompromised hostsNocardia farcinicaOpportunistic infectionsNeurological compromiseFilamentous bacteriaSuppurative diseaseSystem involvementAcid-fastEarly recognitionNocardiaElderly malesVisual symptomsGenusPathogensPD-1/PD-L1 Blockers in NSCLC Brain Metastases: Challenging Paradigms and Clinical Practice
Eguren-Santamaria I, Sanmamed MF, Goldberg SB, Kluger HM, Idoate MA, Lu B, Corral J, Schalper KA, Herbst RS, Gil-Bazo I. PD-1/PD-L1 Blockers in NSCLC Brain Metastases: Challenging Paradigms and Clinical Practice. Clinical Cancer Research 2020, 26: 4186-4197. PMID: 32354698, DOI: 10.1158/1078-0432.ccr-20-0798.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerImmune checkpoint inhibitorsAnti-PD-1/PD-L1 antibodiesAdvanced non-small cell lung cancerNSCLC brain metastasesBrain metastasesPD-L1 antibodiesAnti-PD-1/PD-L1 agentsPD-1/PD-L1 blockersActive central nervous system (CNS) involvementHigh PD-L1 expressionAnti-PD-1/PD-L1 drugsCentral nervous system involvementPivotal phase III trialsActive brain metastasesCNS response ratesPD-L1 agentsPD-L1 blockersSystemic therapy combinationsNervous system involvementPD-L1 expressionPhase III trialsSubset of patientsCell lung cancerPD-L1 drugs
2019
Perihematomal Edema After Intracerebral Hemorrhage in Patients With Active Malignancy
Gusdon AM, Nyquist PA, Torres-Lopez VM, Leasure AC, Falcone GJ, Sheth KN, Sansing LH, Hanley DF, Malani R. Perihematomal Edema After Intracerebral Hemorrhage in Patients With Active Malignancy. Stroke 2019, 51: 129-136. PMID: 31744426, PMCID: PMC7048624, DOI: 10.1161/strokeaha.119.027085.Peer-Reviewed Original ResearchConceptsBlood product transfusionThirty-day mortalityIntracerebral hemorrhagePerihematomal edemaActive malignancyProduct transfusionPHE volumeICH volumeActive cancerPHE growthPlatelet transfusionsCentral nervous system involvementRecurrence of malignancyNervous system involvementNontraumatic intracerebral hemorrhageCancer-specific dataPHE expansionRecent chemotherapyChart reviewConclusions PatientsControl patientsMost patientsHematoma volumeInstitutional databaseSystem involvementCentral Nervous System Involvement in ANCA-Associated Vasculitis: What Neurologists Need to Know
Zheng Y, Zhang Y, Cai M, Lai N, Chen Z, Ding M. Central Nervous System Involvement in ANCA-Associated Vasculitis: What Neurologists Need to Know. Frontiers In Neurology 2019, 9: 1166. PMID: 30687221, PMCID: PMC6335277, DOI: 10.3389/fneur.2018.01166.Peer-Reviewed Original ResearchAnti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitisPosterior reversible encephalopathy syndromeCentral nervous systemSpinal cordANCA serotypeANCA testingClinical spectrumInitiation of induction therapySpectrum of CNS involvementAncillary investigationsAntibody (ANCA)-associated vasculitisPauci-immune small vessel vasculitisCentral nervous system involvementCentral nervous system manifestationsIsolated mass lesionsReversible encephalopathy syndromeANCA-associated vasculitisPositive ANCA testNervous system involvementRelevant case reportsSmall vessel vasculitisCentral nervous system disordersNose and throatCNS presentationAAV patients
2018
NIMG-20. DIFFUSION-WEIGHTED MAGNETIC RESONANCE IMAGING FINDINGS IN PATIENTS WITH CENTRAL NERVOUS SYSTEM INVOLVEMENT OF SYSTEMIC LYMPHOMA
Roque A, Galluzzo D, Barbiero F, Fulbright R, Baehring J. NIMG-20. DIFFUSION-WEIGHTED MAGNETIC RESONANCE IMAGING FINDINGS IN PATIENTS WITH CENTRAL NERVOUS SYSTEM INVOLVEMENT OF SYSTEMIC LYMPHOMA. Neuro-Oncology 2018, 20: vi180-vi180. PMCID: PMC6217327, DOI: 10.1093/neuonc/noy148.746.Peer-Reviewed Original ResearchSystemic non-Hodgkin lymphomaADC lesionsWhite matterSystemic lymphomaSystem involvementDiffusion-weighted magnetic resonance imaging (DWI) findingsMagnetic resonance imaging (MRI) findingsPeritumoral regionAppropriate clinical settingNervous system involvementResonance Imaging FindingsNon-Hodgkin lymphomaLocation of lesionsQuantitative ADC analysisSignificant differencesPost Hoc AnalysisNumber of lesionsDiffusion-weighted imagingNormal white matterAnatomical MRI sequencesCNS disseminationCNS involvementCNS spreadParenchymal metastasesBiopsy confirmationCentral Nervous System Inflammation and Infection during Early, Nonaccelerated Simian-Human Immunodeficiency Virus Infection in Rhesus Macaques
