2025
Connectome-based encoding of subjective drug responses to acute oral methamphetamine
Rodriguez Santos L, Molla H, Babaeianjelodar M, de Wit H, Yip S. Connectome-based encoding of subjective drug responses to acute oral methamphetamine. Neuropsychopharmacology 2025, 1-8. PMID: 40866561, DOI: 10.1038/s41386-025-02215-y.Peer-Reviewed Original ResearchIndividual differencesSubjective responsesResting state functional connectivity dataConnectome-based predictive modelingAcute methamphetamine challengeResponse to methamphetamineFunctional connectivity dataPlacebo-controlled designMental health consequencesHealthy adultsOral methamphetamineMethamphetamine challengeAcute methamphetamineMethamphetamine effectsNeural effectsNeural mechanismsAbused drugsConnectome levelFunctional connectomeMethamphetaminePharmacokinetic factorsPlacebo-ControlledConnectivity dataDouble-blindChronic use
2024
A review of Bruton’s tyrosine kinase inhibitors in multiple sclerosis
Airas L, Bermel R, Chitnis T, Hartung H, Nakahara J, Stuve O, Williams M, Kieseier B, Wiendl H. A review of Bruton’s tyrosine kinase inhibitors in multiple sclerosis. Therapeutic Advances In Neurological Disorders 2024, 17: 17562864241233041. PMID: 38638671, PMCID: PMC11025433, DOI: 10.1177/17562864241233041.Peer-Reviewed Original ResearchBruton tyrosine kinase inhibitorChronic spontaneous urticariaFirst-generation BTK inhibitorSystemic lupus erythematosusBruton's tyrosine kinaseTyrosine kinase inhibitorsMS disease-modifying treatmentsBTK inhibitorsDisease-modifying treatmentsSafety profileB cellsMultiple sclerosisChronic useRheumatoid arthritisSecond-generation BTK inhibitorsB cell depletion therapyTreatment of B-cell malignanciesB-cell modulationDiverse autoimmune conditionsPhase II trialGadolinium-enhancing lesionsB-cell malignanciesMagnetic resonance imaging scansLong-term administrationFemale reproductive health
2023
Chronic use of benzodiazepines: The problem that persists
Louie D, Jegede O, Hermes G. Chronic use of benzodiazepines: The problem that persists. The International Journal Of Psychiatry In Medicine 2023, 58: 426-432. PMID: 36972700, DOI: 10.1177/00912174231166252.Peer-Reviewed Original Research
2021
Opioid Prescribing and Use Among Cancer Survivors: A Mapping Review of Observational and Intervention Studies
Check DK, Avecilla R, Mills C, Dinan MA, Kamal AH, Murphy B, Rezk S, Winn A, Oeffinger K. Opioid Prescribing and Use Among Cancer Survivors: A Mapping Review of Observational and Intervention Studies. Journal Of Pain And Symptom Management 2021, 63: e397-e417. PMID: 34748896, DOI: 10.1016/j.jpainsymman.2021.10.015.Peer-Reviewed Original ResearchConceptsOpioid useOpioid prescribingCancer survivorsHigh-risk opioid prescribingLong-term opioid useEvidence synthesisContinued opioid useLate opioid usePersistent opioid useProlonged opioid useChronic opioid useUse of opioidsHigh-risk medicationsOpioid use outcomesFull-text reviewTitles/abstractsOpioid misuseChronic useInclusion criteriaExclusion criteriaIntervention studiesInterventional researchPrescribingProlonged useStudy designDecreased Opioid Consumption and Durable Pain Relief in Patients Treated with 10 kHz SCS: A Retrospective Analysis of Outcomes from Single-Center
Feng H, Doherty P, Rotte A. Decreased Opioid Consumption and Durable Pain Relief in Patients Treated with 10 kHz SCS: A Retrospective Analysis of Outcomes from Single-Center. Journal Of Pain Research 2021, 14: 2593-2600. PMID: 34466027, PMCID: PMC8403026, DOI: 10.2147/jpr.s312932.Peer-Reviewed Original ResearchPain reliefChronic painOpioid useSingle centerKHz-SCSPatient-reported pain reliefDaily opioid doseDecreased opioid useDurable pain reliefProportion of patientsReal-world cohortReal-world patientsSpinal cord stimulationElectronic medical recordsOpioid consumptionOpioid doseOpioid reductionResponder rateConsecutive patientsOpioid analgesicsRetrospective reviewPatients' qualityCord stimulationChronic useSCS treatmentPredictors of Chronic Opioid Use: A Population-Level Analysis of North Carolina Cancer Survivors Using Multi-Payer Claims
Check DK, Baggett C, Kim K, Roberts AW, Roberts MC, Robinson T, Oeffinger KC, Dinan MA. Predictors of Chronic Opioid Use: A Population-Level Analysis of North Carolina Cancer Survivors Using Multi-Payer Claims. Journal Of The National Cancer Institute 2021, 113: 1581-1589. PMID: 33881543, PMCID: PMC8562975, DOI: 10.1093/jnci/djab082.Peer-Reviewed Original ResearchConceptsChronic opioid useChronic opioid therapyOpioid useCancer survivorsOpioid therapyBaseline depressionLong-term pain managementSubstance useRetrospective cohort studyPopulation-based studyCancer registry dataLow-income survivorsCohort studyPatient characteristicsPain managementActive treatmentNonmetastatic cancerChronic useInsurance statusRelative riskRegistry dataOpioidsPoisson regressionYounger ageAge groups
2020
Chapter 23 Pharmacological cognitive enhancers
Peltier M, Sofuoglu M. Chapter 23 Pharmacological cognitive enhancers. 2020, 303-320. DOI: 10.1016/b978-0-12-815298-0.00023-x.Peer-Reviewed Original ResearchSubstance use disordersSignificant health problemNovel pharmacological targetsSignificant cognitive deficitsChronic usePharmacological treatmentCandidate medicationsTreatment outcomesTreatment strategiesUse disordersHealth problemsPharmacological targetsCognitive deficitsCognitive enhancementSubstance useCognitive enhancersPotential mechanismsCognitive functioningTreatmentPharmacological cognitive enhancementPharmacological cognitive enhancersMedicationsImpairmentCocaine
2019
Pharmacological mechanisms of alcohol analgesic-like properties in mouse models of acute and chronic pain
Neddenriep B, Bagdas D, Contreras K, Ditre J, Wolstenholme J, Miles M, Damaj M. Pharmacological mechanisms of alcohol analgesic-like properties in mouse models of acute and chronic pain. Neuropharmacology 2019, 160: 107793. PMID: 31562845, PMCID: PMC6924270, DOI: 10.1016/j.neuropharm.2019.107793.Peer-Reviewed Original ResearchConceptsAnalgesic-like propertiesComplete Freund's adjuvantAnti-nociceptive propertiesChronic painNeuropathic painChronic constriction injury modelAlcohol useMu-opioid systemOral ethanol administrationPain-like statePeripheral neuropathic painNeuropathic pain modelKappa-selective antagonistAcute alcohol useAnalgesic-like effectsDose-dependent reversalMechanical hypersensitivityAnalgesic effectNerve injuryPain modelAcute modelOpioid systemAcute alcoholFreund's adjuvantChronic use
2016
Sleep abnormalities associated with alcohol, cannabis, cocaine, and opiate use: a comprehensive review
Angarita GA, Emadi N, Hodges S, Morgan PT. Sleep abnormalities associated with alcohol, cannabis, cocaine, and opiate use: a comprehensive review. Addiction Science & Clinical Practice 2016, 11: 9. PMID: 27117064, PMCID: PMC4845302, DOI: 10.1186/s13722-016-0056-7.Peer-Reviewed Original Research
2009
Transient cocaine-associated behavioral symptoms rated with a new instrument, the scale for assessment of positive symptoms for cocaine-induced psychosis (SAPS-CIP).
