2025
Uso da Inteligência Artificial Aplicada ao Eletrocardiograma para Diagnóstico de Disfunção Sistólica Ventricular Esquerda
de Santana W, Pinto M, Barreto S, Foppa M, Giatti L, Khera R, Ribeiro A. Uso da Inteligência Artificial Aplicada ao Eletrocardiograma para Diagnóstico de Disfunção Sistólica Ventricular Esquerda. Arquivos Brasileiros De Cardiologia 2025, 122: e20240740. PMID: 40396866, PMCID: PMC12108124, DOI: 10.36660/abc.20240740.Peer-Reviewed Original ResearchConceptsLeft ventricular systolic dysfunctionLeft ventricular ejection fractionNegative predictive valueDiagnostic odds ratioPositive predictive valueHeart failureDetect left-ventricular systolic dysfunctionPredictive valueVentricular systolic dysfunctionVentricular ejection fractionNegative likelihood ratioPositive likelihood ratioDiagnostic accuracy cross-sectional studyLikelihood ratioCross-sectional studySystolic dysfunctionEjection fractionEvaluating HFAUC-ROCElectrocardiographic alterationsOdds ratioEchocardiogramROC curveScreening toolElectrocardiogram
2024
Diagnostic Accuracy of Pediatrician-performed Digital Retinal Imaging with 3nethra neo for ROP Screening
Garg A, Kumar J, Katoch D, Dutta S, Kumar P. Diagnostic Accuracy of Pediatrician-performed Digital Retinal Imaging with 3nethra neo for ROP Screening. Indian Journal Of Pediatrics 2024, 92: 605-611. PMID: 38372940, DOI: 10.1007/s12098-024-05042-z.Peer-Reviewed Original ResearchConceptsWide-field digital retinal imagingRetinopathy of prematurityBinocular indirect ophthalmoscopyNegative likelihood ratioRetinopathy of prematurity screeningPositive likelihood ratioDiagnostic accuracySeverity of retinopathy of prematurityDigital retinal imagesDetect retinopathy of prematurityReference standardDiagnostic odds ratioLikelihood ratioRetinal imagesIndirect ophthalmoscopyTrained ophthalmologistsAdverse eventsDiagnosing retinopathyDe-identified imagesOphthalmologistsTreatmentObjectivesToPediatriciansResultsThe analysisReferral
2023
Test Characteristics of Emergency Medicine-Performed Point-of-Care Ultrasound for the Diagnosis of Acute Cholecystitis: A Systematic Review and Meta-analysis
Wilson S, Thavanathan R, Cheng W, Stuart J, Kim D, Glen P, Duigenan S, Shorr R, Woo M, Perry J. Test Characteristics of Emergency Medicine-Performed Point-of-Care Ultrasound for the Diagnosis of Acute Cholecystitis: A Systematic Review and Meta-analysis. Annals Of Emergency Medicine 2023, 83: 235-246. PMID: 37855790, DOI: 10.1016/j.annemergmed.2023.09.005.Peer-Reviewed Original ResearchEmergency physician-performed pointAcute cholecystitisCare ultrasoundSystematic reviewFinal diagnosisDiagnostic accuracyEarly surgical managementAcute abdominal painMeta-Analyses (PRISMA) guidelinesPreferred Reporting ItemsFull-text reviewTitles/abstractsReference standardPositive likelihood ratioHierarchical summary receiverNegative likelihood ratioAbdominal painLikelihood ratioClinical suspicionHospital admissionDefinitive managementSurgical managementEmergency departmentBias assessmentEligible studies
2022
Performance of a Multianalyte ‘Rule-Out’ Assay in Pregnant Individuals With Suspected Preeclampsia
Costantine MM, Sibai B, Bombard AT, Sarno M, West H, Haas DM, Tita AT, Paidas MJ, Clark EAS, Boggess K, Grotegut C, Grobman W, Su EJ, Burd I, Saade G, Chavez MR, Paglia MJ, Merriam A, Torres C, Habli M, Macones G, Wen T, Bofill J, Palatnik A, Edwards RK, Haeri S, Oberoi P, Mazloom A, Cooper M, Lockton S, Hankins GD. Performance of a Multianalyte ‘Rule-Out’ Assay in Pregnant Individuals With Suspected Preeclampsia. Hypertension 2022, 79: 1515-1524. PMID: 35545947, PMCID: PMC9172903, DOI: 10.1161/hypertensionaha.122.19038.Peer-Reviewed Original ResearchConceptsDays of enrollmentPregnant individualsStudy cohortNegative predictive value 95.0Multivariate Cox regression modelHigh negative predictive valueMulticenter cohort studyIncidence of preeclampsiaCox regression modelTime of enrollmentNegative predictive valueNegative control groupNegative likelihood ratioCohort studyPreeclampsiaBaseline evaluationPrimary analysisControl groupPredictive valueWeeksModerate sensitivityCohortEnrollmentLikelihood ratioRegression models
2021
Diagnostic performance of a Recombinant Polymerase Amplification Test—Lateral Flow (RPA-LF) for cutaneous leishmaniasis in an endemic setting of Colombia
Cossio A, Jojoa J, del Mar Castro M, Castillo R, Osorio L, Shelite T, Saravia N, Melby P, Travi B. Diagnostic performance of a Recombinant Polymerase Amplification Test—Lateral Flow (RPA-LF) for cutaneous leishmaniasis in an endemic setting of Colombia. PLOS Neglected Tropical Diseases 2021, 15: e0009291. PMID: 33909619, PMCID: PMC8081229, DOI: 10.1371/journal.pntd.0009291.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overChildChild, PreschoolChromatography, AffinityColombiaCross-Sectional StudiesDNA PrimersDNA, KinetoplastDNA, ProtozoanFemaleHumansLeishmaniaLeishmaniasis, CutaneousMaleMiddle AgedMolecular Diagnostic TechniquesNucleic Acid Amplification TechniquesSensitivity and SpecificityYoung AdultConceptsCommunity health workersHealth workersCutaneous leishmaniasisRPA-LFReference centerHealth systemPrimary health facilitiesBurden of diseaseCross-sectional studyYears of ageRoutine diagnostic testsPublic health systemPositive likelihood ratioLeishmania kinetoplast DNANegative likelihood ratioLikelihood ratioUlcerated lesionsPolymerase chain reaction detectionSpecificity 89Endemic settingsEarly diagnosisHealth facilitiesDiagnostic test performanceWeek evolutionReal-time polymerase chain reaction detection
2020
Validation of an immunomodulatory gene signature algorithm to predict response to neoadjuvant immunochemotherapy in patients with primary triple-negative breast cancer.
Iwase T, Pusztai L, Blenman K, Li X, Seitz R, Nielsen T, Schweitzer B, Hout D, Bailey D, Zhang X, Shen Y, Ueno N. Validation of an immunomodulatory gene signature algorithm to predict response to neoadjuvant immunochemotherapy in patients with primary triple-negative breast cancer. Journal Of Clinical Oncology 2020, 38: 3117-3117. DOI: 10.1200/jco.2020.38.15_suppl.3117.Peer-Reviewed Original ResearchPrimary triple-negative breast cancerTriple-negative breast cancerPathological complete responsePD-L1 IHCIM subtypesPredictive valueNeoadjuvant immunochemotherapyBreast cancerPhase I/II trialPretreatment core-needle biopsiesAntigen-presenting immune cellsPossible predictive markerImmune cell populationsImmune cell processesCore needle biopsyNegative predictive valuePositive predictive valueStrong predictive valuePositive likelihood ratioNegative likelihood ratioImmunomodulatory subtypeNeoadjuvant immunotherapyII trialLikelihood ratioComplete responsePooled analysis of the Xpert MTB/RIF assay for diagnosing tuberculous meningitis
Chen YZ, Sun LC, Wen YH, Li ZW, Fan SJ, Tan HK, Qiu M, Pan ZY, Li Q, Zhao YZ, Li ZX, Guo XG. Pooled analysis of the Xpert MTB/RIF assay for diagnosing tuberculous meningitis. Bioscience Reports 2020, 40: bsr20191312. PMID: 31778149, PMCID: PMC6946622, DOI: 10.1042/bsr20191312.Peer-Reviewed Original ResearchConceptsXpert MTB/RIFMTB/RIFTuberculous meningitisPositive likelihood ratioNegative likelihood ratioDiagnostic odds ratioOdds ratioEarly diagnosisCerebrospinal fluidCSF samplesPooled sensitivityLikelihood ratioReceiver operator characteristic curveOverall pooled sensitivityOperator characteristic curveExtrapulmonary tuberculosisDiagnostic delayPooled analysisSummary receiver operator characteristic curveDiagnostic efficacyClinical diagnosisMeningitisPooled specificityRelevant studiesDiagnosis
2019
Performance of the Access Bio/CareStart rapid diagnostic test for the detection of glucose-6-phosphate dehydrogenase deficiency: A systematic review and meta-analysis
Ley B, Satyagraha A, Rahmat H, von Fricken ME, Douglas NM, Pfeffer DA, Espino F, von Seidlein L, Henriques G, Oo NN, Menard D, Parikh S, Bancone G, Karahalios A, Price RN. Performance of the Access Bio/CareStart rapid diagnostic test for the detection of glucose-6-phosphate dehydrogenase deficiency: A systematic review and meta-analysis. PLOS Medicine 2019, 16: e1002992. PMID: 31834890, PMCID: PMC6910667, DOI: 10.1371/journal.pmed.1002992.Peer-Reviewed Original ResearchConceptsNegative predictive valueGlucose-6-phosphate dehydrogenase deficiencyIndividual participant dataSystematic reviewHigh negative predictive valueDehydrogenase deficiencyRandom-effects bivariate modelPrevalence of G6PDdDrug-induced haemolysisCapillary blood samplesRapid diagnostic testsPositive likelihood ratioNegative likelihood ratioLikelihood ratioVivax malariaVenous bloodEndemic settingsInclusion criteriaPooled estimatesBlood samplesRadical curePredictive valueWide geographical representationMale medianRoutine settingComparison of Biomarker Modalities for Predicting Response to PD-1/PD-L1 Checkpoint Blockade
Lu S, Stein JE, Rimm DL, Wang DW, Bell JM, Johnson DB, Sosman JA, Schalper KA, Anders RA, Wang H, Hoyt C, Pardoll DM, Danilova L, Taube JM. Comparison of Biomarker Modalities for Predicting Response to PD-1/PD-L1 Checkpoint Blockade. JAMA Oncology 2019, 5: 1195-1204. PMID: 31318407, PMCID: PMC6646995, DOI: 10.1001/jamaoncol.2019.1549.Peer-Reviewed Original ResearchAnti-PD-1/PD-L1 therapyPD-L1 immunohistochemistryTumor mutational burdenPD-L1 therapyGene expression profilingMutational burdenAnti-PD-1/PD-L1 treatmentPD-1/PD-L1 checkpoint blockadeAnti-PD-1/PD-L1Tumor typesPD-L1 checkpoint blockadeDifferent solid tumor typesPD-L1 treatmentPretreatment tumor tissueImmunotherapy of cancerDrug Administration approvalSearch of PubMedMeta-Analyses (PRISMA) guidelinesSolid tumor typesNegative predictive valuePreferred Reporting ItemsAnnual meeting abstractsNegative likelihood ratioRelative diagnostic performanceCheckpoint blockadeReevaluation of FAST Sensitivity in Pediatric Blunt Abdominal Trauma Patients
Riera A, Hayward H, Silva C, Chen L. Reevaluation of FAST Sensitivity in Pediatric Blunt Abdominal Trauma Patients. Pediatric Emergency Care 2019, 37: e1012-e1019. PMID: 31356479, DOI: 10.1097/pec.0000000000001877.Peer-Reviewed Original ResearchConceptsBlunt abdominal trauma patientsAbdominal trauma patientsFree fluidTrauma patientsUpper quadrantPredictive valueLevel I pediatric trauma centerPediatric trauma centerRetrospective chart reviewRight upper quadrantFAST examinationNegative predictive valuePositive predictive valueNegative likelihood ratioChart reviewBAT patientsMedian ageTrauma centerUpper abdomenIntraperitoneal fluidMAIN OUTCOMEPhysiologic amountsTrauma (FAST) examinationPatientsFocused assessmentDiagnostic accuracy of dobutamine stress echocardiography in the detection of cardiac allograft vasculopathy in heart transplant recipients: A systematic review and meta‐analysis study
Elkaryoni A, Abu‐Sheasha G, Altibi A, Hassan A, Ellakany K, Nanda N. Diagnostic accuracy of dobutamine stress echocardiography in the detection of cardiac allograft vasculopathy in heart transplant recipients: A systematic review and meta‐analysis study. Echocardiography 2019, 36: 528-536. PMID: 30726558, DOI: 10.1111/echo.14268.Peer-Reviewed Original ResearchConceptsDetecting cardiac allograft vasculopathyAccuracy of dobutamine stress echocardiographyCardiac allograft vasculopathyDobutamine stress echocardiographyDiagnostic accuracy of dobutamine stress echocardiographyHeart transplant recipientsStress echocardiographyAllograft vasculopathyArea under curveTransplant recipientsDiagnostic accuracySensitivity of dobutamine stress echocardiographyEarly CAVOdds ratioSummary receiver operating characteristic analysisDetection of cardiac allograft vasculopathyHierarchical summary receiver operating characteristic analysisIntravascular ultrasoundCochrane Central Register of Controlled TrialsCentral Register of Controlled TrialsReceiver operating characteristic analysisCohort of patientsDiagnostic odds ratioNegative likelihood ratioPositive likelihood ratio
2017
A Pivotal Study of Optoacoustic Imaging to Diagnose Benign and Malignant Breast Masses: A New Evaluation Tool for Radiologists
Neuschler EI, Butler R, Young CA, Barke LD, Bertrand ML, Böhm-Vélez M, Destounis S, Donlan P, Grobmyer SR, Katzen J, Kist KA, Lavin PT, Makariou EV, Parris TM, Schilling KJ, Tucker FL, Dogan BE. A Pivotal Study of Optoacoustic Imaging to Diagnose Benign and Malignant Breast Masses: A New Evaluation Tool for Radiologists. Radiology 2017, 287: 172228. PMID: 29178816, DOI: 10.1148/radiol.2017172228.Peer-Reviewed Original ResearchConceptsProbability of malignancyNegative likelihood ratioGrayscale ultrasonographyIndependent readersMalignant breast massesBreast massesBlinded independent readersMalignant massesBI-RADS 3Negative predictive valueData System (BI-RADS) categoryBreast Imaging ReportingBI-RADS categoryLikelihood ratioOA featuresHistologic findingsBI-RADS categoriesNegative examinationsPretest probabilityProtocol deviationsHistologic resultsOnline supplemental materialUltrasonographyDiagnostic utilityPredictive value
2016
Use of transient elastography in patients with HIV–HCV coinfection: A systematic review and meta‐analysis
Njei B, McCarty TR, Luk J, Ewelukwa O, Ditah I, Lim JK. Use of transient elastography in patients with HIV–HCV coinfection: A systematic review and meta‐analysis. Journal Of Gastroenterology And Hepatology 2016, 31: 1684-1693. PMID: 26952020, PMCID: PMC5014713, DOI: 10.1111/jgh.13337.Peer-Reviewed Original ResearchConceptsHIV-HCV coinfectionTransient elastographyMeta-regression analysisDiagnostic accuracyLiver stiffnessModerate fibrosisPooled sensitivityHCV mono-infected individualsMono-infected individualsCD4 cell countCochrane Library databasesAssessment of cirrhosisSearch of PubMedNoninvasive imaging modalityNegative likelihood ratioWeb of ScienceLiver fibrosisInclusion criteriaLibrary databasesCirrhosisCell countSystematic reviewPublication biasPatientsFibrosisDiagnostic Accuracy of Fast Computational Approaches to Derive Fractional Flow Reserve From Diagnostic Coronary Angiography The International Multicenter FAVOR Pilot Study
Tu S, Westra J, Yang J, von Birgelen C, Ferrara A, Pellicano M, Nef H, Tebaldi M, Murasato Y, Lansky A, Barbato E, van der Heijden LC, Reiber JH, Holm NR, Wijns W, Group F. Diagnostic Accuracy of Fast Computational Approaches to Derive Fractional Flow Reserve From Diagnostic Coronary Angiography The International Multicenter FAVOR Pilot Study. JACC Cardiovascular Interventions 2016, 9: 2024-2035. PMID: 27712739, DOI: 10.1016/j.jcin.2016.07.013.Peer-Reviewed Original ResearchMeSH KeywordsAdenosineAdministration, IntravenousAgedArea Under CurveBlood Flow VelocityCardiac CatheterizationChinaComputer SimulationCoronary AngiographyCoronary StenosisCoronary VesselsEuropeFeasibility StudiesFemaleFractional Flow Reserve, MyocardialHumansHyperemiaJapanMaleMiddle AgedModels, CardiovascularMyocardial Perfusion ImagingPilot ProjectsPredictive Value of TestsPrognosisProspective StudiesRadiographic Image Interpretation, Computer-AssistedRegional Blood FlowReproducibility of ResultsROC CurveSeverity of Illness IndexTime FactorsUnited StatesVasodilator AgentsWorkflowConceptsQuantitative flow ratioHyperemic flow velocityReceiver-operating characteristic curveCoronary angiographyDiagnostic accuracyAngiographic percent diameter stenosisDiagnostic coronary angiographyProspective multicenter studyIndependent core laboratoryAdenosine-induced hyperemiaPercent diameter stenosisQuantitative coronary angiographyIntermediate coronary lesionsCharacteristic curveFractional flow reservePositive likelihood ratioOverall diagnostic accuracyNegative likelihood ratioDrug-induced hyperemiaLikelihood ratioCoronary lesionsMulticenter studyDiameter stenosisMaximal hyperemiaFlow reserveDiagnostic accuracy of methicillin-resistant Staphylococcus aureus nasal colonization to predict methicillin-resistant S aureus soft tissue infections
Gunderson CG, Holleck JL, Chang JJ, Merchant N, Lin S, Gupta S. Diagnostic accuracy of methicillin-resistant Staphylococcus aureus nasal colonization to predict methicillin-resistant S aureus soft tissue infections. American Journal Of Infection Control 2016, 44: 1176-1177. PMID: 27311510, DOI: 10.1016/j.ajic.2016.03.039.Peer-Reviewed Original ResearchConceptsSoft tissue infectionsMRSA infectionTissue infectionsPrevalence populationsMethicillin-resistant Staphylococcus aureus nasal colonizationMRSA soft tissue infectionsStaphylococcus aureus nasal colonizationHigh-prevalence populationsLow-prevalence populationsPositive likelihood ratioNegative likelihood ratioNasal MRSALikelihood ratioNasal colonizationClinical utilityInfectionDiagnostic accuracyAdmissionHospitalPopulationMRSAPrevalenceDiagnostic Accuracy of Transcranial Sonography of the Substantia Nigra in Parkinson’s disease: A Systematic Review and Meta-analysis
Li D, He Y, Liu J, Chen S. Diagnostic Accuracy of Transcranial Sonography of the Substantia Nigra in Parkinson’s disease: A Systematic Review and Meta-analysis. Scientific Reports 2016, 6: 20863. PMID: 26878893, PMCID: PMC4754637, DOI: 10.1038/srep20863.Peer-Reviewed Original ResearchConceptsDiagnostic accuracy of transcranial sonographySystematic reviewDiagnostic accuracyMeta-analysisTranscranial sonographyCompared to healthy controlsRandom-effects modelDiagnostic odds ratioNegative likelihood ratioPositive likelihood ratioParkinson's diseaseLikelihood ratioOdds ratioMeta-RegressionSubstantia nigra hyperechogenicityEffect sizePooled specificityObservational studyDiagnosis of PDHealthy controlsNormal controlsClinical utilityDifferentiate PDSubstantia nigraPotential heterogeneityCT Angiography Spot Sign, Hematoma Expansion, and Outcome in Primary Pontine Intracerebral Hemorrhage
Morotti A, Jessel MJ, Brouwers HB, Falcone GJ, Schwab K, Ayres AM, Vashkevich A, Anderson CD, Viswanathan A, Greenberg SM, Gurol ME, Romero JM, Rosand J, Goldstein JN. CT Angiography Spot Sign, Hematoma Expansion, and Outcome in Primary Pontine Intracerebral Hemorrhage. Neurocritical Care 2016, 25: 79-85. PMID: 26759226, PMCID: PMC4940347, DOI: 10.1007/s12028-016-0241-2.Peer-Reviewed Original ResearchConceptsPrimary pontine hemorrhagePositive predictive valueSupratentorial intracerebral hemorrhageIntracerebral hemorrhageHematoma expansionHospital mortalitySpot signNegative predictive valuePredictive valueNon-contrast CT scanCT angiography spot signAbsolute hematoma growthBrainstem ICHTomography angiography spot signConsecutive ICH patientsComputer-assisted volumetric analysisSpot sign presenceNegative likelihood ratioCTA spot signCollected cohortICH patientsPontine hemorrhagePPH casesHematoma growthHematoma volume
2014
Endoscopic ultrasound in the diagnosis of cholangiocarcinoma as the etiology of biliary strictures: a systematic review and meta-analysis
Navaneethan U, Njei B, Venkatesh PG, Lourdusamy V, Sanaka MR. Endoscopic ultrasound in the diagnosis of cholangiocarcinoma as the etiology of biliary strictures: a systematic review and meta-analysis. Gastroenterology Report 2014, 3: 209-215. PMID: 25169922, PMCID: PMC4527262, DOI: 10.1093/gastro/gou057.Peer-Reviewed Original ResearchDiagnosis of cholangiocarcinomaBiliary stricturesEUS-FNAFine-needle aspirationEndoscopic ultrasoundPooled sensitivityEvaluation of cholangiocarcinomaNegative brush cytologyExtrahepatic biliary stricturesMain outcome measurementsCross-sectional imagingNegative likelihood ratioLikelihood ratioNegative cytologyExtrahepatic cholangiocarcinomaMass lesionEmbase databasesBrush cytologyNeedle aspirationCholangiocarcinomaOutcome measurementsPatientsStrictureSystematic reviewEtiologyEffect of Provider Experience on Clinician-Performed Ultrasonography for Hydronephrosis in Patients With Suspected Renal Colic
Herbst MK, Rosenberg G, Daniels B, Gross CP, Singh D, Molinaro AM, Luty S, Moore CL. Effect of Provider Experience on Clinician-Performed Ultrasonography for Hydronephrosis in Patients With Suspected Renal Colic. Annals Of Emergency Medicine 2014, 64: 269-276. PMID: 24630203, PMCID: PMC5131571, DOI: 10.1016/j.annemergmed.2014.01.012.Peer-Reviewed Original ResearchConceptsComputed tomographyRenal colicPositive likelihood ratioNegative likelihood ratioFellowship trainingTest characteristicsEmergency cliniciansUreteral stonesPhysician cliniciansAcademic medical center emergency departmentMedical Center Emergency DepartmentClinician-performed ultrasonographyAbsence of hydronephrosisCenter emergency departmentDegree of hydronephrosisLikelihood ratioDetection of hydronephrosisDirect patient careUnique cliniciansDefinitive test resultsProspective studyEmergency departmentBedside ultrasonographyUltrasonographic resultsEmergency physiciansStaging accuracy of ampullary tumors by endoscopic ultrasound: Meta‐analysis and systematic review
Trikudanathan G, Njei B, Attam R, Arain M, Shaukat A. Staging accuracy of ampullary tumors by endoscopic ultrasound: Meta‐analysis and systematic review. Digestive Endoscopy 2014, 26: 617-626. PMID: 24533918, DOI: 10.1111/den.12234.Peer-Reviewed Original ResearchConceptsEndoscopic ultrasoundAmpullary neoplasmsPooled sensitivityStaging accuracyTumor invasionMeta-analysisRegional lymph node statusAccuracy of endoscopic ultrasoundSpecificity of endoscopic ultrasoundDiagnosing nodal statusEndoscopic ultrasound studiesAccurate preoperative stagingLymph node involvementLymph node statusT1 stage tumorsModerate strength of agreementDiagnostic odds ratioNegative likelihood ratioPositive likelihood ratioPredicting tumor invasionMantel-Haenszel methodLikelihood ratioNodal statusT4 tumorsNode involvement
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