Intermediate Signaling Mechanisms Regulating Human Fetal Membrane Responses to Gram‐Positive Bacterial Peptidoglycan
Georges H, Fischer A, Abrahams V. Intermediate Signaling Mechanisms Regulating Human Fetal Membrane Responses to Gram‐Positive Bacterial Peptidoglycan. American Journal Of Reproductive Immunology 2025, 93: e70090. PMID: 40435036, PMCID: PMC12124414, DOI: 10.1111/aji.70090.Peer-Reviewed Original ResearchConceptsToll-like receptorsPro-inflammatory cytokines IL-1bFetal membrane explantsHuman FM explantsPathogenesis of chorioamnionitisP65-NFkBResponse to Gram-positive bacteriaP38 MAPKElevated levelsTLR2 agonist peptidoglycanCytokines IL-1bChemokine IL-8FM explantsNeonatal morbidityPreterm birthStimulation of TLR4Fetal membranesMembrane weakeningIL-1BIL-8TLR7/8 activationMembrane explantsSecreted factorsERK signalingLipopolysaccharide stimulation
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