2024
Non-canonical type 1 cannabinoid receptor signaling regulates night visual processing in the inner rat retina
Estay S, Morales-Moraga C, Vielma A, Palacios-Muñoz A, Chiu C, Chávez A. Non-canonical type 1 cannabinoid receptor signaling regulates night visual processing in the inner rat retina. IScience 2024, 27: 109920. PMID: 38799553, PMCID: PMC11126983, DOI: 10.1016/j.isci.2024.109920.Peer-Reviewed Original ResearchA17 amacrine cellsRod bipolar cellsVisual processingType 1 cannabinoid receptorGABAergic feedback inhibitionNon-canonical mechanismRat retinal slicesAmacrine cellsCB1R activationRetinal slicesGlutamate releaseInner retinaRat retinaRetinal neuronsRod pathwayCB1RExchange proteinFeedback inhibitionBipolar cellsRod-drivenAxon terminalsTime courseGABAVisual responsesRetina
2015
Exchange Protein Directly Activated by cAMP (EPAC) Regulates Neuronal Polarization through Rap1B
Muñoz-Llancao P, Henríquez D, Wilson C, Bodaleo F, Boddeke E, Lezoualc'h F, Schmidt M, González-Billault C. Exchange Protein Directly Activated by cAMP (EPAC) Regulates Neuronal Polarization through Rap1B. Journal Of Neuroscience 2015, 35: 11315-11329. PMID: 26269639, PMCID: PMC6605123, DOI: 10.1523/jneurosci.3645-14.2015.Peer-Reviewed Original ResearchConceptsNeuronal polarityAcquisition of neuronal polarityAxon specificationGenetic manipulationRap1b activationExchange proteinGuanine exchange factorKnock-outEpac signalingRegulate neuronal polarityProtein kinase A.Axon determinationRap GTPasesWild-type neuronsExchange factorActivation of protein kinase A.Polarity defectsMouse neuronsRat hippocampal neuronsMessenger cAMPMolecular eventsEpacMature axonsCAMP-dependent mechanismPharmacological inhibition
2014
A‐kinase anchoring proteins: cAMP compartmentalization in neurodegenerative and obstructive pulmonary diseases
Poppinga W, Muñoz‐Llancao P, González‐Billault C, Schmidt M. A‐kinase anchoring proteins: cAMP compartmentalization in neurodegenerative and obstructive pulmonary diseases. British Journal Of Pharmacology 2014, 171: 5603-5623. PMID: 25132049, PMCID: PMC4290705, DOI: 10.1111/bph.12882.Peer-Reviewed Original ResearchConceptsA-kinase anchoring proteinsCAMP compartmentationCAMP effector proteinsCompartmentalized cAMP signalingGs protein-coupled receptorsCellular content of cAMPEffector proteinsCompartmentalization of cAMPAnchoring proteinsCAMP compartmentCellular functionsContent of cAMPA-kinaseCAMP SignalingProtein-coupled receptorsActivation of PKAObstructive pulmonary diseaseMessenger cAMPExchange proteinCellular contentAlzheimer's diseaseNeurodegenerative diseasesProteinB2-adrenoceptorsPulmonary disease
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