2025
The prognostic impact of MLH1 promoter hypermethylation in stage I–II endometrial cancer treated with adjuvant radiotherapy: a multi-institutional retrospective study MLH1ph status in stage I-II endometrial cancer
Sherwani Z, Damast S, Fields E, Beriwal S, Horne Z, Kidd E, Leung E, Taunk N, Chino J, Russo A, Dyer M, Albuquerque K, Hathout L. The prognostic impact of MLH1 promoter hypermethylation in stage I–II endometrial cancer treated with adjuvant radiotherapy: a multi-institutional retrospective study MLH1ph status in stage I-II endometrial cancer. International Journal Of Radiation Oncology • Biology • Physics 2025 PMID: 40379143, DOI: 10.1016/j.ijrobp.2025.05.004.Peer-Reviewed Original ResearchRecurrence-free survivalExternal beam radiationVaginal brachytherapyEndometrial cancerAssociated with decreased RFSAbsence of lymphovascular space invasionTreated with adjuvant radiation therapyPromoter hypermethylationStage I-II endometrial cancerProportion of locoregional recurrenceStage IMulti-institutional cohort studyAdjuvant radiation therapyLymphovascular space invasionInstitutional review board approvalPatterns of recurrenceKaplan-Meier methodReview board approvalDeficient mismatch repairMismatch repair statusAdjuvant radiotherapyCox proportional hazardsDistant recurrenceLocoregional recurrenceMyometrial invasion
2024
Clinical Outcomes in Breast Cancer Patients with Underlying Germline PALB2 Mutations Treated with Radiation
Shalaby A, Jan I, Ohri N, Yehia Z, Toppmeyer D, Haffty B. Clinical Outcomes in Breast Cancer Patients with Underlying Germline PALB2 Mutations Treated with Radiation. International Journal Of Radiation Oncology • Biology • Physics 2024, 120: e331-e332. DOI: 10.1016/j.ijrobp.2024.07.731.Peer-Reviewed Original ResearchBreast-conserving surgeryPALB2 variantsBreast cancer patientsInterpretations of pathogenicityClinical outcomesPathogenic variantsHYPO-RTBreast cancer patients treated with radiationCancer patients treated with radiationCancer patientsRisk of radiation toxicitySentinel lymph node dissectionPatients treated with radiationMedical recordsPALB2 pathogenic variantsContralateral breast cancerExternal beam radiationMedian tumor sizeLymph node dissectionSuppression of cancer developmentGrade 2 fibrosisRecurrence 4 monthsMultigene panel testingDNA double-strand break repairDouble-strand break repairThe Prognostic Impact of MLH1 Promoter Hypermethylation in Stage I-II Endometrial Cancer Treated with Adjuvant Radiotherapy
Sherwani Z, Damast S, Fields E, Shah S, Beriwal S, Horne Z, Parks E, Kidd E, Leung E, Khoja L, Taunk N, Chino J, Huang C, Russo A, Dyer M, Albuquerque K, Hathout L. The Prognostic Impact of MLH1 Promoter Hypermethylation in Stage I-II Endometrial Cancer Treated with Adjuvant Radiotherapy. International Journal Of Radiation Oncology • Biology • Physics 2024, 120: s32. DOI: 10.1016/j.ijrobp.2024.07.044.Peer-Reviewed Original ResearchRecurrence-free survivalExternal beam radiationMismatch repair statusOverall survivalAdjuvant radiotherapyVaginal brachytherapyAssociated with decreased RFSPromoter hypermethylationInferior recurrence-free survivalProportion of locoregional recurrenceTreated with adjuvant radiotherapyDepth of myometrial invasionLympho-vascular space invasionMulti-institutional cohort studyRetrospective multi-institutional cohort studyCervical stromal involvementSite of recurrenceKaplan Meier methodPost-surgical resectionCox proportional hazards modelsMulti-institutional studyDeficient mismatch repairProportional hazards modelImpact OSLocoregional recurrence
2023
Prostate cancer disparities among American Indians and Alaskan Natives in the United States
Chu C, Leapman M, Zhao S, Cowan J, Washington S, Cooperberg M. Prostate cancer disparities among American Indians and Alaskan Natives in the United States. Journal Of The National Cancer Institute 2023, 115: 413-420. PMID: 36629492, PMCID: PMC10086629, DOI: 10.1093/jnci/djad002.Peer-Reviewed Original ResearchConceptsProstate cancer-specific mortalityProstate-specific antigenAlaska Native patientsCancer-specific mortalityGleason scoreNative patientsDefinitive treatmentWhite patientsProstate cancerTreatment accessAlaska NativesProvider densityHigher prostate-specific antigenAdvanced prostate cancerPatterns of careExternal beam radiationAmerican IndiansProstate cancer disparitiesCounty-level demographicsHealth policy interventionsLower ratesMultivariable adjustmentBaseline characteristicsPathologic factorsWorse survival
2022
Arthroscopic Synovectomy for Tenosynovial Giant Cell Tumor/Pigmented Villonodular Synovitis in the Posterior Knee Using the Posterior Trans-Septal Portal Technique
Moran J, Miller MD, Schneble CA, Yalcin S, Katz LD, Medvecky MJ. Arthroscopic Synovectomy for Tenosynovial Giant Cell Tumor/Pigmented Villonodular Synovitis in the Posterior Knee Using the Posterior Trans-Septal Portal Technique. JBJS Essential Surgical Techniques 2022, 12: e21.00051. PMID: 35685235, PMCID: PMC9173520, DOI: 10.2106/jbjs.st.21.00051.Peer-Reviewed Case Reports and Technical NotesArthroscopic synovectomyMacrophage-colony stimulating factorPosteromedial portalPosterior septumPosterolateral portalPopliteal arteryVillonodular synovitisPortal techniqueAnterolateral portalPosterior portalInternational Knee Documentation CommitteeBaseline magnetic resonance imagingPosterior compartmentTenosynovial giant cell tumorGood functional outcomeExcellent clinical resultsExternal beam radiationGiant cell tumorPosterior cruciate ligamentPigmented villonodular synovitisFull knee functionMagnetic resonance imagingScar tissue formationUncommon benign proliferationAsymptomatic recurrence
2021
Brachytherapy and non-cancer mortality in patients with oral cavity and oropharynx SCCs
Yu J, Tsay C, Sasaki C, Son YH, Decker RH, Mehra S, Burtness B. Brachytherapy and non-cancer mortality in patients with oral cavity and oropharynx SCCs. Oral Oncology 2021, 122: 105585. PMID: 34688055, DOI: 10.1016/j.oraloncology.2021.105585.Peer-Reviewed Original ResearchConceptsNon-cancer mortalitySecond primary cancerExternal beam radiationOPC patientsPrimary cancerOral cavityHigher cancer-specific mortalityOropharyngeal squamous cell cancerBrachytherapy-treated patientsElectronic medical record dataImpact of brachytherapyInstitutional tumor registryCancer-specific mortalitySquamous cell cancerProportional hazards regressionCause of deathMedical record dataBeam radiationEligible patientsMortality HROropharynx SCCPrimary malignancySmoking historyPrimary outcomeTreatment regimen
2019
1127P Brachytherapy and non-cancer mortality in patients with oral cavity and oropharynx SCCs
Yu J, Tsay C, Sasaki C, Son Y, Decker R, Mehra S, Burtness B. 1127P Brachytherapy and non-cancer mortality in patients with oral cavity and oropharynx SCCs. Annals Of Oncology 2019, 30: v457. DOI: 10.1093/annonc/mdz252.019.Peer-Reviewed Original ResearchNon-cancer mortalityExternal beam radiationOverall survivalCancer mortalityOral cavityOropharyngeal squamous cell cancerBrachytherapy-treated patientsGenentech/RocheImpact of brachytherapyReceipt of brachytherapySecond primary cancerEffect of comorbiditySquamous cell cancerProportional hazards regressionSingle-institution studyHigher cancer mortalityBeam radiationElectronic medical recordsGlaxo Smith KlineBristol-Myers SquibbEligible patientsOropharynx SCCHPV statusPrimary malignancySecondary outcomesRates of Adverse IBD-Related Outcomes for Patients With IBD and Concomitant Prostate Cancer Treated With Radiation Therapy
Feagins LA, Kim J, Chandrakumaran A, Gandle C, Naik KH, Cipher DJ, Hou JK, Yao MD, Gaidos JKJ. Rates of Adverse IBD-Related Outcomes for Patients With IBD and Concomitant Prostate Cancer Treated With Radiation Therapy. Inflammatory Bowel Diseases 2019, 26: 728-733. PMID: 31412114, DOI: 10.1093/ibd/izz175.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseFlare of IBDProstate cancerIBD patientsRadiation treatmentCancer diagnosisRadiation therapyRates of IBDInflammatory bowel disease flaresMultiple logistic regression analysisConcomitant prostate cancerVeterans Affairs hospital systemCharlson Comorbidity IndexRetrospective cohort studyRadiation-treated patientsExternal beam radiationBest treatment approachProstate cancer stageLogistic regression analysisProstate cancer diagnosisDisease flareIBD characteristicsComorbidity indexCohort studyBowel disease
2018
Patterns of failure in high-metastatic node number human papillomavirus-positive oropharyngeal carcinoma
Lee NCJ, Kelly JR, Park HS, An Y, Judson BL, Burtness BA, Husain ZA. Patterns of failure in high-metastatic node number human papillomavirus-positive oropharyngeal carcinoma. Oral Oncology 2018, 85: 35-39. PMID: 30220317, DOI: 10.1016/j.oraloncology.2018.08.001.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBrachytherapyCarcinoma, Squamous CellCombined Modality TherapyFemaleFollow-Up StudiesHumansLymphatic MetastasisMaleMiddle AgedNeck DissectionNeoplasm MetastasisNeoplasm Recurrence, LocalOropharyngeal NeoplasmsPapillomavirus InfectionsProgression-Free SurvivalProportional Hazards ModelsRadiotherapy, AdjuvantRetrospective StudiesSalvage TherapyConceptsProgression-free survivalInvolved lymph nodesDistant metastasisPatterns of failureLocoregional recurrenceLymph nodesHuman papillomavirus-positive oropharyngeal carcinomaMultivariate analysisEdition American Joint CommitteeRate of DMWorse progression-free survivalHigh DM rateDedicated clinical trialsAmerican Joint CommitteeCancer (AJCC) staging systemProportional hazards regressionExternal beam radiationOropharynx cancerFree survivalNeck dissectionOropharyngeal carcinomaOverall survivalDisease recurrenceIntraoperative brachytherapyOPC patients
2017
Long‐term outcomes of Group D retinoblastoma eyes during the intravitreal melphalan era
Berry JL, Shah S, Bechtold M, Zolfaghari E, Jubran R, Kim JW. Long‐term outcomes of Group D retinoblastoma eyes during the intravitreal melphalan era. Pediatric Blood & Cancer 2017, 64 PMID: 28646513, DOI: 10.1002/pbc.26696.Peer-Reviewed Original ResearchConceptsGroup D eyesGroup D retinoblastoma eyesD eyesSystemic chemoreductionIntravitreal melphalanSalvage rateRetinoblastoma eyesIntravitreal melphalan injectionRetrospective chart reviewOverall salvage ratePrimary outcome measurementLong-term outcomesExternal beam radiationOcular salvageSalvage therapyVitreous seedsChart reviewGlobe salvageIntravitreal injectionKaplan-MeierTreatment modalitiesTumor recurrenceMelphalan injectionOutcome measurementsMelphalan
2016
Palliative care for hepatocellular carcinoma: Analysis of the National Cancer Data Base.
Hammad A, Robbins J, Turaga K, Christians K, Gamblin T, Johnston F. Palliative care for hepatocellular carcinoma: Analysis of the National Cancer Data Base. Journal Of Clinical Oncology 2016, 34: 390-390. DOI: 10.1200/jco.2016.34.4_suppl.390.Peer-Reviewed Original ResearchPredictors of survivalNational Cancer DatabaseNegative predictors of survivalHepatocellular carcinomaCharlson Comorbidity IndexPain therapyPalliative carePalliative radiotherapySurvival benefitPalliative therapyNational Cancer Data BaseLate stage hepatocellular carcinomaPositive predictor of survivalReceipt of palliative careExternal beam radiationHazards modelStage IV diseaseStage hepatocellular carcinomaMultivariate proportional hazards modelSignificant survival benefitLog-rank testLate stage diseaseNegative predictorProportional hazards modelImprove quality of life
2015
A Case-Based Illustration of Urinary Symptoms Following Radiation Therapy for Prostate Cancer
Polland A, Leapman M, Stone N. A Case-Based Illustration of Urinary Symptoms Following Radiation Therapy for Prostate Cancer. 2015, 151-172. DOI: 10.1007/978-3-319-23817-3_11.Peer-Reviewed Original ResearchRadiation therapyProstate cancerLower urinary tract symptomsUrinary tract symptomsValuable treatment optionUrinary side effectsExternal beam radiationPosttreatment courseUrinary symptomsTract symptomsCounseling patientsUrinary effectsTreatment optionsSide effectsClinical scenariosTherapyPatientsBeam radiationSymptomsCancerIncontinenceHematuriaBrachytherapyRacial disparities in the use of SBRT for treating early-stage lung cancer
Corso CD, Park HS, Kim AW, Yu JB, Husain Z, Decker RH. Racial disparities in the use of SBRT for treating early-stage lung cancer. Lung Cancer 2015, 89: 133-138. PMID: 26051446, DOI: 10.1016/j.lungcan.2015.05.002.Peer-Reviewed Original ResearchConceptsStereotactic body radiotherapyUse of SBRTEarly-stage lung cancerBlack patientsExternal beam radiationWhite patientsAggressive therapyLung cancerRacial disparitiesNon-operative cohortNational Cancer DatabaseStage I NSCLCPrimary treatment modalitySurgical resection rateMultivariable logistic regressionPopulation-based studyPotential racial disparitiesInoperable candidatesSBRT useSBRT utilizationInoperable patientsResection rateSurgical resectionMultivariable analysisSurgical interventionA Phase I Study of CUDC-101, a Multitarget Inhibitor of HDACs, EGFR, and HER2, in Combination with Chemoradiation in Patients with Head and Neck Squamous Cell Carcinoma
Galloway TJ, Wirth LJ, Colevas AD, Gilbert J, Bauman JE, Saba NF, Raben D, Mehra R, W. A, Atoyan R, Wang J, Burtness B, Jimeno A. A Phase I Study of CUDC-101, a Multitarget Inhibitor of HDACs, EGFR, and HER2, in Combination with Chemoradiation in Patients with Head and Neck Squamous Cell Carcinoma. Clinical Cancer Research 2015, 21: 1566-1573. PMID: 25573383, PMCID: PMC6607903, DOI: 10.1158/1078-0432.ccr-14-2820.Peer-Reviewed Original ResearchConceptsHuman growth factor receptor 2Peripheral blood mononuclear cellsEpidermal growth factor receptorDose-limiting toxicityAdverse eventsCUDC-101Tumor biopsiesHistone deacetylaseNeck squamous cell cancerNeck squamous cell carcinomaHigh-risk HNSCCGrowth factor receptor 2Squamous cell cancerSquamous cell carcinomaBlood mononuclear cellsExternal beam radiationTreatment of HNSCCRoute of administrationOne-week runFactor receptor 2Concurrent cisplatinGrowth factor receptorRisk patientsCell cancerCell carcinoma
2014
High-dose-rate Interstitial Brachytherapy Boost with a Pedicled Latissimus Dorsi Myocutaneous Flap for Myxofibrosarcoma of the Arm
Lane J, Pomahac B, Raut C, Baldini E, Devlin P. High-dose-rate Interstitial Brachytherapy Boost with a Pedicled Latissimus Dorsi Myocutaneous Flap for Myxofibrosarcoma of the Arm. Plastic & Reconstructive Surgery Global Open 2014, 2: e229. PMID: 25426346, PMCID: PMC4236374, DOI: 10.1097/gox.0000000000000188.Peer-Reviewed Original ResearchPedicled latissimus dorsi myocutaneous flapLatissimus dorsi myocutaneous flapMyocutaneous flapPreoperative external beam radiationRate interstitial brachytherapy boostGy of brachytherapyPostoperative day 58Evidence of recurrencePostoperative day 7External beam radiationInterstitial brachytherapy boostFinal pathologySurgical debridementBrachytherapy boostRadical resectionFat necrosisMedial armSurgical bedNeurovascular structuresDay 7Brachytherapy cathetersMyxofibrosarcomaGood functionDay 58Flap
2013
Interventional Radiology in the Multidisciplinary Management of Liver Lesions: Pre- and Postoperative Roles
Ward T, Madoff D, Weintraub J. Interventional Radiology in the Multidisciplinary Management of Liver Lesions: Pre- and Postoperative Roles. Seminars In Liver Disease 2013, 33: 213-225. PMID: 23943102, DOI: 10.1055/s-0033-1351778.Peer-Reviewed Original ResearchConceptsLocoregional therapyHepatobiliary surgeonsPostoperative roleInterventional radiologistsLiver lesionsColorectal cancer metastasisExternal beam radiationMultiple treatment modalitiesNontransplant candidatesTransplant criteriaVascular complicationsPostoperative settingMultidisciplinary managementTreatment modalitiesPreoperative roleComplex careInterventional radiologyRadiation oncologistsCancer metastasisPatientsMultidisciplinary approachResectionTransplantationOncologistsLesions
2012
Penile metastases originating from a pancreatic primary tumor: a case report
Tello T, Zeidan Y, Bush K, Schwartz E, Kunz P, Chang D. Penile metastases originating from a pancreatic primary tumor: a case report. Journal Of Radiation Oncology 2012, 2: 107-112. DOI: 10.1007/s13566-012-0076-1.Peer-Reviewed Original ResearchPenile metastasisPancreatic adenocarcinomaPrimary tumorPancreatic primary tumorExternal beam radiationPrimary pancreatic adenocarcinomaFine needle aspiratesPalliative radiationPenile painPain controlDifficulty urinatingPancreatic bodyInfiltrative massMetastatic adenocarcinomaCase reportPancreatic massPenile diseaseRadiation therapyComputed tomographyGenitourinary systemPenile nodulesNeedle aspiratesAdenocarcinomaMetastasisBeam radiationThe relations between age and androgen deprivation therapy use among men receiving radiation therapy for prostate cancer in the Medicare population.
Quon J, Yu J, Soulos P, Gross C. The relations between age and androgen deprivation therapy use among men receiving radiation therapy for prostate cancer in the Medicare population. Journal Of Clinical Oncology 2012, 30: e15150-e15150. DOI: 10.1200/jco.2012.30.15_suppl.e15150.Peer-Reviewed Original ResearchHigh-risk groupShort life expectancyRisk groupsProstate cancerLife expectancyNational Comprehensive Cancer Network guidelinesAndrogen deprivation therapy useConcurrent androgen deprivation therapyEnd Results-Medicare databaseAndrogen deprivation therapyLow-risk cancersExternal beam radiationLow-risk groupLonger life expectancyDeprivation therapyNCCN guidelinesOlder patientsClinical factorsTherapy useGuideline recommendationsTumor characteristicsNetwork guidelinesCancer characteristicsRadiation therapyMedicare population
2010
An Updated Report on the Pathologic Complete Response and Survival Outcome of Southwest Oncology Group (SWOG S0536): A Phase II Trial of Oxaliplatin (oxp) Plus Protracted Infusion 5-Fluorouracil (PIFU) and External Beam Radiation (EBRT) Prior to Surgery(s) for Potentially Curable Esophageal Adenocarcinoma (EA) with Molecular Correlates
Leichman L, Goldman B, Thomas C, Billingsley K, Corless C, Lenz H, Iqbal S, Benedetti J, Gold P, Blanke C. An Updated Report on the Pathologic Complete Response and Survival Outcome of Southwest Oncology Group (SWOG S0536): A Phase II Trial of Oxaliplatin (oxp) Plus Protracted Infusion 5-Fluorouracil (PIFU) and External Beam Radiation (EBRT) Prior to Surgery(s) for Potentially Curable Esophageal Adenocarcinoma (EA) with Molecular Correlates. International Journal Of Radiation Oncology • Biology • Physics 2010, 78: s28-s29. DOI: 10.1016/j.ijrobp.2010.07.106.Peer-Reviewed Original ResearchPostoperative Vaginal Cuff Brachytherapy Alone (VB) Provides Equally Effective Treatment with Less Toxicity Than External Beam Radiation and Vaginal Cuff Brachytherapy (EXT + VB) in the Treatment of Stage II Endometrial Adenocarcinoma
Galper S, Harrington J, Ratner E, Deng Y, Zelterman D, Hui P, Rutherford T, Higgins S. Postoperative Vaginal Cuff Brachytherapy Alone (VB) Provides Equally Effective Treatment with Less Toxicity Than External Beam Radiation and Vaginal Cuff Brachytherapy (EXT + VB) in the Treatment of Stage II Endometrial Adenocarcinoma. International Journal Of Radiation Oncology • Biology • Physics 2010, 78: s415-s416. DOI: 10.1016/j.ijrobp.2010.07.978.Peer-Reviewed Original Research
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