2021
Adaptive immunity induces mutualism between commensal eukaryotes
Ost KS, O’Meara T, Stephens WZ, Chiaro T, Zhou H, Penman J, Bell R, Catanzaro JR, Song D, Singh S, Call DH, Hwang-Wong E, Hanson KE, Valentine JF, Christensen KA, O’Connell R, Cormack B, Ibrahim AS, Palm NW, Noble SM, Round JL. Adaptive immunity induces mutualism between commensal eukaryotes. Nature 2021, 596: 114-118. PMID: 34262174, PMCID: PMC8904204, DOI: 10.1038/s41586-021-03722-w.Peer-Reviewed Original ResearchConceptsAdaptive immunityIntestinal immunoglobulin A (IgA) responseIntestinal IgA responsesImmunoglobulin A ResponsesIgA responsesIntestinal damageImmune responseIntestinal microbiotaRelevant vaccinesImmune systemA responsesCommensal fungiImmune selectionCandida speciesImmunityHyphal morphotypesIgAPathogenesisMiceC. albicansPathogenic Candida speciesCandida albicansAlbicansColitisResponse
2018
Central nervous system histoplasmosis
Wheat J, Myint T, Guo Y, Kemmer P, Hage C, Terry C, Azar MM, Riddell J, Ender P, Chen S, Shehab K, Cleveland K, Esguerra E, Johnson J, Wright P, Douglas V, Vergidis P, Ooi W, Baddley J, Bamberger D, Khairy R, Vikram H, Jenny-Avital E, Sivasubramanian G, Bowlware K, Pahud B, Sarria J, Tsai T, Assi M, Mocherla S, Prakash V, Allen D, Passaretti C, Huprikar S, Anderson A. Central nervous system histoplasmosis. Medicine 2018, 97: e0245. PMID: 29595679, PMCID: PMC5895412, DOI: 10.1097/md.0000000000010245.Peer-Reviewed Original ResearchConceptsCentral nervous system histoplasmosisPercent of patientsCerebrospinal fluidAmphotericin BCentral nervous system involvementSingle-center case seriesNervous system involvementLiposomal amphotericin BCenter case seriesOutcome of treatmentAnti-Histoplasma antibodiesRecognition of infectionPatients 54 yearsCNS histoplasmosisDeoxycholate formulationDisseminated histoplasmosisMost patientsAntigen testingAntibody testingCase seriesImmunodeficiency syndromeHistoplasma antigenHistoplasmosis infectionSystem involvementYear survival
2016
Concurrent cryptococcal meningitis and disseminated tuberculosis occurring in an immunocompetent male
Musabende M, Mukabatsinda C, Riviello ED, Ogbuagu O. Concurrent cryptococcal meningitis and disseminated tuberculosis occurring in an immunocompetent male. BMJ Case Reports 2016, 2016: bcr2015213380. PMID: 26917794, PMCID: PMC4769440, DOI: 10.1136/bcr-2015-213380.Peer-Reviewed Case Reports and Technical NotesMeSH KeywordsAntigens, FungalAntitubercular AgentsCoinfectionHumansMaleMeningitis, CryptococcalMiddle AgedTreatment OutcomeTuberculosis, MiliaryConceptsHigh-dose oral fluconazoleConcurrent cryptococcal meningitisPositive cryptococcal antigenHIV-negative menCerebrospinal fluid analysisHIV antibody testConventional amphotericin BAcid-fast bacilliDisease-endemic areasDisseminated tuberculosisGeneXpert testImmunocompromising conditionsInduction therapyMiliary infiltratesOral fluconazoleCryptococcal antigenCryptococcal meningitisDry coughAntitubercular therapyImmunocompetent maleBronchoalveolar lavageNeutrophilic pleocytosisOpportunistic infectionsDisseminated infectionCase report
2010
Decreased Serum Antibody Responses to Recombinant Pneumocystis Antigens in HIV-Infected and Uninfected Current Smokers
Crothers K, Daly KR, Rimland D, Goetz MB, Gibert CL, Butt AA, Justice AC, Djawe K, Levin L, Walzer PD. Decreased Serum Antibody Responses to Recombinant Pneumocystis Antigens in HIV-Infected and Uninfected Current Smokers. MSphere 2010, 18: 380-386. PMID: 21191078, PMCID: PMC3067379, DOI: 10.1128/cvi.00421-10.Peer-Reviewed Original ResearchConceptsRespiratory syncytial virusChronic obstructive pulmonary diseaseAntibody responseEnzyme-linked immunosorbent assayP. jiroveciiCurrent smokersSerum antibodiesHIV-negative subjectsObstructive pulmonary diseaseInjection drug useSerum antibody responseMultivariate Tobit regression modelsHazardous alcohol useCross-sectional analysisUninfected patientsCurrent smokingHIV infectionIndependent predictorsPulmonary diseaseSyncytial virusImmunosuppressive effectsSerologic studiesSubsequent riskPneumocystis jiroveciiDrug use
2005
Concerted Evolution in the Repeats of an Immunomodulating Cell Surface Protein, SOWgp, of the Human Pathogenic Fungi Coccidioides immitis and C. posadasii
Johannesson H, Townsend JP, Hung CY, Cole GT, Taylor JW. Concerted Evolution in the Repeats of an Immunomodulating Cell Surface Protein, SOWgp, of the Human Pathogenic Fungi Coccidioides immitis and C. posadasii. Genetics 2005, 171: 109-117. PMID: 15965255, PMCID: PMC1456504, DOI: 10.1534/genetics.105.040923.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, FungalCoccidioidesCoccidioidomycosisDNA, FungalEvolution, MolecularGene ConversionGenetic VariationHumansMembrane GlycoproteinsMutationPhylogenyPolymorphism, GeneticRecombination, GeneticRepetitive Sequences, Nucleic AcidSequence Analysis, DNASpecies SpecificityTandem Repeat SequencesConceptsPathogenic fungus Coccidioides immitisConcerted evolutionProtein-coding genesC. posadasiiGenetic distance analysisPoint mutation rateHost-pathogen interactionsCell surface proteinsGenome dynamicsPathogen's benefitMultigene familyUnequal crossingGeographic rangeFungus Coccidioides immitisRepetitive domainEntire geneMutation rateRepetitive arraysSurface proteinsDistance analysisGenesHost immune systemImmune systemImmunodominant proteinsParasitic phase
1999
Role of the C-C chemokine, TCA3, in the protective anticryptococcal cell-mediated immune response.
Doyle H, Murphy J. Role of the C-C chemokine, TCA3, in the protective anticryptococcal cell-mediated immune response. The Journal Of Immunology 1999, 162: 4824-33. PMID: 10202026, DOI: 10.4049/jimmunol.162.8.4824.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, FungalAntigens, FungalCell MovementChemokine CCL1Chemokine CCL3Chemokine CCL4Chemokines, CCCryptococcosisCryptococcus neoformansCytokinesFemaleGelatin Sponge, AbsorbableHypersensitivity, DelayedImmunity, CellularKineticsLeukocytesMacrophage Inflammatory ProteinsMiceMice, Inbred CBANeutrophilsReceptors, CCR8Recombinant ProteinsConceptsDelayed-type hypersensitivityMIP-1alphaC chemokinesAnticryptococcal cell-mediated immune responseCell-mediated immune responsesCell-mediated immune reactionsMacrophage inflammatory protein-1alphaMonocyte chemotactic protein-1DTH reaction sitesNumber of neutrophilsActivated T lymphocytesGelatin sponge modelCMI responsesNaive miceDTH reactionInfected miceCMI reactionsT cellsT lymphocytesImmune responseImmune reactionsCellular infiltrationLymphocytesChemokinesNeutrophilsCriteria for assessing cutaneous anergy in women with or at risk for HIV infection
Klein R, Flanigan T, Schuman P, Smith D, Vlahov D, Group* F. Criteria for assessing cutaneous anergy in women with or at risk for HIV infection. Journal Of Allergy And Clinical Immunology 1999, 103: 93-98. PMID: 9893191, DOI: 10.1016/s0091-6749(99)70531-2.Peer-Reviewed Original ResearchConceptsHIV statusCutaneous anergyHIV infectionTetanus antigensTuberculin reactionLevel of immunodeficiencyHIV-seronegative womenPositive tuberculin reactionAcademic medical centerAnergy testingLow CD4Seronegative subjectsHIV-seronegativeMumps antigenSeropositive subjectsSeropositive womenHIV-seropositiveLymphocyte levelsRisk womenTuberculin antigenTetanus toxoidCutaneous testingMedical CenterClinical utilityAntigen combinations
1997
MIP-1α contributes to the anticryptococcal delayed-type hypersensitivity reaction and protection against Cryptococcus neoformans
Doyle H, Murphy J. MIP-1α contributes to the anticryptococcal delayed-type hypersensitivity reaction and protection against Cryptococcus neoformans. Journal Of Leukocyte Biology 1997, 61: 147-155. PMID: 9021919, DOI: 10.1002/jlb.61.2.147.Peer-Reviewed Original ResearchConceptsMIP-1 alphaMIP-1 alpha levelsDelayed-type hypersensitivity reactionImmunized miceHypersensitivity reactionsC. neoformansCell-mediated immune responsesInflammatory protein-1 alphaCryptococcus neoformansAlpha levelsDTH reaction sitesInflux of neutrophilsNumber of neutrophilsProtein-1 alphaClearance of microorganismsGelatin sponge modelCMI responsesCryptococcal antigenNeutrophil influxNaive miceDTH reactionLeukocyte infiltrationMIP-1αChemotactic cytokinesImmune response
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