2024
Dietary modulation of gut microbiota affects susceptibility to drug-induced liver injury
Pan H, Song D, Wang Z, Yang X, Luo P, Li W, Li Y, Gong M, Zhang C. Dietary modulation of gut microbiota affects susceptibility to drug-induced liver injury. Gut Microbes 2024, 16: 2439534. PMID: 39673542, PMCID: PMC11649229, DOI: 10.1080/19490976.2024.2439534.Peer-Reviewed Original ResearchConceptsGut microbiotaDrug-induced liver injuryIndole-3-lactic acidComposition of human gut microbiotaWestern style dietDietary modulators of gut microbiotaModulation of gut microbiotaHuman gut microbiotaGut microbiota transplantationModulating gut microbiotaSusceptibility to drug-induced liver injuryIncidence of drug-induced liver injuryDietary fiber interventionLiver injuryDiet-induced variationsBile acid metabolismMicrobiotaTranslocation of lipopolysaccharideImprove liver functionSignaling pathwayDietary shiftsMicrobiota transplantationFiber interventionAcid metabolismIntestinal barrierExpanding the spectrum of progressive familial intrahepatic cholestasis: A report of 3 cases
Jiao J, Morotti R, Shafizadeh N, Jain D. Expanding the spectrum of progressive familial intrahepatic cholestasis: A report of 3 cases. American Journal Of Clinical Pathology 2024, 163: 332-339. PMID: 39333837, DOI: 10.1093/ajcp/aqae123.Peer-Reviewed Original ResearchProgressive familial intrahepatic cholestasisATP-binding cassette subfamily B member 4Whole-exome sequencingFamilial intrahepatic cholestasisIntrahepatic cholestasisDiagnostic challengeGroup of autosomal recessive disordersAbnormal liver function testsHomozygous splice site variantDrug-induced liver injuryHeterozygous frameshift mutationHeterozygous missense mutationLiver function testsAged 2 monthsAutosomal recessive disorderSplice site variantHistory of alcoholismABCB4 mutationsPediatric ageLiver biopsyClinical historyRecessive disorderLiver injuryMolecular testingHeterogeneous presentationSafety of naltrexone in patients with cirrhosis
Thompson R, Taddei T, Kaplan D, Rabiee A. Safety of naltrexone in patients with cirrhosis. JHEP Reports 2024, 6: 101095. PMID: 38961852, PMCID: PMC11220533, DOI: 10.1016/j.jhepr.2024.101095.Peer-Reviewed Original ResearchDrug-induced liver injuryRoussel Uclaf Causality Assessment MethodAlcohol use disorderInitiation of naltrexoneSafety of naltrexoneUse disorderRetrospective studyDevelopment of drug-induced liver injuryRoussel Uclaf Causality Assessment Method scoreLiver injuryLiver diseaseRetrospective study of patientsTreatment of alcohol use disordersTreat alcohol use disorderLiver enzyme elevationAlcohol-related cirrhosisCohort of patientsAlkaline phosphatase elevationDiagnosis of cirrhosisStudy of patientsAssociated with developmentCausality Assessment MethodPrescribed naltrexoneDecompensated cirrhosisEnzyme elevation
2022
Assessment of the Frequency, Phenotypes, and Outcomes of Acute Liver Injury Associated with Amoxicillin/Clavulanate in 1.4 Million Patients in the Veterans Health Administration
Suzuki A, Tillmann H, Williams J, Hauser R, Frund J, Suzuki M, Prior F, Aithal G, Lucena M, Andrade R, Tong W, Hunt C. Assessment of the Frequency, Phenotypes, and Outcomes of Acute Liver Injury Associated with Amoxicillin/Clavulanate in 1.4 Million Patients in the Veterans Health Administration. Drug Safety 2022, 46: 129-143. PMID: 36547811, DOI: 10.1007/s40264-022-01255-3.Peer-Reviewed Original ResearchConceptsPre-existing liver conditionsAcute liver injuryAmoxicillin/clavulanateDrug-induced liver injuryLiver injuryLiver conditionsElectronic health record systemsHealth record systemsSignificant drug-induced liver injuryAcute Liver Injury AssociatedLiver Injury AssociatedOverall mortality riskGeneral patient populationVeterans Health AdministrationAlkaline phosphatase elevationSignificant health issueRecord systemLarge electronic health record datasetsElectronic health record datasetBilirubin elevationCholestatic injuryInpatient exposureInjury AssociatedLarge electronic health record systemHepatocellular injury
2021
Significant Liver Injury During Hospitalization for COVID-19 Is Not Associated With Liver Insufficiency or Death
Chew M, Tang Z, Radcliffe C, Caruana D, Doilicho N, Ciarleglio MM, Deng Y, Garcia-Tsao G. Significant Liver Injury During Hospitalization for COVID-19 Is Not Associated With Liver Insufficiency or Death. Clinical Gastroenterology And Hepatology 2021, 19: 2182-2191.e7. PMID: 34004326, PMCID: PMC8123528, DOI: 10.1016/j.cgh.2021.05.022.Peer-Reviewed Original ResearchConceptsSignificant liver injuryLiver injuryLiver insufficiencyCOVID-19High-sensitivity C-reactive protein valuesC-reactive protein valuesDrug-induced liver injuryHepatocellular liver injuryInternational normalized ratioMultivariate logistic regressionHyperinflammatory stateTocilizumab useVasopressor useConcomitant medicationsConsecutive patientsIndependent predictorsLiver failureBilirubin levelsD-dimerTest abnormalitiesNormalized ratioAlanine aminotransferaseHospitalizationPatientsInjury
2020
Abnormal Liver Function Tests in Patients With COVID‐19: Relevance and Potential Pathogenesis
Bertolini A, van de Peppel I, Bodewes FAJA, Moshage H, Fantin A, Farinati F, Fiorotto R, Jonker JW, Strazzabosco M, Verkade HJ, Peserico G. Abnormal Liver Function Tests in Patients With COVID‐19: Relevance and Potential Pathogenesis. Hepatology 2020, 72: 1864-1872. PMID: 32702162, PMCID: PMC7404414, DOI: 10.1002/hep.31480.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAbnormal liver function testsLiver function testsCOVID-19 patientsAspartate aminotransferaseFunction testsHospitalized coronavirus disease 2019 (COVID-19) patientsSevere COVID-19 diseaseCoronavirus disease 2019 (COVID-19) patientsElevated liver function testsPre-existing liver diseaseDrug-induced liver injuryCOVID-19Hyper-inflammatory statusAlanine aminotransferase levelsLopinavir/ritonavirOvert liver failureStart of treatmentUse of acetaminophenCause of deathPlasma aspartate aminotransferaseUpper reference limitSARS-CoV-2COVID-19 diseaseAlkaline phosphataseALT elevation
2019
2258 Cascara Sagrada: A Dangerous Herbal Stool Softener: A Case Report and Literature Review
Flores E, Mbachi C, Randhawa T, Vohra I, Agrawal R, Mba B. 2258 Cascara Sagrada: A Dangerous Herbal Stool Softener: A Case Report and Literature Review. The American Journal Of Gastroenterology 2019, 114: s1262-s1264. DOI: 10.14309/01.ajg.0000598564.97179.71.Peer-Reviewed Case Reports and Technical NotesLiver injuryTotal bilirubinCascara sagradaHerbal supplementsDrug-induced liver injuryClay-colored stoolsDark-colored urineMild transaminase elevationsBile duct injuryLiver function testsChronic inflammatory infiltrateShort-term treatmentAnabolic steroid useSerum enzyme elevationsAutoimmune panelDuct injuryPortal hypertensionTransaminase elevationStool softenersClose followEnzyme elevationInitial presentationLiver biopsyLiver ultrasoundBiliary dilatation
2017
A Case of Carbamazepine-induced Severe Cholestatic Hepatitis: Case Report and Review of Literature
Ganesh S, Shukla L, Kandasamy A, Benegal V. A Case of Carbamazepine-induced Severe Cholestatic Hepatitis: Case Report and Review of Literature. Indian Journal Of Psychological Medicine 2017, 39: 688-690. PMID: 29200572, PMCID: PMC5688903, DOI: 10.4103/ijpsym.ijpsym_19_17.Peer-Reviewed Case Reports and Technical NotesSevere cholestatic hepatitisCholestatic hepatitisDrug-induced liver injuryCausality assessment scaleFemale patient presentingInitiation of carbamazepineReview of literatureLiver injuryClinical manifestationsPatient presentingCase reportPrescribed drugsAssessment ScaleField of neuropsychiatryHepatitisCarbamazepinePatientsPresentingEtiopathogenesisInjury
2015
Drug-induced fulminant hepatic failure in pregnancy
Firoz T, Webber D, Rowe H. Drug-induced fulminant hepatic failure in pregnancy. Obstetric Medicine 2015, 8: 190-192. PMID: 27512479, PMCID: PMC4935052, DOI: 10.1177/1753495x15598909.Peer-Reviewed Original ResearchFulminant hepatic failureHepatic failureLiver failureGestational ageLiver diseaseDrug-induced liver injuryAbnormal liver functionWeeks gestational agePregnant patientsElevated liverLiver biopsyLiver injuryLiver functionSignificant causePregnancyPatientsMedicationsLabetalolMethyldopaDiseaseFailureCauseJaundiceBiopsyHepatotoxicity