Tang YL, Kranzler HR, Gelernter J, Farrer LA, Pearson D, Cubells JF. Transient cocaine-associated behavioral symptoms rated with a new instrument, the scale for assessment of positive symptoms for cocaine-induced psychosis (SAPS-CIP). American Journal On Addictions 2009, 18: 339-45. PMID: 19874151, PMCID: PMC2878659, DOI: 10.3109/10550490903077937.Peer-Reviewed Original ResearchConceptsCocaine-Induced PsychosisProportion of subjectsBehavioral symptomsSAPS-CIPAgitated behaviorsPositive symptomsStereotyped behaviorSevere behavioral symptomsSexual behaviorCocaine-dependent subjectsCommon vulnerability factorsChronic useSeverity scorePsychotic symptomsCocaine useSymptomsPsychosisSubstantial minorityCurrent reportSubjectsCocaineHallucinations
2007
Cocaine and Sleep: Early Abstinence
Morgan PT, Malison RT. Cocaine and Sleep: Early Abstinence. The Scientific World JOURNAL 2007, 7: 223-230. PMID: 17982597, PMCID: PMC5900952, DOI: 10.1100/tsw.2007.209.Peer-Reviewed Original ResearchConceptsSubjective reportsCognitive performance declineCompulsive cocaine useCocaine useDiminished sleepWeeks of abstinenceEarly abstinenceSubjective measuresPerformance declineSleep disturbancesAbstinenceSleepIndication of recoveryRelevant literatureDisordersMeasuresCocaineSignificant deteriorationChronic useRelationshipDysregulationOlder Patient Perspectives on Long-Term Anxiolytic Benzodiazepine Use and Discontinuation: A Qualitative Study
Cook JM, Biyanova T, Masci C, Coyne JC. Older Patient Perspectives on Long-Term Anxiolytic Benzodiazepine Use and Discontinuation: A Qualitative Study. Journal Of General Internal Medicine 2007, 22: 1094-1100. PMID: 17492325, PMCID: PMC2305752, DOI: 10.1007/s11606-007-0205-5.Peer-Reviewed Original ResearchConceptsChronic useBenzodiazepine useBenzodiazepine usersSemi-structured patient interviewsAcceptable intervention strategiesPrimary care physiciansOlder patients' perspectivesChronic benzodiazepine usersIntervention strategiesYears of ageImportance of preventionEarly intervention strategiesMedication characteristicsCare physiciansPatient factorsPatient interviewsParticipantsThe participantsPatient's perspectiveChronic usersSide effectsOrdinary medicationsDiscontinuationOlder adultsDesignThe designMedicationsPhysicians’ Perspectives on Prescribing Benzodiazepines for Older Adults: A Qualitative Study
Cook JM, Marshall R, Masci C, Coyne JC. Physicians’ Perspectives on Prescribing Benzodiazepines for Older Adults: A Qualitative Study. Journal Of General Internal Medicine 2007, 22: 303-307. PMID: 17356959, PMCID: PMC1824720, DOI: 10.1007/s11606-006-0021-3.Peer-Reviewed Original ResearchConceptsCare physiciansOlder adultsOlder community-residing adultsConclusionsPrimary care physiciansImportant clinical focusRisks of benzodiazepinesPrimary care physiciansUse of benzodiazepinesPublic health problemStrong patient satisfactionCommunity-residing adultsLong-term useRenewal of prescriptionsPrescribing benzodiazepinesOlder patientsPrescription renewalsBenzodiazepine useChronic usePatient satisfactionBenzodiazepine dependencyPatient educationHigh prevalencePractice guidelinesEffective treatmentVigilant monitoring
2003
Gastrointestinal health care resource utilization with chronic use of COX-2-specific inhibitors versus traditional NSAIDs1 1The Institute for Effectiveness Research, LLC, is a subsidiary of Medco Health Solutions, Inc., a Merck Company.
Laine L, Wogen J, Yu H. Gastrointestinal health care resource utilization with chronic use of COX-2-specific inhibitors versus traditional NSAIDs1 1The Institute for Effectiveness Research, LLC, is a subsidiary of Medco Health Solutions, Inc., a Merck Company. Gastroenterology 2003, 125: 389-395. PMID: 12891540, DOI: 10.1016/s0016-5085(03)00900-4.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnti-Inflammatory Agents, Non-SteroidalCohort StudiesCost-Benefit AnalysisCyclooxygenase 2Cyclooxygenase 2 InhibitorsCyclooxygenase InhibitorsFemaleGastrointestinal DiseasesHealth ResourcesHumansIsoenzymesLongitudinal StudiesMaleMembrane ProteinsMiddle AgedProstaglandin-Endoperoxide SynthasesRetrospective StudiesConceptsChronic NSAID therapyCoxib therapyNSAID therapyChronic nonsteroidal anti-inflammatory drug (NSAID) therapyNonsteroidal anti-inflammatory drug therapyAnti-inflammatory drug therapyHealth care resource utilizationCOX-2-specific inhibitorsU.S. administrative claims databaseMedco Health SolutionsProportion of patientsAdministrative claims databaseGastrointestinal eventsNewer coxibsInitial prescriptionChronic useClaims databaseDrug therapyClinical trialsDrug costsNew NSAIDClinical practicePatientsTherapyAbstractText
2002
Effect of nicotine and nicotinic receptors on anxiety and depression
Picciotto MR, Brunzell DH, Caldarone BJ. Effect of nicotine and nicotinic receptors on anxiety and depression. Neuroreport 2002, 13: 1097-1106. PMID: 12151749, DOI: 10.1097/00001756-200207020-00006.Peer-Reviewed Original ResearchConceptsNicotine treatmentActivation of nAChRsDorsal raphe nucleusEffects of nicotineMesolimbic dopamine systemNicotinic acetylcholine receptorsNicotine administrationMonoaminergic transmissionChronic useRaphe nucleusAnxiolytic actionLateral septumNicotinic receptorsClassical neurotransmittersNormal brainAnimal studiesDopamine systemBrain areasAcetylcholine receptorsNicotineEnsemble of studiesNAChRsAnxiety modelsAdministration studiesDepression
2000
Neurobiological Adaptations to Psychostimulants and Opiates as a Basis of Treatment Development
SEVARINO K, OLIVETO A, KOSTEN T. Neurobiological Adaptations to Psychostimulants and Opiates as a Basis of Treatment Development. Annals Of The New York Academy Of Sciences 2000, 909: 51-87. PMID: 10911924, DOI: 10.1111/j.1749-6632.2000.tb06676.x.Peer-Reviewed Original ResearchConceptsOpiate withdrawalLocus coeruleus noradrenergic neuronsWorldwide public health issueTreatment developmentNeurobiological adaptationsCerebral perfusion abnormalitiesTrials of antidepressantsPublic health issueNew treatment developmentCocaine vaccineAntagonist therapyNoradrenergic neuronsHeroin effectsChronic usePerfusion abnormalitiesSerotonin neurotransmissionOpiate dependenceClinical experienceOpiate maintenanceCocaine dependenceBehavioral treatmentOpiate addictionIllicit substancesHealth issuesPsychostimulants
1997
Chronic neuroleptic exposure in bipolar outpatients.
Sernyak MJ, Godleski LS, Griffin RA, Mazure CM, Woods SW. Chronic neuroleptic exposure in bipolar outpatients. The Journal Of Clinical Psychiatry 1997, 58: 193-5. PMID: 9184612, DOI: 10.4088/jcp.v58n0503.Peer-Reviewed Original ResearchConceptsChronic neuroleptic exposureNeuroleptic exposureBipolar outpatientsBipolar disorderConnecticut Mental Health CenterChronic neuroleptic administrationMental health centersComputerized administrative databasesNeuroleptic medicationChlorpromazine equivalentsNeuroleptic administrationChronic useMedical recordsAdministrative databasesNeuroleptic dosageHealth centersBipolar patientsPatientsOutpatientsReview criteriaDisordersExposurePast yearMedicationsDiagnosis
1991
Effects of Substance Abuse on Ventricular and Sulcal Measures Assessed by Computerised Tomography
Cascella N, Pearlson G, Wong D, Broussolle E, Nagoshi C, Margolin R, London E. Effects of Substance Abuse on Ventricular and Sulcal Measures Assessed by Computerised Tomography. The British Journal Of Psychiatry 1991, 159: 217-221. PMID: 1773237, DOI: 10.1192/bjp.159.2.217.Peer-Reviewed Original ResearchConceptsSubstance abuseSulcal measuresCocaine useSulcal widthWider third ventriclesEffect of ageBrain atrophyBrain ratioChronic useComputerised tomographyThird ventricleNormal controlsAlcohol consumptionBrain morphologyAlcohol usePolydrug abusersSignificant predictorsAgeVentricleSeverityTomographyPositive correlationAbusePossible effectsVentricular
1987
Cocaine and Chest Pain
Decker S, Fins J, Frances R. Cocaine and Chest Pain. Psychiatric Services 1987, 38: 464-466. PMID: 3596482, DOI: 10.1176/ps.38.5.464.Peer-Reviewed Original ResearchConceptsChest painTreatment of cocaine abusePotential withdrawal symptomsAcute cocaine intoxicationCalcium channel blockersSafety of agentsWithdrawal symptomsCocaine abuseCocaine intoxicationChannel blockersChronic useAdverse effectsPainTreatmentAntidepressantsCocaineBlockersPatientsPropranololAbuseSymptomsEfficacyWithdrawalClinicians
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply