2023
Randomized trial comparing standard versus light intensity parent training for anxious youth
Storch E, Guzick A, Ayton D, Palo A, Kook M, Candelari A, Maye C, McNeel M, Trent E, Garcia J, Onyeka O, Rast C, Shimshoni Y, Lebowitz E, Goodman W. Randomized trial comparing standard versus light intensity parent training for anxious youth. Behaviour Research And Therapy 2023, 173: 104451. PMID: 38154287, DOI: 10.1016/j.brat.2023.104451.Peer-Reviewed Original ResearchObsessive-compulsive disorderAnxiety severityAnxious Childhood EmotionsParent-reported anxietyPost-treatment anxietyTreatment conditionsAnxious youthChildhood EmotionsParent trainingFamily accommodationSupportive parentingAnxiety treatmentDiverse sampleAnxietyOne monthSignificant anxietyYouthChange scoresIndependent evaluatorsFunctional impairmentParentsFurther supportSessionsTotal change scoresEmotionsNeighborhood Social Environment and Body Mass Index: The Mediating Role of Mental Wellbeing
Cunningham S, Mandelbaum J, Shebl F, Abraham M, Duffany K. Neighborhood Social Environment and Body Mass Index: The Mediating Role of Mental Wellbeing. International Journal Of Environmental Research And Public Health 2023, 20: 6602. PMID: 37623185, PMCID: PMC10454589, DOI: 10.3390/ijerph20166602.Peer-Reviewed Original ResearchConceptsBody mass indexNeighborhood social environmentPhysical activityMass indexMental wellbeingLow physical activityNeighborhood-built environmentObesity riskObesogenic behaviorsBehavioral interventionsPrevention effortsPopulation healthSignificant totalZip codesRandom sampleAssociationStudy findingsFurther supportWellbeingSocial environmentActivity
2022
Bidirectional relationships between cannabis use, anxiety and depressive symptoms in the mediation of the association with psychotic experience: further support for an affective pathway to psychosis
Radhakrishnan R, Pries LK, Erzin G, Have M, de Graaf R, van Dorsselaer S, Gunther N, Bak M, Rutten BPF, van Os J, Guloksuz S. Bidirectional relationships between cannabis use, anxiety and depressive symptoms in the mediation of the association with psychotic experience: further support for an affective pathway to psychosis. Psychological Medicine 2022, 53: 5551-5557. PMID: 36093677, PMCID: PMC10482707, DOI: 10.1017/s0033291722002756.Peer-Reviewed Original ResearchConceptsAnxiety/depressive symptomsDepressive symptomsCannabis usePE incidencePsychotic experiencesFirst longitudinal cohort studyNetherlands Mental Health SurveyLongitudinal cohort studyMental Health SurveyRole of cannabisBidirectional relationshipCohort studyHealth SurveyIncidence studyAffective symptomsSymptomsCannabisEducation statusLongitudinal studyPsychosisIncidenceAnxietyTemporal relationshipMediation analysisFurther supportWhen immunotherapy meets surgery in non-small cell lung cancer
Herbst RS, Wang M, Chen L. When immunotherapy meets surgery in non-small cell lung cancer. Cancer Cell 2022, 40: 603-605. PMID: 35660136, DOI: 10.1016/j.ccell.2022.05.010.Peer-Reviewed Original Research
2018
Individuals with Psychopathic Traits view Distracting Neutral Information as Negatively Valenced
Tillem S, Baskin-Sommers A. Individuals with Psychopathic Traits view Distracting Neutral Information as Negatively Valenced. International Journal Of Forensic Mental Health 2018, 17: 25-34. DOI: 10.1080/14999013.2017.1405126.Peer-Reviewed Original ResearchNeutral informationPsychopathic individualsInterpersonal-affective traitsAdult male offendersAttention abnormalitiesLocalizer taskAffective informationAffective valenceCognitive scienceInterpersonal deficitsAffective responsesTrait viewMale offendersPsychopathyDevaluationIndividualsFurther supportValenceNeurobiologyOffendersTaskDeficitsInformationAttentionContext
2017
Driven exercise in the absence of binge eating: Implications for purging disorder
Lydecker JA, Shea M, Grilo CM. Driven exercise in the absence of binge eating: Implications for purging disorder. International Journal Of Eating Disorders 2017, 51: 139-145. PMID: 29215743, PMCID: PMC5796839, DOI: 10.1002/eat.22811.Peer-Reviewed Original ResearchConceptsEating-disorder psychopathologyClinical significancePhysical activityCompensatory behaviorsBinge-eating episodesAbsence of bingeEating Disorder PsychopathologyLower depression levelsLow-frequency thresholdsWeb-based surveyDepression levelsSmall sample sizeHigher depressionOverall frequencyLaxativesTreatment researchMost domainsExerciseBingePsychopathologyDisordersDepressionParticipantsSimilar levelsFurther support
2016
Chromosomal microarray analysis in clinical evaluation of neurodevelopmental disorders-reporting a novel deletion of SETDB1 and illustration of counseling challenge
Xu Q, Goldstein J, Wang P, Gadi IK, Labreche H, Rehder C, Wang WP, McConkie A, Xu X, Jiang YH. Chromosomal microarray analysis in clinical evaluation of neurodevelopmental disorders-reporting a novel deletion of SETDB1 and illustration of counseling challenge. Pediatric Research 2016, 80: 371-381. PMID: 27119313, PMCID: PMC5382808, DOI: 10.1038/pr.2016.101.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAlgorithmsAutistic DisorderChildChild, PreschoolChromatinComparative Genomic HybridizationCounselingDevelopmental DisabilitiesDNA Copy Number VariationsFemaleGene DeletionGene RearrangementHistone-Lysine N-MethyltransferaseHumansInfantIntellectual DisabilityMaleMicroarray AnalysisNeurodevelopmental DisordersPedigreeProtein MethyltransferasesConceptsNeurodevelopmental disordersAutism spectrum disorderIntellectual disabilityDevelopmental disabilitiesCopy number variationsChromosomal microarray analysisEtiological evaluationClinical evaluationClinical significanceUnknown significanceCNV analysisGenetics clinicEtiology of ASDCounseling familiesDisordersVariable penetranceClinicMicroarray analysisNovel deletionSpectrum disorderDisabilityCounseling challengesFurther supportEtiologyCohortThe interpretation of hepatic venous pressure gradient tracings – excellent interobserver agreement unrelated to experience
Tandon P, Ripoll C, Assis D, Wongcharatrawee S, Groszmann RJ, Garcia-Tsao G. The interpretation of hepatic venous pressure gradient tracings – excellent interobserver agreement unrelated to experience. Liver International 2016, 36: 1160-1166. PMID: 26763558, DOI: 10.1111/liv.13065.Peer-Reviewed Original ResearchConceptsHepatic venous pressure gradientIntraclass correlation coefficientPortal hypertensionBaseline hepatic venous pressure gradientObserver readingsInterobserver agreementVenous pressure gradientTherapy of patientsBland-Altman plotsPearson's linear regressionSingle centerBland-Altman techniqueCirrhosisLogistic regressionMean differencePatientsHypertensionMmHgExperienced observersResearch settingsPredictorsFurther supportSignificant linear relationshipLinear regressionHepatologists
2014
A nucleolytic lupus autoantibody is toxic to BRCA2-deficient cancer cells
Noble PW, Young MR, Bernatsky S, Weisbart RH, Hansen JE. A nucleolytic lupus autoantibody is toxic to BRCA2-deficient cancer cells. Scientific Reports 2014, 4: 5958. PMID: 25091037, PMCID: PMC5380011, DOI: 10.1038/srep05958.Peer-Reviewed Original ResearchConceptsLupus autoantibodiesTherapeutic agentsCancer cellsSystemic lupus erythematosusBRCA2-deficient cellsLupus erythematosusBRCA2-deficient cancer cellsDLD1 colon cancer cellsColon cancer cellsSuch antibodiesLower riskAutoantibodiesSpecific cancersAntibodiesMalignancyDifferential effectsToxic effectsPotential utilityCellsAgentsFurther supportDNA-damaging agentsErythematosusTherapyCancer
2013
Tissue plasminogen activator via cross-collateralization for tandem internal carotid and middle cerebral artery occlusion.
Bulsara KR, Ediriwickrema A, Pepper J, Robertson F, Aruny J, Schindler J. Tissue plasminogen activator via cross-collateralization for tandem internal carotid and middle cerebral artery occlusion. World Journal Of Clinical Cases 2013, 1: 290-4. PMID: 24364024, PMCID: PMC3868713, DOI: 10.12998/wjcc.v1.i9.290.Peer-Reviewed Original ResearchTissue plasminogen activatorMiddle cerebral artery occlusionTandem internal carotidCerebral artery occlusionArtery occlusionInternal carotidIntra-arterial tissue plasminogen activatorPlasminogen activatorEndovascular carotid stentingFurther embolic eventsHealth Stroke ScaleSystemic thrombolysisCarotid dissectionStroke ScaleEmbolic eventsCarotid stentingPoor outcomeCurrent treatmentHigh riskFull recoveryNational InstituteCarotidDissectionOcclusionFurther support
2012
Enhancing Prolonged Exposure Therapy for Posttraumatic Stress Disorder with D-Cycloserine: Further Support for Treatments That Promote Experience-Dependent Neuroplasticity
Krystal JH. Enhancing Prolonged Exposure Therapy for Posttraumatic Stress Disorder with D-Cycloserine: Further Support for Treatments That Promote Experience-Dependent Neuroplasticity. Biological Psychiatry 2012, 71: 932-934. PMID: 22579302, DOI: 10.1016/j.biopsych.2012.03.031.Peer-Reviewed Original Research
2010
Environmental induction of the fetal epigenome
Odom LN, Taylor HS. Environmental induction of the fetal epigenome. Expert Review Of Obstetrics & Gynecology 2010, 5: 657-664. PMID: 21297874, PMCID: PMC3032386, DOI: 10.1586/eog.10.58.Peer-Reviewed Original ResearchFetal epigenomeReproductive-age womenMaternal environmentUtero exposureBarker hypothesisHealthy adultsHealthcare providersAdult HealthVulnerable timeProfound epigenetic effectsEnvironmental exposuresFetusesEpigenetic alterationsEpigenomic alterationsExposureAlterationsNumerous studiesEpigenetic effectsFurther supportPregnancyDiseaseDNA methylationTesting a new cognitive behavioural treatment for obesity: A randomized controlled trial with three-year follow-up
Cooper Z, Doll HA, Hawker DM, Byrne S, Bonner G, Eeley E, O’Connor M, Fairburn CG. Testing a new cognitive behavioural treatment for obesity: A randomized controlled trial with three-year follow-up. Behaviour Research And Therapy 2010, 48: 706-713. PMID: 20691328, PMCID: PMC2923743, DOI: 10.1016/j.brat.2010.03.008.Peer-Reviewed Original ResearchConceptsNew cognitive behavioural treatmentCognitive-behavioral treatmentBehavioral treatmentPsychological treatmentPsychological methodsBehavior therapyLong-term effectsFemale participantsWeight regainWeight lossNew treatmentsParticipantsFurther supportAverage weight lossObesityPresent studyMain treatmentTreatmentThree yearsShort-term perspectiveAbsence of dataPeopleFindingsSupportGreat majority
2002
Heterotopic Nephrogenic Rests in the Colon and Multiple Congenital Anomalies: Possibly Related Association
Jain D, Martel M, Reyes-Múgica M, Parkash V. Heterotopic Nephrogenic Rests in the Colon and Multiple Congenital Anomalies: Possibly Related Association. Pediatric And Developmental Pathology 2002, 5: 587-591. PMID: 12375130, DOI: 10.1007/s10024-002-0055-4.Peer-Reviewed Original ResearchMice heterozygous for mutation in Atm, the gene involved in ataxia-telangiectasia, have heightened susceptibility to cancer
Spring K, Ahangari F, Scott SP, Waring P, Purdie DM, Chen PC, Hourigan K, Ramsay J, McKinnon PJ, Swift M, Lavin MF. Mice heterozygous for mutation in Atm, the gene involved in ataxia-telangiectasia, have heightened susceptibility to cancer. Nature Genetics 2002, 32: 185-190. PMID: 12195425, DOI: 10.1038/ng958.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAtaxia TelangiectasiaAtaxia Telangiectasia Mutated ProteinsCell Cycle ProteinsCell SurvivalChromosomesDNA-Binding ProteinsFemaleGamma RaysGenetic Predisposition to DiseaseHeterozygoteHumansMaleMiceMice, Inbred C57BLMutation, MissenseNeoplasmsPenetranceProtein Serine-Threonine KinasesTumor Suppressor ProteinsConceptsAtaxia telangiectasiaATM kinase activityDominant negative effectATM cDNAGenome instabilityHeterozygous miceRadiation-induced chromosomal aberrationsKinase activityCancer predispositionFrame deletionMutationsControl cellsGenesChromosomal aberrationsCellsCDNAMouse carriersDeletionMiceHeterozygous carriersAtmFirst timeExpressionFurther support
2001
Development and Application of a Genotypic AZT Resistance Assay: Quantitative Assessment of the Resistance Profile of Clinical Samples and the Relative Predictive Ability of a Resistance Index.
Kyriakides TC, Heimer RR. Development and Application of a Genotypic AZT Resistance Assay: Quantitative Assessment of the Resistance Profile of Clinical Samples and the Relative Predictive Ability of a Resistance Index. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2001, 28: 211. PMID: 11694826, DOI: 10.1097/00042560-200111010-00002.Peer-Reviewed Original ResearchConceptsViral loadCD4 countResistance indexAZT resistanceResistance profilesBaseline viral loadHIV disease progressionLigase chain reaction assayMonths of treatmentWild-type HIV-1Resistance assaysAntiretroviral therapyDisease progressionSurrogate markerChain reaction assaysHIV-1PatientsAZTPredictive abilityClinical samplesReaction assaysCountAssaysRelative predictive abilityFurther supportDevelopment and Application of a Genotypic AZT Resistance Assay
Kyriakides T, Heimer R. Development and Application of a Genotypic AZT Resistance Assay. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2001, 28: 211-220. DOI: 10.1097/00126334-200111010-00002.Peer-Reviewed Original ResearchViral loadCD4 countAZT resistanceResistance indexResistance profilesBaseline viral loadHIV disease progressionLigase chain reaction assayMonths of treatmentResistance assaysAntiretroviral therapyDisease progressionSurrogate markerChain reaction assaysHIV-1PatientsAZTPredictive abilityReaction assaysCountAssaysFurther supportIndexAntiretroviralsHIV
1998
Periodicity of Thalamic Spindle Waves Is Abolished by ZD7288,a Blocker of I h
Lüthi A, Bal T, McCormick D. Periodicity of Thalamic Spindle Waves Is Abolished by ZD7288,a Blocker of I h. Journal Of Neurophysiology 1998, 79: 3284-3289. PMID: 9636128, DOI: 10.1152/jn.1998.79.6.3284.Peer-Reviewed Original ResearchConceptsSpindle wavesHyperpolarization-activated cation current IhCurrent-clamp recordingsIntracellular recording techniquesBlock of IhVoltage-clamp recordingsRebound burstsThalamic activityRefractory periodPacemaker currentLocal applicationZD7288AfterdepolarizationsCurrent IhRecording techniquesRepetitive hyperpolarizationNetwork activityHyperpolarizationSlow rhythmicityFurther supportIH
1997
RNA Dependent DNA Replication Fidelity of HIV-1 Reverse Transcriptase: Evidence of Discrimination between DNA and RNA Substrates †
Kerr S, Anderson K. RNA Dependent DNA Replication Fidelity of HIV-1 Reverse Transcriptase: Evidence of Discrimination between DNA and RNA Substrates †. Biochemistry 1997, 36: 14056-14063. PMID: 9369477, DOI: 10.1021/bi971385+.Peer-Reviewed Original Research
1995
HIV Incidence Among New Haven Needle Exchange Participants
Kaplan E, Heimer R. HIV Incidence Among New Haven Needle Exchange Participants. JAIDS Journal Of Acquired Immune Deficiency Syndromes 1995, 10: 175-176. PMID: 7552482, DOI: 10.1097/00042560-199510020-00010.Peer-Reviewed Original Research
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