2022
Dorsal Column Stimulation and Cannabinoids in the Treatment of Chronic Nociceptive and Neuropathic Pain: a Review of the Clinical and Pre-clinical Data
Odonkor CA, AlFarra T, Adekoya P, Orhurhu V, Rodríguez T, Sottosanti E, Kaye AD. Dorsal Column Stimulation and Cannabinoids in the Treatment of Chronic Nociceptive and Neuropathic Pain: a Review of the Clinical and Pre-clinical Data. Current Pain And Headache Reports 2022, 26: 103-118. PMID: 35119602, DOI: 10.1007/s11916-022-01008-y.Peer-Reviewed Original ResearchConceptsSpinal cord stimulationNociceptive painLong-term healthcare costsPain treatment modalitiesDorsal column stimulationPre-clinical dataHigh safety profileCannabinoid-based medicationsPain-signaling pathwaysQuality of lifeMinimal side effectsOpioid consumptionNeuropathic painPain reliefAdjunctive therapySecondary outcomesPain managementCannabinoid therapyClinical efficacyCord stimulationSafety profileCombination therapyFunctional statusTreatment modalitiesFunctional capacity
2012
Ca2+/calmodulin-dependent protein kinase II is associated with pelvic pain of neurogenic cystitis
Yang W, Rudick C, Hoxha E, Allsop S, Dimitrakoff J, Klumpp D. Ca2+/calmodulin-dependent protein kinase II is associated with pelvic pain of neurogenic cystitis. American Journal Of Physiology. Renal Physiology 2012, 303: f350-f356. PMID: 22647634, PMCID: PMC3433862, DOI: 10.1152/ajprenal.00077.2012.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBehavior, AnimalCalcium-Calmodulin-Dependent Protein Kinase Type 2CystitisDose-Response Relationship, DrugFemaleHerpesvirus 1, SuidHyperalgesiaImage Processing, Computer-AssistedImmunohistochemistryInjections, SpinalIsoenzymesMiceMice, Inbred C57BLMicroarray AnalysisPelvic PainPhosphorylationPosterior Horn CellsReal-Time Polymerase Chain ReactionRNARNA, MessengerSpinal CordTranscription, GeneticConceptsSacral spinal cordPelvic painNeurogenic cystitisProtein kinase IISpinal cordDorsal hornAssociated with urothelial lesionsChronic bladder inflammatory diseaseDevelopment of pelvic painMurine neurogenic cystitis modelCaMKII inhibitor KN-93Interstitial cystitis/painful bladder syndromeAssociated with pelvic painCa(2+)/calmodulin-dependent protein kinase IIAbductor caudalis dorsalisProgressive pelvic painPostinfection dayKinase IIInhibitor KN-93Pain-signaling pathwaysFemale C57BL/6J miceCa2+/calmodulin-dependent protein kinase IIPostinfection day 2Pelvic/perineal areaCystitis model
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