2024
Compartmentalized pooling generates orientation selectivity in wide-field amacrine cells
Lei W, Clark D, Demb J. Compartmentalized pooling generates orientation selectivity in wide-field amacrine cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2411130121. PMID: 39602271, PMCID: PMC11626119, DOI: 10.1073/pnas.2411130121.Peer-Reviewed Original ResearchConceptsOrientation selectivityBand-pass spatial frequency tuningVisual systemReceptive fieldsSpatial frequency tuningWide-field amacrine cellsReceptive field modelOrientation detectionKappa-opioid receptorsAmacrine cellsDetecting orientationVisual sceneFrequency tuningGlycinergic inhibitionOpioid receptorsField modelSpecific membrane resistanceExcitatory inputSynaptic inputsCalcium imagingMouse retinaCalcium signalingDendritic compartmentsMicrocircuit levelPolarizationNon-canonical type 1 cannabinoid receptor signaling regulates night visual processing in the inner rat retina
Estay S, Morales-Moraga C, Vielma A, Palacios-Muñoz A, Chiu C, Chávez A. Non-canonical type 1 cannabinoid receptor signaling regulates night visual processing in the inner rat retina. IScience 2024, 27: 109920. PMID: 38799553, PMCID: PMC11126983, DOI: 10.1016/j.isci.2024.109920.Peer-Reviewed Original ResearchA17 amacrine cellsRod bipolar cellsVisual processingType 1 cannabinoid receptorGABAergic feedback inhibitionNon-canonical mechanismRat retinal slicesAmacrine cellsCB1R activationRetinal slicesGlutamate releaseInner retinaRat retinaRetinal neuronsRod pathwayCB1RExchange proteinFeedback inhibitionBipolar cellsRod-drivenAxon terminalsTime courseGABAVisual responsesRetina
2023
Direct comparison reveals algorithmic similarities in fly and mouse visual motion detection
Chen J, Gish C, Fransen J, Salazar-Gatzimas E, Clark D, Borghuis B. Direct comparison reveals algorithmic similarities in fly and mouse visual motion detection. IScience 2023, 26: 107928. PMID: 37810236, PMCID: PMC10550730, DOI: 10.1016/j.isci.2023.107928.Peer-Reviewed Original ResearchMolecular mechanismsStarburst amacrine cellsSpatiotemporal receptive-field structureReceptive field structureAmacrine cellsT4 neuronsSpeciesNeuronal morphologyNeuron typesAnalogous neuronsNeural circuitsVisual motion detectionCellsVisual motionMotion stimuliVertebratesInvertebratesMiceMotion processingNeuronsSimilarityApparent motion stimuliFlies
2021
Photoreceptive Ganglion Cells Drive Circuits for Local Inhibition in the Mouse Retina
Pottackal J, Walsh HL, Rahmani P, Zhang K, Justice NJ, Demb JB. Photoreceptive Ganglion Cells Drive Circuits for Local Inhibition in the Mouse Retina. Journal Of Neuroscience 2021, 41: 1489-1504. PMID: 33397711, PMCID: PMC7896016, DOI: 10.1523/jneurosci.0674-20.2020.Peer-Reviewed Original ResearchMeSH KeywordsAmacrine CellsAnimalsCorticotropin-Releasing HormoneElectrophysiological PhenomenaExcitatory Postsynaptic PotentialsFemalegamma-Aminobutyric AcidGap JunctionsMaleMiceMice, Inbred C57BLNeural InhibitionNeuronsOptogeneticsPhotoreceptor Cells, VertebrateRetinaRetinal Cone Photoreceptor CellsRetinal Ganglion CellsRetinal Rod Photoreceptor CellsRod OpsinsSynapsesConceptsGap junction-mediated electrical synapsesAmacrine cellsElectrical synapsesIpRGC activityGanglion cellsRetinal interneuronsRetinal circuitsPhotosensitive retinal ganglion cellsGABAergic amacrine cellsRetinal ganglion cellsWhole-cell recordingsSpecific RGC typesAbsence of rodsIpRGC typesRGC typesPharmacological blockadeRetinal neuronsMelanopsin expressionMature retinaMouse retinaSynaptic circuitsNeuronal circuitsInterneuronsOptogenetic stimulationLocal inhibition
