2024
Quantitative single-molecule analysis of assembly and Ca2+-dependent disassembly of synaptotagmin oligomers on lipid bilayers
Li F, Coleman J, Redondo-Morata L, Kalyana Sundaram R, Stroeva E, Rothman J, Pincet F. Quantitative single-molecule analysis of assembly and Ca2+-dependent disassembly of synaptotagmin oligomers on lipid bilayers. Communications Biology 2024, 7: 1608. PMID: 39627539, PMCID: PMC11615320, DOI: 10.1038/s42003-024-07317-9.Peer-Reviewed Original ResearchConceptsSyt-1Lipid bilayerRing-like oligomersCa2+-evoked releaseSynaptotagmin-1Single-molecule imaging methodsSynaptic vesiclesBiochemical evidencePhysiological requirementsOligomerizationAnalysis of assembliesBilayerOligomersCa2+LipidAssemblyCa2Classes of oligomersMutationsVesiclesDisassemblyEvoked release
2023
Cell cycle controls long-range calcium signaling in the regenerating epidermis
Moore J, Bhaskar D, Gao F, Matte-Martone C, Du S, Lathrop E, Ganesan S, Shao L, Norris R, Sanz N, Annusver K, Kasper M, Cox A, Hendry C, Rieck B, Krishnaswamy S, Greco V. Cell cycle controls long-range calcium signaling in the regenerating epidermis. Journal Of Cell Biology 2023, 222: e202302095. PMID: 37102999, PMCID: PMC10140546, DOI: 10.1083/jcb.202302095.Peer-Reviewed Original ResearchCalcium- and sodium-activated potassium channels (K<sub>Ca</sub>, K<sub>Na</sub>) in GtoPdb v.2023.1
Aldrich R, Chandy K, Grissmer S, Gutman G, Kaczmarek L, Wei A, Wulff H. Calcium- and sodium-activated potassium channels (KCa, KNa) in GtoPdb v.2023.1. IUPHAR/BPS Guide To Pharmacology CITE 2023, 2023 DOI: 10.2218/gtopdb/f69/2023.1.Peer-Reviewed Original ResearchMitochondrial calcium signaling in cholangiocarcinoma
Loyola-Machado A, Guerra M, Nathanson M. Mitochondrial calcium signaling in cholangiocarcinoma. Hepatoma Research 2023, 9: null-null. DOI: 10.20517/2394-5079.2023.28.Peer-Reviewed Original ResearchPrimary liver cancerNew pharmacological agentsPathogenesis of cholangiocarcinomaMitochondrial Ca2Liver cancerCholangiocarcinomaPharmacological agentsIntracellular Ca2Molecular alterationsDruggable targetsER-mitochondrial contact sitesCancer cellsKey regulatory moleculesMetabolic reprogramingReceptor familyMitochondrial healthMitochondrial calciumEnergy metabolismCell deathPathways of interestLatest findingsTreatmentCa2Regulatory moleculesContact sites
2022
Complex effects on CaV2.1 channel gating caused by a CACNA1A variant associated with a severe neurodevelopmental disorder
Grosso B, Kramer A, Tyagi S, Bennett D, Tifft C, D’Souza P, Wangler M, Macnamara E, Meza U, Bannister R. Complex effects on CaV2.1 channel gating caused by a CACNA1A variant associated with a severe neurodevelopmental disorder. Scientific Reports 2022, 12: 9186. PMID: 35655070, PMCID: PMC9163077, DOI: 10.1038/s41598-022-12789-y.Peer-Reviewed Original ResearchConceptsCongenital ataxiaQ-type Ca2Function mutationsSevere neurodevelopmental disorderTsA-201 cellsCerebral edemaFocal seizuresCaV2.1 channelsCentral synapsesChannel dysfunctionNeurological disordersNeuromuscular junctionCACNA1A variantsNeurotransmitter releaseΑ1A subunitAction potential-like stimuliReversal potentialNeurodevelopmental disordersComplex functional effectsFunctional effectsDisordersAtaxiaMissense mutationsCa2Channel gating
2021
Calcium- and sodium-activated potassium channels (K<sub>Ca</sub>, K<sub>Na</sub>) in GtoPdb v.2021.3
Aldrich R, Chandy K, Grissmer S, Gutman G, Kaczmarek L, Wei A, Wulff H. Calcium- and sodium-activated potassium channels (KCa, KNa) in GtoPdb v.2021.3. IUPHAR/BPS Guide To Pharmacology CITE 2021, 2021 DOI: 10.2218/gtopdb/f69/2021.3.Peer-Reviewed Original Research
2020
Inositol 1,4,5 trisphosphate receptors in secretory epithelial cells of the gastrointestinal tract
Lemos F, Guerra M, de Fátima Leite M. Inositol 1,4,5 trisphosphate receptors in secretory epithelial cells of the gastrointestinal tract. Current Opinion In Physiology 2020, 17: 169-174. DOI: 10.1016/j.cophys.2020.08.003.Peer-Reviewed Original ResearchEpithelial cellsFatty liver diseaseIntracellular calcium signalingLiver diseaseAcute pancreatitisSecretory epithelial cellsPathophysiological roleGastrointestinal tractElectrolyte secretionSolid tumorsIntracellular Ca2Main intracellular Ca2Number of diseasesDiseaseCell proliferationCalcium signalingEnergy metabolismReceptorsMolecular mechanismsSubcellular localizationTrisphosphate receptorPhysiological functionsCellsInositol 1Ca2Fam20C regulates protein secretion by Cab45 phosphorylation
Hecht TK, Blank B, Steger M, Lopez V, Beck G, Ramazanov B, Mann M, Tagliabracci V, von Blume J. Fam20C regulates protein secretion by Cab45 phosphorylation. Journal Of Cell Biology 2020, 219: e201910089. PMID: 32422653, PMCID: PMC7265331, DOI: 10.1083/jcb.201910089.Peer-Reviewed Original ResearchCalcium Signaling in Cholangiocytes
Hernandez E, Nathanson M. Calcium Signaling in Cholangiocytes. 2020, 105-111. DOI: 10.1201/9780367813888-10.Peer-Reviewed Original ResearchCa2+ Signaling in the Liver
Guerra M, Leite M, Nathanson M. Ca2+ Signaling in the Liver. 2020, 496-508. DOI: 10.1002/9781119436812.ch40.ChaptersBile duct epitheliumDuct epitheliumNon-alcoholic fatty liver diseaseBile acid-independent bile flowBile acid-dependent flowFatty liver diseaseLiver diseaseBile flowElectrolyte secretionLipid metabolismGrowth factorLiverCell populationsRat liverVariety of mechanismsEpitheliumCa2Recent studiesCell cycleHepatocytesLesser extentPathogenesisDiseaseNeurotransmittersHormone
2019
Calcium- and sodium-activated potassium channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
Aldrich R, Chandy K, Grissmer S, Gutman G, Kaczmarek L, Wei A, Wulff H. Calcium- and sodium-activated potassium channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide To Pharmacology CITE 2019, 2019 DOI: 10.2218/gtopdb/f69/2019.4.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2017
Reversible stacking of lipid nanodiscs for structural studies of clotting factors
Grushin K, White M, Stoilova-McPhie S. Reversible stacking of lipid nanodiscs for structural studies of clotting factors. Nanotechnology Reviews 2017, 6: 139-148. DOI: 10.1515/ntrev-2016-0073.Peer-Reviewed Original ResearchMembrane scaffold proteinND populationMembrane-associated proteinsDifferent membrane scaffold proteinsSize of nanodiscsDiscoidal phospholipid bilayerLipid nanodiscsLipid ratioCryo-EMBiophysical studiesMacromolecular compositionFunctional studiesNanodiscsLipid compositionStructural studiesPhospholipid bilayersProteinMillimolar concentrationsCa2Lipid mixturesMSP1D1ND formMicroscopy studiesElectron microscopy studiesPopulation
2016
STEP activation by Gαq coupled GPCRs opposes Src regulation of NMDA receptors containing the GluN2A subunit
Tian M, Xu J, Lei G, Lombroso PJ, Jackson MF, MacDonald JF. STEP activation by Gαq coupled GPCRs opposes Src regulation of NMDA receptors containing the GluN2A subunit. Scientific Reports 2016, 6: 36684. PMID: 27857196, PMCID: PMC5114553, DOI: 10.1038/srep36684.Peer-Reviewed Original ResearchConceptsStriatal-enriched protein tyrosine phosphataseFamily of kinasesProtein tyrosine phosphataseM1R stimulationN-methyl-D-aspartate receptorsM1 muscarinic acetylcholine receptorSrc recruitmentTyrosine phosphataseSrc regulationNMDAR functionIntracellular Ca2Step activationMuscarinic acetylcholine receptorsGluN2A subunitGαqAcetylcholine receptorsHigh intracellular Ca2Function of NMDARsSynaptic plasticityPhosphataseNMDAR activationActivationReceptorsRecruitmentCa2Secretory cargo sorting by Ca2+-dependent Cab45 oligomerization at the trans-Golgi network
Crevenna AH, Blank B, Maiser A, Emin D, Prescher J, Beck G, Kienzle C, Bartnik K, Habermann B, Pakdel M, Leonhardt H, Lamb DC, von Blume J. Secretory cargo sorting by Ca2+-dependent Cab45 oligomerization at the trans-Golgi network. Journal Of Cell Biology 2016, 213: 305-314. PMID: 27138253, PMCID: PMC4862333, DOI: 10.1083/jcb.201601089.Peer-Reviewed Original ResearchConceptsTrans-Golgi networkSecretory cargoSecretory proteinsSpecific cargo moleculesTransmembrane cargoCargo moleculesSuperresolution microscopyIntact cellsCab45Lysosomal hydrolasesExtracellular spaceDependent mannerCargoProteinOligomerizationSortingHydrolasesDependent changesMicrodomainsMutationsOligomersElucidationCellsCa2Control of plasma membrane lipid homeostasis by the extended synaptotagmins
Saheki Y, Bian X, Schauder CM, Sawaki Y, Surma MA, Klose C, Pincet F, Reinisch KM, De Camilli P. Control of plasma membrane lipid homeostasis by the extended synaptotagmins. Nature Cell Biology 2016, 18: 504-515. PMID: 27065097, PMCID: PMC4848133, DOI: 10.1038/ncb3339.Peer-Reviewed Original ResearchConceptsSMP domainE-Syt1ER-PM tethersMembrane lipid homeostasisPlasma membrane lipidsEndoplasmic reticulum proteinAccumulation of diacylglycerolE-SytsExtended synaptotagminsMolecular basisMajor glycerolipidsReticulum proteinsMetabolic recyclingMembrane lipidsLipid homeostasisPLC activationSynaptotagminSustained accumulationHomeostatic responseDiacylglycerolGlycerolipidsMetabolic changesGenomeCa2Accumulation
2012
Regulation of Intercellular Calcium Signaling Through Calcium Interactions with Connexin-Based Channels
Orellana J, Sánchez H, Schalper K, Figueroa V, Sáez J. Regulation of Intercellular Calcium Signaling Through Calcium Interactions with Connexin-Based Channels. Advances In Experimental Medicine And Biology 2012, 740: 777-794. PMID: 22453969, DOI: 10.1007/978-94-007-2888-2_34.Peer-Reviewed Original ResearchConceptsGap junction channelsConnexin-based channelsExtra-cellular milieuNumerous cellular eventsCell-cell interactionsMembrane proteinsMolecular basisCellular eventsIntercellular communicationJunction channelsRole of Ca2ConnexinsIntercellular calciumHemichannelsIntercellular propagationIntercellular Ca2RegulationCalcium wavesCalcium interactionCa2ProteinPathwayInteractionFamily
2010
Prostaglandin E2 induces glutamate release from subventricular zone astrocytes.
Dave KA, Platel JC, Huang F, Tian D, Stamboulian-Platel S, Bordey A. Prostaglandin E2 induces glutamate release from subventricular zone astrocytes. Neuron Glia Biology 2010, 6: 201-7. PMID: 21211110, DOI: 10.1017/s1740925x10000244.Peer-Reviewed Original ResearchConceptsAmbient glutamate levelsProstaglandin E2Subventricular zoneGlutamate releaseAstrocyte-like cellsGlutamate levelsGramicidin-perforated patch-clamp techniquesIntracellular Ca2Application of PGE2Aspartate receptor channelsPatch-clamp techniqueLateral ventricleSVZ cellsPGE2 releaseChoroid plexusMature astrocytesNeuroblast survivalEnzyme immunoassayReceptor channelsAstrocytesE2Ca2CellsReleaseLesser extent
2009
Ca2+ Signaling in the Liver
Leite F, Guerra M, Nathanson M. Ca2+ Signaling in the Liver. 2009, 485-510. DOI: 10.1002/9780470747919.ch32.ChaptersTRPA1 Antagonists Block the Noxious Effects of Toxic Industrial Isocyanates and Tear Gases
Bessac B, Sivula M, von Hehn C, Caceres A, Escalera J, Jordt S. TRPA1 Antagonists Block the Noxious Effects of Toxic Industrial Isocyanates and Tear Gases. The FASEB Journal 2009, 23: 580.11-580.11. DOI: 10.1096/fasebj.23.1_supplement.580.11.Peer-Reviewed Original ResearchTransient receptor potential ankyrin 1Tear gas agentsSame neuronal receptorNoxious effectsTear gasesActivation of Ca2Adverse health effectsNocifensive behaviorAirway irritationCutaneous exposureTRPA1 antagonistSensory neuronsAnkyrin 1Neuronal receptorsPharmacological inhibitionGenetic ablationHealth effectsMembrane currentsFrequent exposureNoxious chemicalsExposureIon channelsSimilar responsesCa2Lacrimation
2008
Role of the NO-cGMP cascade in regulation of L-type Ca2+ currents in isolated cardiomyocytes
Grushin K, Nenov M, Dynnik V, Semushina S, Pakhomova I, Murashev A, Kokoz Y. Role of the NO-cGMP cascade in regulation of L-type Ca2+ currents in isolated cardiomyocytes. Biochemistry (Moscow), Supplement Series A: Membrane And Cell Biology 2008, 2: 243. DOI: 10.1134/s1990747808030082.Peer-Reviewed Original ResearchL-type Ca2NO-cGMP cascadeSodium nitroprussideVoltage-dependent L-type Ca2Basal L-type Ca2Inhibitory effectNO synthase blockerCombination of acetylcholineInhibition of amplitudeRat ventricular myocytesSynthase blockerEffect of arginineEffects of compoundsCyclic nucleotide systemVentricular myocytesBasal currentNitroprussideMM arginineMammalian cardiomyocytesPKG-dependent phosphorylationAcetylcholineExogenous NO sourcesInhibitionCGMP-dependent phosphorylationCa2
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