2025
Ni/Ti Dual Catalyzed Cross-Electrophile Coupling between Unactivated Alkyl Chlorides and Aryl Halides
Oniani D, Jia X, Mane E, Charboneau D, Chow J, Hazari N, Huang H, Lee M, Mercado B, Uehling M, Wedal J. Ni/Ti Dual Catalyzed Cross-Electrophile Coupling between Unactivated Alkyl Chlorides and Aryl Halides. ACS Catalysis 2025, 15: 11726-11738. DOI: 10.1021/acscatal.5c01995.Peer-Reviewed Original ResearchCross-electrophile couplingUnactivated alkyl chloridesAlkyl chloridesAryl halidesTi catalystAlkyl radicalsTertiary alkyl chloridesSecondary alkyl chloridesStoichiometric experimentsReactive catalystCatalytic cycleNi catalystsCatalystSubstrate classesHalidesArylRare exampleRate of radical productionMechanistic studiesAlkylationChlorideRadicalsInert substrateIntermediateReactionExploring the complexity of MECP2 function in Rett syndrome
Liu Y, Whitfield T, Bell G, Guo R, Flamier A, Young R, Jaenisch R. Exploring the complexity of MECP2 function in Rett syndrome. Nature Reviews Neuroscience 2025, 26: 379-398. PMID: 40360671, DOI: 10.1038/s41583-025-00926-1.Peer-Reviewed Original ResearchConceptsMethylated DNA binding protein MeCP2Neuronal gene regulationReview recent insightsChromatin structureTranscriptional regulationGene regulationInteraction hubProtein MeCP2Cofactor interactionsTranscription factorsEpigenetic regulationRett syndromeProteomic studiesDiverse processesMolecular mechanismsMeCP2 functionTherapeutic designMeCP2Neuronal functionRegulationModel systemNeurodevelopmental disordersRepressorChromatinMechanistic studies
2024
C–H Activation and Sequential Addition to Dienes and Imines: Synthesis of Amines with β‑Quaternary Centers and Mechanistic Studies on the Complex Interplay Between the Catalyst and Three Reactants
Goodner R, Brandes D, Morais G, Tao Q, Tassone J, Mercado B, Chen S, Ellman J. C–H Activation and Sequential Addition to Dienes and Imines: Synthesis of Amines with β‑Quaternary Centers and Mechanistic Studies on the Complex Interplay Between the Catalyst and Three Reactants. ACS Catalysis 2024, 14: 18124-18133. PMID: 39744644, PMCID: PMC11687383, DOI: 10.1021/acscatal.4c05866.Peer-Reviewed Original ResearchRhodacycle intermediateCatalytic cycleX-ray structure analysisDensity functional theory calculationsC-H activationDeuterium labeling studiesSynthesis of aminesTransition state structuresFunctional theory calculationsFormaldimine precursorsEthyl glyoxylateHigh diastereoselectivityN-CbzNitrogen substituentQuaternary centerAlkyl substituentsAlkyl sulfonamidesC-HTheory calculationsRhodacycleState structuresCarbon sitesDienesX-rayMechanistic studiesCatalyst–Substrate Pairings for Carbocyclic and Heterocyclic Systems in Atroposelective Quinazolinone Synthesis
Guo M, Miller S. Catalyst–Substrate Pairings for Carbocyclic and Heterocyclic Systems in Atroposelective Quinazolinone Synthesis. ACS Catalysis 2024, 14: 17226-17232. PMID: 39912118, PMCID: PMC11793914, DOI: 10.1021/acscatal.4c05014.Peer-Reviewed Original ResearchChiral phosphoric acidPositive nonlinear effectNon-covalent interactionsQuinazolinone synthesisHeterocyclic systemsCatalyst scaffoldHigh enantioselectivityNitrogen heteroatomsEnantiomeric ratioCatalystReaction developmentCatalytic scaffoldMechanistic studiesEnantioselectivityPhosphoric acidSubstrateCarbocyclesCyclocondensationHeterocyclesHeteroatomsScaffoldsReactionSynthesisReactivityYieldEndothelial γ-protocadherins inhibit KLF2 and KLF4 to promote atherosclerosis
Joshi D, Coon B, Chakraborty R, Deng H, Yang Z, Babar M, Fernandez-Tussy P, Meredith E, Attanasio J, Joshi N, Traylor J, Orr A, Fernandez-Hernando C, Libreros S, Schwartz M. Endothelial γ-protocadherins inhibit KLF2 and KLF4 to promote atherosclerosis. Nature Cardiovascular Research 2024, 3: 1035-1048. PMID: 39232138, PMCID: PMC11399086, DOI: 10.1038/s44161-024-00522-z.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAtherosclerosisCadherin Related ProteinsCadherinsDisease Models, AnimalEndothelial CellsHuman Umbilical Vein Endothelial CellsHumansKruppel-Like Factor 4Kruppel-Like Transcription FactorsMaleMiceMice, Inbred C57BLMice, KnockoutPlaque, AtheroscleroticReceptors, NotchSignal TransductionConceptsAtherosclerotic cardiovascular diseaseIntracellular domainNotch intracellular domainTranscription factor KLF2Mechanisms of vascular inflammationAnti-inflammatory programVascular endothelial cellsHost defenseCleavage resultsAntibody blockadeGenetic deletionVascular inflammationViral infectionImmune systemEndothelial cellsCardiovascular diseasePromote atherosclerosisBlood flowKLF2KLF4Suppressive signalsEndotheliumMechanistic studiesCorrection to “Design, Synthesis, and Mechanistic Studies of (R)‑3-Amino-5,5-difluorocyclohex-1-ene-1-carboxylic Acid as an Inactivator of Human Ornithine Aminotransferase”
Devitt A, Vargas A, Zhu W, Des Soye B, Butun F, Alt T, Kaley N, Ferreira G, Moran G, Kelleher N, Liu D, Silverman R. Correction to “Design, Synthesis, and Mechanistic Studies of (R)‑3-Amino-5,5-difluorocyclohex-1-ene-1-carboxylic Acid as an Inactivator of Human Ornithine Aminotransferase”. ACS Chemical Biology 2024, 19: 1850-1850. PMID: 39023367, DOI: 10.1021/acschembio.4c00478.Peer-Reviewed Original ResearchMechanistic studiesHuman ornithine aminotransferaseDesign, Synthesis, and Mechanistic Studies of (R)‑3-Amino-5,5-difluorocyclohex-1-ene-1-carboxylic Acid as an Inactivator of Human Ornithine Aminotransferase
Devitt A, Vargas A, Zhu W, Soye B, Butun F, Alt T, Kaley N, Ferreira G, Moran G, Kelleher N, Liu D, Silverman R. Design, Synthesis, and Mechanistic Studies of (R)‑3-Amino-5,5-difluorocyclohex-1-ene-1-carboxylic Acid as an Inactivator of Human Ornithine Aminotransferase. ACS Chemical Biology 2024, 19: 1066-1081. PMID: 38630468, PMCID: PMC11274680, DOI: 10.1021/acschembio.4c00022.Peer-Reviewed Original ResearchConceptsActive siteX-ray crystallographyIntact protein mass spectrometryHuman ornithine aminotransferaseNucleophilic additionRing scaffoldMass spectrometryIntermediate speciesProtein mass spectrometryIncreased selectivityTransient state kinetic studiesX-rayMechanistic studiesAdductsSolvent accessibilityKinetic studiesHepatocellular carcinomaProgression of hepatocellular carcinomaMechanism of inactivationStructural evidencePrevalence of hepatocellular carcinomaTreatment of hepatocellular carcinomaCyclohexeneCyclopenteneCrystallographyEnantioselective Sulfonimidamide Acylation via a Cinchona Alkaloid-Catalyzed Desymmetrization: Scope, Data Science, and Mechanistic Investigation
Haas B, Lim N, Jermaks J, Gaster E, Guo M, Malig T, Werth J, Zhang H, Toste F, Gosselin F, Miller S, Sigman M. Enantioselective Sulfonimidamide Acylation via a Cinchona Alkaloid-Catalyzed Desymmetrization: Scope, Data Science, and Mechanistic Investigation. Journal Of The American Chemical Society 2024, 146: 8536-8546. PMID: 38480482, PMCID: PMC10990064, DOI: 10.1021/jacs.4c00374.Peer-Reviewed Original ResearchConceptsDensity functional theoryStructure-activity relationshipBis-acylationExcellent yieldsAsymmetric acylationTetrahedral intermediateSynthetic chemistryFunctional theoryMechanistic investigationsReaction kineticsMechanistic studiesSulfonimidamidesDesymmetrizationEnantioselectivityStructural studiesCatalystAcylPharmacophoreCinchonaIntermediateReactionChemistryKineticsYield
2023
Synthesis of N‐Acylsulfenamides from (Hetero)Aryl Iodides and Boronic Acids by One‐Pot Sulfur‐Arylation and Dealkylation
Greenwood N, Cerny N, Deziel A, Ellman J. Synthesis of N‐Acylsulfenamides from (Hetero)Aryl Iodides and Boronic Acids by One‐Pot Sulfur‐Arylation and Dealkylation. Angewandte Chemie International Edition 2023, 63: e202315701. PMID: 38015869, PMCID: PMC10813656, DOI: 10.1002/anie.202315701.Peer-Reviewed Original ResearchS bond formationOne-pot approachBoronic acidsBond formationComplex bioactive compoundsComplex precursorSulfur functionalizationDiverse electrophilesSulfur groupsReaction conditionsDrug apixabanDrug precursorsS-substituentsThermal eliminationReaction inputConcerted eliminationMechanistic studiesBioactive compoundsSynthesisIodideBroad scopePrecursorsFunctionalizationCatalystAcidSynthesis of N‐Acylsulfenamides from (Hetero)Aryl Iodides and Boronic Acids by One‐Pot Sulfur‐Arylation and Dealkylation
Greenwood N, Cerny N, Deziel A, Ellman J. Synthesis of N‐Acylsulfenamides from (Hetero)Aryl Iodides and Boronic Acids by One‐Pot Sulfur‐Arylation and Dealkylation. Angewandte Chemie 2023, 136 DOI: 10.1002/ange.202315701.Peer-Reviewed Original ResearchOne-pot approachBoronic acidsBond formationComplex bioactive compoundsComplex precursorSulfur functionalizationDiverse electrophilesSulfur groupsReaction conditionsDrug apixabanDrug precursorsS-substituentsThermal eliminationReaction inputConcerted eliminationMechanistic studiesBioactive compoundsSynthesisIodideBroad scopePrecursorsFunctionalizationCatalystAcidStyreneElectrocatalytic, Homogeneous Ammonia Oxidation in Water to Nitrate and Nitrite with a Copper Complex
Liu H, Lant H, Troiano J, Hu G, Mercado B, Crabtree R, Brudvig G. Electrocatalytic, Homogeneous Ammonia Oxidation in Water to Nitrate and Nitrite with a Copper Complex. ECS Meeting Abstracts 2023, MA2023-01: 2691-2691. DOI: 10.1149/ma2023-01552691mtgabs.Peer-Reviewed Original ResearchWater oxidationAmmonia oxidationO bond formationInitial mechanistic studiesMolecular catalystsCopper complexesMetal electrocatalystsFaradaic efficiencyAqueous mediaBond formationHigh selectivityOxidation processN2 productTitle reactionOxidationMechanistic studiesCatalysisComplexesRoom temperatureFriendly productionWaterElectrocatalystsElectrocatalyticNitrateCatalyst
2022
Mitochondrial dysfunction induces ALK5-SMAD2-mediated hypovascularization and arteriovenous malformations in mouse retinas
Zhang H, Li B, Huang Q, López-Giráldez F, Tanaka Y, Lin Q, Mehta S, Wang G, Graham M, Liu X, Park I, Eichmann A, Min W, Zhou J. Mitochondrial dysfunction induces ALK5-SMAD2-mediated hypovascularization and arteriovenous malformations in mouse retinas. Nature Communications 2022, 13: 7637. PMID: 36496409, PMCID: PMC9741628, DOI: 10.1038/s41467-022-35262-w.Peer-Reviewed Original ResearchConceptsMitochondrial dysfunctionThioredoxin 2Single-cell RNA-seq analysisRNA-seq analysisMutant miceNuclear genesMitochondrial proteinsMitochondrial localizationHuman retinal diseasesTranscriptional factorsGene expressionMutant retinasMitochondrial activityExtracellular matrixNovel mechanismVascular maturationArteriovenous malformationsGenetic deficiencyVessel growthSmad2Mouse retinaVascular malformationsMechanistic studiesBasement membraneRetinal vascular malformationsImine Directed Cp*RhIII‐Catalyzed N−H Functionalization and Annulation with Amino Amides, Aldehydes, and Diazo Compounds
Zoll A, Molas J, Mercado B, Ellman J. Imine Directed Cp*RhIII‐Catalyzed N−H Functionalization and Annulation with Amino Amides, Aldehydes, and Diazo Compounds. Angewandte Chemie International Edition 2022, 62: e202210822. PMID: 36331194, PMCID: PMC9805510, DOI: 10.1002/anie.202210822.Peer-Reviewed Original ResearchConceptsDiazo compoundsH functionalizationAmino amidesX-ray crystallographic characterizationFive-membered rhodacycleAmino acid side chainsAcid side chainsRange of functionalitiesCrystallographic characterizationAlkyl aldehydesSide chainsEfficient reactantsFunctionalizationMinimal racemizationFirst exampleMechanistic studiesIminesAldehydesAnnulationEfficient transformationAmidesCompoundsCatalyzedPiperazinonesRhodacycleImine Directed Cp*RhIII‐Catalyzed N−H Functionalization and Annulation with Amino Amides, Aldehydes, and Diazo Compounds
Zoll A, Molas J, Mercado B, Ellman J. Imine Directed Cp*RhIII‐Catalyzed N−H Functionalization and Annulation with Amino Amides, Aldehydes, and Diazo Compounds. Angewandte Chemie 2022, 135 DOI: 10.1002/ange.202210822.Peer-Reviewed Original ResearchDiazo compoundsAmino amidesX-ray crystallographic characterizationFive-membered rhodacycleAmino acid side chainsAcid side chainsRange of functionalitiesCrystallographic characterizationAlkyl aldehydesSide chainsEfficient reactantsFunctionalizationMinimal racemizationFirst exampleMechanistic studiesIminesAldehydesAnnulationAmidesEfficient transformationCompoundsCatalyzedPiperazinonesRhodacycleReactantsVisible Light-Mediated, Diastereoselective Epimerization of Morpholines and Piperazines to More Stable Isomers
Shen Z, Vargas-Rivera M, Rigby E, Chen S, Ellman J. Visible Light-Mediated, Diastereoselective Epimerization of Morpholines and Piperazines to More Stable Isomers. ACS Catalysis 2022, 12: 12860-12868. PMID: 36406894, PMCID: PMC9668057, DOI: 10.1021/acscatal.2c03672.Peer-Reviewed Original ResearchHydrogen atom transferReversible hydrogen atom transferDensity functional theory calculationsDeuterium-labelling reactionFunctional theory calculationsFunctional group compatibilityHAT mechanismAtom transferStereoselective epimerizationHAT pathwayNitrogen heterocyclesLuminescence quenchingStable isomerDiastereomer pairsTheory calculationsGroup compatibilityVisible lightStable stereoisomersStereochemical configurationSubstitution patternLabeling reactionRelative energiesMorpholineEpimerizationMechanistic studiesNeighboring mutation‐mediated enhancement of dengue virus infectivity and spread
Chen L, Zhang X, Guo X, Peng W, Zhu Y, Wang Z, Yu X, Shi H, Li Y, Zhang L, Wang L, Wang P, Cheng G. Neighboring mutation‐mediated enhancement of dengue virus infectivity and spread. EMBO Reports 2022, 23: embr202255671. PMID: 36197120, PMCID: PMC9638853, DOI: 10.15252/embr.202255671.Peer-Reviewed Original ResearchUVB-mediated DNA damage induces matrix metalloproteinases to promote photoaging in an AhR- and SP1-dependent manner
Kim DJ, Iwasaki A, Chien AL, Kang S. UVB-mediated DNA damage induces matrix metalloproteinases to promote photoaging in an AhR- and SP1-dependent manner. JCI Insight 2022, 7: e156344. PMID: 35316219, PMCID: PMC9090247, DOI: 10.1172/jci.insight.156344.Peer-Reviewed Original ResearchConceptsSpecificity protein 1DNA damageSp1-dependent mannerProtein 1Activator protein-1HaCaT human immortalized keratinocytesExtracellular matrix componentsTranscription factorsAryl hydrocarbon receptorHuman immortalized keratinocytesMatrix componentsHydrocarbon receptorPotential targetImmortalized keratinocytesROSSun-exposed skinType IV collagenMMP2 expressionAhRMatrix metalloproteinasesMechanistic studiesMMP2IV collagenTopical treatmentMMP-1Mapping genomic loci implicates genes and synaptic biology in schizophrenia
Trubetskoy V, Pardiñas A, Qi T, Panagiotaropoulou G, Awasthi S, Bigdeli T, Bryois J, Chen C, Dennison C, Hall L, Lam M, Watanabe K, Frei O, Ge T, Harwood J, Koopmans F, Magnusson S, Richards A, Sidorenko J, Wu Y, Zeng J, Grove J, Kim M, Li Z, Voloudakis G, Zhang W, Adams M, Agartz I, Atkinson E, Agerbo E, Al Eissa M, Albus M, Alexander M, Alizadeh B, Alptekin K, Als T, Amin F, Arolt V, Arrojo M, Athanasiu L, Azevedo M, Bacanu S, Bass N, Begemann M, Belliveau R, Bene J, Benyamin B, Bergen S, Blasi G, Bobes J, Bonassi S, Braun A, Bressan R, Bromet E, Bruggeman R, Buckley P, Buckner R, Bybjerg-Grauholm J, Cahn W, Cairns M, Calkins M, Carr V, Castle D, Catts S, Chambert K, Chan R, Chaumette B, Cheng W, Cheung E, Chong S, Cohen D, Consoli A, Cordeiro Q, Costas J, Curtis C, Davidson M, Davis K, de Haan L, Degenhardt F, DeLisi L, Demontis D, Dickerson F, Dikeos D, Dinan T, Djurovic S, Duan J, Ducci G, Dudbridge F, Eriksson J, Fañanás L, Faraone S, Fiorentino A, Forstner A, Frank J, Freimer N, Fromer M, Frustaci A, Gadelha A, Genovese G, Gershon E, Giannitelli M, Giegling I, Giusti-Rodríguez P, Godard S, Goldstein J, González Peñas J, González-Pinto A, Gopal S, Gratten J, Green M, Greenwood T, Guillin O, Gülöksüz S, Gur R, Gur R, Gutiérrez B, Hahn E, Hakonarson H, Haroutunian V, Hartmann A, Harvey C, Hayward C, Henskens F, Herms S, Hoffmann P, Howrigan D, Ikeda M, Iyegbe C, Joa I, Julià A, Kähler A, Kam-Thong T, Kamatani Y, Karachanak-Yankova S, Kebir O, Keller M, Kelly B, Khrunin A, Kim S, Klovins J, Kondratiev N, Konte B, Kraft J, Kubo M, Kučinskas V, Kučinskiene Z, Kusumawardhani A, Kuzelova-Ptackova H, Landi S, Lazzeroni L, Lee P, Legge S, Lehrer D, Lencer R, Lerer B, Li M, Lieberman J, Light G, Limborska S, Liu C, Lönnqvist J, Loughland C, Lubinski J, Luykx J, Lynham A, Macek M, Mackinnon A, Magnusson P, Maher B, Maier W, Malaspina D, Mallet J, Marder S, Marsal S, Martin A, Martorell L, Mattheisen M, McCarley R, McDonald C, McGrath J, Medeiros H, Meier S, Melegh B, Melle I, Mesholam-Gately R, Metspalu A, Michie P, Milani L, Milanova V, Mitjans M, Molden E, Molina E, Molto M, Mondelli V, Moreno C, Morley C, Muntané G, Murphy K, Myin-Germeys I, Nenadić I, Nestadt G, Nikitina-Zake L, Noto C, Nuechterlein K, O’Brien N, O’Neill F, Oh S, Olincy A, Ota V, Pantelis C, Papadimitriou G, Parellada M, Paunio T, Pellegrino R, Periyasamy S, Perkins D, Pfuhlmann B, Pietiläinen O, Pimm J, Porteous D, Powell J, Quattrone D, Quested D, Radant A, Rampino A, Rapaport M, Rautanen A, Reichenberg A, Roe C, Roffman J, Roth J, Rothermundt M, Rutten B, Saker-Delye S, Salomaa V, Sanjuan J, Santoro M, Savitz A, Schall U, Scott R, Seidman L, Sharp S, Shi J, Siever L, Sigurdsson E, Sim K, Skarabis N, Slominsky P, So H, Sobell J, Söderman E, Stain H, Steen N, Steixner-Kumar A, Stögmann E, Stone W, Straub R, Streit F, Strengman E, Stroup T, Subramaniam M, Sugar C, Suvisaari J, Svrakic D, Swerdlow N, Szatkiewicz J, Ta T, Takahashi A, Terao C, Thibaut F, Toncheva D, Tooney P, Torretta S, Tosato S, Tura G, Turetsky B, Üçok A, Vaaler A, van Amelsvoort T, van Winkel R, Veijola J, Waddington J, Walter H, Waterreus A, Webb B, Weiser M, Williams N, Witt S, Wormley B, Wu J, Xu Z, Yolken R, Zai C, Zhou W, Zhu F, Zimprich F, Atbaşoğlu E, Ayub M, Benner C, Bertolino A, Black D, Bray N, Breen G, Buccola N, Byerley W, Chen W, Cloninger C, Crespo-Facorro B, Donohoe G, Freedman R, Galletly C, Gandal M, Gennarelli M, Hougaard D, Hwu H, Jablensky A, McCarroll S, Moran J, Mors O, Mortensen P, Müller-Myhsok B, Neil A, Nordentoft M, Pato M, Petryshen T, Pirinen M, Pulver A, Schulze T, Silverman J, Smoller J, Stahl E, Tsuang D, Vilella E, Wang S, Xu S, Adolfsson R, Arango C, Baune B, Belangero S, Børglum A, Braff D, Bramon E, Buxbaum J, Campion D, Cervilla J, Cichon S, Collier D, Corvin A, Curtis D, Forti M, Domenici E, Ehrenreich H, Escott-Price V, Esko T, Fanous A, Gareeva A, Gawlik M, Gejman P, Gill M, Glatt S, Golimbet V, Hong K, Hultman C, Hyman S, Iwata N, Jönsson E, Kahn R, Kennedy J, Khusnutdinova E, Kirov G, Knowles J, Krebs M, Laurent-Levinson C, Lee J, Lencz T, Levinson D, Li Q, Liu J, Malhotra A, Malhotra D, McIntosh A, McQuillin A, Menezes P, Morgan V, Morris D, Mowry B, Murray R, Nimgaonkar V, Nöthen M, Ophoff R, Paciga S, Palotie A, Pato C, Qin S, Rietschel M, Riley B, Rivera M, Rujescu D, Saka M, Sanders A, Schwab S, Serretti A, Sham P, Shi Y, St Clair D, Stefánsson H, Stefansson K, Tsuang M, van Os J, Vawter M, Weinberger D, Werge T, Wildenauer D, Yu X, Yue W, Holmans P, Pocklington A, Roussos P, Vassos E, Verhage M, Visscher P, Yang J, Posthuma D, Andreassen O, Kendler K, Owen M, Wray N, Daly M, Huang H, Neale B, Sullivan P, Ripke S, Walters J, O’Donovan M. Mapping genomic loci implicates genes and synaptic biology in schizophrenia. Nature 2022, 604: 502-508. PMID: 35396580, PMCID: PMC9392466, DOI: 10.1038/s41586-022-04434-5.Peer-Reviewed Original ResearchConceptsGenomic lociTwo-stage genome-wide association studyVariant associationsDistinct genomic lociGenome-wide association studiesTranscription factor Sp4Functional genomics dataCommon variant associationsRare variant associationsCommon risk allelesSynaptic biologyGenomic dataBiological processesAssociation studiesGenesCell typesNeurodevelopmental disordersRegion variationLociFundamental processesNeuronal functionSuch variantsRisk allelesMechanistic studiesVariantsSystematic identification of biomarker-driven drug combinations to overcome resistance
Rees M, Brenan L, do Carmo M, Duggan P, Bajrami B, Arciprete M, Boghossian A, Vaimberg E, Ferrara S, Lewis T, Rosenberg D, Sangpo T, Roth J, Kaushik V, Piccioni F, Doench J, Root D, Johannessen C. Systematic identification of biomarker-driven drug combinations to overcome resistance. Nature Chemical Biology 2022, 18: 615-624. PMID: 35332332, DOI: 10.1038/s41589-022-00996-7.Peer-Reviewed Original ResearchConceptsSmall molecule responsesCell linesGSK-J4Gene expression featuresMonoacylglycerol lipaseGene knockoutSerine hydrolaseCancer cell linesSystematic identificationCell viability profileInsensitive cell linesNovel relationshipSmall moleculesMechanism of actionEnzymatic modificationSpecific mechanismsViability profileIntrinsic resistanceVariable responseMechanistic studiesRational candidatesMechanism
2021
Metabolism of cancer cells commonly responds to irradiation by a transient early mitochondrial shutdown
Krysztofiak A, Szymonowicz K, Hlouschek J, Xiang K, Waterkamp C, Larafa S, Goetting I, Vega-Rubin-de-Celis S, Theiss C, Matschke V, Hoffmann D, Jendrossek V, Matschke J. Metabolism of cancer cells commonly responds to irradiation by a transient early mitochondrial shutdown. IScience 2021, 24: 103366. PMID: 34825138, PMCID: PMC8603201, DOI: 10.1016/j.isci.2021.103366.Peer-Reviewed Original ResearchCommon metabolic responseCompensatory glycolysisDSB repair kineticsMitochondrial respiratory chainRepair kineticsRadiation-induced DNAFuture mechanistic studiesDNA repairDNA repair kineticsRespiratory chainCancer metabolismMitochondrial functionStress conditionsMetabolic vulnerabilitiesCancer cell linesMetabolic targetsCancer cellsCell linesMitochondrial recoveryGlycolysisNew hypothesisMetabolic responseMetabolismMechanistic studiesDiscovery
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