2012
Sterile Inflammation in the Liver
Kubes P, Mehal WZ. Sterile Inflammation in the Liver. Gastroenterology 2012, 143: 1158-1172. PMID: 22982943, DOI: 10.1053/j.gastro.2012.09.008.Peer-Reviewed Original ResearchMeSH KeywordsAcetaminophenAdenosine TriphosphateCaspase 1Chemical and Drug Induced Liver InjuryChemotaxis, LeukocyteCytokinesFatty LiverFatty Liver, AlcoholicHepatitisHMGB1 ProteinHumansInflammasomesInterleukin-1betaNeutrophilsNon-alcoholic Fatty Liver DiseaseNucleic AcidsReceptors, Pattern RecognitionReperfusion InjurySignal TransductionUric AcidConceptsDamage-associated molecular patternsPattern recognition receptorsImmune cellsSterile inflammationRecognition receptorsCellular pattern recognition receptorsDrug-induced liver injuryEndogenous damage-associated molecular patternsSuch damage-associated molecular patternsMolecular patternsSite of injuryPathogen-associated molecular patternsProtease caspase-1Alcoholic steatohepatitisLiver injuryNonalcoholic steatohepatitisLiver diseaseProinflammatory cytokinesSpecific therapyInterleukin-1βLiver pathologyTissue injuryImmune responseTherapeutic targetActivate receptors
2011
Acute Hepatitis E Infection Accounts for Some Cases of Suspected Drug-Induced Liver Injury
Davern TJ, Chalasani N, Fontana RJ, Hayashi PH, Protiva P, Kleiner DE, Engle RE, Nguyen H, Emerson SU, Purcell RH, Tillmann HL, Gu J, Serrano J, Hoofnagle JH, Network D. Acute Hepatitis E Infection Accounts for Some Cases of Suspected Drug-Induced Liver Injury. Gastroenterology 2011, 141: 1665-1672.e9. PMID: 21855518, PMCID: PMC3654540, DOI: 10.1053/j.gastro.2011.07.051.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAcute Lung InjuryAdultAgedAged, 80 and overChemical and Drug Induced Liver InjuryDiagnosis, DifferentialFemaleHepatitis AntibodiesHepatitis EHepatitis E virusHumansImmunoglobulin GImmunoglobulin MMaleMiddle AgedPrevalenceProspective StudiesRetrospective StudiesUnited StatesConceptsDrug-induced liver injuryDrug-Induced Liver Injury NetworkAnti-HEV IgMAnti-HEV IgGLiver injuryHEV infectionAcute hepatitis E infectionHepatitis E virus infectionDrug-induced liver diseaseAcute hepatitis EAnti-HEV IgM.Acute viral hepatitisE virus infectionHepatitis E infectionViral hepatitis AAcute liver injuryHuman immunodeficiency virusE infectionHEV RNAClinical reassessmentHepatitis EViral hepatitisHepatitis AClinical featuresLiver disease
2009
S1590 Immuno-Allergic (I-a) Manifestations of Drug-Induced Liver Injury (DILI) in the USA. Results from the Prospective Study of the DILI Network
Bonkovsky H, Agrawal S, Fontana R, Chalasani N, Watkins P, Davern T, Serrano J, Protiva P, Boling J, Rochon J, Kleiner D. S1590 Immuno-Allergic (I-a) Manifestations of Drug-Induced Liver Injury (DILI) in the USA. Results from the Prospective Study of the DILI Network. Gastroenterology 2009, 136: a-820. DOI: 10.1016/s0016-5085(09)63780-x.Peer-Reviewed Original Research
2008
Reliability of the Roussel Uclaf Causality Assessment Method for assessing causality in drug‐induced liver injury
Rochon J, Protiva P, Seeff LB, Fontana RJ, Liangpunsakul S, Watkins PB, Davern T, McHutchison JG, Network D. Reliability of the Roussel Uclaf Causality Assessment Method for assessing causality in drug‐induced liver injury. Hepatology 2008, 48: 1175-1183. PMID: 18798340, PMCID: PMC3618289, DOI: 10.1002/hep.22442.Peer-Reviewed Original ResearchConceptsRoussel Uclaf Causality Assessment MethodDrug-induced liver injuryCausality Assessment MethodLiver injuryDrug-induced liver injury casesDrug-Induced Liver Injury NetworkLiver injury casesCases of hepatotoxicityInterrater reliabilityStrength of associationDeviation ageCase of drugsTest-retest reliabilityTest-retest differencesCausality assessmentInjury casesInjuryFive-category scaleSame reviewersSame assessorPhenytoinReviewersIsoniazidAmoxicillinResearch settings
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