New applications of clioquinol in the treatment of inflammation disease by directly targeting arginine 335 of NLRP3
Chen P, Wang Y, Tang H, Zhou C, Liu Z, Gao S, Wang T, Xu Y, Ji S. New applications of clioquinol in the treatment of inflammation disease by directly targeting arginine 335 of NLRP3. Journal Of Pharmaceutical Analysis 2024, 15: 101069. PMID: 39902456, PMCID: PMC11788862, DOI: 10.1016/j.jpha.2024.101069.Peer-Reviewed Original ResearchNOD-like receptor protein 3Innate immune-mediated inflammationExperimental acute peritonitisInhibition of nod-like receptor protein 3Treatment of inflammation diseasesTumor necrosis factor-aImmune-mediated inflammationLowered serum levelsNOD-like receptor protein 3 inflammasomeReduced cytokine secretionNLRP3 inflammasome assemblyTarget arginineNACHT domainComponent proteinsReceptor protein 3Inflammasome assemblyAcute peritonitisSerum levelsCytokine secretionTreatment strategiesInterleukin-1bTNF-aInhibitory concentrationIL-1BInhibiting NLRP3 activation
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