Hsu DC, Sunyakumthorn P, Wegner M, Schuetz A, Silsorn D, Estes JD, Deleage C, Tomusange K, Lakhashe SK, Ruprecht RM, Lombardini E, Im-Erbsin R, Kuncharin Y, Phuang-Ngern Y, Inthawong D, Chuenarom W, Burke R, Robb ML, Ndhlovu LC, Ananworanich J, Valcour V, O'Connell RJ, Spudich S, Michael NL, Vasan S. Central Nervous System Inflammation and Infection during Early, Nonaccelerated Simian-Human Immunodeficiency Virus Infection in Rhesus Macaques. Journal Of Virology 2018, 92: 10.1128/jvi.00222-18. PMID: 29563297, PMCID: PMC5952152, DOI: 10.1128/jvi.00222-18.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CDAntigens, Differentiation, MyelomonocyticBrainCD4 Lymphocyte CountCD4-Positive T-LymphocytesCells, CulturedDisease Models, AnimalHIV-1HumansMacaca mulattaMacrophagesMeningesMicrogliaMonocytesParenchymal TissueReceptors, Cell SurfaceRNA, ViralSimian Acquired Immunodeficiency SyndromeSimian immunodeficiency virusViral LoadConceptsSimian-human immunodeficiency virusSimian immunodeficiency virusCD68/CD163Immunodeficiency virus infectionCentral nervous systemBrain parenchymaHIV envelopeImmunodeficiency virusVirus infectionEarly human immunodeficiency virus (HIV) infectionSimian-human immunodeficiency virus (SHIV) infectionCentral nervous system inflammationHuman immunodeficiency virus (HIV) infectionCentral nervous system involvementPathogenic simian immunodeficiency virusRhesus macaquesT-cell-mediated processEarly clinical courseSHIV-infected animalsNervous system inflammationT-cell countsCell-mediated inflammationNervous system involvementEnd-stage diseaseHIV cure strategiesCentral nervous system histoplasmosis
Wheat J, Myint T, Guo Y, Kemmer P, Hage C, Terry C, Azar MM, Riddell J, Ender P, Chen S, Shehab K, Cleveland K, Esguerra E, Johnson J, Wright P, Douglas V, Vergidis P, Ooi W, Baddley J, Bamberger D, Khairy R, Vikram H, Jenny-Avital E, Sivasubramanian G, Bowlware K, Pahud B, Sarria J, Tsai T, Assi M, Mocherla S, Prakash V, Allen D, Passaretti C, Huprikar S, Anderson A. Central nervous system histoplasmosis. Medicine 2018, 97: e0245. PMID: 29595679, PMCID: PMC5895412, DOI: 10.1097/md.0000000000010245.Peer-Reviewed Original ResearchConceptsCentral nervous system histoplasmosisPercent of patientsCerebrospinal fluidAmphotericin BCentral nervous system involvementSingle-center case seriesNervous system involvementLiposomal amphotericin BCenter case seriesOutcome of treatmentAnti-Histoplasma antibodiesRecognition of infectionPatients 54 yearsCNS histoplasmosisDeoxycholate formulationDisseminated histoplasmosisMost patientsAntigen testingAntibody testingCase seriesImmunodeficiency syndromeHistoplasma antigenHistoplasmosis infectionSystem involvementYear survival
2017
CNS Leukemia
An Y, Roberts K. CNS Leukemia. 2017, 311-333. DOI: 10.1007/978-3-319-55430-3_17.Peer-Reviewed Original ResearchAcute myeloid leukemiaAcute lymphoblastic leukemiaAllogeneic stem cell transplantCentral nervous system involvementPediatric acute lymphoblastic leukemiaInduction systemic therapyHigh-risk patientsNervous system involvementTotal body irradiationStem cell transplantUse of radiotherapyHigh cure ratesIntensity of therapyBlood-brain barrierCNS leukemiaCNS relapseCNS lymphomaPalliative therapySystemic therapyPrognostic factorsBody irradiationCell transplantRisk stratificationCure rateCommon cancerA Dual Case of Peritonitis and Central Nervous System Infection Caused by Nutritionally Variant Streptococcal Species
Vivar S, Girotto JE, Murray TS. A Dual Case of Peritonitis and Central Nervous System Infection Caused by Nutritionally Variant Streptococcal Species. Case Reports In Infectious Diseases 2017, 2017: 6012964. PMID: 28239499, PMCID: PMC5292362, DOI: 10.1155/2017/6012964.Peer-Reviewed Original ResearchNutritional variant streptococciCentral nervous system infectionCentral nervous system involvementEtiology of peritonitisVentriculoperitoneal shunt revisionNervous system infectionNervous system involvementCause of peritonitisEfficacy of treatmentClinical responseSystem infectionVP shuntShunt revisionSystem involvementInvasive infectionsPrevious neurosurgeryCNS penetrationVariant streptococciPeritonitisSusceptibility testingPotential roleSignificant pathogenStreptococcal speciesSecond agentInfection
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