2023
The cellular architecture of memory modules in Drosophila supports stochastic input integration
Hafez O, Escribano B, Ziegler R, Hirtz J, Niebur E, Pielage J. The cellular architecture of memory modules in Drosophila supports stochastic input integration. ELife 2023, 12: e77578. PMID: 36916672, PMCID: PMC10069864, DOI: 10.7554/elife.77578.Peer-Reviewed Original ResearchConceptsKenyon cellsDecision moduleEfficient storageComputational principlesMushroom bodiesMB output neuronsPatch-clamp recordingsSpiking behaviorOutput neuronsMemory modulesInput integrationOdor inputSynaptic inputsStochastic connectionsArchitectureSynaptic localizationSynaptic connectionsDecision makingComputational modelInputMemoryNeuronsCellular architectureValenced informationModulation
2022
Reversal of synapse loss in Alzheimer mouse models by targeting mGluR5 to prevent synaptic tagging by C1Q
Spurrier J, Nicholson L, Fang XT, Stoner AJ, Toyonaga T, Holden D, Siegert TR, Laird W, Allnutt MA, Chiasseu M, Brody AH, Takahashi H, Nies SH, Pérez-Cañamás A, Sadasivam P, Lee S, Li S, Zhang L, Huang YH, Carson RE, Cai Z, Strittmatter SM. Reversal of synapse loss in Alzheimer mouse models by targeting mGluR5 to prevent synaptic tagging by C1Q. Science Translational Medicine 2022, 14: eabi8593. PMID: 35648810, PMCID: PMC9554345, DOI: 10.1126/scitranslmed.abi8593.Peer-Reviewed Original ResearchConceptsPositron emission tomographySilent allosteric modulatorsAlzheimer's diseaseMouse modelPhospho-tau accumulationAged mouse modelAlzheimer mouse modelImmune-mediated attackSAM treatmentMicroglial mediatorsSynaptic engulfmentSynaptic lossAD miceComplement component C1qSynapse lossGlutamate responseSynaptic densityDrug washoutSynaptic localizationTherapeutic benefitCognitive impairmentAllosteric modulatorsEmission tomographyNonhuman primatesComponent C1q
2020
Classical complement cascade initiating C1q protein within neurons in the aged rhesus macaque dorsolateral prefrontal cortex
Datta D, Leslie SN, Morozov YM, Duque A, Rakic P, van Dyck CH, Nairn AC, Arnsten AFT. Classical complement cascade initiating C1q protein within neurons in the aged rhesus macaque dorsolateral prefrontal cortex. Journal Of Neuroinflammation 2020, 17: 8. PMID: 31906973, PMCID: PMC6945481, DOI: 10.1186/s12974-019-1683-1.Peer-Reviewed Original ResearchConceptsRat medial PFCPrimate dlPFCC1q levelsMedial PFCLayer IIIC1q proteinPrecise anatomical distributionMacaque dorsolateral prefrontal cortexAge-related degenerationDorsolateral prefrontal cortexAge-related changesC1q expressionSynapse lossBackgroundCognitive impairmentSpine lossComplement signalingInhibitory synapsesAnatomical distributionSynaptic localizationDisease pathogenesisGlial phagocytosisAlzheimer's diseaseClassical complementPrimate cortexPrefrontal cortex
2019
Molecular constituents and localization of the ionotropic GABA receptor complex in vivo
Tomita S. Molecular constituents and localization of the ionotropic GABA receptor complex in vivo. Current Opinion In Neurobiology 2019, 57: 81-86. PMID: 30784980, PMCID: PMC6629498, DOI: 10.1016/j.conb.2019.01.017.Peer-Reviewed Original ResearchConceptsNative receptor complexReceptor complexPore-forming subunitMolecular constituentsNew mechanistic insightsProtein familySubunit assemblyMajor molecular constituentsProperties of GABASynaptic localizationIonotropic GABA receptorsPrimary neuronsMechanistic insightsGABA receptor complexNative GABAReceptor regulationGABA receptorsNeuroligin-2R complexesGABAFast inhibitionPharmacological propertiesComplexesLocalizationSubunits
2017
Assembly rules for GABAA receptor complexes in the brain
Martenson JS, Yamasaki T, Chaudhury NH, Albrecht D, Tomita S. Assembly rules for GABAA receptor complexes in the brain. ELife 2017, 6: e30826. PMID: 28816653, PMCID: PMC5577914, DOI: 10.7554/elife.27443.Peer-Reviewed Original ResearchGARLH Family Proteins Stabilize GABAA Receptors at Synapses
Yamasaki T, Hoyos-Ramirez E, Martenson JS, Morimoto-Tomita M, Tomita S. GARLH Family Proteins Stabilize GABAA Receptors at Synapses. Neuron 2017, 93: 1138-1152.e6. PMID: 28279354, PMCID: PMC5347473, DOI: 10.1016/j.neuron.2017.02.023.Peer-Reviewed Original ResearchConceptsInhibitory transmissionSynaptic transmissionSynaptic localizationInhibitory synaptic transmissionFast inhibitory transmissionFast synaptic transmissionIonotropic neurotransmitter receptorsLigand-gated ion channelsAuxiliary subunitsGABAA receptorsIonotropic GABANeurotransmitter receptorsNeuroligin-2GABAReceptorsAnion channelIon channelsBrainHippocampusFindingsSynapses
2016
Synaptic Ribbons Require Ribeye for Electron Density, Proper Synaptic Localization, and Recruitment of Calcium Channels
Lv C, Stewart WJ, Akanyeti O, Frederick C, Zhu J, Santos-Sacchi J, Sheets L, Liao JC, Zenisek D. Synaptic Ribbons Require Ribeye for Electron Density, Proper Synaptic Localization, and Recruitment of Calcium Channels. Cell Reports 2016, 15: 2784-2795. PMID: 27292637, PMCID: PMC5334794, DOI: 10.1016/j.celrep.2016.05.045.Peer-Reviewed Original ResearchConceptsNeuromast hair cellsProper synaptic localizationHair cellsSynaptic ribbonsZebrafish genesProper localizationCalcium channelsSynaptic vesiclesSmall vesiclesEnhanced exocytosisFrameshift mutationRibeye proteinsSynaptic localizationVesiclesRelease sitesCellsRibeyeRibbon-like structuresNon-spiking cellsSensory systemsLocalizationGenesExocytosisSimilar numberProtein
2014
Synaptic localization of neurotransmitter receptors: comparing mechanisms for AMPA and GABAA receptors
Martenson JS, Tomita S. Synaptic localization of neurotransmitter receptors: comparing mechanisms for AMPA and GABAA receptors. Current Opinion In Pharmacology 2014, 20: 102-108. PMID: 25529200, PMCID: PMC4318715, DOI: 10.1016/j.coph.2014.11.011.Peer-Reviewed Original ResearchConceptsSynaptic localizationBasal transmissionGABAA receptorsSynaptic transmissionAMPA receptorsNeurotransmitter receptorsSynaptic plasticityFast synaptic transmissionMultiple receptor subunitsIonotropic neurotransmitter receptorsSynaptic insertionReceptor numberReceptor subunitsReceptorsPrecise mechanismReceptor propertiesAuxiliary subunitsTARP auxiliary subunitsRecent findingsDistinct mechanismsAMPAPostsynapsesPlasticitySynapsesPharmacology
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply