2023
Imaging biomarkers in the idiopathic inflammatory myopathies
Zubair A, Salam S, Dimachkie M, Machado P, Roy B. Imaging biomarkers in the idiopathic inflammatory myopathies. Frontiers In Neurology 2023, 14: 1146015. PMID: 37181575, PMCID: PMC10166883, DOI: 10.3389/fneur.2023.1146015.Peer-Reviewed Original ResearchIdiopathic inflammatory myopathiesManagement of IIMMagnetic resonance imagingElectrical impedance myographyPositron emission tomographyInflammatory myopathiesMuscle ultrasoundExtra-muscular manifestationsMuscle strength testingQuality of lifeObjective assessmentMuscle inflammationPatient managementTreatment responseBetter objective assessmentMuscle damageMuscle healthResonance imagingEmission tomographyClinical settingMuscle diseaseBiomarkersImpedance myographyMyopathyFurther validation
2022
Defining the structure-activity relationship for a novel class of allosteric MKP5 inhibitors
Gannam Z, Jamali H, Kweon OS, Herrington J, Shillingford SR, Papini C, Gentzel E, Lolis E, Bennett AM, Ellman JA, Anderson KS. Defining the structure-activity relationship for a novel class of allosteric MKP5 inhibitors. European Journal Of Medicinal Chemistry 2022, 243: 114712. PMID: 36116232, PMCID: PMC9830533, DOI: 10.1016/j.ejmech.2022.114712.Peer-Reviewed Original ResearchMeSH KeywordsStructure-Activity RelationshipConceptsStress-responsive MAPKsEnzyme-inhibitor complexDystrophic muscle diseasePhosphatase 5Muscle diseaseAllosteric inhibitorsNumber of diseasesNovel classProtein kinase phosphatase 5Structure-activity relationshipsPotential therapeutic targetMKP5X-ray crystal structureTherapeutic targetPotential therapeuticsInhibitorsLead compoundsInhibitionProper positioningMAPKCrystal structureMitogenTyr435Derivative compoundsInteractionSarcomere protein modulation: The new frontier in cardiovascular medicine and beyond
Morelli C, Ingrasciotta G, Jacoby D, Masri A, Olivotto I. Sarcomere protein modulation: The new frontier in cardiovascular medicine and beyond. European Journal Of Internal Medicine 2022, 102: 1-7. PMID: 35534374, DOI: 10.1016/j.ejim.2022.04.020.Peer-Reviewed Original ResearchConceptsHeart failureCardiovascular medicineVentricular outflow obstructionHeart muscle diseaseDegenerative neuromuscular diseaseSpecific disease mechanismsCardiovascular deathOutflow obstructionSystolic functionRandomized trialsUnderlying pathophysiologyCardiac patientsOmecamtiv mecarbilHypertrophic cardiomyopathyFunctional capacityNeuromuscular diseaseMuscle diseaseAvailable evidenceContractile proteinsSkeletal muscleTranslational researchPromising targetDiseaseDisease mechanismsFailure
2020
An allosteric site on MKP5 reveals a strategy for small-molecule inhibition
Gannam Z, Min K, Shillingford SR, Zhang L, Herrington J, Abriola L, Gareiss PC, Pantouris G, Tzouvelekis A, Kaminski N, Zhang X, Yu J, Jamali H, Ellman JA, Lolis E, Anderson KS, Bennett AM. An allosteric site on MKP5 reveals a strategy for small-molecule inhibition. Science Signaling 2020, 13 PMID: 32843541, PMCID: PMC7569488, DOI: 10.1126/scisignal.aba3043.Peer-Reviewed Original ResearchMeSH KeywordsAllosteric SiteAmino Acid SequenceAnimalsCell DifferentiationCell LineDual-Specificity PhosphatasesEnzyme InhibitorsFemaleHigh-Throughput Screening AssaysHumansKineticsMiceMice, KnockoutMitogen-Activated Protein Kinase PhosphatasesMyoblastsProtein BindingSequence Homology, Amino AcidSignal TransductionSmall Molecule LibrariesConceptsDystrophic muscle diseaseMitogen-activated protein kinaseMuscle diseaseTGF-β1Promising therapeutic targetP38 mitogen-activated protein kinaseTherapeutic strategiesTherapeutic targetSmall molecule inhibitionSmad2 phosphorylationDiseasePotential targetSmall-molecule screenInhibitorsTreatmentInhibition
2019
Estimating prevalence for limb-girdle muscular dystrophy based on public sequencing databases
Liu W, Pajusalu S, Lake NJ, Zhou G, Ioannidis N, Mittal P, Johnson NE, Weihl CC, Williams BA, Albrecht DE, Rufibach LE, Lek M. Estimating prevalence for limb-girdle muscular dystrophy based on public sequencing databases. Genetics In Medicine 2019, 21: 2512-2520. PMID: 31105274, DOI: 10.1038/s41436-019-0544-8.Peer-Reviewed Original ResearchConceptsMuscular dystrophyLimb-girdle muscular dystrophyClinical trialsGene-level mechanismsLower incidencePossible underdiagnosisGeneral populationEpidemiological studiesEpidemiology dataPrevalence estimatesGenetic subtypesMuscle diseaseLGMD subtypesDisease prevalencePrevalenceRecessive diseaseSubtypesPublic sequencing databasesDiseaseTrialsLGMDDystrophyHeterogeneous categorySequencing databases
2014
The Challenge of Next Generation Sequencing in the Context of Neuromuscular Diseases
Lek M, MacArthur D. The Challenge of Next Generation Sequencing in the Context of Neuromuscular Diseases. Journal Of Neuromuscular Diseases 2014, 1: 135-149. PMID: 27858772, DOI: 10.3233/jnd-140032.Peer-Reviewed Original Research
2013
Improved regenerative myogenesis and muscular dystrophy in mice lacking Mkp5
Shi H, Verma M, Zhang L, Dong C, Flavell RA, Bennett AM. Improved regenerative myogenesis and muscular dystrophy in mice lacking Mkp5. Journal Of Clinical Investigation 2013, 123: 2064-2077. PMID: 23543058, PMCID: PMC3635719, DOI: 10.1172/jci64375.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell ProliferationCrosses, GeneticDual-Specificity PhosphatasesDystrophinFemaleMaleMAP Kinase Kinase 4MAP Kinase Signaling SystemMiceMice, Inbred C57BLMice, KnockoutMuscle, SkeletalMusclesMuscular Dystrophy, DuchenneMutationp38 Mitogen-Activated Protein KinasesRegenerationStem CellsConceptsMuscle stem cell functionMitogen-activated protein kinaseStem cell functionMKP-5MAPK phosphataseSkeletal muscle diseasesRegenerative myogenesisCell functionMuscle stem cell proliferationP38 mitogen-activated protein kinaseMuscle stem cellsDegenerative skeletal muscle diseaseStem cell proliferationEssential negative regulatorProtein kinaseMuscle diseaseNegative regulatorMAPK activityGenetic lossMKP5Muscle phenotypeDystrophic muscle phenotypeStem cellsMuscular dystrophyCell proliferation
2012
Autoantibodies Produced at the Site of Tissue Damage Provide Evidence of Humoral Autoimmunity in Inclusion Body Myositis
Ray A, Amato AA, Bradshaw EM, Felice KJ, DiCapua DB, Goldstein JM, Lundberg IE, Nowak RJ, Ploegh HL, Spooner E, Wu Q, Willis SN, O’Connor K. Autoantibodies Produced at the Site of Tissue Damage Provide Evidence of Humoral Autoimmunity in Inclusion Body Myositis. PLOS ONE 2012, 7: e46709. PMID: 23071619, PMCID: PMC3465259, DOI: 10.1371/journal.pone.0046709.Peer-Reviewed Original ResearchConceptsInclusion body myositisHumoral immune responseImmune responsePlasma cellsTissue damageBody myositisAntibody-secreting plasma cellsCell linesSingle plasma cellsMajor intermediate filament proteinMuscle tissueIBM patientsHumoral autoimmunityInflammatory myopathiesHuman-derived cell linesIBM muscleMuscle tissue sectionsMuscle tissue homogenatesMuscle diseaseTissue homogenatesTissue sectionsIntermediate filament proteinsMyositisAutoantibodiesDisease
