2019
Bone marrow transplantation for adolescents and young adults with sickle cell disease: Results of a prospective multicenter pilot study
Krishnamurti L, Neuberg D, Sullivan K, Kamani N, Abraham A, Campigotto F, Zhang W, Dahdoul T, De Castro L, Parikh S, Bakshi N, Haight A, Hassell K, Loving R, Rosenthal J, Smith S, Smith W, Spearman M, Stevenson K, Wu C, Wiedl C, Waller E, Walters M. Bone marrow transplantation for adolescents and young adults with sickle cell disease: Results of a prospective multicenter pilot study. American Journal Of Hematology 2019, 94: 446-454. PMID: 30637784, PMCID: PMC6542639, DOI: 10.1002/ajh.25401.Peer-Reviewed Original ResearchConceptsSevere sickle cell diseaseBone marrow transplantationEvent-free survivalSickle cell diseaseMarrow transplantationCell diseaseElevated tricuspid regurgitant jet velocityRegular red blood cell transfusionsSevere SCDDonor bone marrow transplantationOne-year overall survivalSecond bone marrow transplantationTricuspid regurgitant jet velocityRed blood cell transfusionProspective multicenter pilot studyDeveloped chronic GVHDHost disease (GVHD) prophylaxisStable donor chimerismAcute chest syndromeSecondary graft failureBlood cell transfusionHealth-related qualityPhysical function domainProspective clinical trialsRegurgitant jet velocity
2007
Depletion of CD8 Memory T Cells for Induction of Tolerance of a Previously Transplanted Kidney Allograft
Koyama I, Nadazdin O, Boskovic S, Ochiai T, Smith R, Sykes M, Sogawa H, Murakami T, Strom T, Colvin R, Sachs D, Benichou G, Cosimi A, Kawai T. Depletion of CD8 Memory T Cells for Induction of Tolerance of a Previously Transplanted Kidney Allograft. American Journal Of Transplantation 2007, 7: 1055-1061. PMID: 17286617, PMCID: PMC3785402, DOI: 10.1111/j.1600-6143.2006.01703.x.Peer-Reviewed Original ResearchConceptsDonor bone marrow transplantationMemory T cellsCD8 memory T cellsInduce mixed chimerismTransplanted kidney allograftT cellsAllograft toleranceMixed chimerismKidney allograftsLow dose total body irradiationInduce renal allograft toleranceMemory T cell functionAnti-CD8 monoclonal antibodyLevels of memory T cellsDepletion of naive T cellsRenal allograft toleranceTotal body irradiationBone marrow transplantationAnti-CD154 antibodyNaive T cellsT cell functionTransplanted organInduction of toleranceConditioning regimenAntithymocyte globulin
2002
Effect of mixed hematopoietic chimerism on cardiac allograft survival in cynomolgus monkeys1
Kawai T, Cosimi A, Wee S, Houser S, Andrews D, Sogawa H, Phelan J, Boskovic S, Nadazdin O, Abrahamian G, Colvin R, Sach D, Madsen J. Effect of mixed hematopoietic chimerism on cardiac allograft survival in cynomolgus monkeys1. Transplantation 2002, 73: 1757-1764. PMID: 12084998, DOI: 10.1097/00007890-200206150-00011.Peer-Reviewed Original ResearchConceptsDonor bone marrow transplantationKidney allograft recipientsCell-mediated lympholysisBone marrow transplantationAllograft recipientsAllograft survivalMultilineage chimerismCardiac allograftsHematopoietic chimerismMarrow transplantationLong-term acceptancePosttransplant courseIn vitro mixed leukocyte reactionLong-term heart allograft survivalLow-dose total body irradiationInduction of mixed chimerismMHC-mismatched nonhuman primatesDay 0Tolerance to cardiac allograftsImmunological responseMHC-mismatched donorsHeart allograft survivalCardiac allograft survivalHeart allograft recipientsDonor-specific hyporesponsiveness
2001
LONG-TERM ISLET ALLOGRAFT FUNCTION IN THE ABSENCE OF CHRONIC IMMUNOSUPPRESSION: A CASE REPORT OF A NONHUMAN PRIMATE PREVIOUSLY MADE TOLERANT TO A RENAL ALLOGRAFT FROM THE SAME DONOR1
Kawai T, Sogawa H, Koulmanda M, Smith R, O’Neil J, Wee S, Boskovic S, Sykes M, Colvin R, Sachs D, Auchincloss H, Cosimi A, Ko D. LONG-TERM ISLET ALLOGRAFT FUNCTION IN THE ABSENCE OF CHRONIC IMMUNOSUPPRESSION: A CASE REPORT OF A NONHUMAN PRIMATE PREVIOUSLY MADE TOLERANT TO A RENAL ALLOGRAFT FROM THE SAME DONOR1. Transplantation 2001, 72: 351-354. PMID: 11477369, DOI: 10.1097/00007890-200107270-00036.Peer-Reviewed Original ResearchMeSH KeywordsABO Blood-Group SystemAnimalsAntilymphocyte SerumBlood GlucoseBone Marrow TransplantationCell SeparationC-PeptideCyclosporineDiabetes Mellitus, ExperimentalGraft SurvivalHistocompatibility TestingImmunosuppression TherapyInsulinIslets of LangerhansMacaca fascicularisMajor Histocompatibility ComplexMaleSplenectomyTransplantation, HomologousWhole-Body IrradiationConceptsDonor bone marrow transplantationEvidence of rejectionLong-term toleranceLong-term islet allograft functionHistological evidenceIslet transplantationHistologic evidence of rejectionWeeks of cyclosporineSolid organ allograftsTotal body irradiationBone marrow transplantationStreptozocin-induced diabetesIslet allograft functionNonmyeloablative conditioningThymic irradiationChronic immunosuppressionRecurrent diabetesAllograft functionBody irradiationMarrow transplantationNative nephrectomyKidney allograftsOrgan allograftsRenal allograftsKidney rejection
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