2014
Loss of Polycystin-1 Inhibits Bicc1 Expression during Mouse Development
Lian P, Li A, Li Y, Liu H, Liang D, Hu B, Lin D, Jiang T, Moeckel G, Qin D, Wu G. Loss of Polycystin-1 Inhibits Bicc1 Expression during Mouse Development. PLOS ONE 2014, 9: e88816. PMID: 24594709, PMCID: PMC3940423, DOI: 10.1371/journal.pone.0088816.Peer-Reviewed Original ResearchConceptsAutosomal dominant polycystic kidney diseasePolycystic kidney diseasePolycystin-1Gene productsKidney developmentKidney diseaseRNA-binding proteinMouse kidney developmentPKD1 gene productEmbryonic day 8.5Human autosomal dominant polycystic kidney diseaseNew molecular linkTemporal expression patternsEarly ureteric budDominant polycystic kidney diseaseC. elegansHuman polycystic kidney diseaseMouse embryogenesisMouse developmentPostnatal kidney developmentMouse homologueCystic phenotypeExpression patternsMolecular linkMultiple species
1997
PKD1 interacts with PKD2 through a probable coiled-coil domain
Qian F, Germino F, Cai Y, Zhang X, Somlo S, Germino G. PKD1 interacts with PKD2 through a probable coiled-coil domain. Nature Genetics 1997, 16: 179-183. PMID: 9171830, DOI: 10.1038/ng0697-179.Peer-Reviewed Original ResearchConceptsCoiled-coil domainC-terminusPKD1 gene productAutosomal dominant polycystic kidney diseaseSite-specific mutagenesisLarge cystic kidneysGene productsHomotypic interactionsTubular morphogenesisStructural basisHeterotypic interactionsPKD2TerminusRecent discoveryPathogenic mutationsDominant polycystic kidney diseasePKD1Cystic kidneysPolycystic kidney diseaseCommon pathwayAffected individualsMorphogenesisPolycystinsMutagenesisGenes
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