2023
Increased anti‐oxidative action compensates for collagen tissue degeneration in vitiligo dermis
Yokoi K, Yasumizu Y, Ohkura N, Shinzawa K, Okuzaki D, Shimoda N, Ando H, Yamada N, Fujimoto M, Tanemura A. Increased anti‐oxidative action compensates for collagen tissue degeneration in vitiligo dermis. Pigment Cell & Melanoma Research 2023, 36: 355-364. PMID: 37230937, DOI: 10.1111/pcmr.13094.Peer-Reviewed Original ResearchConceptsCollagen-related genesUninvolved perilesional skinOxidative stressSignaling Pathway ActivationCollagen homeostasisVitiligo lesionsPathway activationPerilesional skinExpression levelsAnti-oxidant enzymesAnti-oxidative actionDegraded collagen fibersNrf2 signaling pathway activationDefense systemProduction of oxidative stress
2020
Macrophage inhibitory factor (MIF) gene polymorphisms are associated with disease susceptibility and with circulating MIF levels in active non‐segmental vitiligo in patients from western Mexico
Garcia‐Orozco A, Martinez‐Magaña I, Riera‐Leal A, Muñoz‐Valle J, Martinez‐Guzman M, Quiñones‐Venegas R, Sánchez‐Zuno G, Fafutis‐Morris M. Macrophage inhibitory factor (MIF) gene polymorphisms are associated with disease susceptibility and with circulating MIF levels in active non‐segmental vitiligo in patients from western Mexico. Molecular Genetics & Genomic Medicine 2020, 8: e1416. PMID: 32705792, PMCID: PMC7549602, DOI: 10.1002/mgg3.1416.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibition factorNon-segmental vitiligoActive non-segmental vitiligoSerum concentrationsActivation of immune cellsExpression of MIFCirculating MIF levelsMacrophage inhibitory factorWestern Mexican populationPathogenesis of vitiligoAssociated with disease susceptibilityMigration inhibition factorIn situ expressionMIF levelsActive vitiligoAutomated immunohistochemistryDisease activityIFN-gReal-time PCRGene polymorphismsImmune cellsControl subjectsProinflammatory cytokinesTNF-aIL-1BCutaneous immune-related adverse events to checkpoint inhibitors
Malviya N, Tattersall IW, Leventhal J, Alloo A. Cutaneous immune-related adverse events to checkpoint inhibitors. Clinics In Dermatology 2020, 38: 660-678. PMID: 33341200, DOI: 10.1016/j.clindermatol.2020.06.011.Peer-Reviewed Original ResearchConceptsAdverse reactionsCheckpoint inhibitorsImmune-related adverse reactionsCheckpoint inhibitor therapyCutaneous adverse eventsOngoing cancer treatmentPD-1 inhibitorsCTLA-4 inhibitorsImmune checkpoint inhibitorsCutaneous adverse reactionsPD-L1 inhibitorsDevelopment of immunotherapySuch adverse reactionsImmunomodulatory therapyTreatment interruptionAssociated morbidityPatient comorbiditiesAdverse eventsCutaneous toxicityInhibitor therapyImmune statusHematologic malignanciesEarly recognitionCancer treatmentManagement guidelinesNear total body vitiligo secondary to immunotherapy for metastatic melanoma
Olamiju B, Leventhal J. Near total body vitiligo secondary to immunotherapy for metastatic melanoma. British Journal Of Dermatology 2020, 183: e2-e2. PMID: 32147813, DOI: 10.1111/bjd.18944.Peer-Reviewed Case Reports and Technical Notes
2018
Rapid Repigmentation of Vitiligo Using Tofacitinib Plus Low-Dose, Narrowband UV-B Phototherapy
Kim R, Heaton H, Liu LY, King BA. Rapid Repigmentation of Vitiligo Using Tofacitinib Plus Low-Dose, Narrowband UV-B Phototherapy. JAMA Dermatology 2018, 154: 370-371. PMID: 29387870, DOI: 10.1001/jamadermatol.2017.5778.Peer-Reviewed Original Research
2017
JAK inhibitors in dermatology: The promise of a new drug class
Damsky W, King BA. JAK inhibitors in dermatology: The promise of a new drug class. Journal Of The American Academy Of Dermatology 2017, 76: 736-744. PMID: 28139263, PMCID: PMC6035868, DOI: 10.1016/j.jaad.2016.12.005.Peer-Reviewed Original ResearchMeSH KeywordsAlopecia AreataAnti-Inflammatory AgentsAzetidinesClinical Trials as TopicDermatitis, AtopicDermatologic AgentsHumansJanus KinasesMolecular Targeted TherapyNitrilesPiperidinesProtein Kinase InhibitorsPsoriasisPurinesPyrazolesPyrimidinesPyrrolesSignal TransductionSkin DiseasesSulfonamidesVitiligoConceptsJAK inhibitorsSoluble inflammatory mediatorsNew drug classesUseful therapeutic strategyDifferent proinflammatoryAtopic dermatitisInflammatory mediatorsInflammatory dermatosesAlopecia areataDrug classesJanus kinase-signal transducerTherapeutic strategiesJAK inhibitionDermatologic therapyKinase-signal transducerTargeted therapeuticsActivator of transcriptionDermatologyJAK-STATInhibitorsPromising new classEarlier reportsInhibition
2005
Less Keratinocyte-Derived Factors Related to More Keratinocyte Apoptosis in Depigmented than Normally Pigmented Suction-Blistered Epidermis May Cause Passive Melanocyte Death in Vitiligo
Lee AY, Kim NH, Choi WI, Youm YH. Less Keratinocyte-Derived Factors Related to More Keratinocyte Apoptosis in Depigmented than Normally Pigmented Suction-Blistered Epidermis May Cause Passive Melanocyte Death in Vitiligo. Journal Of Investigative Dermatology 2005, 124: 976-983. PMID: 15854039, DOI: 10.1111/j.0022-202x.2005.23667.x.Peer-Reviewed Original Research
2004
Keratinocytes in the depigmented epidermis of vitiligo are more vulnerable to trauma (suction) than keratinocytes in the normally pigmented epidermis, resulting in their apoptosis
Lee A, Youm Y, Kim N, Yang H, Choi W. Keratinocytes in the depigmented epidermis of vitiligo are more vulnerable to trauma (suction) than keratinocytes in the normally pigmented epidermis, resulting in their apoptosis. British Journal Of Dermatology 2004, 151: 995-1003. PMID: 15541077, DOI: 10.1111/j.1365-2133.2004.06136.x.Peer-Reviewed Original ResearchAdolescentAdultApoptosisbcl-2-Associated X ProteinCASP8 and FADD-Like Apoptosis Regulating ProteinCaspasesChildEpidermisFemaleHumansIntracellular Signaling Peptides and ProteinsKeratinocytesMaleMiddle AgedPoly(ADP-ribose) PolymerasesProto-Oncogene Proteins c-bcl-2SuctionTumor Suppressor Protein p53Vitiligo
2000
Return of Hyperpigmentation within a Café-au-Lait Macule following Treatment of Vitiligo
Schaffer J, Bolognia J, Watsky K. Return of Hyperpigmentation within a Café-au-Lait Macule following Treatment of Vitiligo. Dermatology 2000, 201: 284-284. PMID: 11096214, DOI: 10.1159/000018485.Peer-Reviewed Case Reports and Technical NotesA Figurate Papulosquamous Variant of Inflammatory Vitiligo
Lee D, Lazova R, Bolognia J. A Figurate Papulosquamous Variant of Inflammatory Vitiligo. Dermatology 2000, 200: 270-274. PMID: 10828641, DOI: 10.1159/000018374.Peer-Reviewed Case Reports and Technical NotesConceptsInflammatory vitiligoSuperficial perivascular infiltrateErythematous rimLichenoid infiltrateSerpiginous lesionsPerivascular infiltratesHistological spectrumMononuclear cellsScaly plaquesCase reportHistological correlatesVitiligoSimilar findingsClassic descriptionInfiltratesPlaquesStratum corneumLichenoidPatientsLesionsParakeratosis
1999
Flip-Top Pigment Transplantation: A Novel Transplantation Procedure for the Treatment of Depigmentation
McGovern T, Bolognia J, Leffell D. Flip-Top Pigment Transplantation: A Novel Transplantation Procedure for the Treatment of Depigmentation. JAMA Dermatology 1999, 135: 1305-1307. PMID: 10566827, DOI: 10.1001/archderm.135.11.1305.Peer-Reviewed Original ResearchVitiligo and Crohn's disease in children.
Pashankar D, Prendiville J, Israel D. Vitiligo and Crohn's disease in children. Journal Of Pediatric Gastroenterology And Nutrition 1999, 28: 227-9. PMID: 9932864, DOI: 10.1097/00005176-199902000-00029.Peer-Reviewed Original Research
1995
Pentachrome vitiligo
Fargnoli M, Bolognia J. Pentachrome vitiligo. Journal Of The American Academy Of Dermatology 1995, 33: 853-856. PMID: 7593796, DOI: 10.1016/0190-9622(95)90422-0.Peer-Reviewed Case Reports and Technical Notes
1993
White mutants in mice shedding light on humans.
Halaban R, Moellmann G. White mutants in mice shedding light on humans. Journal Of Investigative Dermatology 1993, 100: 176s-185s. PMID: 8433006, DOI: 10.1038/jid.1993.10.Peer-Reviewed Original ResearchConceptsMembrane receptor tyrosine kinasesMouse mutant modelsPink-eyed dilutionDefective signal transductionReceptor kinase activityEnzyme activityC-kitDistinct enzyme activitiesIdentification of mutationsRespective enzyme activitiesPiebald phenotypeShares homologyLocus proteinSignal transductionKinase activityCatalase BMolecular geneticsTyrosine kinaseWhite mutantsMutant modelsHair melanocytesDopachrome tautomerasePoint mutationsTyrosinase-negative albinismNormal pigmentation
1990
Recent Advances in the Molecular Biology of Pigmentation: Mouse Models
Halaban R, Moellmann G. Recent Advances in the Molecular Biology of Pigmentation: Mouse Models. Pigment Cell & Melanoma Research 1990, 3: 67-78. PMID: 1409441, DOI: 10.1111/j.1600-0749.1990.tb00352.x.Peer-Reviewed Original Research
1970
White spots in tuberous sclerosis
Hurwitz S, Braverman I. White spots in tuberous sclerosis. The Journal Of Pediatrics 1970, 77: 587-594. PMID: 5454707, DOI: 10.1016/s0022-3476(70)80199-8.Peer-Reviewed Original Research
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