2025
The Prognostic Impact of MLH1 Promoter Hypermethylation in Stage I-II Endometrial Cancer Treated With Adjuvant Radiation Therapy: A Multi-Institutional Retrospective Study
Sherwani Z, Damast S, Fields E, Beriwal S, Horne Z, Kidd E, Leung E, Taunk N, Chino J, Russo A, Dyer M, Albuquerque K, Hathout L. The Prognostic Impact of MLH1 Promoter Hypermethylation in Stage I-II Endometrial Cancer Treated With Adjuvant Radiation Therapy: A Multi-Institutional Retrospective Study. International Journal Of Radiation Oncology • Biology • Physics 2025, 123: 495-502. PMID: 40379143, DOI: 10.1016/j.ijrobp.2025.05.004.Peer-Reviewed Original ResearchRecurrence-free survivalExternal beam radiationVaginal brachytherapyEndometrial cancerAssociated with decreased RFSAbsence of lymphovascular space invasionTreated with adjuvant radiation therapyPromoter hypermethylationStage I-II endometrial cancerProportion of locoregional recurrenceStage IMulti-institutional cohort studyAdjuvant radiation therapyLymphovascular space invasionInstitutional review board approvalPatterns of recurrenceKaplan-Meier methodReview board approvalDeficient mismatch repairMismatch repair statusAdjuvant radiotherapyCox proportional hazardsDistant recurrenceLocoregional recurrenceMyometrial invasion
2024
Prognostic Effect of Mismatch Repair Status in Early-Stage Endometrial Cancer Treated With Adjuvant Radiation: A Multi-institutional Analysis
Hathout L, Sherwani Z, Alegun J, Ohri N, Fields E, Shah S, Beriwal S, Horne Z, Kidd E, Leung E, Song J, Taunk N, Chino J, Huang C, Russo A, Dyer M, Li J, Albuquerque K, Damast S. Prognostic Effect of Mismatch Repair Status in Early-Stage Endometrial Cancer Treated With Adjuvant Radiation: A Multi-institutional Analysis. International Journal Of Radiation Oncology • Biology • Physics 2024, 119: 1158-1165. PMID: 38253292, DOI: 10.1016/j.ijrobp.2024.01.203.Peer-Reviewed Original ResearchRecurrence-free survivalEndometrioid endometrial adenocarcinomaMismatch repair statusAdjuvant radiation therapyOverall survivalRadiation therapyVaginal brachytherapyMismatch repair deficiencyAssociated with worse recurrence-free survivalMulti-institutional retrospective cohort studyTreated with adjuvant radiation therapyAssociated with recurrence-free survivalMultivariate analysisExternal beam radiation therapyRecurrence-free survival ratesMismatch repair deficiency statusBeam radiation therapyGrades 1 to 2Kaplan-Meier methodOutcomes of patientsMulti-institutional analysisRetrospective cohort studyCox proportional hazards modelsProportional hazards modelAdjuvant radiation
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply