2024
Free-breathing 3D cardiac extracellular volume (ECV) mapping using a linear tangent space alignment (LTSA) model
Lee W, Han P, Marin T, Mounime I, Eslahi S, Djebra Y, Chi D, Fakhri G, Ma C. Free-breathing 3D cardiac extracellular volume (ECV) mapping using a linear tangent space alignment (LTSA) model. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2024 DOI: 10.58530/2024/1493.Peer-Reviewed Original ResearchParticipant Diversity in United States Randomized Controlled Trials of Antibacterials for Staphylococcus aureus Infections, 2000–2021
Kwon J, Pelletiers W, Peña J, van Duin D, Ledbetter L, Baum K, Ruffin F, Knisely J, Bizzell E, Fowler V, Chambers H, Pettigrew M. Participant Diversity in United States Randomized Controlled Trials of Antibacterials for Staphylococcus aureus Infections, 2000–2021. Clinical Infectious Diseases 2024, 79: 141-147. PMID: 38306502, PMCID: PMC11259209, DOI: 10.1093/cid/ciae049.Peer-Reviewed Original ResearchMethicillin-resistant S. aureusRandomized Controlled TrialsPhase 2/3 trialsPhase 4 trialIncidence of methicillin-resistant S. aureusTreat Staphylococcus aureus infectionsStaphylococcus aureus infectionStandard of carePercentage of study participantsIncidence ratiosClinical trialsEthnicity of participantsControlled TrialsStandardized reporting methodsBlack participantsStudy sizeInfectionDisease populationTrialsStudy participantsAntibacterial agentsIncreased recruitmentIndustry sponsorshipEthnicity dataSex
2023
Total Hip Arthroplasty in Patients Who Have Marfan Syndrome: Adverse Events and 5-Year Revision Rates
Day W, Jayaram R, Rubin L, Grauer J. Total Hip Arthroplasty in Patients Who Have Marfan Syndrome: Adverse Events and 5-Year Revision Rates. The Journal Of Arthroplasty 2023, 39: s275-s278. PMID: 37952742, DOI: 10.1016/j.arth.2023.10.052.Peer-Reviewed Original ResearchTotal hip arthroplastyAdverse eventsMarfan syndromeMultivariable analysisHip arthroplastyUnderwent total hip arthroplastyPostoperative adverse eventsVenous thromboembolic eventsPerioperative care pathwaysUrinary tract infectionConnective tissue diseaseLog-rank testRare disease populationComorbidity indexThromboembolic eventsCardiac eventsPostoperative courseTract infectionsAdult patientsTissue diseaseHip pathologyRevision rateCare pathwayDisease populationGreater oddsUse of Immersive Virtual Reality Spaces to Engage Adolescent and Young Adult Patients With Cancer in Therapist-Guided Support Groups: Protocol for a Pre-Post Study
Marks A, Garbatini A, Hieftje K, Puthenpura V, Weser V, Fernandes C. Use of Immersive Virtual Reality Spaces to Engage Adolescent and Young Adult Patients With Cancer in Therapist-Guided Support Groups: Protocol for a Pre-Post Study. JMIR Research Protocols 2023, 12: e48761. PMID: 37943596, PMCID: PMC10667982, DOI: 10.2196/48761.Peer-Reviewed Original ResearchINTERNATIONAL REGISTERED REPORT IDENTIFIERYoung adult patientsSupport groupsAdult patientsYoung adultsMean attendance rateSupport group interventionNon-Hispanic blacksNon-Hispanic whitesOverall retention rateNon-Hispanic AsiansRare disease populationPeer support groupsFacilitated support groupBone marrow failureMedian ageCommon diagnosisPreliminary efficacyHematologic malignanciesDisease populationLife measuresPatientsFinal intervention sessionTransgender femalesPsychosocial support
2022
Implementation of an Appointment‐Based Cardiac Rehabilitation Approach: A Single‐Center Experience
Wright CX, Fournier S, Deng Y, Meng C, Hiller S, Oen‐Hsiao J, Dreyer RP. Implementation of an Appointment‐Based Cardiac Rehabilitation Approach: A Single‐Center Experience. Journal Of The American Heart Association 2022, 11: e024066. PMID: 35499969, PMCID: PMC9238587, DOI: 10.1161/jaha.121.024066.Peer-Reviewed Original ResearchConceptsLogistic regression modelsHealth outcomesCR programSex/age subgroupMultivariable logistic regression modelCardiovascular disease populationsDose-response benefitsSingle-center experienceDietary fat intakeBenign prostatic hyperplasiaFinal logistic regression modelLack of exerciseYale New Haven HealthPredictors of completionRegression modelsBlack patientsFat intakeMean ageProstatic hyperplasiaBlack raceCR completionRisk factorsCardiovascular diseaseDisease populationAge subgroupsUnderstanding Sociodemographic Disparities in Maternal-Fetal Surgery Study Participation
Wilpers A, Lynn AY, Eichhorn B, Powne AB, Lagueux M, Batten J, Bahtiyar MO, Gross CP. Understanding Sociodemographic Disparities in Maternal-Fetal Surgery Study Participation. Fetal Diagnosis And Therapy 2022, 49: 125-137. PMID: 35272297, PMCID: PMC9117502, DOI: 10.1159/000523867.Peer-Reviewed Original ResearchConceptsTwin-twin transfusion syndromeCongenital diaphragmatic herniaGravidity/parityPotential health disparitiesRandomized control trialSurgery StudyDisease groupSociodemographic variablesExclusion criteriaHealth disparitiesCommon disease groupMaternal-fetal surgeryParticipants' sociodemographic characteristicsMedian sample sizeTransfusion syndromeDiaphragmatic herniaThoracic lesionsMaternal agePacific Islander personsPrevalence ratiosSacrococcygeal teratomaSociodemographic disparitiesFetal anomaliesDisease populationFetal surgeryTotal shoulder arthroplasty for osteoarthritis in patients with Parkinson's disease: a matched comparison of 90-day adverse events and 5-year implant survival
Moore HG, Kahan JB, Sherman JJZ, Burroughs PJ, Donohue KW, Grauer JN. Total shoulder arthroplasty for osteoarthritis in patients with Parkinson's disease: a matched comparison of 90-day adverse events and 5-year implant survival. Journal Of Shoulder And Elbow Surgery 2022, 31: 1436-1441. PMID: 35176495, DOI: 10.1016/j.jse.2022.01.113.Peer-Reviewed Original ResearchConceptsTotal shoulder arthroplastyImplant survivalAdverse eventsParkinson's diseaseShoulder arthroplastyDisease cohortDisease populationHigher oddsShort-term adverse eventsNinety-day incidenceChronic kidney diseaseCongestive heart failureCoronary artery diseaseElixhauser Comorbidity IndexLong-term outcomesLog-rank testCase-control studyParkinson's disease cohortParkinson's disease populationShort-term riskPeriprosthetic dislocationComorbidity indexPostoperative periodProsthetic dislocationArtery disease
2021
Comparison of Design, Eligibility, and Outcomes of Neuroendocrine Neoplasm Trials Initiated From 2000 to 2009 vs 2010 to 2020
Das S, Du L, Lee CL, Arhin ND, Chan JA, Kohn EC, Halperin DM, Berlin J, LaFerriere H, Singh S, Kunz PL, Dasari A. Comparison of Design, Eligibility, and Outcomes of Neuroendocrine Neoplasm Trials Initiated From 2000 to 2009 vs 2010 to 2020. JAMA Network Open 2021, 4: e2131744. PMID: 34705010, PMCID: PMC8552059, DOI: 10.1001/jamanetworkopen.2021.31744.Peer-Reviewed Original ResearchConceptsNeuroendocrine neoplasmsClinical trialsNational Cancer Institute Clinical TrialsEU Clinical Trials RegisterCoprimary end pointsObjective response rateProgression-free survivalClinical Trials RegisterKi-67 indexAllied Health LiteratureQuality improvement studyPhase IISpecific disease populationsWeb of ScienceDrug licensureTrials RegisterCochrane DatabaseTumor differentiationNovel agentsDisease populationInclusion criteriaMAIN OUTCOMECumulative IndexEnrollment periodResponse rateThe clinical spectrum of SARS-CoV-2 infection in Gaucher disease: Effect of both a pandemic and a rare disease that disrupts the immune system
Narayanan P, Nair S, Balwani M, Malinis M, Mistry P. The clinical spectrum of SARS-CoV-2 infection in Gaucher disease: Effect of both a pandemic and a rare disease that disrupts the immune system. Molecular Genetics And Metabolism 2021, 135: 115-121. PMID: 34412940, PMCID: PMC8361210, DOI: 10.1016/j.ymgme.2021.08.004.Peer-Reviewed Case Reports and Technical NotesConceptsSARS-CoV-2 infectionType 1 Gaucher diseaseSARS-CoV-2Gaucher diseaseRare diseaseCOVID-19Immune system dysfunctionRare disease populationMedian agePediatric patientsCase seriesFemale patientsAdverse outcomesClinical spectrumIntensive careGD patientsSystem dysfunctionRetrospective analysisDisease populationHigh riskGeneral populationPatientsImmune systemDiseaseSimilar frequencyUS Food and Drug Administration utilization of postmarketing requirements and postmarketing commitments, 2009–2018
Skydel JJ, Zhang AD, Dhruva SS, Ross JS, Wallach JD. US Food and Drug Administration utilization of postmarketing requirements and postmarketing commitments, 2009–2018. Clinical Trials 2021, 18: 488-499. PMID: 33863236, PMCID: PMC8292154, DOI: 10.1177/17407745211005044.Peer-Reviewed Original ResearchConceptsClinical studiesPostmarketing requirementsUS FoodDrug AdministrationNew therapeuticsClinical evidenceNew prospective cohort studyProspective cohort studyCross-sectional studyDrug Administration approvalCohort studyRetrospective studyUnapproved indicationsAdministration approvalClinical indicationsClinical trialsBACKGROUND/Median numberDisease populationTherapeutic safetyTherapeutic indicationsSecondary analysisNovel therapeuticsSmall molecule drugsOriginal approval
2020
Microsurgery in the sickle cell trait population: is it actually safe?
Abraham PF, Allam O, Park KE, Alperovich M. Microsurgery in the sickle cell trait population: is it actually safe? BMJ Case Reports 2020, 13: e234924. PMID: 32381529, PMCID: PMC7222880, DOI: 10.1136/bcr-2020-234924.Peer-Reviewed Original ResearchConceptsSickle cell traitCell traitSickle cell disease patientsSickle cell trait patientsPoor vascular flowPostoperative day 2Indocyanine green angiographySickle cell diseaseMicrovascular free flapsSickle cell disease populationVenous congestionDisease patientsGreen angiographyVenous anastomosisCell diseaseMicrovascular compromiseDisease populationFree flapPatent anastomosisDay 2Flap transferVascular flowArterial Doppler signalsPatientsOperating roomA potential association of an interferon gene signature with RBC alloimmunization in sickle cell disease
Madany E, Kadi N, Pandya S, Hendrickson J, Gibb D. A potential association of an interferon gene signature with RBC alloimmunization in sickle cell disease. The Journal Of Immunology 2020, 204: 145.18-145.18. DOI: 10.4049/jimmunol.204.supp.145.18.Peer-Reviewed Original ResearchSickle cell diseaseInterferon-stimulated genesRBC alloimmunizationMore alloantibodiesGene signatureSCD patientsCell diseaseFrequency of alloimmunizationChronic inflammatory stateInterferon gene signatureProduction of alloantibodiesMultiple interferon-stimulated genesType 1 interferonMyxovirus resistance protein 1Resistance protein 1Alloimmunization frequencyCompatible RBCsRBC transfusionInflammatory stateMxA expressionDisease populationTransfusion modelAlloimmunizationPatientsSiglec-1Microsurgery in the Sickle Cell Trait Population: Is It Actually Safe?
Alperovich M, Park E, Alperovich M, Allam O, Abraham P. Microsurgery in the Sickle Cell Trait Population: Is It Actually Safe? Surgical Case Reports 2020, 1-2. DOI: 10.31487/j.scr.2020.04.02.Peer-Reviewed Original ResearchDeep inferior epigastric perforatorSickle cell traitCell traitSickle cell disease patientsSickle cell trait patientsPoor vascular flowPostoperative day twoIndocyanine green angiographyInferior epigastric perforatorSickle cell diseaseMicrovascular free flapsSickle cell disease populationVenous congestionDisease patientsGreen angiographyVenous anastomosisMicrovascular compromiseCell diseaseDisease populationPatent anastomosisFree flapFlap transferVascular flowArterial Doppler signalsDay twoHigh Prevalence of Male Sexual Dysfunction in a Prospective Multicenter VA Inflammatory Bowel Disease Population
Gaidos J, Naik K, Dave J, Yao M, Hou J, Cipher D, Smith A, Feagins L. High Prevalence of Male Sexual Dysfunction in a Prospective Multicenter VA Inflammatory Bowel Disease Population. Crohn's & Colitis 360 2020, 2: otaa004. PMID: 36777954, PMCID: PMC9801960, DOI: 10.1093/crocol/otaa004.Peer-Reviewed Original ResearchQuality of lifePoor QOLInflammatory bowel diseaseSexual dysfunctionErectile dysfunctionInflammatory bowel disease populationMean age 50 yearsSevere erectile dysfunctionAge 50 yearsMale sexual dysfunctionIBD historySexual desireBiologic useBowel diseaseRisk factorsHigh prevalenceDisease populationMale veteransDysfunctionFunction surveyPrevalenceHypertensionDisease
2019
Atlas-Based Tongue Muscle Correlation Analysis From Tagged and High-Resolution Magnetic Resonance Imaging.
Xing F, Stone M, Goldsmith T, Prince J, El Fakhri G, Woo J. Atlas-Based Tongue Muscle Correlation Analysis From Tagged and High-Resolution Magnetic Resonance Imaging. Journal Of Speech Language And Hearing Research 2019, 62: 2258-2269. PMID: 31265364, PMCID: PMC6808360, DOI: 10.1044/2019_jslhr-s-18-0495.Peer-Reviewed Original ResearchConceptsInternal tongue musclesFloor of mouthMagnetic resonance imagingHigh-resolution magnetic resonance imagingMuscle pairsTongue musclesRehabilitation strategiesSpeech sound productionResonance imagingCoordination patternsSpeech motor controlMuscle locationDisease populationMotion of muscleMotor controlIntersubjective behaviorsManually labeled masksMuscleGlossectomy patientsExtrinsic tongue musclesControl subjectsBloc movementFunctional lossPatientsMotion patterns
2018
Mo1812 - Prevalence and Risk Factors for Male Sexual Dysfunction in a Prospective Multicenter Va Inflammatory Bowel Disease Population
Gaidos J, Herbst K, Dave J, Yao M, Hou J, Smith A, Feagins L. Mo1812 - Prevalence and Risk Factors for Male Sexual Dysfunction in a Prospective Multicenter Va Inflammatory Bowel Disease Population. Gastroenterology 2018, 154: s-811. DOI: 10.1016/s0016-5085(18)32776-8.Peer-Reviewed Original ResearchCaring for Life-Limiting Illness in Ethiopia: A Mixed-Methods Assessment of Outpatient Palliative Care Needs
Reid EA, Gudina EK, Ayers N, Tigineh W, Azmera YM. Caring for Life-Limiting Illness in Ethiopia: A Mixed-Methods Assessment of Outpatient Palliative Care Needs. Journal Of Palliative Medicine 2018, 21: 622-630. PMID: 29425055, DOI: 10.1089/jpm.2017.0419.Peer-Reviewed Original ResearchConceptsLife-limiting illnessPalliative care needsPalliative carePsychosocial distressCare needsSevere painOncology patientsUnmet palliative care needsCost of careMajority of subjectsHospital deathPain controlUntreated painOutpatient clinicOverall burdenDisease populationHigh-income countriesPainPatient's homePhysical symptomsDistress scoresIncurable diseaseMixed-methods assessmentIllnessSevere disability
2016
Delayed methimazole-induced agranulocytosis in a 6-year old patient with Graves’ disease
Puthenpura V, Desai K, Bauer A, Marshall I. Delayed methimazole-induced agranulocytosis in a 6-year old patient with Graves’ disease. International Journal Of Pediatric Endocrinology 2016, 2016: 16. PMID: 27605984, PMCID: PMC5013617, DOI: 10.1186/s13633-016-0034-6.Peer-Reviewed Original ResearchOlder patientsMMI therapySide effectsMethimazole-induced agranulocytosisMonths of treatmentRare side effectSerious side effectsDose-dependent mannerMethimazole therapyPediatric GravesCase presentationWeDisease populationUnusual casePatientsInconclusive dataTherapyAgranulocytosisDependent mannerTypical timelineMonthsGravesIncidenceConclusionsThisDiseaseCase series and literature review of skeletal tumors and their incidence in the Gaucher disease population
Murugesan V, Lischuk A, Haims A, Lackman R, Brooks JS, Mankin H, Mistry PK. Case series and literature review of skeletal tumors and their incidence in the Gaucher disease population. American Journal Of Hematology 2016, 91: 736-741. PMID: 27102845, DOI: 10.1002/ajh.24398.Peer-Reviewed Original Research
2013
Rare Nonconservative LRP6 Mutations Are Associated with Metabolic Syndrome
Singh R, Smith E, Fathzadeh M, Liu W, Go G, Subrahmanyan L, Faramarzi S, McKenna W, Mani A. Rare Nonconservative LRP6 Mutations Are Associated with Metabolic Syndrome. Human Mutation 2013, 34: 1221-1225. PMID: 23703864, PMCID: PMC3745535, DOI: 10.1002/humu.22360.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCase-Control StudiesCoronary DiseaseEuropeFemaleGenetic Predisposition to DiseaseGenetic VariationGlycosylationHumansLow Density Lipoprotein Receptor-Related Protein-6MaleMetabolic SyndromeMiddle AgedMutationPedigreePhylogenySequence AlignmentUnited StatesWnt ProteinsYoung AdultConceptsCoronary artery diseaseMetabolic syndromeLRP6 mutationFamilial coronary artery diseaseArtery diseaseDisease populationSyndromeConserved glycosylation siteNovel mutationsFunction mutationsPropeller domainRare mutationsEuropean controlsLRP6MutationsCritical roleMetabolic traitsWhite AmericansPrevalenceDisease
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