2017
Role of Intrinsic (Graft) Versus Extrinsic (Host) Factors in the Growth of Transplanted Organs Following Allogeneic and Xenogeneic Transplantation
Tanabe T, Watanabe H, Shah J, Sahara H, Shimizu A, Nomura S, Asfour A, Danton M, Boyd L, Meyers A, Ekanayake-Alper D, Sachs D, Yamada K. Role of Intrinsic (Graft) Versus Extrinsic (Host) Factors in the Growth of Transplanted Organs Following Allogeneic and Xenogeneic Transplantation. American Journal Of Transplantation 2017, 17: 1778-1790. PMID: 28117931, PMCID: PMC5489354, DOI: 10.1111/ajt.14210.Peer-Reviewed Original ResearchConceptsIncreased serum creatinineDeterioration of organ functionRecipient body weightEvidence of rejectionLife Support OrganizationMiniature swineEarly growthLung allograftsSerum creatininePig graftsOrgan dysfunctionGraft volumeCortical ischemiaOrgan transplantationBody weightBaboon recipientsSwine kidneyXenograft kidneysXenogeneic transplantationTransplantationOrgan functionDonor organsKidneyTransplanted organSwine
2008
Pathology of an Islet Transplant 2 Years After Transplantation: Evidence for a Nonimmunological Loss
Smith RN, Kent SC, Nagle J, Selig M, Iafrate AJ, Najafian N, Hafler DA, Auchincloss H, Orban T, Cagliero E. Pathology of an Islet Transplant 2 Years After Transplantation: Evidence for a Nonimmunological Loss. Transplantation 2008, 86: 54-62. PMID: 18622278, DOI: 10.1097/tp.0b013e318173a5da.Peer-Reviewed Original ResearchConceptsAllogeneic sensitizationIslet transplantsELISPOT assayRecurrent diabetic nephropathyEvidence of rejectionC-peptide secretionCause of deathNative pancreatic isletsHypertensive strokeIntrahepatic isletsDiabetic nephropathyInsulin independenceAllogeneic isletsAtrophic pancreasPathological findingsImmunological basisEdmonton protocolPortal veinComplete autopsyIslet transplantationImmunohistochemical analysisPortal venulesDrug toxicityEarly changesPhysiological abnormalities
2004
CD154 Blockade for Induction of Mixed Chimerism and Prolonged Renal Allograft Survival in Nonhuman Primates
Kawai T, Sogawa H, Boskovic S, Abrahamian G, Smith R, Wee S, Andrews D, Nadazdin O, Koyama I, Sykes M, Winn H, Colvin R, Sachs D, Cosimi A. CD154 Blockade for Induction of Mixed Chimerism and Prolonged Renal Allograft Survival in Nonhuman Primates. American Journal Of Transplantation 2004, 4: 1391-1398. PMID: 15307826, DOI: 10.1111/j.1600-6143.2004.00523.x.Peer-Reviewed Original ResearchConceptsDonor bone marrowCD154 blockadeCostimulatory blockadeMixed chimerismAllograft toleranceAllograft survivalLong-term survival of renal allograftsDonor bone marrow engraftmentInduce renal allograft toleranceInduction of mixed chimerismInduction of allograft toleranceIncidence of acute rejectionProlonged renal allograft survivalAnti-CD154 monoclonal antibodySurvival of renal allograftsLate chronic rejectionDiscontinuation of immunosuppressionRenal allograft toleranceTransient mixed chimerismRenal allograft survivalEvidence of rejectionNonhuman primatesLong-term survivalLong-term survivorsConditioning regimen
2001
LONG-TERM ISLET ALLOGRAFT FUNCTION IN THE ABSENCE OF CHRONIC IMMUNOSUPPRESSION: A CASE REPORT OF A NONHUMAN PRIMATE PREVIOUSLY MADE TOLERANT TO A RENAL ALLOGRAFT FROM THE SAME DONOR1
Kawai T, Sogawa H, Koulmanda M, Smith R, O’Neil J, Wee S, Boskovic S, Sykes M, Colvin R, Sachs D, Auchincloss H, Cosimi A, Ko D. LONG-TERM ISLET ALLOGRAFT FUNCTION IN THE ABSENCE OF CHRONIC IMMUNOSUPPRESSION: A CASE REPORT OF A NONHUMAN PRIMATE PREVIOUSLY MADE TOLERANT TO A RENAL ALLOGRAFT FROM THE SAME DONOR1. Transplantation 2001, 72: 351-354. PMID: 11477369, DOI: 10.1097/00007890-200107270-00036.Peer-Reviewed Original ResearchMeSH KeywordsABO Blood-Group SystemAnimalsAntilymphocyte SerumBlood GlucoseBone Marrow TransplantationCell SeparationC-PeptideCyclosporineDiabetes Mellitus, ExperimentalGraft SurvivalHistocompatibility TestingImmunosuppression TherapyInsulinIslets of LangerhansMacaca fascicularisMajor Histocompatibility ComplexMaleSplenectomyTransplantation, HomologousWhole-Body IrradiationConceptsDonor bone marrow transplantationEvidence of rejectionLong-term toleranceLong-term islet allograft functionHistological evidenceIslet transplantationHistologic evidence of rejectionWeeks of cyclosporineSolid organ allograftsTotal body irradiationBone marrow transplantationStreptozocin-induced diabetesIslet allograft functionNonmyeloablative conditioningThymic irradiationChronic immunosuppressionRecurrent diabetesAllograft functionBody irradiationMarrow transplantationNative nephrectomyKidney allograftsOrgan allograftsRenal allograftsKidney rejection
1994
THE CORRELATION OF INTRAGRAFT CYTOKINE EXPRESSION WITH REJECTION IN RAT SMALL INTESTINE TRANSPLANTATION
McDIARMID S, FARMER D, KUNIYOSHI J, ROBERT M, KHADAVI A, SHAKED A, BUSUTTIL R. THE CORRELATION OF INTRAGRAFT CYTOKINE EXPRESSION WITH REJECTION IN RAT SMALL INTESTINE TRANSPLANTATION. Transplantation 1994, 58: 690-697. DOI: 10.1097/00007890-199409000-00009.Peer-Reviewed Original ResearchSmall intestine transplantationReverse transcriptase-PCRInterleukin-2POD 14POD 3POD 7Cytokine expressionIL-6Tumor necrosis factor αIntragraft cytokine expressionSeverity of rejectionEvidence of rejectionIL-2 receptorNecrosis factor αSemiquantitative reverse transcriptase-PCRRat small intestineExpression of mRNAIntestine transplantationLewis recipientsHistologic rejectionAllograft groupIntragraft expressionMild rejectionPOD 5Histologic evidenceTHE CORRELATION OF INTRAGRAFT CYTOKINE EXPRESSION WITH REJECTION IN RAT SMALL INTESTINE TRANSPLANTATION
McDIARMID S, FARMER D, KUNIYOSHI J, ROBERT M, KHADAVI A, SHAKED A, BUSUTTIL R. THE CORRELATION OF INTRAGRAFT CYTOKINE EXPRESSION WITH REJECTION IN RAT SMALL INTESTINE TRANSPLANTATION. Transplantation 1994, 58: 690-697. PMID: 7940688, DOI: 10.1097/00007890-199409270-00009.Peer-Reviewed Original ResearchConceptsSmall intestine transplantationInterleukin-6Reverse transcriptase-PCRTNF-alphaInterleukin-2IFN-gammaPOD 14POD 3POD 7Cytokine expressionTumor necrosis factor alphaIntragraft cytokine expressionSeverity of rejectionEvidence of rejectionIL-2 receptorNecrosis factor alphaSemiquantitative reverse transcriptase-PCRRat small intestineExpression of mRNAIntestine transplantationGraft lossLewis recipientsHistologic rejectionIntragraft expressionMild rejection
1991
Granzyme A and perforin as markers for rejection in cardiac transplantation
Griffiths G, Namikawa R, Billingham M, Weissman I, Mueller C, Liu C, Young J. Granzyme A and perforin as markers for rejection in cardiac transplantation. European Journal Of Immunology 1991, 21: 687-692. PMID: 2009911, DOI: 10.1002/eji.1830210322.Peer-Reviewed Original ResearchConceptsRejection episodesCardiac transplantationGranzyme ATransplant rejectionHigh doses of immunosuppressionExpressing granzyme ADoses of immunosuppressantsMarkers of transplant rejectionEvidence of rejectionPerforin-expressing lymphocytesConventional grading systemIn situ hybridizationInfiltrating lymphocytesPredictive markerHistological criteriaBiopsyPerforinDonor heartsGranzymeHigh dosesHistological evidenceTransplantationHistological damageLymphocytesGrading system
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