2022
Tranexamic Acid Administration at Hospital Admission Decreases Transfusion Rates in Geriatric Hip Fracture Patients Undergoing Surgery
Moran J, Kahan JB, Morris J, Joo PY, O’Connor M. Tranexamic Acid Administration at Hospital Admission Decreases Transfusion Rates in Geriatric Hip Fracture Patients Undergoing Surgery. Geriatric Orthopaedic Surgery & Rehabilitation 2022, 13: 21514593221124414. PMID: 36081840, PMCID: PMC9445454, DOI: 10.1177/21514593221124414.Peer-Reviewed Original ResearchHip fracture patientsFragility hip fracture patientsRed blood cell transfusionBlood cell transfusionTranexamic acid administrationTransfusion rateFracture patientsTXA dosingCell transfusionVascular eventsHip fractureHospital admissionAcid administrationGeriatric hip fracture patientsMajor adverse vascular eventsInfusion-related adverse eventsUse of TXAFragility hip fractureLower transfusion rateAdverse vascular eventsPost-operative bleedingSubset of patientsSubgroup of patientsHip fracture serviceActive malignancy
2021
Expanded use of tranexamic acid is safe and decreases transfusion rates in patients with geriatric hip fractures
Kahan JB, Morris J, Li D, Moran J, O'Connor MI. Expanded use of tranexamic acid is safe and decreases transfusion rates in patients with geriatric hip fractures. OTA International The Open Access Journal Of Orthopaedic Trauma 2021, 4: e147. PMID: 34765898, PMCID: PMC8575430, DOI: 10.1097/oi9.0000000000000147.Peer-Reviewed Original ResearchRed blood cell transfusionMinor adverse eventsBlood cell transfusionFragility hip fractureAdverse eventsTransfusion rateHip fractureEligible patientsCell transfusionVascular eventsFragility hip fracture patientsMajor adverse vascular eventsAcademic tertiary care centerPrognostic Level IIIUse of TXAGeriatric hip fracturesRetrospective cohort studyHip fracture patientsLower transfusion rateTertiary care centerAdverse vascular eventsActive malignancyIneligible patientsPreoperative hemoglobinAnticoagulant use
2019
Pre-arrest and intra-arrest prognostic factors associated with survival after in-hospital cardiac arrest: systematic review and meta-analysis
Fernando SM, Tran A, Cheng W, Rochwerg B, Taljaard M, Vaillancourt C, Rowan KM, Harrison DA, Nolan JP, Kyeremanteng K, McIsaac DI, Guyatt GH, Perry JJ. Pre-arrest and intra-arrest prognostic factors associated with survival after in-hospital cardiac arrest: systematic review and meta-analysis. The BMJ 2019, 367: l6373. PMID: 31801749, PMCID: PMC6891802, DOI: 10.1136/bmj.l6373.Peer-Reviewed Original ResearchConceptsHospital cardiac arrestCardiac arrestPrognostic factorsSystematic reviewReduced oddsPrimary analysisInitial shockable rhythmIntra-arrest factorsPre-arrest factorsHigh-certainty evidenceChronic kidney diseaseDuration of resuscitationRisk of biasEnglish-language studiesWeb of ScienceActive malignancyCertainty evidenceCohort studyGRADE approachOdds of survivalCochrane DatabaseMale sexKidney diseaseShockable rhythmRelevant confoundersPerihematomal Edema After Intracerebral Hemorrhage in Patients With Active Malignancy
Gusdon AM, Nyquist PA, Torres-Lopez VM, Leasure AC, Falcone GJ, Sheth KN, Sansing LH, Hanley DF, Malani R. Perihematomal Edema After Intracerebral Hemorrhage in Patients With Active Malignancy. Stroke 2019, 51: 129-136. PMID: 31744426, PMCID: PMC7048624, DOI: 10.1161/strokeaha.119.027085.Peer-Reviewed Original ResearchConceptsBlood product transfusionThirty-day mortalityIntracerebral hemorrhagePerihematomal edemaActive malignancyProduct transfusionPHE volumeICH volumeActive cancerPHE growthPlatelet transfusionsCentral nervous system involvementRecurrence of malignancyNervous system involvementNontraumatic intracerebral hemorrhageCancer-specific dataPHE expansionRecent chemotherapyChart reviewConclusions PatientsControl patientsMost patientsHematoma volumeInstitutional databaseSystem involvement
2016
Clinical and echocardiographic predictors of mortality in acute pulmonary embolism
Dahhan T, Siddiqui I, Tapson VF, Velazquez EJ, Sun S, Davenport CA, Samad Z, Rajagopal S. Clinical and echocardiographic predictors of mortality in acute pulmonary embolism. Cardiovascular Ultrasound 2016, 14: 44. PMID: 27793158, PMCID: PMC5086059, DOI: 10.1186/s12947-016-0087-y.Peer-Reviewed Original ResearchConceptsAcute pulmonary embolismChronic obstructive pulmonary diseaseBody mass indexTricuspid annular plane systolic excursionPulmonary artery acceleration timePulmonary embolismActive malignancyEjection fractionClinical parametersMass indexNYHA class III symptomsRV myocardial performance indexAnnular plane systolic excursionLeft ventricular ejection fractionMedian body mass indexClass III symptomsFraction area changeRV Tei indexSpeckle-tracking strainOutcomes of patientsAbsence of hypertensionTroponin T levelsMyocardial performance indexObstructive pulmonary diseaseSystolic blood pressure
