2024
COVID-19-associated rhino-orbito-cerebral mucormycosis: a single center prospective study of 264 patients
Kim U, Perzia B, Kulkarni P, Rajiniganth M, Sundar B, Robin A, Shukla A, Maeng M. COVID-19-associated rhino-orbito-cerebral mucormycosis: a single center prospective study of 264 patients. Orbit 2024, 44: 24-33. PMID: 39051497, DOI: 10.1080/01676830.2024.2377249.Peer-Reviewed Original ResearchTranscutaneous retrobulbar amphotericin BRhino-orbital-cerebral mucormycosisRhino-orbitalCavernous sinusBiopsy-proven mucormycosisOutbreak of mucormycosisRetrobulbar amphotericin BNo light perceptionAssociated with high mortalityAssociated with increased mortalityEndoscopic sinus debridementPre-existing diabetesCerebral diseaseSymptomatic COVID-19Asymptomatic COVID-19Oral posaconazoleSinus debridementEye involvementWorse visionVision recoveryNew diabetesImmune dysregulationAmphotericin BClinical outcomesWeekly imaging
2023
Dosing implications for liposomal amphotericin B in pregnancy
O'Grady N, McManus D, Briggs N, Azar M, Topal J, Davis M. Dosing implications for liposomal amphotericin B in pregnancy. Pharmacotherapy The Journal Of Human Pharmacology And Drug Therapy 2023, 43: 452-462. PMID: 36862037, DOI: 10.1002/phar.2784.Peer-Reviewed Original ResearchConceptsIdeal body weightLiposomal amphotericin BMucocutaneous leishmaniasisBody weightAmphotericin BInfectious Diseases SocietyTotal body weightPregnant patientsDiseases SocietyAmerica guidelinesPreferred agentPregnancyParasitic infectionsOpportunistic fungalAdverse effectsPatientsTreatmentLeishmaniasisLambsDaysUse of lambsGuidelinesRegimensWeightFetusesAcquired Disorders of Hypomagnesemia
Rosner M, Ha N, Palmer B, Perazella M. Acquired Disorders of Hypomagnesemia. Mayo Clinic Proceedings 2023, 98: 581-596. PMID: 36872194, DOI: 10.1016/j.mayocp.2022.12.002.Peer-Reviewed Original ResearchConceptsReduced glomerular filtration rateBody storesBody magnesium storesGlomerular filtration rateSerum magnesium levelsTotal body storesDevelopment of symptomsIntravenous replacementOrgan dysfunctionMagnesium disordersRenal lossMagnesium replacementFiltration rateSevere casesMagnesium storesHypomagnesemiaClinical experienceClinical practiceMagnesium levelsAcquired disordersAmphotericin BMagnesium handlingOptimal managementMedicationsLaboratory assessment
2022
Rapidly enlarging pulmonary mass due to immune reconstitution inflammatory syndrome (IRIS) in an immunocompetent host with pulmonary Cryptococcus neoformans.
Tucker M, Sheikh AM, Villanueva MS. Rapidly enlarging pulmonary mass due to immune reconstitution inflammatory syndrome (IRIS) in an immunocompetent host with pulmonary Cryptococcus neoformans. BMJ Case Reports 2022, 15: e247495. PMID: 35351746, PMCID: PMC8966528, DOI: 10.1136/bcr-2021-247495.Peer-Reviewed Case Reports and Technical NotesConceptsImmune reconstitution inflammatory syndromeReconstitution inflammatory syndromeInflammatory syndromePulmonary massImmunocompetent hostsInitial induction courseLarge pulmonary massWeeks of fluconazoleLiposomal amphotericin BCritical vascular structuresInduction therapyImmunocompetent manInduction courseSecond courseAmphotericin BCryptococcus neoformansVascular structuresSignificant decreaseCryptococcomaSyndromeWeeksPrednisoneTherapyFlucytosineDisease
2021
Species distribution and antifungal susceptibility of Aspergillus clinical isolates in Lebanon
Osman M, Bidon B, Abboud C, Zakaria A, Hamze B, Achcar M, Mallat H, Dannaoui E, Dabboussi F, Papon N, Bouchara J, Hamze M. Species distribution and antifungal susceptibility of Aspergillus clinical isolates in Lebanon. Future Microbiology 2021, 16: 13-26. PMID: 33438473, DOI: 10.2217/fmb-2020-0141.Peer-Reviewed Original ResearchConceptsAntifungal susceptibilityAspergillus clinical isolatesAntifungal susceptibility patternsReverse transcription-quantitative PCRNational Reference CenterOverall drug resistanceTranscription-quantitative PCRInvasive mycosesSusceptibility patternsHealth strategiesEUCAST recommendationsReference centerClinical isolatesAmphotericin BDrug resistanceResistant isolatesMajor causeGene mutationsExpression levelsIsolatesEpidemiologySusceptibilityMycoses
2020
Diagnosis of oesophageal mucormycosis managed with medical therapy alone
Ringer M, Pischel L, Azar MM. Diagnosis of oesophageal mucormycosis managed with medical therapy alone. BMJ Case Reports 2020, 13: e236869. PMID: 33093060, PMCID: PMC7583061, DOI: 10.1136/bcr-2020-236869.Peer-Reviewed Original ResearchConceptsIdarubicin/cytarabineLiposomal amphotericin BAcute myeloid leukemiaFebrile neutropeniaInduction chemotherapyPosaconazole therapyClinical characteristicsMedical therapySurgical morbiditySurgical interventionAggressive infectionDevastating manifestationMyeloid leukemiaCT scanInvasive moldsMucormycosisLebanese menAmphotericin BPatientsDiagnosisTherapyReportOdynophagiaNeutropeniaThrombocytopeniaCurrent Concepts in the Epidemiology, Diagnosis, and Management of Histoplasmosis Syndromes
Azar MM, Loyd JL, Relich RF, Wheat LJ, Hage CA. Current Concepts in the Epidemiology, Diagnosis, and Management of Histoplasmosis Syndromes. Seminars In Respiratory And Critical Care Medicine 2020, 41: 013-030. PMID: 32000281, DOI: 10.1055/s-0039-1698429.Peer-Reviewed Original ResearchConceptsDisseminated diseaseCurrent evidence-based approachesProgressive disseminated diseaseCommon clinical presentationCommunity-acquired pneumoniaChronic pulmonary diseaseSelf-limiting diseaseLiposomal amphotericin BManagement of histoplasmosisEvidence-based approachHistoplasmosis syndromeImmunocompetent patientsPulmonary diseaseClinical presentationCrohn's diseasePreferred agentClinical manifestationsCommon conditionMilder casesAmphotericin BHistoplasmosisAmphotericin B.DiseaseEpidemiologyGlobal disease
2019
Fungal Pneumonia
Murray T, Girotto J, Bennett N. Fungal Pneumonia. 2019, 95-106. DOI: 10.1007/978-3-319-91080-2_9.Peer-Reviewed Original Research
2018
A rare case of visceral leishmaniasis in an immunocompetent traveler returning to the United States from Europe
Haque L, Villanueva M, Russo A, Yuan Y, Lee EJ, Topal J, Podoltsev N. A rare case of visceral leishmaniasis in an immunocompetent traveler returning to the United States from Europe. PLOS Neglected Tropical Diseases 2018, 12: e0006727. PMID: 30286207, PMCID: PMC6171829, DOI: 10.1371/journal.pntd.0006727.Peer-Reviewed Case Reports and Technical NotesConceptsVisceral leishmaniasisHealthy travelersRare caseEndemic areasEndemic visceral leishmaniasisSuccessful initial treatmentLiposomal amphotericin BBone marrow biopsyImmunocompetent adultsImmunocompetent travelersNight sweatsImmunocompetent individualsInitial treatmentMarrow biopsyRelapseAmphotericin BPreventive measuresLeishmaniasisTreatmentUnited StatesExtensive experiencePancytopeniaSplenomegalyBiopsyPatientsNecrotizing fasciitis caused by Mucor indicus in a pediatric bone marrow transplant recipient
Bloch D, Gonzalez MD, Haight A, Abramowsky C, Yildirim I. Necrotizing fasciitis caused by Mucor indicus in a pediatric bone marrow transplant recipient. Pediatric Transplantation 2018, 22: e13294. PMID: 30246483, PMCID: PMC6460914, DOI: 10.1111/petr.13294.Peer-Reviewed Original ResearchConceptsPediatric bone marrow transplant recipientsBone marrow transplant recipientsMarrow transplant recipientsLiposomal amphotericin BSubcutaneous cellular tissueMultiple debridementsTransplant recipientsCase reportRare fungal organismRisk factorsAmphotericin BSusceptibility testingFasciitisFungal organismsAnaerobic bacteriaFatal cryptococcal meningitis in an AIDS patient complicated with immune reconstitution syndrome refractory to prolonged amphotericin B treatment
Bandaranayake TD, Ogbuagu OE, Mahajan A, Vortmeyer AO, Villanueva MS. Fatal cryptococcal meningitis in an AIDS patient complicated with immune reconstitution syndrome refractory to prolonged amphotericin B treatment. International Journal Of STD & AIDS 2018, 29: 1250-1254. PMID: 29749873, DOI: 10.1177/0956462418773219.Peer-Reviewed Case Reports and Technical NotesConceptsCentral nervous system diseaseNervous system diseasesCryptococcal meningitisSystem diseasesSevere central nervous system diseaseFatal cryptococcal meningitisLiposomal amphotericin BAmphotericin B treatmentImmune recoveryPatient refractoryAntiretroviral therapyTherapeutic challengeTreatment failureAIDS patientsCystic lesionsFatal casesTreatment approachesMeningitisAmphotericin BC. neoformansMultiple coursesCryptococcus neoformansPatientsB treatmentDiseaseCentral nervous system histoplasmosis
Wheat J, Myint T, Guo Y, Kemmer P, Hage C, Terry C, Azar MM, Riddell J, Ender P, Chen S, Shehab K, Cleveland K, Esguerra E, Johnson J, Wright P, Douglas V, Vergidis P, Ooi W, Baddley J, Bamberger D, Khairy R, Vikram H, Jenny-Avital E, Sivasubramanian G, Bowlware K, Pahud B, Sarria J, Tsai T, Assi M, Mocherla S, Prakash V, Allen D, Passaretti C, Huprikar S, Anderson A. Central nervous system histoplasmosis. Medicine 2018, 97: e0245. PMID: 29595679, PMCID: PMC5895412, DOI: 10.1097/md.0000000000010245.Peer-Reviewed Original ResearchConceptsCentral nervous system histoplasmosisPercent of patientsCerebrospinal fluidAmphotericin BCentral nervous system involvementSingle-center case seriesNervous system involvementLiposomal amphotericin BCenter case seriesOutcome of treatmentAnti-Histoplasma antibodiesRecognition of infectionPatients 54 yearsCNS histoplasmosisDeoxycholate formulationDisseminated histoplasmosisMost patientsAntigen testingAntibody testingCase seriesImmunodeficiency syndromeHistoplasma antigenHistoplasmosis infectionSystem involvementYear survival
2017
Combination liposomal amphotericin B, posaconazole and oral amphotericin B for treatment of gastrointestinal Mucorales in an immunocompromised patient
Anderson A, McManus D, Perreault S, Lo YC, Seropian S, Topal JE. Combination liposomal amphotericin B, posaconazole and oral amphotericin B for treatment of gastrointestinal Mucorales in an immunocompromised patient. Medical Mycology Case Reports 2017, 17: 11-13. PMID: 28580237, PMCID: PMC5447657, DOI: 10.1016/j.mmcr.2017.05.004.Peer-Reviewed Original ResearchClinical Perspectives in the Diagnosis and Management of Histoplasmosis
Azar MM, Hage CA. Clinical Perspectives in the Diagnosis and Management of Histoplasmosis. Clinics In Chest Medicine 2017, 38: 403-415. PMID: 28797485, DOI: 10.1016/j.ccm.2017.04.004.BooksConceptsAcute pulmonary histoplasmosisDrug of choiceManagement of histoplasmosisDisseminated presentationPulmonary histoplasmosisMild diseaseClinical spectrumDimorphic fungus Histoplasma capsulatumHistoplasmosisAmphotericin BFungus Histoplasma capsulatumClinical perspectiveDiseaseHistoplasma capsulatumMultipronged approachNumber of travelersDiagnosisPatientsTherapyItraconazoleSeverity
2015
Blastomycosis in Indiana Clinical and Epidemiologic Patterns of Disease Gleaned from a Multicenter Retrospective Study
Azar MM, Assi R, Relich RF, Schmitt BH, Norris S, Wheat LJ, Hage CA. Blastomycosis in Indiana Clinical and Epidemiologic Patterns of Disease Gleaned from a Multicenter Retrospective Study. CHEST Journal 2015, 148: 1276-1284. PMID: 26020566, DOI: 10.1378/chest.15-0289.Peer-Reviewed Original ResearchConceptsDiabetes mellitusEpidemiologic patternsIncidence of blastomycosisMulticenter retrospective studyCases of blastomycosisMultilobar pneumoniaICU admissionExtrapulmonary diseaseRetrospective studyMean ageIncidence rateFungal antigensEndemic areasLarge seriesAmphotericin BBlastomycosisTotal mortalityIncidenceMellitusPneumoniaSignificant increaseDiseaseIndiana ClinicalARDSImmunosuppression
2010
Risks and outcome of fungal infection in neutropenic children with hematologic diseases.
Aytaç S, Yildirim I, Ceyhan M, Cetin M, Tuncer M, Kara A, Cengiz AB, Seçmeer G, Yetgin S. Risks and outcome of fungal infection in neutropenic children with hematologic diseases. The Turkish Journal Of Pediatrics 2010, 52: 121-5. PMID: 20560245.Peer-Reviewed Original ResearchConceptsFebrile neutropenic episodesAcute myeloid leukemiaNeutropenic episodesAcute lymphoblastic leukemiaAplastic anemiaAntifungal treatmentFungal infectionsMortality rateAmphotericin BNeutropenic childrenRetrospective studyLymphoblastic leukemiaMyeloid leukemiaHematologic diseasesTreatment groupsPatientsWhole groupInfectionEpisodesLeukemiaMortalityAnemiaGroupDiseaseFluconazole
1998
Cerebral aspergillosis in a liver transplant recipient: a case report of long-term survival after combined treatment with liposomal amphotericin B and surgery
Iemmolo R, Rossanese A, Rotilio A, Mattisi G, Gerunda G, Merenda R, Neri D, Crepaldi G, Strazzabosco M. Cerebral aspergillosis in a liver transplant recipient: a case report of long-term survival after combined treatment with liposomal amphotericin B and surgery. Journal Of Hepatology 1998, 28: 518-522. PMID: 9551693, DOI: 10.1016/s0168-8278(98)80329-2.Peer-Reviewed Original ResearchConceptsLiver transplant recipientsLiposomal amphotericin BTransplant recipientsCerebral aspergillosisAmphotericin BLife-threatening complicationsLiposomal amphotericin B.Complication-free survivalRisk of recurrenceSystemic side effectsAspergillus fumigatus infectionLong-term survivalSurgical excisionCase reportFumigatus infectionLimited efficacyCerebrospinal fluidSide effectsMortality rateAmphotericin B.AspergillosisRecipientsSurvivalTreatmentFirst report
1996
Prevention and Treatment of Cryptococcal Meningitis in Patients with AIDS
Villanueva M, Quagliarello V. Prevention and Treatment of Cryptococcal Meningitis in Patients with AIDS. CNS Drugs 1996, 5: 246-256. DOI: 10.2165/00023210-199605040-00003.Peer-Reviewed Original ResearchCryptococcal meningitisClinical studiesAggressive initial treatmentLifelong suppressive therapyProspective clinical studySuppressive therapyProlonged immunosuppressionFungal meningitisClinical presentationInitial treatmentRare diagnosisTreatment strategiesAmphotericin BOptimal managementMeningitisPatientsAIDS epidemicTreatmentAIDSDiseaseImmunosuppressionHIVTherapyDiagnosisFluconazoleInhibition by Nystatin of Kv1.3 Channels Expressed in Chinese Hamster Ovary Cells
HAHN S, WANG L, KACZMAREK L. Inhibition by Nystatin of Kv1.3 Channels Expressed in Chinese Hamster Ovary Cells. Neuropharmacology 1996, 35: 895-901. PMID: 8938720, DOI: 10.1016/0028-3908(96)00094-9.Peer-Reviewed Original ResearchConceptsKv1.3 currentsEffect of nystatinPerforated patch recordingsChinese hamster ovary cellsPatch-clamp techniqueWhole-cell configurationConcentration-dependent reductionHamster ovary cellsRectifier potassium channelHalf-maximal inhibitionPotassium channel Kv1.3Patch recordingsMaximal inhibitionAmphotericin BOvary cellsKv1.3 channelsPotassium channelsTetraethylammoniumChannel Kv1.3Intracellular solutionInhibitionRapid blockNystatinDrugsApparent inactivation
1995
Invasive Candida guilliermondii infection: in vitro susceptibility studies and molecular analysis.
Vazquez J, Lundstrom T, Dembry L, Chandrasekar P, Boikov D, Parri M, Zervos M. Invasive Candida guilliermondii infection: in vitro susceptibility studies and molecular analysis. Bone Marrow Transplantation 1995, 16: 849-53. PMID: 8750282.Peer-Reviewed Original ResearchConceptsHigh-dose amphotericin BMinimum inhibitory concentration (MIC) rangeSustained neutropeniaPurulent pericarditisAplastic anemiaC. guilliermondiiInhibitory concentration rangePoor responseClinical isolatesAmphotericin BProlonged durationHigh MICsInitial misidentificationTherapyEnvironmental isolatesIsolatesControl strainMolecular analysisNeutropeniaPericarditisFungemiaAnemiaBMTFlucytosineAmB
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