2024
The Current and Future State of Vaccines for Lyme Disease
Plotkin S, Shapiro E. The Current and Future State of Vaccines for Lyme Disease. Clinical Infectious Diseases 2024, ciae639. PMID: 39711074, DOI: 10.1093/cid/ciae639.Peer-Reviewed Original Research
2020
Increased mosquito abundance and species richness in Connecticut, United States 2001–2019
Petruff T, McMillan J, Shepard J, Andreadis T, Armstrong P. Increased mosquito abundance and species richness in Connecticut, United States 2001–2019. Scientific Reports 2020, 10: 19287. PMID: 33159108, PMCID: PMC7648108, DOI: 10.1038/s41598-020-76231-x.Peer-Reviewed Original ResearchConceptsMosquito community compositionSpecies richnessCommunity compositionTotal species richnessLandscape-level changesNorthward range expansionAdditive mixed effects modelsMultiple insect taxaLand cover classificationMosquito surveillance dataLand useRange expansionHistorical declineInsect taxaMosquito abundanceMultiple speciesRichnessPsorophora genusCover classificationNortheast U.S.United States 2001Southern portionMosquito populationsMixed effects modelsPathogen transmission
2018
Using evolutionary genomics, transcriptomics, and systems biology to reveal gene networks underlying fungal development
Wang Z, Gudibanda A, Ugwuowo U, Trail F, Townsend J. Using evolutionary genomics, transcriptomics, and systems biology to reveal gene networks underlying fungal development. Fungal Biology Reviews 2018, 32: 249-264. DOI: 10.1016/j.fbr.2018.02.001.ChaptersModel speciesFungal developmentGenome-wide gene expression dataEvolutionary developmental biologyEvo-devo researchGenome-wide analysisSystems biology strategiesGene expression dataEvolutionary genomicsSpecies phylogenyGenetic screenDevelopmental biologyDevelopmental traitsGene networksRegulatory networksFungal modelCell biologyModern biologyFossil recordKnockout strategiesDevelopmental processesMultiple speciesSystems biologyMolecular geneticsExpression dataUrban rat races: spatial population genomics of brown rats (Rattus norvegicus) compared across multiple cities
Combs M, Byers K, Ghersi B, Blum M, Caccone A, Costa F, Himsworth C, Richardson J, Munshi-South J. Urban rat races: spatial population genomics of brown rats (Rattus norvegicus) compared across multiple cities. Proceedings Of The Royal Society B 2018, 285: 20180245. PMID: 29875297, PMCID: PMC6015871, DOI: 10.1098/rspb.2018.0245.Peer-Reviewed Original ResearchConceptsGene flowGenome-wide single nucleotide polymorphismsSpatial population genomicsGenome-wide diversityShortest distance classesGenerality of predictionsPopulation genomicsGenetic discontinuityLimited dispersalNeutral evolutionSingle nucleotide polymorphismsMultiple speciesPest managementSame speciesBrown ratsDifferent biomesDistance classesNucleotide polymorphismsAnimal movementSpeciesGenomicsMajor waterwaysCoancestryClustering analysisDispersal
2016
P013 Development of the IPD-MHC database
Robinson J, Maccari G, Bontrop R, Ho C, Grimholt U, Kaufman J, Guethlein L, Ballingall K, Marsh S, Hammond J. P013 Development of the IPD-MHC database. Human Immunology 2016, 77: 51. DOI: 10.1016/j.humimm.2016.07.078.Peer-Reviewed Original ResearchIPD-MHC DatabaseNomenclature CommitteeCross-species alignmentPrimer design toolsLocus-specific databasesNomenclature systemIPD-IMGT/HLA DatabaseIPD-MHCNGS dataBioinformatics challengesMHC sequencesSequence variantsCurated databaseIPD-IMGT/HLANon-human speciesFrequent speciesMultiple speciesNomenclatural standardsSpeciesBioinformaticsBiological resourcesSequenceNomenclatureData submissionLociS0117 Development of the ipd-MHC Database
Robinson J, Maccari G, Bontrop R, Ho S, Grimholt U, Kaufman J, Guethlein L, Ballingall K, Marsh S, Hammond J. S0117 Development of the ipd-MHC Database. Journal Of Animal Science 2016, 94: 9-9. DOI: 10.2527/jas2016.94supplement49x.Peer-Reviewed Original ResearchIPD-MHC DatabaseNomenclature CommitteeCross-species alignmentPrimer design toolsLocus-specific databasesNomenclature systemIPD-IMGT/HLA DatabaseIPD-MHCNGS dataBioinformatics challengesMHC sequencesSequence variantsCurated databaseIPD-IMGT/HLANon-human speciesFrequent speciesMultiple speciesNomenclatural standardsSpeciesBioinformaticsBiological resourcesSequenceNomenclatureData submissionPrimersA Novel Di-Leucine Motif at the N-Terminus of Human Organic Solute Transporter Beta Is Essential for Protein Association and Membrane Localization
Xu S, Soroka CJ, Sun AQ, Backos DS, Mennone A, Suchy FJ, Boyer JL. A Novel Di-Leucine Motif at the N-Terminus of Human Organic Solute Transporter Beta Is Essential for Protein Association and Membrane Localization. PLOS ONE 2016, 11: e0158269. PMID: 27351185, PMCID: PMC4924846, DOI: 10.1371/journal.pone.0158269.Peer-Reviewed Original ResearchConceptsMembrane localizationAlpha subunitBeta subunitDileucine motifPlasma membrane localizationDi-leucine motifExtracellular N-terminal regionCo-immunoprecipitation studiesBasolateral membrane localizationN-terminal regionSite-directed mutagenesisAA mutantProtein associationBeta mutantsN-terminusMultiple speciesPhysical associationMembrane biotinylationHEK293 cellsSubunitsAA mutationsMembrane expressionAlpha/betaMutantsMotif
2014
Loss of Polycystin-1 Inhibits Bicc1 Expression during Mouse Development
Lian P, Li A, Li Y, Liu H, Liang D, Hu B, Lin D, Jiang T, Moeckel G, Qin D, Wu G. Loss of Polycystin-1 Inhibits Bicc1 Expression during Mouse Development. PLOS ONE 2014, 9: e88816. PMID: 24594709, PMCID: PMC3940423, DOI: 10.1371/journal.pone.0088816.Peer-Reviewed Original ResearchConceptsAutosomal dominant polycystic kidney diseasePolycystic kidney diseasePolycystin-1Gene productsKidney developmentKidney diseaseRNA-binding proteinMouse kidney developmentPKD1 gene productEmbryonic day 8.5Human autosomal dominant polycystic kidney diseaseNew molecular linkTemporal expression patternsEarly ureteric budDominant polycystic kidney diseaseC. elegansHuman polycystic kidney diseaseMouse embryogenesisMouse developmentPostnatal kidney developmentMouse homologueCystic phenotypeExpression patternsMolecular linkMultiple speciesOrthoClust: an orthology-based network framework for clustering data across multiple species
Yan KK, Wang D, Rozowsky J, Zheng H, Cheng C, Gerstein M. OrthoClust: an orthology-based network framework for clustering data across multiple species. Genome Biology 2014, 15: r100. PMID: 25249401, PMCID: PMC4289247, DOI: 10.1186/gb-2014-15-8-r100.Peer-Reviewed Original ResearchConceptsMultiple speciesCo-association networksRNA-seq expression profilesNon-coding RNAsOrthology relationshipsCaenorhabditis elegansDrosophila melanogasterModENCODE consortiumIndividual speciesGenomic dataExpression profilesHigh-dimensional genomic dataUncharacterized elementsAnalogous functionsSpeciesMelanogasterElegansGenesRNAOrganismsComputational frameworkConsortium
2012
Genetics of germ cell development
Lesch BJ, Page DC. Genetics of germ cell development. Nature Reviews Genetics 2012, 13: 781-794. PMID: 23044825, DOI: 10.1038/nrg3294.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsGerm cell developmentGerm cellsHaploid genomeMultiple speciesCell developmentPluripotent stem cell systemsRepressive chromatin configurationGerm cell identityRNA polymerase IIGerm cell biologyStem cell systemEarly germ cellsPolymerase IICell identityDiploid genomeChromatin configurationIndividual organismsCell biologyMitotic proliferationGenomeSame speciesDifferent speciesGermline precursorsLater stepsMeiosis
2005
Designing Experiments Using Spotted Microarrays to Detect Gene Regulation Differences Within and Among Species
Townsend JP, Taylor JW. Designing Experiments Using Spotted Microarrays to Detect Gene Regulation Differences Within and Among Species. Methods In Enzymology 2005, 395: 597-617. PMID: 15865986, DOI: 10.1016/s0076-6879(05)95031-3.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsGene expressionGenome-wide gene expressionGene regulation differencesDifferential gene expressionMultiple developmental stagesMultiple environmental conditionsMultiple speciesDevelopmental stagesRegulation differencesSpeciesEnvironmental conditionsMultiple individualsMicroarrayExpressionSuch studiesStatistical powerExperimental protocol
2003
The mTOR/p70 S6K1 pathway regulates vascular smooth muscle cell differentiation
Martin K, Rzucidlo E, Merenick B, Fingar D, Brown D, Wagner R, Powell R. The mTOR/p70 S6K1 pathway regulates vascular smooth muscle cell differentiation. American Journal Of Physiology - Cell Physiology 2003, 286: c507-c517. PMID: 14592809, DOI: 10.1152/ajpcell.00201.2003.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAorta, ThoracicBiomarkersCattleCell Cycle ProteinsCell DifferentiationCells, CulturedCyclin-Dependent Kinase Inhibitor p21Cyclin-Dependent Kinase Inhibitor p27CyclinsEndothelium, VascularExtracellular Matrix ProteinsImmunosuppressive AgentsMuscle ContractionMuscle, Smooth, VascularPhenotypeProtein KinasesRibosomal Protein S6 Kinases, 70-kDaSignal TransductionSirolimusTOR Serine-Threonine KinasesTumor Suppressor ProteinsConceptsVascular smooth muscle cellsVSMC differentiationVascular smooth muscle cell differentiationSmooth muscle cell differentiationVSMC gene expressionRapamycin-sensitive mTORMuscle cell differentiationContractile morphologyCyclin-dependent kinase inhibitorCell cycle withdrawalExtracellular matrix protein synthesisContractile proteinsMTOR pathway inhibitor rapamycinMuscle alpha-actinTranscriptional controlMatrix protein synthesisNovel functionGene expressionMigratory phenotypeRapamycin inductionMultiple speciesCell differentiationInhibitor rapamycinS6K1 pathwayProtein synthesis
1997
Polarity and the development of the outer blood-retinal barrier.
Rizzolo L. Polarity and the development of the outer blood-retinal barrier. Histology And Histopathology 1997, 12: 1057-67. PMID: 9302567.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
1967
Studies on polynucleotides LXXV. Specificity of tRNA for codon recognition as studied by the ribosomal binding technique
Söll D, Cherayil J, Bock R. Studies on polynucleotides LXXV. Specificity of tRNA for codon recognition as studied by the ribosomal binding technique. Journal Of Molecular Biology 1967, 29: 97-112. PMID: 4861614, DOI: 10.1016/0022-2836(67)90183-0.Peer-Reviewed Original ResearchConceptsTransfer RNAAmino acidsE. coliIndividual amino acidsCodon recognitionMultiple codonsMultiple speciesRespective amino acidsWobble hypothesisYeast transfer RNAEscherichia coliCodonRNAColiYeastSpeciesBindingRecognition patternsTRNARibosomesThird letterStimulation of bindingTrinucleotideAcidInteresting differences
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