2024
Intravenous Thrombolysis in Patients With Cervical Artery Dissection
Shu L, Akpokiere F, Mandel D, Field T, Leon Guerrero C, Henninger N, Muppa J, Affan M, Haq Lodhi O, Heldner M, Antonenko K, Seiffge D, Arnold M, Salehi Omran S, Crandall R, Lester E, López-Mena D, Arauz A, Nehme A, Boulanger M, Touzé E, Sousa J, Sargento-Freitas J, Barata V, Castro-Chaves P, Brito M, Khan M, Mallick D, Rothstein A, Khazaal O, Kaufmann J, Engelter S, Traenka C, Aguiar de Sousa D, Soares M, Rosa S, Zhou L, Gandhi P, Mancini S, Metanis I, Leker R, Pan K, Dantu V, Baumgartner K, Burton T, Von Rennenberg R, Nolte C, Choi R, MacDonald J, Bavarsad Shahripour R, Guo X, Ghannam M, Almajali M, Samaniego E, Rioux B, Zine-Eddine F, Poppe A, Fonseca A, Baptista M, Cruz D, Romoli M, De Marco G, Longoni M, Keser Z, Griffin K, Kuohn L, Frontera J, Amar J, Giles J, Zedde M, Pascarella R, Grisendi I, Nzwalo H, Liebeskind D, Molaie A, Cavalier A, Kam W, Mac Grory B, Al Kasab S, Anadani M, Kicielinski K, Eltatawy A, Chervak L, Chulluncuy Rivas R, Aziz Y, Mistry E, Bakradze E, Tran T, Rodrigo-Gisbert M, Requena M, Saleh Velez F, Garcia J, Muddasani V, de Havenon A, Sanchez S, Vishnu V, Yaddanapudi S, Adams L, Browngoehl A, Ranasinghe T, Dunston R, Lynch Z, Penckofer M, Siegler J, Mayer S, Willey J, Zubair A, Cheng Y, Sharma R, Marto J, Krupka D, Klein P, Nguyen T, Asad S, Sarwat Z, Balabhadra A, Patel S, Secchi T, Martins S, Mantovani G, Kim Y, Krishnaiah B, Elangovan C, Lingam S, Qureshi A, Fridman S, Alvarado A, Khasiyev F, Linares G, Mannino M, Terruso V, Tountopoulou A, Tentolouris-Piperas V, Martinez-Marino M, Carrasco Wall V, Indraswari F, El Jamal S, Liu S, Zhou M, Alvi M, Ali F, Sarvath M, Morsi R, Kass-Hout T, Shi F, Zhang J, Sokhi D, Said J, Mongare N, Simpkins A, Gomez R, Sen S, Ghani M, Elnazeir M, Wangqin R, Xiao H, Kala N, Khan F, Stretz C, Mohammadzadeh N, Goldstein E, Furie K, Yaghi S. Intravenous Thrombolysis in Patients With Cervical Artery Dissection. Neurology 2024, 103: e209843. PMID: 39298709, PMCID: PMC11415265, DOI: 10.1212/wnl.0000000000209843.Peer-Reviewed Original ResearchConceptsAcute ischemic stroke symptomsCervical artery dissectionFunctional independenceIntravenous thrombolysisIschemic stroke symptomsStroke symptomsArtery dissectionIncidence of symptomatic intracranial hemorrhageIschemic strokeSymptomatic intracranial hemorrhageSuspected ischemic strokeClass III evidenceMedian ageSymptomatic ICHIntracranial hemorrhageSecondary analysisGuideline recommendationsICH riskIII evidenceFunctional outcomesPatientsThrombolysisCeADYoung adultsDissectionMobile stroke units: Beyond thrombolysis
Krothapalli N, Hasan D, Lusk J, Poli S, Hussain S, de Havenon A, Grotta J, Grory B. Mobile stroke units: Beyond thrombolysis. Journal Of The Neurological Sciences 2024, 463: 123123. PMID: 38981417, DOI: 10.1016/j.jns.2024.123123.Peer-Reviewed Original Research
2023
Priorities for Advancements in Neuroimaging in the Diagnostic Workup of Acute Stroke
Samaniego E, Boltze J, Lyden P, Hill M, Campbell B, Silva G, Sheth K, Fisher M, Hillis A, Nguyen T, Carone D, Favilla C, Deljkich E, Albers G, Heit J, Lansberg M, Aksoy D, Broderick J, Castonguay A, Ghosh S, Grotta J, Harston G, Houser G, Kuchenbecker K, Latour L, Liebeskind D, Kylan Lynch J, Maier C, Mistry E, Mocco J, Nogueira R, Saver J, van Vlimmeren M, Wakhloo A, Wechsler L. Priorities for Advancements in Neuroimaging in the Diagnostic Workup of Acute Stroke. Stroke 2023, 54: 3190-3201. PMID: 37942645, PMCID: PMC10841844, DOI: 10.1161/strokeaha.123.044985.Peer-Reviewed Original ResearchConceptsAcute strokeDiagnostic workupAcute ischemic stroke treatmentAcute ischemic strokeComprehensive stroke centerHigh-resolution vessel wallCerebral Infarction (TICI) scaleIschemic stroke treatmentMobile stroke unitIschemic strokeStroke centersStroke treatmentStroke unitReperfusion outcomesPatient outcomesEarly ischemiaCone beamStrokeVessel wallWorkupAcademic investigatorsOutcomesTomographyThrombolysisReperfusionTrends in Use of Intravenous Thrombolysis and Endovascular Thrombectomy in Patients With Acute Stroke With Large Vessel Occlusion 2016 to 2020 and Impact of COVID‐19 Pandemic
Khunte M, Chen H, Khunte A, Payabvash S, Gandhi D, Malhotra A. Trends in Use of Intravenous Thrombolysis and Endovascular Thrombectomy in Patients With Acute Stroke With Large Vessel Occlusion 2016 to 2020 and Impact of COVID‐19 Pandemic. Journal Of The American Heart Association 2023, 12: e029579. PMID: 37889182, PMCID: PMC10727381, DOI: 10.1161/jaha.122.029579.Peer-Reviewed Original ResearchBalloon rupture with eversion during innominate vein angioplasty requiring surgical retrieval
Ali S, Lee S, Strosberg D, Aboian E, Guzman R, Chaar C. Balloon rupture with eversion during innominate vein angioplasty requiring surgical retrieval. Journal Of Vascular Surgery Cases And Innovative Techniques 2023, 9: 101242. PMID: 37799841, PMCID: PMC10548437, DOI: 10.1016/j.jvscit.2023.101242.Peer-Reviewed Original ResearchSuction thrombectomy of catheter-associated right atrial thrombus in two patients
Deshmukh A, Cornman-Homonoff J. Suction thrombectomy of catheter-associated right atrial thrombus in two patients. The Journal Of Vascular Access 2023, 25: 1020-1022. PMID: 36971395, DOI: 10.1177/11297298231162879.Peer-Reviewed Original ResearchRight atrial thrombusSuction thrombectomyAtrial thrombusLife-threatening conditionInstitutional review boardSystemic anticoagulationOpen surgeryComplete resolutionInfected thrombusLabel useThrombectomyThrombusReview boardTreatment rangePatientsAnticoagulationThrombolysisSurgeryCatheterUnique roleCRATSystemic Thrombolysis in Acute Pulmonary Embolism: Dose Considerations in Administration of Thrombolytics
Savarimuthu S, Singh I, Khosla A. Systemic Thrombolysis in Acute Pulmonary Embolism: Dose Considerations in Administration of Thrombolytics. 2023, 59-69. DOI: 10.1142/9781800612778_0005.Peer-Reviewed Original ResearchHigh-risk pulmonary embolismHalf-dose thrombolysisAcute pulmonary embolismPulmonary embolismMajor bleeding eventsAdministration of thrombolyticsBleeding eventsMajor bleedsSystemic thrombolysisRespiratory failureCardiopulmonary effectsHaemodynamic collapseClinical outcomesThrombolytic therapyCardiac arrestSelect populationThrombolysisEmbolismSubstantial riskLarge-scale studiesDose considerationsOutcomesRiskThrombolyticsTherapyClotTriever system for mechanical thrombectomy of deep vein thrombosis
