2014
Polarized Granzyme Release Is Required for Antigen-Driven Transendothelial Migration of Human Effector Memory CD4 T Cells
Manes TD, Pober JS. Polarized Granzyme Release Is Required for Antigen-Driven Transendothelial Migration of Human Effector Memory CD4 T Cells. The Journal Of Immunology 2014, 193: 5809-5815. PMID: 25367116, PMCID: PMC4258477, DOI: 10.4049/jimmunol.1401665.Peer-Reviewed Original ResearchConceptsEffector memory CD4 T cellsMemory CD4 T cellsCD4 T cellsT cellsTransendothelial migrationImmune synapse formationEndothelial cell monolayersInflammatory chemokinesMorphologic manifestationsGranzyme releaseSynapse formationTCR recognitionGranule dischargeDynein-driven transportChemokinesCell monolayersEarly eventsEndotheliumCytosolic granulesCellsMTOC reorientationProteolytic activityMicrotubule organizing centerMolecular requirementsGranule function
1993
Molecular requirements for the cell-surface expression of multisubunit ion-transporting ATPases. Identification of protein domains that participate in Na,K-ATPase and H,K-ATPase subunit assembly
Gottardi CJ, Caplan MJ. Molecular requirements for the cell-surface expression of multisubunit ion-transporting ATPases. Identification of protein domains that participate in Na,K-ATPase and H,K-ATPase subunit assembly. Journal Of Biological Chemistry 1993, 268: 14342-14347. PMID: 8390991, DOI: 10.1016/s0021-9258(19)85246-8.Peer-Reviewed Original ResearchConceptsK-ATPase alpha subunitK-ATPase beta subunitAlpha subunitBeta subunitCell surface expressionTerminal halfK-ATPaseCell surface deliveryEfficient cell surface expressionK-ATPase alphaNH2-terminal halfCOS-1 cellsIon-transporting ATPasesProtein domainsK-ATPase enzymeSubunit assemblySurface deliveryIntracellular vesiclesSubunit chimerasIndividual subunitsActive enzymeMolecular requirementsSubunitsCell surfaceBeta protein
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