2025
Avelumab first-line maintenance for advanced urothelial carcinoma: long-term outcomes from the JAVELIN Bladder 100 trial in older patients ☆
Gupta S, Duran M, Sridhar S, Powles T, Bellmunt J, Park S, Gurney H, Tsuchiya N, Petrylak D, Tomita Y, di Pietro A, Manitz J, Tyroller K, Hoffman J, Jacob N, Grivas P. Avelumab first-line maintenance for advanced urothelial carcinoma: long-term outcomes from the JAVELIN Bladder 100 trial in older patients ☆. ESMO Open 2025, 10: 104506. PMID: 40107155, PMCID: PMC11964637, DOI: 10.1016/j.esmoop.2025.104506.Peer-Reviewed Original ResearchConceptsProgression-free survivalPlatinum-based chemotherapyOverall survivalUrothelial carcinomaProgression-free survival analysisOlder ageAdvanced urothelial carcinomaFirst-line maintenanceMetastatic urothelial carcinomaProlonged overall survivalPhase III trialsKaplan-Meier methodQuality-adjusted timeLong-term outcomesJAVELIN BladderMedian OSIII trialsFirst-linePrimary endpointAvelumabBladder cancerOlder patientsAge subgroupsSupportive carePatients
2022
Implementation of an Appointment‐Based Cardiac Rehabilitation Approach: A Single‐Center Experience
Wright CX, Fournier S, Deng Y, Meng C, Hiller S, Oen‐Hsiao J, Dreyer RP. Implementation of an Appointment‐Based Cardiac Rehabilitation Approach: A Single‐Center Experience. Journal Of The American Heart Association 2022, 11: e024066. PMID: 35499969, PMCID: PMC9238587, DOI: 10.1161/jaha.121.024066.Peer-Reviewed Original ResearchConceptsLogistic regression modelsHealth outcomesCR programSex/age subgroupMultivariable logistic regression modelCardiovascular disease populationsDose-response benefitsSingle-center experienceDietary fat intakeBenign prostatic hyperplasiaFinal logistic regression modelLack of exerciseYale New Haven HealthPredictors of completionRegression modelsBlack patientsFat intakeMean ageProstatic hyperplasiaBlack raceCR completionRisk factorsCardiovascular diseaseDisease populationAge subgroupsCost-Related Medication Nonadherence in Adults With Diabetes in the United States: The National Health Interview Survey 2013-2018.
Taha MB, Valero-Elizondo J, Yahya T, Caraballo C, Khera R, Patel KV, Ali HJR, Sharma G, Mossialos E, Cainzos-Achirica M, Nasir K. Cost-Related Medication Nonadherence in Adults With Diabetes in the United States: The National Health Interview Survey 2013-2018. Diabetes Care 2022, 45: 594-603. PMID: 35015860, DOI: 10.2337/dc21-1757.Peer-Reviewed Original ResearchConceptsCost-related medication nonadherenceNational Health Interview SurveyLack of insuranceMedication nonadherenceNational Health Interview Survey 2013Duration of diabetesHigher comorbidity burdenSelf-reported diabetesHealth Interview SurveyWorse health outcomesHealth-related expendituresComorbidity burdenInsulin useCurrent smokingLess medicationMedication adherenceFemale sexWeighted prevalenceHigher oddsAge subgroupsSkipping dosesDiabetesHealth outcomesElderly adultsNHIS participants
2021
Association between osteoarthritis and the incidence of Parkinson’s disease in the United Kingdom
Jacob L, Smith L, Koyanagi A, Schnitzler A, Shin J, Kostev K. Association between osteoarthritis and the incidence of Parkinson’s disease in the United Kingdom. Clinical Parkinsonism & Related Disorders 2021, 5: 100120. PMID: 34888519, PMCID: PMC8637132, DOI: 10.1016/j.prdoa.2021.100120.Peer-Reviewed Original ResearchEptacog Beta Efficacy in Children and Adolescents with Hemophilia A or B and Inhibitors: Subset Analysis Suggests Improved Caregiver Capacity to Assess Bleeding Episode Resolution with Subject Age
Young G, Pipe S, Hermans C, Carcao M, Castaman G, Davis J, Ducore J, Dunn A, Escobar M, Journeycake J, Khan O, Mahlangu J, Meeks S, Mitha I, Négrier C, Nowak-Göttl U, Recht M, Chrisentery-Singleton T, Stasyshyn O, Vilchevska K, Martinez L, Wang M, Windyga J, Alexander W, Al-Sabbagh A, Bonzo D, Macie C, Mitchell I, Wilkinson T, Shapiro A. Eptacog Beta Efficacy in Children and Adolescents with Hemophilia A or B and Inhibitors: Subset Analysis Suggests Improved Caregiver Capacity to Assess Bleeding Episode Resolution with Subject Age. Blood 2021, 138: 3195. DOI: 10.1182/blood-2021-147434.Peer-Reviewed Original ResearchInitial dosing regimensEntity's Board of DirectorsEptacog betaBleeding episodesPhase 3 trialCSL BehringPediatric age subgroupsConfidence intervalsTreatment successHemophilia AYears subgroupIncreasing subject ageAge subgroupsSubject ageBeta infusionAdvisory CommitteeResearch fundingOregon Health & Science UniversitySuccess proportionTreatment of bleeding episodesControl of bleeding episodesModerate bleeding episodesTreat bleeding episodesNational Hemophilia FoundationOpen-label trialRates of Neuropsychiatric Disorders and Gestational Age at Birth in a Danish Population
Xia Y, Xiao J, Yu Y, Tseng WL, Lebowitz E, DeWan AT, Pedersen LH, Olsen J, Li J, Liew Z. Rates of Neuropsychiatric Disorders and Gestational Age at Birth in a Danish Population. JAMA Network Open 2021, 4: e2114913. PMID: 34185070, PMCID: PMC8243234, DOI: 10.1001/jamanetworkopen.2021.14913.Peer-Reviewed Original ResearchConceptsIncidence rate ratiosLate pretermNeuropsychiatric disordersMajor neuropsychiatric disordersEarly termTerm birthsGestational agePostterm birthSingleton birthsAdult-onset neuropsychiatric disordersDanish Medical Birth RegisterLower incidence rate ratiosGestational age subgroupsMedical Birth RegisterGestational age groupsHigh ratePostterm groupGestational durationCohort studyNationwide registersPerinatal factorsPreterm birthBirth RegisterVery pretermAge subgroupsAirway Growth in Preoperative Patients with Crouzon Syndrome
Lu X, Forte AJ, Park KE, Allam O, Smetona J, Alperovich M, Steinbacher DM, Tonello C, Alonso N, Persing JA. Airway Growth in Preoperative Patients with Crouzon Syndrome. Facial Plastic Surgery & Aesthetic Medicine 2021, 23: 191-197. PMID: 33577380, DOI: 10.1089/fpsam.2020.0441.Peer-Reviewed Original ResearchConceptsYears of ageNasal airway volumeAirway volumeCrouzon syndromePharyngeal airwayCross-sectional areaAirway cross-sectional areaObstructive sleep apneaMonths of agePreoperative patientsSleep apneaMaximal constrictionAirway developmentAirway growthTomography scanAge subgroupsCT scanPatientsSyndromeCrouzon patientsNatural historyAgeNormal dimensionsAirwayMaterialise software
2019
Temporal Evaluation of Craniofacial Relationships in Apert Syndrome
Lu X, Forte AJ, Sawh-Martinez R, Wu R, Cabrejo R, Gabrick K, Steinbacher DM, Alperovich M, Alonso N, Persing JA. Temporal Evaluation of Craniofacial Relationships in Apert Syndrome. Journal Of Craniofacial Surgery 2019, 30: 317-325. PMID: 30358751, DOI: 10.1097/scs.0000000000004836.Peer-Reviewed Original ResearchConceptsYears of ageApert syndromeNasal spineComputed tomography scanMaxillary planeAnterior nasal spineMonths of ageApert syndrome patientsPosterior nasal spineSella-nasion planeTomography scanSyndrome patientsAge subgroupsAnatomic relationshipsSyndromeFacial deformityAngulation changeFrankfort horizontal planeCranial base lengthMonthsIntracellular regulatory mechanismsCraniofacial malformationsAgeDeformityMaterialize software
2018
Orbit, zygoma, and maxilla growth patterns in Crouzon syndrome
Lu X, Forte AJ, Sawh-Martinez R, Wu R, Cabrejo R, Steinbacher DM, Alperovich M, Alonso N, Persing JA. Orbit, zygoma, and maxilla growth patterns in Crouzon syndrome. International Journal Of Oral And Maxillofacial Surgery 2018, 48: 309-321. PMID: 30389113, DOI: 10.1016/j.ijom.2018.10.013.Peer-Reviewed Original ResearchConceptsCrouzon syndromeCT scanAnteroposterior lengthWidth of maxillaPreoperative CT scanMonths-2 yearsMonths of agePrincipal deformityControl subjectsGlobe projectionAge subgroupsMaxillary wideningSecondary deformitiesOrbital wallAnterior protrusionSyndromeFacial malformationsMonthsDeformityAnteroposterior positionZygomatic regionCranial baseZygomaMalformationsMaterialise software
2015
United States trends in thrombolysis for older adults with acute ischemic stroke
George B, Asemota A, Dorsey E, Haider A, Smart B, Urrutia V, Schneider E. United States trends in thrombolysis for older adults with acute ischemic stroke. Clinical Neurology And Neurosurgery 2015, 139: 16-23. PMID: 26363362, DOI: 10.1016/j.clineuro.2015.08.031.Peer-Reviewed Original ResearchConceptsNationwide Inpatient SampleAcute ischemic strokeIschemic strokeOlder adultsStudy periodHospital mortality rateAdult stroke patientsHigh-volume hospitalsLength of stayRate of thrombolysisHigh-volume facilitiesPopulation-based ratesCochran-Armitage testThrombolysis groupVolume hospitalsUrban patientsThrombolysis useIntracerebral hemorrhageStroke patientsPrimary diagnosisInpatient SampleOdds ratioHospitalization dataThrombolysisAge subgroupsNational Trends in Hospital Readmission Rates among Medicare Fee-for-Service Survivors of Mitral Valve Surgery, 1999–2010
Dodson JA, Wang Y, Murugiah K, Dharmarajan K, Cooper Z, Hashim S, Nuti SV, Spatz E, Desai N, Krumholz HM. National Trends in Hospital Readmission Rates among Medicare Fee-for-Service Survivors of Mitral Valve Surgery, 1999–2010. PLOS ONE 2015, 10: e0132470. PMID: 26147225, PMCID: PMC4493110, DOI: 10.1371/journal.pone.0132470.Peer-Reviewed Original ResearchConceptsMitral valve surgeryLength of stayHospital LOSReadmission ratesHospital readmission ratesOlder patientsHospital readmissionMedicare feeMean hospital LOSSurvival rateProportional hazards regressionYears of ageValve surgeryHazards regressionService patientsWorse outcomesAge subgroupsPatientsOlder adultsSurvivorsNational trendsReadmissionModest declineWomenSubgroups
1995
Twenty most frequent DRG groups among Medicare inpatients age 65 or older in Connecticut hospitals, fiscal years 1991, 1992, and 1993.
Hennen J, Krumholz HM, Radford MJ. Twenty most frequent DRG groups among Medicare inpatients age 65 or older in Connecticut hospitals, fiscal years 1991, 1992, and 1993. Connecticut Medicine 1995, 59: 11-5. PMID: 7859443.Peer-Reviewed Original ResearchConceptsDRG categoriesConnecticut acute care hospitalsElderly Medicare beneficiariesElderly Medicare patientsAge group 65Acute care hospitalsInpatients age 65Care hospitalFiscal year 1991Inpatient admissionsInpatients ageConnecticut hospitalsGroup 65Medicare patientsAge subgroupsMedicare beneficiariesThree-year study periodAge 65Study periodDRG groupsNumber of dischargesMedicare dischargesHospitalYear periodYears
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