Chan S, Gaupp F, Mojibian H. ClotTriever system for mechanical thrombectomy of deep vein thrombosis. Future Cardiology 2023, 19: 29-38. PMID: 36637020, DOI: 10.2217/fca-2022-0100.Peer-Reviewed Original ResearchConceptsDeep vein thrombosisClotTriever systemVein thrombosisMechanical thrombectomyCatheter-directed thrombolytic therapyCatheter-directed thrombolysisPercutaneous mechanical thrombectomyHigh bleeding riskPost-thrombotic syndromeCurrent treatment strategiesLong-term symptomsRemoval of clotsBleeding riskThrombolytic therapyImproved outcomesTreatment strategiesThrombectomy devicesUS FDAThrombosisThrombectomyClotsThrombolysisThrombusSyndromeTherapy
2022
Spoke‐Administered Thrombolysis Improves Large‐Vessel Occlusion Early Recanalization: The Real‐World Experience of a Large Academic Hub‐and‐Spoke Telestroke Network
Kraft A, Regenhardt R, Awad A, Rosenthal J, Dmytriw A, Vranic J, Bonkhoff A, Bretzner M, Hirsch J, Rabinov J, Stapleton C, Schwamm L, Singhal A, Rost N, Leslie‐Mazwi T, Patel A. Spoke‐Administered Thrombolysis Improves Large‐Vessel Occlusion Early Recanalization: The Real‐World Experience of a Large Academic Hub‐and‐Spoke Telestroke Network. Stroke Vascular And Interventional Neurology 2022, 3 PMID: 36816048, PMCID: PMC9936963, DOI: 10.1161/svin.122.000427.Peer-Reviewed Original ResearchIntravenous thrombolysisMechanical thrombectomyEarly recanalizationInterhospital transferLarge vessel occlusion strokeLack of efficacyReal-world analysisVessel imagingEligible patientsMedian ageOcclusion strokeRecent trialsStroke NetworkTelestroke networkInclusion criteriaPatientsIVT useReal-world experienceNIHSSThrombolysisRecanalizationHospitalLVOImagingER ratesIV tenecteplase: A non-inferior alternative to alteplase?
Zubair AS, Sheth KN. IV tenecteplase: A non-inferior alternative to alteplase? Med 2022, 3: 519-520. PMID: 35963230, DOI: 10.1016/j.medj.2022.07.006.Peer-Reviewed Original ResearchAcute ischemic stroke on anti-Xa inhibitors: Pharmacokinetics and outcomes
Basso C, Goldstein E, Dai X, Rana M, Shu L, Chen C, Sweeney J, Stretz C, Smith EE, Gurol ME, de Havenon A, Burton T, Fussell-Louie D, Furie K, Yaghi S. Acute ischemic stroke on anti-Xa inhibitors: Pharmacokinetics and outcomes. Journal Of Stroke And Cerebrovascular Diseases 2022, 31: 106612. PMID: 35863261, DOI: 10.1016/j.jstrokecerebrovasdis.2022.106612.Peer-Reviewed Original ResearchConceptsDOAC useAcute ischemic stroke patientsSingle-center retrospective studyAnti-Xa inhibitorsAnti-Xa levelsCenter retrospective studyAcute ischemic strokeIschemic stroke patientsEfficacy of thrombolysisRisk of mortalityDOAC therapyXa levelsIschemic strokeConsecutive patientsSuch patientsStroke patientsThrombolytic therapyAtrial fibrillationRetrospective studyPharmacokinetic correlatesDrug levelsPatientsThrombolysisDOACIngestion2022 Brief Practice Update on Intravenous Thrombolysis Before Thrombectomy in Patients With Large Vessel Occlusion Acute Ischemic Stroke: A Statement from Society of Vascular and Interventional Neurology Guidelines and Practice Standards (GAPS) Committee
Masoud H, de Havenon A, Castonguay A, Asif K, Nguyen T, Mehta B, Abdalkader M, Gutierrez S, Leslie‐Mazwi T, Mansour O, Ma A, Czap A, Kenmuir C, Sheth S, Novakovic‐White R, Nour M, Jadhav A, Janardhan V, Hassan A, Liebeskind D, Malik A, Zaidat O. 2022 Brief Practice Update on Intravenous Thrombolysis Before Thrombectomy in Patients With Large Vessel Occlusion Acute Ischemic Stroke: A Statement from Society of Vascular and Interventional Neurology Guidelines and Practice Standards (GAPS) Committee. Stroke Vascular And Interventional Neurology 2022, 2 DOI: 10.1161/svin.121.000276.Peer-Reviewed Original ResearchSociety of VascularAcute ischemic strokeLarge vessel occlusionIntravenous thrombolysisNeurology guidelinesPractice UpdateIschemic strokeMechanical thrombectomyVessel occlusionClinical trialsLarge vessel occlusion acute ischemic strokeEmergent large vessel occlusionIschemic stroke patientsRecent clinical trialsClass of recommendationRecent clinical dataClinical trial resultsLevel of evidenceClinical trial dataClinical decision makingStroke patientsCombination therapyClinical dataThrombolysisCurrent evidenceRight heart thrombi (RHT) and clot in transit with concomitant PE management: Approach and considerations
Khosla A, Mojibian H, Assi R, Tantawy H, Singh I, Pollak J. Right heart thrombi (RHT) and clot in transit with concomitant PE management: Approach and considerations. Pulmonary Circulation 2022, 12: e12080. PMID: 35514771, PMCID: PMC9063956, DOI: 10.1002/pul2.12080.Peer-Reviewed Original ResearchRight heart thrombusConcomitant pulmonary embolismPulmonary embolismHeart thrombusTreatment strategiesLimited clinical dataMultiple treatment strategiesMultiple medical specialtiesSystemic thrombolysisSurgical therapyExact incidenceRisk stratificationPoor outcomeUse of pointClinical dilemmaClinical dataTreatment considerationsPE managementCare ultrasoundMultiple specialtiesMedical specialtiesThrombusSpecialtiesAnticoagulationThrombolysisIn a hub-and-spoke network, spoke-administered thrombolysis reduces mechanical thrombectomy procedure time and number of passes
Kraft A, Awad A, Rosenthal J, Dmytriw A, Vranic J, Bonkhoff A, Bretzner M, Hirsch J, Rabinov J, Stapleton C, Schwamm L, Rost N, Leslie-Mazwi T, Patel A, Regenhardt R. In a hub-and-spoke network, spoke-administered thrombolysis reduces mechanical thrombectomy procedure time and number of passes. Interventional Neuroradiology 2022, 29: 315-320. PMID: 35317663, PMCID: PMC10369105, DOI: 10.1177/15910199221087498.Peer-Reviewed Original ResearchConceptsLarge vessel occlusion strokeIntravenous thrombolysisIVT-treated patientsMechanical thrombectomyProcedure timePuncture timeImproved reperfusionBaseline characteristicsTICI 2bIVT patientsOcclusion strokeOperative reportsProcedural characteristicsTelestroke networkPatientsReperfusionIncreased proportionThrombolysisTechnical difficultiesNIHSSThrombectomyHospitalStrokeMinPREDICTORS OF POOR OUTCOMES AMONG PATIENTS UNDERGOING CATHETER-DIRECTED THROMBOLYSIS FOR DEEP VEIN THROMBOSIS
Bhalla A, Ahmed Z, Mena-Hurtado C, Attaran R. PREDICTORS OF POOR OUTCOMES AMONG PATIENTS UNDERGOING CATHETER-DIRECTED THROMBOLYSIS FOR DEEP VEIN THROMBOSIS. Journal Of The American College Of Cardiology 2022, 79: 803. DOI: 10.1016/s0735-1097(22)01794-6.Peer-Reviewed Original Research
2021
Temporal Trends in Stroke Thrombolysis in the US by Race and Ethnicity, 2009-2018
Suolang D, Chen BJ, Wang NY, Gottesman RF, Faigle R. Temporal Trends in Stroke Thrombolysis in the US by Race and Ethnicity, 2009-2018. JAMA 2021, 326: 1741-1743. PMID: 34633406, PMCID: PMC8506301, DOI: 10.1001/jama.2021.12966.Peer-Reviewed Original ResearchEmergency Care of Patients with Acute Ischemic Stroke
Zubair AS, Sheth KN. Emergency Care of Patients with Acute Ischemic Stroke. Neurologic Clinics 2021, 39: 391-404. PMID: 33896525, DOI: 10.1016/j.ncl.2021.02.001.BooksConceptsAcute ischemic strokeIschemic strokeAcute ischemic stroke managementIschemic stroke managementLong-term disabilityEndovascular therapyStroke managementTreatment optionsLeading causePatient outcomesEmergency careGolden hourInitial evaluationMajor causeStrokeFirst hourPatientsCauseHoursThrombolysisMorbidityTherapyMortalityCare
2020
FlowTriever System for mechanical thromboembolectomy
Mojibian HR, Chow E, Pollak J. FlowTriever System for mechanical thromboembolectomy. Future Cardiology 2020, 17: 585-592. PMID: 33084387, DOI: 10.2217/fca-2020-0104.Peer-Reviewed Original ResearchConceptsCatheter-directed infusionFlowTriever SystemMechanical thromboembolectomyInari FlowTriever SystemAspiration thrombectomy deviceLytic therapyPulmonary embolismBenefits patientsThrombectomy devicesClinical usePatientsThromboembolectomyInfusionSubstantial numberThrombolysisContraindicationsEmbolismThrombolyticsTherapyInitial Stroke Evaluation
Amin H, Schindler J. Initial Stroke Evaluation. 2020, 5-9. DOI: 10.1007/978-3-030-52552-1_2.ChaptersStroke evaluationLarge vessel occlusionAcute stroke evaluationIntra-cerebral hemorrhageIntravenous thrombolysisStroke neurologistsEmergency departmentPhysical examinationVessel occlusionEmergency physiciansCT scanPatientsTimely assessmentSystematic evaluationThrombectomyThrombolysisHemorrhageNeurologistsEvaluationNursesPhysiciansOcclusionOutcomes with catheter‐directed thrombolysis compared with anticoagulation alone in patients with acute deep venous thrombosis
Abraham B, Sedhom R, Megaly M, Saad M, Elbadawi A, Elgendy IY, Omer M, Narayanan MA, Mena‐Hurtado C, Pershad A, Shamoun F, Lalonde T, Attallah A. Outcomes with catheter‐directed thrombolysis compared with anticoagulation alone in patients with acute deep venous thrombosis. Catheterization And Cardiovascular Interventions 2020, 97: e61-e70. PMID: 32936517, DOI: 10.1002/ccd.29226.Peer-Reviewed Original ResearchConceptsAcute deep venous thrombosisCatheter-directed thrombolysisDeep venous thrombosisVenous patencyPostthrombotic syndromeVenous thrombosisManagement of DVTMajor bleedingHospital stayMean followCDT groupBlood transfusionAnticoagulationHigher oddsHigh riskLower riskPatientsSystematic reviewPatencyThromboembolismThrombolysisThrombosisSyndromeHigh rateRisk
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