2023
Association of Lipoprotein(a) Levels With Myocardial Fibrosis in the Multi-Ethnic Study of Atherosclerosis
Chehab O, Abdollahi A, Whelton S, Wu C, Ambale-Venkatesh B, Post W, Bluemke D, Tsai M, Lima J. Association of Lipoprotein(a) Levels With Myocardial Fibrosis in the Multi-Ethnic Study of Atherosclerosis. Journal Of The American College Of Cardiology 2023, 82: 2280-2291. PMID: 38057070, PMCID: PMC11730445, DOI: 10.1016/j.jacc.2023.10.016.Peer-Reviewed Original ResearchConceptsCardiac magnetic resonanceInterstitial myocardial fibrosisNative T1 timeMyocardial fibrosisCardiac remodelingMulti-Ethnic Study of AtherosclerosisElevated Lp(aMyocardial scarAssociated with greater prevalenceCardiac magnetic resonance measurementsMulti-Ethnic StudyMeasurement of extracellular volumeParameters of cardiac remodelingAssociated with left atrial enlargementStudy of atherosclerosisLate gadolinium enhancementLeft atrial remodelingCine cardiac magnetic resonanceLeft atrial enlargementAssociation of lipoprotein(aT1 timesAssociation of Lp(aGreater prevalencePrognostic thresholdGadolinium enhancement
2016
Validation of the prognostic value of MMP‐7 in idiopathic pulmonary fibrosis
Tzouvelekis A, Herazo‐Maya J, Slade M, Chu J, Deiuliis G, Ryu C, Li Q, Sakamoto K, Ibarra G, Pan H, Gulati M, Antin‐Ozerkis D, Herzog EL, Kaminski N. Validation of the prognostic value of MMP‐7 in idiopathic pulmonary fibrosis. Respirology 2016, 22: 486-493. PMID: 27761978, PMCID: PMC5352520, DOI: 10.1111/resp.12920.Peer-Reviewed Original ResearchConceptsTransplant-free survivalIdiopathic pulmonary fibrosisMMP-7 concentrationsMatrix metalloproteinase-7IPF patientsCause mortalityPulmonary fibrosisHealthy controlsMultivariate Cox proportional hazards modelCox proportional hazards modelPulmonary function parametersVariable clinical courseBaseline pulmonary function parametersProportional hazards modelIPF biomarkersProgressive diseaseClinical coursePoor prognosisPrognostic valueVital capacityIndependent biomarkerLung capacityPrognostic thresholdPlasma concentrationsMortality risk
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