2015
Ischemic Stroke Patients with Active Malignancy or Extracardiac Shunts Are More Likely to Have a Right-to-Left Shunt Found by TCD Than Echocardiogram
de Havenon A, Moore A, Sultan-Qurraie A, Majersik JJ, Stoddard G, Tirschwell D. Ischemic Stroke Patients with Active Malignancy or Extracardiac Shunts Are More Likely to Have a Right-to-Left Shunt Found by TCD Than Echocardiogram. Translational Stroke Research 2015, 6: 361-364. PMID: 26205844, DOI: 10.1007/s12975-015-0414-x.Peer-Reviewed Original ResearchConceptsIschemic stroke patientsTranscranial DopplerActive malignancyLeft shuntIschemic strokeExtracardiac shuntsStroke patientsPositive transcranial DopplersRecent ischemic strokePercent of patientsComorbid medical conditionsPatent foramen ovalePulmonary arteriovenous malformationsDetection of rightNegative TTEOccult malignancyTOAST classificationCryptogenic strokeStroke subtypesForamen ovaleStandard workupShunt statusArteriovenous malformationsMedical conditionsPatientsRisk Factors for Adverse Outcomes in Patients Hospitalized With Lower Gastrointestinal Bleeding
Sengupta N, Tapper E, Patwardhan V, Ketwaroo G, Thaker A, Leffler D, Feuerstein J. Risk Factors for Adverse Outcomes in Patients Hospitalized With Lower Gastrointestinal Bleeding. Mayo Clinic Proceedings 2015, 90: 1021-1029. PMID: 26141075, PMCID: PMC4770256, DOI: 10.1016/j.mayocp.2015.04.024.Peer-Reviewed Original ResearchConceptsRecurrent lower gastrointestinal bleedingLower gastrointestinal bleedingCharlson Comorbidity Index scoreComorbidity Index scoreActive malignancyRisk factorsGastrointestinal bleedingAdverse outcomesMultivariable Cox proportional hazards regression modelsHigher Charlson Comorbidity Index scoresIndex scoreCox proportional hazards regression modelProportional hazards regression modelsBeth Israel Deaconess Medical CenterProspective observational studyHazards regression modelsAssociation of variablesRecurrent bleedingHospital dischargeConsecutive patientsHospital readmissionObservational studyMedical CenterMortality riskPatients
2010
Clinical Features From the History and Physical Examination That Predict the Presence or Absence of Pulmonary Embolism in Symptomatic Emergency Department Patients: Results of a Prospective, Multicenter Study
Courtney DM, Kline JA, Kabrhel C, Moore CL, Smithline HA, Nordenholz KE, Richman PB, Plewa MC. Clinical Features From the History and Physical Examination That Predict the Presence or Absence of Pulmonary Embolism in Symptomatic Emergency Department Patients: Results of a Prospective, Multicenter Study. Annals Of Emergency Medicine 2010, 55: 307-315.e1. PMID: 20045580, PMCID: PMC2847003, DOI: 10.1016/j.annemergmed.2009.11.010.Peer-Reviewed Original ResearchMeSH KeywordsAdultChest PainConfidence IntervalsEmergency Service, HospitalFemaleHumansLogistic ModelsMaleMedical History TakingMiddle AgedOdds RatioPhysical ExaminationPredictive Value of TestsProspective StudiesPulmonary EmbolismRisk FactorsSex FactorsThrombophiliaTomography, X-Ray ComputedVenous ThromboembolismVenous ThrombosisConceptsPleuritic chest painDeep venous thrombosisPulmonary embolismEmergency department patientsVenous thromboembolismChest painOdds ratioDepartment patientsVenous thrombosisFamily historySymptomatic emergency department (ED) patientsUS emergency department patientsPrediction rulePossible pulmonary embolismSubsternal chest painUnilateral leg swellingVenous thromboembolism outcomesProspective cohort studyAdjusted odds ratioActive malignancyRecent surgeryCohort studyLeg swellingPrimary outcomeFemale patients
2009
Risk of Thromboembolism Varies, Depending on Category of Immobility in Outpatients
Beam DM, Courtney DM, Kabrhel C, Moore CL, Richman PB, Kline JA. Risk of Thromboembolism Varies, Depending on Category of Immobility in Outpatients. Annals Of Emergency Medicine 2009, 54: 147-152. PMID: 19135280, DOI: 10.1016/j.annemergmed.2008.10.033.Peer-Reviewed Original ResearchConceptsVenous thromboembolismOdds ratioSymptomatic ED patientsPrevious venous thromboembolismEmergency department patientsSignificant risk factorsLongitudinal outcome studyPositive imaging resultsCause of immobilityActive malignancyLimb immobilityNeurologic paralysisRecent surgeryDepartment patientsClinical featuresED patientsRisk factorsThromboembolismLarge cohortPresence of limbsOutcome studiesUnilateral legPatientsTypes of immobilityMultivariate analysis
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