2017
Orexin-A Suppresses Signal Transmission to Dopaminergic Amacrine Cells From Outer and Inner Retinal Photoreceptors
Qiao SN, Zhou W, Liu LL, Zhang DQ, Zhong YM. Orexin-A Suppresses Signal Transmission to Dopaminergic Amacrine Cells From Outer and Inner Retinal Photoreceptors. Investigative Ophthalmology & Visual Science 2017, 58: 4712-4721. PMID: 28910447, PMCID: PMC5598320, DOI: 10.1167/iovs.17-21835.Peer-Reviewed Original ResearchConceptsDopaminergic amacrine cellsInner retinal photoreceptorsOrexin receptorsAmacrine cellsVisual functionRetinal photoreceptorsWhole-cell voltage-clamp techniqueOuter retinal photoreceptorsVoltage-clamp techniqueNeuropeptide orexinEndogenous orexinsDopaminergic systemUpstream neuronsOrexinCone functionMammalian retinaMouse retinaGenetic deletionRetinaVertebrate retinaIpRGCsReceptorsLight-induced responsesPhotoreceptorsResponseQuantitative Limits on Small Molecule Transport via the Electropermeome — Measuring and Modeling Single Nanosecond Perturbations
Sözer EB, Levine ZA, Vernier PT. Quantitative Limits on Small Molecule Transport via the Electropermeome — Measuring and Modeling Single Nanosecond Perturbations. Scientific Reports 2017, 7: 57. PMID: 28246401, PMCID: PMC5428338, DOI: 10.1038/s41598-017-00092-0.Peer-Reviewed Original Research
2014
The ATP-Competitive mTOR Inhibitor INK128 Enhances In Vitro and In Vivo Radiosensitivity of Pancreatic Carcinoma Cells
Hayman T, Wahba A, Rath B, Bae H, Kramp T, Shankavaram U, Camphausen K, Tofilon P. The ATP-Competitive mTOR Inhibitor INK128 Enhances In Vitro and In Vivo Radiosensitivity of Pancreatic Carcinoma Cells. Clinical Cancer Research 2014, 20: 110-119. PMID: 24198241, PMCID: PMC3947297, DOI: 10.1158/1078-0432.ccr-13-2136.Peer-Reviewed Original ResearchConceptsCap-complex formationGene translationPancreatic carcinoma cellsMTOR activityPancreatic carcinoma cell linesCell linesDNA double-strand breaksATP-competitive mTOR inhibitorsCarcinoma cellsΓH2AX fociCarcinoma cell linesPolysome-bound mRNADouble-strand breaksRadiation-induced γH2AX fociAberrant mTOR activityComplex formationDNA repairFibroblast cell lineMicroarray analysisRegulatory roleINK128Normal fibroblast cell lineMTOR inhibitionVivo radiosensitivityClonogenic survival
2010
Optimization of N-benzyl-benzoxazol-2-ones as receptor antagonists of macrophage migration inhibitory factor (MIF)
Hare AA, Leng L, Gandavadi S, Du X, Cournia Z, Bucala R, Jorgensen WL. Optimization of N-benzyl-benzoxazol-2-ones as receptor antagonists of macrophage migration inhibitory factor (MIF). Bioorganic & Medicinal Chemistry Letters 2010, 20: 5811-5814. PMID: 20728358, PMCID: PMC2939296, DOI: 10.1016/j.bmcl.2010.07.129.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorCytokine macrophage migration inhibitory factorMigration inhibitory factorHuman synovial fibroblastsReceptor CD74Receptor antagonistSynovial fibroblastsInhibitory factorAdditional studiesERK1/2 phosphorylationCell proliferationTautomerase activityAntagonistPotent inhibitorBinding assaysInhibitorsAssaysInflammationCD74
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