2023
Higher HDL cholesterol levels are associated with increased markers of interstitial myocardial fibrosis in the MultiEthnic Study of Atherosclerosis (MESA)
Chehab O, Akl E, Abdollahi A, Zeitoun R, Ambale-Venkatesh B, Wu C, Tracy R, Blumenthal R, Post W, Lima J, Rodriguez A. Higher HDL cholesterol levels are associated with increased markers of interstitial myocardial fibrosis in the MultiEthnic Study of Atherosclerosis (MESA). Scientific Reports 2023, 13: 20115. PMID: 37978334, PMCID: PMC10656454, DOI: 10.1038/s41598-023-46811-8.Peer-Reviewed Original ResearchConceptsMultiethnic Study of AtherosclerosisHDL-C categoryInterstitial myocardial fibrosisLevels of HDL-CLate gadolinium enhancementHDL-C levelsIncreased levels of HDL-CHDL-CCardiovascular diseaseCardiovascular disease risk factorsAssociation of HDL-CPrevalence of myocardial scarAssociated with increased markersCommunity-based settingsHDL-C measurementsHigher HDL cholesterol levelsMyocardial fibrosisMyocardial scarStudy of atherosclerosisHigher HDL-CLow HDL-CHistory of myocardial infarctionHDL-C associationLogistic regression modelsMultiethnic Study
2022
DNA Methylation Mediates the Association Between Individual and Neighborhood Social Disadvantage and Cardiovascular Risk Factors
Wang Y, Zhao W, Ammous F, Song Y, Du J, Shang L, Ratliff S, Moore K, Kelly K, Needham B, Roux A, Liu Y, Butler K, Kardia S, Mukherjee B, Zhou X, Smith J. DNA Methylation Mediates the Association Between Individual and Neighborhood Social Disadvantage and Cardiovascular Risk Factors. Frontiers In Cardiovascular Medicine 2022, 9: 848768. PMID: 35665255, PMCID: PMC9162507, DOI: 10.3389/fcvm.2022.848768.Peer-Reviewed Original ResearchBody mass indexCardiovascular risk factorsNeighborhood socioeconomic disadvantageMulti-Ethnic Study of AtherosclerosisNeighborhood-level disadvantagePoor cardiovascular healthSocioeconomic statusSocioeconomic disadvantageRisk factorsCardiovascular healthAssociated with poor cardiovascular healthSocial disadvantageAdult socioeconomic statusBody mass index adjustmentAssociations of individual-HDL-CPrincipal components of ancestryGenetic principal componentsMeasures of obesityLow socioeconomic statusPopulation-based cohortMulti-Ethnic StudyStudy of atherosclerosisHDL-C associationHigh-density lipoprotein cholesterol
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