2020
Receptoral Mechanisms for Fast Cholinergic Transmission in Direction-Selective Retinal Circuitry
Pottackal J, Singer JH, Demb JB. Receptoral Mechanisms for Fast Cholinergic Transmission in Direction-Selective Retinal Circuitry. Frontiers In Cellular Neuroscience 2020, 14: 604163. PMID: 33324168, PMCID: PMC7726240, DOI: 10.3389/fncel.2020.604163.Peer-Reviewed Original ResearchDirection-selective ganglion cellsStarburst amacrine cellsFast cholinergic transmissionGABAergic inhibitionCholinergic transmissionGABAergic transmissionCholinergic excitationPostsynaptic currentsSynaptic mechanismsConventional synaptic transmissionReceptoral mechanismsReceptor blockadeAmacrine cellsGanglion cellsRetinal circuitryParacrine natureSynaptic transmissionConventional synapsesMammalian retinaMouse retinaParacrine transmissionParacrine modeDirection selectivityDistinct temporal propertiesReceptor kineticsConnectomic analysis reveals an interneuron with an integral role in the retinal circuit for night vision
Park SJ, Lieberman EE, Ke JB, Rho N, Ghorbani P, Rahmani P, Jun NY, Lee HL, Kim IJ, Briggman KL, Demb JB, Singer JH. Connectomic analysis reveals an interneuron with an integral role in the retinal circuit for night vision. ELife 2020, 9: e56077. PMID: 32412412, PMCID: PMC7228767, DOI: 10.7554/elife.56077.Peer-Reviewed Original ResearchConceptsAII amacrine cellsProjection neuronsSingle interneuron typeConnectomic analysisBipolar cell pathwaysNovel neural circuitGABAergic cellsAmacrine cellsCentral neuronsGanglion cellsSynaptic layersRetinal circuitsInterneuron typesSurround inhibitionMouse retinaNight visionON responseExcitatory centerOptogenetic analysesNeural circuitsInhibitory surroundCell pathwaysRod photoreceptorsReceptive fieldsRb pathwayA retinal circuit for the suppressed-by-contrast receptive field of a polyaxonal amacrine cell
Jia Y, Lee S, Zhuo Y, Zhou ZJ. A retinal circuit for the suppressed-by-contrast receptive field of a polyaxonal amacrine cell. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 9577-9583. PMID: 32273387, PMCID: PMC7196907, DOI: 10.1073/pnas.1913417117.Peer-Reviewed Original ResearchConceptsPolyaxonal amacrine cellsAmacrine cellsGanglion cellsReceptive fieldsRetinal output neuronsTrigger featuresVGluT3 cellsRetinal activityCell dendritesRetinal circuitsLocal controlIntricate circuitryDownstream circuitsOutput neuronsDifferent subpopulationsRetinaDifferential connectivityDistal tipForm of crosstalkCellsDiverse populationsVisual processingCritical roleGlycinergicAmacrine
2019
TRPC5 regulates axonal outgrowth in developing retinal ganglion cells
Oda M, Yamamoto H, Matsumoto H, Ishizaki Y, Shibasaki K. TRPC5 regulates axonal outgrowth in developing retinal ganglion cells. Laboratory Investigation 2019, 100: 297-310. PMID: 31844148, DOI: 10.1038/s41374-019-0347-1.Peer-Reviewed Original ResearchConceptsRetinal ganglion cellsGanglion cell layerRetinal ganglion cell axon outgrowthTRPC5 expressionDepletion of intracellular calcium storesAmacrine cellsExcessive Ca<sup>2+</sup> entryDeath of retinal ganglion cellsExpression of TRPC5Ganglion cellsAxonal outgrowthIntracellular calcium storesMuller glial cellsNitric oxideMature retinal ganglion cellsRetinal cell typesIn situ hybridizationCentral nervous systemTRPC5 activityCalcium storesTRPC5Characteristic cell morphologyMouse retinaGlial cellsHippocampal neurons
2018
Convergence and Divergence of CRH Amacrine Cells in Mouse Retinal Circuitry
