2016
Subpallial Enhancer Transgenic Lines: a Data and Tool Resource to Study Transcriptional Regulation of GABAergic Cell Fate
Silberberg SN, Taher L, Lindtner S, Sandberg M, Nord AS, Vogt D, Mckinsey GL, Hoch R, Pattabiraman K, Zhang D, Ferran JL, Rajkovic A, Golonzhka O, Kim C, Zeng H, Puelles L, Visel A, Rubenstein JLR. Subpallial Enhancer Transgenic Lines: a Data and Tool Resource to Study Transcriptional Regulation of GABAergic Cell Fate. Neuron 2016, 92: 59-74. PMID: 27710791, PMCID: PMC5063253, DOI: 10.1016/j.neuron.2016.09.027.Peer-Reviewed Original ResearchConceptsGABAergic cell fateEnhancer activityTranscriptional regulationCell fateNovel molecular mechanismStable transgenic mouse linesTranscriptional circuitryTransgenic linesTranscription factorsTranscriptional mechanismsDifferent enhancer elementsFate mapEnhancer elementsMolecular mechanismsTransgenic mouse lineForebrain developmentDistinct domainsMouse linesRegulationAmygdala neuronsBasal gangliaFateSpecific subtypesMutantsUnique tool
2015
Function and Circuitry of VIP+ Interneurons in the Mouse Retina
Park SJ, Borghuis BG, Rahmani P, Zeng Q, Kim IJ, Demb JB. Function and Circuitry of VIP+ Interneurons in the Mouse Retina. Journal Of Neuroscience 2015, 35: 10685-10700. PMID: 26224854, PMCID: PMC4518048, DOI: 10.1523/jneurosci.0222-15.2015.Peer-Reviewed Original ResearchConceptsGanglion cell layerAmacrine cell typesInner nuclear layerAmacrine cellsGanglion cellsINL cellsON pathwayGanglion cell dendritesGanglion cell typesBipolar cell terminalsWhole-cell recordingsCell typesNervous system functionSpatial tuningBipolar cell pathwaysTransgenic mouse lineGCL cellsOptic nerveGABAergic interneuronsRetinal functionCell dendritesRetinal circuitryInhibitory interneuronsNuclear layerBipolar interneurons
2012
MyD88 Expression on Villin Inhibits Obesity in High Fat Diet Mice (120.5)
Chao C, Xiang Y, Wang Y, Peng J, Hu Y, Tai N, Hoshi N, Zhou Z, Medzhitov R, Wen L. MyD88 Expression on Villin Inhibits Obesity in High Fat Diet Mice (120.5). The Journal Of Immunology 2012, 188: 120.5-120.5. DOI: 10.4049/jimmunol.188.supp.120.5.Peer-Reviewed Original ResearchHigh-fat dietWhite adipose tissue weightEpithelial brush borderTotal body fat massHigh-fat diet miceAdipose tissue weightMesenteric lymph nodesInsulin tolerance testWild-type B6Body fat massFat diet miceLower body weightWhite adipose tissueBrush borderTransgenic mouse lineInhibits obesityMore EnterococcusLymph nodesMetabolic syndromeDiet miceB6 miceIL-6MyD88 expressionFat dietTolerance test
2011
Galanin negatively modulates opiate withdrawal via galanin receptor 1
Holmes FE, Armenaki A, Iismaa TP, Einstein EB, Shine J, Picciotto MR, Wynick D, Zachariou V. Galanin negatively modulates opiate withdrawal via galanin receptor 1. Psychopharmacology 2011, 220: 619-625. PMID: 21969124, PMCID: PMC3324978, DOI: 10.1007/s00213-011-2515-x.Peer-Reviewed Original ResearchConceptsGalanin receptor 1Chronic morphine administrationMorphine administrationLocus coeruleusGalanin expressionOpiate withdrawalReceptor 1Distinct G protein-coupled receptorsPrecipitation of withdrawalAction of morphineDoses of morphineWild-type miceTransgenic mouse lineG protein-coupled receptorsExpress galaninGalanin levelsWild-type controlsProtein-coupled receptorsNeuropeptide galaninMorphine dependenceWithdrawal signsOpiate dependenceGalaninTransgenic miceGalR2 gene
2006
The FGF system positively regulates vascular integrity after ischemic injury
Murakami M, Moodie K, Zhuang Z, Ko I, Stan R, Simons M. The FGF system positively regulates vascular integrity after ischemic injury. The FASEB Journal 2006, 20: a636-a636. DOI: 10.1096/fasebj.20.4.a636-b.Peer-Reviewed Original ResearchIschemic injuryFemoral arteryTen-week-old miceVascular integrityEndothelial cellsRight femoral arteryTissue cGMP levelsFemoral artery ligationGrowth factor systemFibroblast growth factor (FGF) systemRat femoral arteryConditional transgenic mouse lineTransgenic mouse lineFGF systemAortic endothelial cellsEndothelial barrier functionBovine aortic endothelial cellsIschemic sideArtery ligationVascular leakageHindlimb ischemiaOld miceIschemic regionCGMP levelsFoot loss
2001
Flanking regulatory sequences of the locus encoding the murine GDNF receptor, c‐ret, directs lac Z (β‐galactosidase) expression in developing somatosensory system
Sukumaran M, Waxman S, Wood J, Pachnis V. Flanking regulatory sequences of the locus encoding the murine GDNF receptor, c‐ret, directs lac Z (β‐galactosidase) expression in developing somatosensory system. Developmental Dynamics 2001, 222: 389-402. PMID: 11747074, DOI: 10.1002/dvdy.1192.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornBase SequenceChromosome MappingCloning, MolecularConsensus SequenceDrosophila ProteinsEmbryo, MammalianGanglia, SensoryGene ExpressionGene Expression Regulation, DevelopmentalGenes, RegulatorGlial Cell Line-Derived Neurotrophic Factor ReceptorsLac OperonLectinsMiceMice, TransgenicNeurons, AfferentNociceptorsPromoter Regions, GeneticProtein Structure, TertiaryProto-Oncogene ProteinsProto-Oncogene Proteins c-retReceptor Protein-Tyrosine KinasesSpinal CordTranscription Initiation SiteConceptsRegulatory domainLac Z expressionZ expressionCell type-specific expressionDistal regulatory domainEndogenous gene expressionCis-regulatory domainsTranscription initiation siteEntire structural geneSpecific regulatory domainsLac Z reporter geneStructural geneMouse genomeLateral mesodermRegulatory sequencesCpG islandsDNA sequencesPrimitive streakReporter geneFlanking sequencesCosmid contigGene expressionSpecific expressionTransgenic mouse lineInitiation site
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply