2024
Transcriptional Profiling Underscores the Role of Preprocurement Allograft Metabolism and Innate Immune Status on Outcomes in Human Liver Transplantation
Kim J, Zimmermann M, Mathison A, Lomberk G, Urrutia R, Hong J. Transcriptional Profiling Underscores the Role of Preprocurement Allograft Metabolism and Innate Immune Status on Outcomes in Human Liver Transplantation. Annals Of Surgery Open 2024, 5: e444-e444. PMID: 38911661, PMCID: PMC11191965, DOI: 10.1097/as9.0000000000000444.Peer-Reviewed Original ResearchOrthotopic liver transplantationIschemia-reperfusion injuryCold ischemiaLiver transplantationPrimary orthotopic liver transplantationGraft ischemia-reperfusion injuryClinical orthotopic liver transplantationEffects of ischemia-reperfusion injuryLiver graft ischemia-reperfusion injuryHuman orthotopic liver transplantationTherapeutic targetLiver allograft biopsiesHuman liver transplantationInflammatory response genesIAF groupAllograft injuryDecreased metabolic activityAllograft dysfunctionAllograft functionAllograft biopsiesGene expressionSurrogate markerFatty acid-metabolizing activitiesMetabolic activityHistological evaluation
2017
Transcriptional Response of Respiratory Epithelium to Nontuberculous Mycobacteria
Matsuyama M, Martins A, Shallom S, Kamenyeva O, Kashyap A, Sampaio E, Kabat J, Olivier K, Zelazny A, Tsang J, Holland S. Transcriptional Response of Respiratory Epithelium to Nontuberculous Mycobacteria. American Journal Of Respiratory Cell And Molecular Biology 2017, 58: 241-252. PMID: 28915071, PMCID: PMC5806000, DOI: 10.1165/rcmb.2017-0218oc.Peer-Reviewed Original ResearchConceptsCholesterol biosynthesisUpregulation of genesRespiratory epitheliumGene expression signaturesCiliary genesTranscriptional responseRNA sequencingEpithelial cell infectionResponse genesInflammatory response genesHost responseCytokine/chemokine productionRespiratory epithelial cell culturesEpithelial cell culturesPulmonary nontuberculous mycobacteria (NTM) diseaseExpression signaturesMajor host responsesCytokines/chemokinesGenesRespiratory epithelial cellsCiliary functionNontuberculous mycobacteria diseaseCell infectionMultiplicity of infectionBiosynthesisInflammatory Mediators during the Pre‐implantation Period Play a Key Role in the Pathogenesis of Preeclampsia in the Spontaneous Preeclamptic‐like BPH/5 Mouse
Sones J, Merriam A, Grenier J, Douglas N, Davisson R. Inflammatory Mediators during the Pre‐implantation Period Play a Key Role in the Pathogenesis of Preeclampsia in the Spontaneous Preeclamptic‐like BPH/5 Mouse. The FASEB Journal 2017, 31 DOI: 10.1096/fasebj.31.1_supplement.1033.9.Peer-Reviewed Original ResearchLate gestational hypertensionFetal growth restrictionBPH/5 miceMaternal syndromeC3 gene expressionPregnancy outcomesPreeclamptic pregnanciesDecidual inflammationGrowth restrictionFetal adverse pregnancy outcomesFetal morbidity/mortalityImplantation sitesBPH/5 mouse modelPregnancy time pointsAdverse pregnancy outcomesPoor pregnancy outcomesTime pointsSeverity of preeclampsiaAnti-inflammatory therapyMorbidity/mortalityDevelopment of preeclampsiaPathogenesis of preeclampsiaInnate immune systemPre-implantation periodInflammatory response genes
2014
Aging Mesenchymal Stem Cells Fail to Protect Because of Impaired Migration and Antiinflammatory Response
Bustos ML, Huleihel L, Kapetanaki MG, Lino-Cardenas CL, Mroz L, Ellis BM, McVerry BJ, Richards TJ, Kaminski N, Cerdenes N, Mora AL, Rojas M. Aging Mesenchymal Stem Cells Fail to Protect Because of Impaired Migration and Antiinflammatory Response. American Journal Of Respiratory And Critical Care Medicine 2014, 189: 787-798. PMID: 24559482, PMCID: PMC4061541, DOI: 10.1164/rccm.201306-1043oc.Peer-Reviewed Original ResearchConceptsBone marrow-derived MSCsMesenchymal stem cellsChemokine receptorsAcute lung injuryAcute lung diseaseSite of injuryAge-dependent decreaseBone marrow-derived mesenchymal stem cellsMarrow-derived mesenchymal stem cellsInflammatory response genesSuch age-related changesAge-related phenomenonStem cellsAge-related changesAdoptive transferLung injuryEndotoxemic miceLung diseaseAntiinflammatory responseFunctional impairmentMore inflammationProtective effectOld miceParacrine mechanismsAlveolar epithelium
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