Park SJH, Pottackal J, Ke JB, Jun NY, Rahmani P, Kim IJ, Singer JH, Demb JB. Convergence and Divergence of CRH Amacrine Cells in Mouse Retinal Circuitry. Journal Of Neuroscience 2018, 38: 3753-3766. PMID: 29572434, PMCID: PMC5895998, DOI: 10.1523/jneurosci.2518-17.2018.Peer-Reviewed Original ResearchConceptsAlpha ganglion cellsGanglion cell typesAmacrine cellsGanglion cellsCRH cellsAlpha cellsGABAergic synapsesInhibitory interneuronsExcitation/inhibition balanceCorticotropin-releasing hormoneCre transgenic miceFire action potentialsTonic excitatory driveCell typesBalance of excitationGABA releaseExcitatory circuitsRetinal circuitryExcitatory driveInhibition balanceInhibitory inputsMammalian retinaMouse retinaAction potentialsOptogenetic analyses
2017
Local synaptic integration enables ON-OFF asymmetric and layer-specific visual information processing in vGluT3 amacrine cell dendrites
Chen M, Lee S, Zhou ZJ. Local synaptic integration enables ON-OFF asymmetric and layer-specific visual information processing in vGluT3 amacrine cell dendrites. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 11518-11523. PMID: 28973895, PMCID: PMC5664540, DOI: 10.1073/pnas.1711622114.Peer-Reviewed Original ResearchConceptsInner plexiform layerAmacrine cellsSynaptic inhibitionSegregation of ONVGluT3 amacrine cellsGanglion cell typesBipolar cell terminalsSmall-field amacrine cellsOFF sublayersDendritic varicositiesPlexiform layerReceptive field sizeSynaptic processingSynaptic integrationDendritic responsesMammalian retinaOFF segregationNeuronal organizationTwo-photon imagingDendritic treeIPL depthOFF pathwaysCell terminalsDendritic functionVisual information processingSelective synaptic connections in the retinal pathway for night vision
Beaudoin DL, Kupershtok M, Demb JB. Selective synaptic connections in the retinal pathway for night vision. The Journal Of Comparative Neurology 2017, 527: 117-132. PMID: 28856684, PMCID: PMC5832573, DOI: 10.1002/cne.24313.Peer-Reviewed Original ResearchConceptsAII amacrine cellsRetinal ganglion cellsAmacrine cellsRGC typesBipolar terminalsSynaptic connectionsCertain retinal ganglion cellsConnected retinal ganglion cellsIonotropic glutamate receptor antagonistsOFF alpha cellsGlutamate receptor antagonistsInner plexiform layerBipolar cell terminalsSelective synaptic connectionsBipolar cell activityOFF alphaRetinal connectionsRetinal pathwaysPlexiform layerReceptor antagonistDirect synapsesGanglion cellsGlycinergic synapsesInhibitory currentsMammalian retinaOrexin-A Suppresses Signal Transmission to Dopaminergic Amacrine Cells From Outer and Inner Retinal Photoreceptors
Qiao SN, Zhou W, Liu LL, Zhang DQ, Zhong YM. Orexin-A Suppresses Signal Transmission to Dopaminergic Amacrine Cells From Outer and Inner Retinal Photoreceptors. Investigative Ophthalmology & Visual Science 2017, 58: 4712-4721. PMID: 28910447, PMCID: PMC5598320, DOI: 10.1167/iovs.17-21835.Peer-Reviewed Original ResearchConceptsDopaminergic amacrine cellsInner retinal photoreceptorsOrexin receptorsAmacrine cellsVisual functionRetinal photoreceptorsWhole-cell voltage-clamp techniqueOuter retinal photoreceptorsVoltage-clamp techniqueNeuropeptide orexinEndogenous orexinsDopaminergic systemUpstream neuronsOrexinCone functionMammalian retinaMouse retinaGenetic deletionRetinaVertebrate retinaIpRGCsReceptorsLight-induced responsesPhotoreceptorsResponse
2016
Multiple cone pathways are involved in photic regulation of retinal dopamine
Qiao SN, Zhang Z, Ribelayga CP, Zhong YM, Zhang DQ. Multiple cone pathways are involved in photic regulation of retinal dopamine. Scientific Reports 2016, 6: 28916. PMID: 27356880, PMCID: PMC4928117, DOI: 10.1038/srep28916.Peer-Reviewed Original ResearchConceptsDopaminergic amacrine cellsRetinal dopamineAmacrine cellsBipolar cellsPhotosensitive retinal ganglion cellsCone-mediated responsesOFF bipolar cellsRetinal ganglion cellsParallel excitatoryInhibitory circuitsGanglion cellsExcitatory inputsDopamine releaseInhibitory responsesCone functionKey neurotransmitterNeural pathwaysCone pathwaysType 1Dye injectionDopamineRetinaPhotic regulationCellsDAC activityRetinal Wave Patterns Are Governed by Mutual Excitation among Starburst Amacrine Cells and Drive the Refinement and Maintenance of Visual Circuits
Xu HP, Burbridge TJ, Ye M, Chen M, Ge X, Zhou ZJ, Crair MC. Retinal Wave Patterns Are Governed by Mutual Excitation among Starburst Amacrine Cells and Drive the Refinement and Maintenance of Visual Circuits. Journal Of Neuroscience 2016, 36: 3871-3886. PMID: 27030771, PMCID: PMC4812142, DOI: 10.1523/jneurosci.3549-15.2016.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAge FactorsAmacrine CellsAnimalsAnimals, NewbornCalciumCholera ToxinCholine O-AcetyltransferaseCholinergic AgentsGene Expression Regulation, DevelopmentalGreen Fluorescent ProteinsIn Vitro TechniquesMiceMice, TransgenicPatch-Clamp TechniquesReceptors, NicotinicRetinaRetinal Ganglion CellsVesicular Glutamate Transport Protein 1Visual PathwaysConceptsEye-specific segregationVisual circuit developmentStarburst amacrine cellsStage III retinal wavesRetinal ganglion cellsRetinal wavesAmacrine cellsGlutamatergic wavesGanglion cellsSpontaneous activityVisual circuitsStage IICircuit developmentHigher-order visual areasNicotinic acetylcholine receptorsRetinal cell typesMammalian visual systemAcetylcholine receptorsΒ2-nAChRsVisual areasPatterned activityPatterning of activityΒ2 subunitCell typesCellsSegregated Glycine-Glutamate Co-transmission from vGluT3 Amacrine Cells to Contrast-Suppressed and Contrast-Enhanced Retinal Circuits
Lee S, Zhang Y, Chen M, Zhou ZJ. Segregated Glycine-Glutamate Co-transmission from vGluT3 Amacrine Cells to Contrast-Suppressed and Contrast-Enhanced Retinal Circuits. Neuron 2016, 90: 27-34. PMID: 26996083, PMCID: PMC4824647, DOI: 10.1016/j.neuron.2016.02.023.Peer-Reviewed Original ResearchConceptsUniformity detectorsAmacrine cellsGanglion cellsOFF alpha ganglion cellsSpecific synaptic circuitryVGluT3 amacrine cellsAlpha ganglion cellsSeparate neuronal circuitsInhibitory driveExcitatory neurotransmitterSynaptic circuitryGlycinergic synapsesRetinal circuitsMouse retinaNeuronal circuitsSingle interneuronSingle neuronsDale's principleNeuronsNeurotransmittersTrigger featuresCoordinated inhibitionSynapsesGlutamateCells
2015
Function and Circuitry of VIP+ Interneurons in the Mouse Retina
Park SJ, Borghuis BG, Rahmani P, Zeng Q, Kim IJ, Demb JB. Function and Circuitry of VIP+ Interneurons in the Mouse Retina. Journal Of Neuroscience 2015, 35: 10685-10700. PMID: 26224854, PMCID: PMC4518048, DOI: 10.1523/jneurosci.0222-15.2015.Peer-Reviewed Original ResearchConceptsGanglion cell layerAmacrine cell typesInner nuclear layerAmacrine cellsGanglion cellsINL cellsON pathwayGanglion cell dendritesGanglion cell typesBipolar cell terminalsWhole-cell recordingsCell typesNervous system functionSpatial tuningBipolar cell pathwaysTransgenic mouse lineGCL cellsOptic nerveGABAergic interneuronsRetinal functionCell dendritesRetinal circuitryInhibitory interneuronsNuclear layerBipolar interneurons
2014
An Unconventional Glutamatergic Circuit in the Retina Formed by vGluT3 Amacrine Cells
Lee S, Chen L, Chen M, Ye M, Seal RP, Zhou ZJ. An Unconventional Glutamatergic Circuit in the Retina Formed by vGluT3 Amacrine Cells. Neuron 2014, 84: 708-715. PMID: 25456497, PMCID: PMC4254642, DOI: 10.1016/j.neuron.2014.10.021.Peer-Reviewed Original ResearchConceptsDirection-selective ganglion cellsAmacrine cellsGlutamatergic circuitsGanglion cellsCalcium-dependent glutamate releaseVGluT3 amacrine cellsExcitatory glutamatergic inputGanglion cell activityOFF light responsesReceptive field structureOFF channelsGlutamate releaseGlutamatergic inputsInner retinaExcitatory inputsInhibitory neuronsBipolar cellsMouse retinaCell activityOFF responsesRetinaExcitatory interactionsVertebrate retinaCellsVisual signalsExcitatory Synaptic Inputs to Mouse On-Off Direction-Selective Retinal Ganglion Cells Lack Direction Tuning
Park SJ, Kim IJ, Looger LL, Demb JB, Borghuis BG. Excitatory Synaptic Inputs to Mouse On-Off Direction-Selective Retinal Ganglion Cells Lack Direction Tuning. Journal Of Neuroscience 2014, 34: 3976-3981. PMID: 24623775, PMCID: PMC3951696, DOI: 10.1523/jneurosci.5017-13.2014.Peer-Reviewed Original ResearchConceptsDirection-selective ganglion cellsOFF direction-selective ganglion cellsStarburst amacrine cellsGlutamate releaseBipolar cellsExcitatory currentsPreferred direction motionBipolar cell typesExcitatory synaptic inputsNull-direction inhibitionGABA-A receptorsWhole-cell recordingsNull-direction motionDSGC dendritesGABA releaseCholinergic inputAmacrine cellsGanglion cellsSynaptic mechanismsSynaptic inputsMammalian retinaMouse retinaIntensity-based glutamate-sensing fluorescent reporterDirection selectivityDirection tuning
2013
Adaptation to Background Light Enables Contrast Coding at Rod Bipolar Cell Synapses
Ke JB, Wang YV, Borghuis BG, Cembrowski MS, Riecke H, Kath WL, Demb JB, Singer JH. Adaptation to Background Light Enables Contrast Coding at Rod Bipolar Cell Synapses. Neuron 2013, 81: 388-401. PMID: 24373883, PMCID: PMC4267681, DOI: 10.1016/j.neuron.2013.10.054.Peer-Reviewed Original ResearchMeSH Keywords2-Amino-5-phosphonovalerateAdaptation, OcularAnimalsBiophysicsComputer SimulationExcitatory Amino Acid AntagonistsGlucosamine 6-Phosphate N-AcetyltransferaseGreen Fluorescent ProteinsIn Vitro TechniquesLightMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicModels, NeurologicalPatch-Clamp TechniquesQuinoxalinesRetinal Bipolar CellsRetinal Rod Photoreceptor CellsSynapsesVisual PathwaysTranssynaptic Tracing with Vesicular Stomatitis Virus Reveals Novel Retinal Circuitry
Beier KT, Borghuis BG, El-Danaf RN, Huberman AD, Demb JB, Cepko CL. Transsynaptic Tracing with Vesicular Stomatitis Virus Reveals Novel Retinal Circuitry. Journal Of Neuroscience 2013, 33: 35-51. PMID: 23283320, PMCID: PMC3711516, DOI: 10.1523/jneurosci.0245-12.2013.Peer-Reviewed Original ResearchConceptsStarburst amacrine cellsVesicular stomatitis virusDirection-selective retinal ganglion cellsRetinal ganglion cell typesGanglion cell typesRetinal ganglion cellsStomatitis virusCell typesDensity of neuropilTranssynaptic tracerNeurotropic virusesPresynaptic sourceAmacrine cellsSynaptic relationshipsGanglion cellsRetinal circuitryPostsynaptic neuronsSynaptic partnersMouse retinaViral tracersCell type-specific dissectionNeural circuitsNeural circuitryViral spreadVirus
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply