2019
The Genome-Wide Impact of Trisomy 21 on DNA Methylation and Its Implications for Hematologic Malignancies
Wiemels J, Muskens I, Li S, Pandey P, Roy R, Hansen H, Siegmund K, Mueller B, Ma X, Metayer C, de Smith A. The Genome-Wide Impact of Trisomy 21 on DNA Methylation and Its Implications for Hematologic Malignancies. Blood 2019, 134: 2510. DOI: 10.1182/blood-2019-131455.Peer-Reviewed Original ResearchTransient abnormal myelopoiesisNon-DS subjectsDS neonatesDown syndromeTrisomy 21Hematopoietic stem cellsBlood cell proportionsT cellsHigher CD8 T cellsCell proportionEpigenome-wide association studiesMean beta valueNon-DS controlsCD8 T cellsCD4 T cellsLow B cellsAcute lymphoblastic leukemiaAcute megakaryoblastic leukemiaMulti-Ethnic StudyNeonatal DNA methylationEthnicity-stratified analysisSignificant DMRsIllumina Infinium MethylationEPIC arrayChromosome 21Non-Latino whites
2018
GWAS in childhood acute lymphoblastic leukemia reveals novel genetic associations at chromosomes 17q12 and 8q24.21
Wiemels JL, Walsh KM, de Smith AJ, Metayer C, Gonseth S, Hansen HM, Francis SS, Ojha J, Smirnov I, Barcellos L, Xiao X, Morimoto L, McKean-Cowdin R, Wang R, Yu H, Hoh J, DeWan AT, Ma X. GWAS in childhood acute lymphoblastic leukemia reveals novel genetic associations at chromosomes 17q12 and 8q24.21. Nature Communications 2018, 9: 286. PMID: 29348612, PMCID: PMC5773513, DOI: 10.1038/s41467-017-02596-9.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentCaliforniaChild, PreschoolChromosomes, Human, Pair 17Chromosomes, Human, Pair 8FemaleGene FrequencyGenetic Predisposition to DiseaseGenome-Wide Association StudyHispanic or LatinoHumansInfantInfant, NewbornMalePolymorphism, Single NucleotidePrecursor Cell Lymphoblastic Leukemia-LymphomaRisk FactorsConceptsNew risk lociRisk lociGenome-wide association studiesGrowth regulation pathwaysGenetic associationAcute lymphoblastic leukemiaNovel genetic associationsChildhood acute lymphoblastic leukemiaGenetic Epidemiology ResearchTranscription factorsStrong genetic associationGene expressionAssociation studiesLymphocyte developmentMYC oncogeneChromosome 17q12Oncology GroupLymphoblastic leukemiaLociChildren's Oncology GroupCalifornia Childhood Leukemia StudyChildhood Leukemia StudyStructural contactsYear of birthNon-Latino whites
2015
Health Literacy as a Social Determinant of Health in Asian American Immigrants: Findings from a Population-Based Survey in California
Lee HY, Rhee TG, Kim NK, Ahluwalia JS. Health Literacy as a Social Determinant of Health in Asian American Immigrants: Findings from a Population-Based Survey in California. Journal Of General Internal Medicine 2015, 30: 1118-1124. PMID: 25715993, PMCID: PMC4510223, DOI: 10.1007/s11606-015-3217-6.Peer-Reviewed Original ResearchConceptsSelf-rated health statusCalifornia Health Interview SurveyNon-Latino whitesHealth literacyHealth outcomesHealth statusDepression symptomsMain health outcomesHealth Interview SurveyPopulation-based sampling strategySymptoms of depressionAsian American immigrantsMain MeasuresWeCauses of heterogeneityResultsThe levelsSignificant associationHealth disparitiesSocial determinantsLow levelsInterview SurveySouth Asian immigrantsSymptomsOutcomesAmerican immigrantsOnly group
2010
The Latino adolescent male mortality peak revisited: attribution of homicide and motor vehicle crash death
Vaca FE, Anderson CL, Hayes-Bautista DE. The Latino adolescent male mortality peak revisited: attribution of homicide and motor vehicle crash death. Injury Prevention 2010, 17: 102. PMID: 21134905, PMCID: PMC3065499, DOI: 10.1136/ip.2010.028886.Peer-Reviewed Original ResearchConceptsCause of deathNon-Latino whitesMortality rateMotor vehicle crash mortality ratesRate ratioYears age groupMortality rate ratiosFavorable health profilesAge group 15Lower mortality rateMotor vehicle crash deathsMortality peaksEpidemiological paradoxCalifornia mortality dataEpidemiologic paradoxHealth profileAge groupsMortality disparitiesLower educationMortality dataStudy periodLatino adolescent malesGroup 15White femalesAdolescent males
2009
U.S. motor vehicle fatality trends in young Latino males.
Vaca F, Anderson CL. U.S. motor vehicle fatality trends in young Latino males. AAAM Annual Conference 2009, 53: 77-82. PMID: 20184834, PMCID: PMC3256799.Peer-Reviewed Original ResearchConceptsNon-Latino whitesFatality rateFatality trendsStudy periodFavorable health profilesMotor vehicle crash fatalitiesMales ages 15Specific exposure dataInjury fatalitiesMortality burdenEpidemiologic paradoxRestraint useHealth profileMortality rateBlood alcoholMale mortality ratesMotor vehicle fatalitiesLower educationMotor vehicle fatality ratesAge 15Young malesExposure dataHealth careDriver fatalitiesYoung Latino males
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