2011
Direct visualization of myosin-binding protein C bridging myosin and actin filaments in intact muscle
Luther PK, Winkler H, Taylor K, Zoghbi ME, Craig R, Padrón R, Squire JM, Liu J. Direct visualization of myosin-binding protein C bridging myosin and actin filaments in intact muscle. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 11423-11428. PMID: 21705660, PMCID: PMC3136262, DOI: 10.1073/pnas.1103216108.Peer-Reviewed Original Research
2002
Role of K+ channels in L-6 myoblast migration
Van Lunteren E, Sankey C, Moyer M, Snajdar RM. Role of K+ channels in L-6 myoblast migration. Journal Of Muscle Research And Cell Motility 2002, 23: 197-204. PMID: 12500899, DOI: 10.1023/a:1020967106084.Peer-Reviewed Original ResearchConceptsGenetic muscle diseasesMuscle injuryMyoblast transplantationReparative responseMyoblast migrationMuscle diseaseTetraethylammoniumApaminGlibenclamideCell migrationPresent studyConfluent culturesMigration of myoblastsΔ-dendrotoxinCellsTransplantationCharybdotoxinInjuryAgentsDendrotoxinDiseaseTotal distance
1995
Dilated heart muscle disease associated with HIV infection
Herskowitz A, Willoughby S, Vlahov D, Baughman K, Ansari A. Dilated heart muscle disease associated with HIV infection. European Heart Journal 1995, 16: 50-55. PMID: 8682102, DOI: 10.1093/eurheartj/16.suppl_o.50.Peer-Reviewed Original ResearchConceptsHeart muscle diseaseLate-stage HIV infectionCD4 T-cell countGlobal left ventricular dysfunctionT-cell countsLeft ventricular dysfunctionHIV infectionRisk factorsVentricular dysfunctionClinical characteristicsCardiac dysfunctionMuscle diseaseNew York Heart Association class IIILow CD4 T-cell countsSevere global left ventricular dysfunctionCell countAnti-heart antibodiesCardiotropic virus infectionImmunologic risk factorsNon-infectious complicationsPrimary cardiac failureSymptomatic cardiac dysfunctionSymptomatic heart diseaseCongestive heart failureHIV risk factors
1992
Autoantibodies to small nuclear and cytoplasmic ribonucleoproteins in japanese patients with inflammatory muscle disease
Hirakata M, Mimori T, Akizuki M, Craft J, Hardin J, Homma M. Autoantibodies to small nuclear and cytoplasmic ribonucleoproteins in japanese patients with inflammatory muscle disease. Arthritis & Rheumatism 1992, 35: 449-456. PMID: 1567494, DOI: 10.1002/art.1780350415.Peer-Reviewed Original ResearchConceptsInflammatory muscle diseaseJapanese patientsChronic interstitial lung diseaseMuscle diseaseAnti-PM/SclDifferent etiologic mechanismsTRNA synthetase antibodiesDistinct clinical subsetInterstitial lung diseasePM/DMControl patientsImmunogenetic backgroundOverlap syndromeClinical subsetsRheumatic diseasesSevere myositisAutoimmune responseRNP antibodiesAutoantibody specificitiesLung diseaseClinical correlationClinical significanceClinical comparisonSynthetase antibodiesEtiologic mechanisms
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