2025
B-cell infiltration distinguishes mucosal from skin patterns of rejection in facial vascularized composite allografts
Kauke-Navarro M, Crisler W, Younis N, Khetani R, Sadigh S, Teague J, Ho Sui S, Ko C, Zhan Q, Steuart S, Treister N, Pober J, Azzi J, Clark R, Pomahac B. B-cell infiltration distinguishes mucosal from skin patterns of rejection in facial vascularized composite allografts. American Journal Of Transplantation 2025, 25: 1193-1207. PMID: 39842779, DOI: 10.1016/j.ajt.2025.01.013.Peer-Reviewed Original ResearchFacial Vascularized Composite AllotransplantationPeripheral blood mononuclear cellsB cell infiltrationB cellsMucosal rejectionRejection monitoringFacial vascularized composite allograftT cell-mediated rejectionSigns of immune activationNon-rejection biopsiesGranzyme B expressionB cell populationsInnate-like B cellsBlood mononuclear cellsVascularized Composite AllograftsVascularized Composite AllotransplantationAcute rejectionOral mucosaT cellsPattern of rejectionImmune activationMucosal biopsiesPlasma cellsSkin biopsiesMononuclear cells
2024
Long-term posttransplant-related bone volumetric changes in eight face transplant recipients – A single-center retrospective case series
Huelsboemer L, Boroumand S, Boroumand T, Vafa A, Parikh N, Chiarella L, Knoedler L, Stögner V, Hung P, Sadigh S, Haykal S, Pomahac B, Kauke-Navarro M. Long-term posttransplant-related bone volumetric changes in eight face transplant recipients – A single-center retrospective case series. Journal Of Plastic Reconstructive & Aesthetic Surgery 2024, 101: 220-230. PMID: 39848075, DOI: 10.1016/j.bjps.2024.11.025.Peer-Reviewed Original ResearchFacial vascularized composite allograftBone volume changesBone volumeChronic rejection processRetrospective case seriesComputed tomography scanBone volume lossWilcoxon rank sum testNative boneSignificant median decreaseBone volume stabilityRank sum testFace transplant recipientsBone remodeling ratesVascularized Composite AllograftsChronic immunosuppressionTooth lossTransplant recipientsAllograft cohortCase seriesTomography scanVolume lossMedian decreaseMedical comorbiditiesHistopathological analysisLymphadenopathy and lymph node rejection following facial vascularized composite allotransplantation
Kauke-Navarro M, Sadigh S, Lee C, Panayi A, Knoedler L, Knoedler S, Stoegner V, Huelsboemer L, Jamil A, Ko C, Lian C, Murphy G, Pomahac B. Lymphadenopathy and lymph node rejection following facial vascularized composite allotransplantation. Journal Of Plastic Reconstructive & Aesthetic Surgery 2024, 91: 268-275. PMID: 38430863, DOI: 10.1016/j.bjps.2024.02.024.Peer-Reviewed Original ResearchLymph nodesVascularized Composite AllograftsGranzyme BDonor-derived immune cellsFacial vascularized composite allograftMedian time of presentationFacial Vascularized Composite AllotransplantationImmunological processesGranzyme B expressionCytotoxic T cellsNecrotizing histiocytic lymphadenitisHead and neckRetrospective cohort studyTime of presentationStages of follow-upCoexistence of donorFace transplant patientsBilateral adenopathyIncreased histiocytesSuperficial lymph nodesVascularized Composite AllotransplantationBilateral lymphadenopathyAllograft rejectionTransplant patientsDendritic cells
2023
Insights from immunoproteomic profiling of a rejected full-face transplant
Lee C, Wang D, Kauke-Navarro M, Russell-Goldman E, Xu S, Mucciarone K, Sohrabi S, Lian C, Pomahac B, Murphy G. Insights from immunoproteomic profiling of a rejected full-face transplant. American Journal Of Transplantation 2023, 23: 1058-1061. PMID: 37037378, DOI: 10.1016/j.ajt.2023.04.008.Peer-Reviewed Original ResearchConceptsVascularized Composite AllograftsT cellsChronic rejectionCD8-positive T cellsEffector T cellsFull face transplantArteriosclerotic alterationsIntragraft arteriesVCA rejectionGraft arteryAccelerated arteriosclerosisRecipient originPunch biopsyAtherogenic responseComposite allograftsImmunoproteomic profilingDioxygenase 1Target endotheliumArteryEndotheliumProteomic profilingPathway componentsCellsRejectionAllografts
2018
Living Donation of Vascularized Composite Allografts
Pomahac B, Alhefzi M, Bueno E, McDiarmid S, Levin L. Living Donation of Vascularized Composite Allografts. Plastic & Reconstructive Surgery 2018, 142: 405e-411e. PMID: 29927830, DOI: 10.1097/prs.0000000000004659.Peer-Reviewed Original ResearchConceptsComposite allotransplantationComposite allograftsOrgan procurementSolid organ transplantationVascularized Composite AllograftsKidney transplant communityCurrent guidelinesOrgan transplantationTransplant communityTransplantation SocietyClinical scenariosReconstructive strategiesAesthetic outcomeTransplantation NetworkReconstructive ladderReconstructive surgeonTransplant medicineOrgan donationAllotransplantationMedicaid ServicesEthics CommitteeAllograftsDonationSpecific recommendationsExtensive type
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