2023
Maternal sensitivity and child internalizing and externalizing behavior: a mediating role for glucocorticoid receptor gene (NR3C1) methylation?
Creasey N, Beijers R, O'Donnell K, de Weerth C, Tollenaar M. Maternal sensitivity and child internalizing and externalizing behavior: a mediating role for glucocorticoid receptor gene (NR3C1) methylation? Development And Psychopathology 2023, 36: 967-978. PMID: 36896668, DOI: 10.1017/s0954579423000226.Peer-Reviewed Original ResearchAge 5 weeksChild mental healthMaternal sensitivityMental healthGlucocorticoid receptor gene methylationAge 6 yearsChildren's internalizingMethylation levelsMother-infant interactionDNA methylation levelsAnimal modelsEarly infancyStress regulatory systemsExternalizing behaviorsEarly caregiving environmentGene DNA methylationAge 6Longitudinal studyLower DNA methylation levelsResponsive caregivingSame childrenCommunity sampleCaregiving environmentGene methylationDNA methylation
2020
Young adult outcomes of childhood prophylaxis for severe hemophilia A: results of the Joint Outcome Continuation Study
Warren B, Thornhill D, Stein J, Fadell M, Ingram J, Funk S, Norton K, Lane H, Bennett C, Dunn A, Recht M, Shapiro A, Manco-Johnson M. Young adult outcomes of childhood prophylaxis for severe hemophilia A: results of the Joint Outcome Continuation Study. Blood Advances 2020, 4: 2451-2459. PMID: 32492157, PMCID: PMC7284094, DOI: 10.1182/bloodadvances.2019001311.Peer-Reviewed Original ResearchConceptsSevere hemophilia AHemophilia AFactor VIIIDelayed prophylaxisMagnetic resonance imagingRandomized to prophylaxisHigh-titer inhibitorsAnnualized bleeding rateInitiation of prophylaxisJoint damageReduce joint damagePhysical examination scoresProphylactic factor VIIIAge 6 yearsRandomized Controlled TrialsProphylaxis groupEarly prophylaxisSevere HARetrospective studyEpisodic treatmentProphylaxisPrimary outcomeDelayed initiationOdds ratioSecondary outcomesSUN-LB19 Novel Homozygous Mutation in BMP1 Causing Osteogenesis Imperfecta
Choksi I, Carpenter T, Robinson C. SUN-LB19 Novel Homozygous Mutation in BMP1 Causing Osteogenesis Imperfecta. Journal Of The Endocrine Society 2020, 4: sun-lb19. PMCID: PMC7209160, DOI: 10.1210/jendso/bvaa046.2020.Peer-Reviewed Original ResearchVertebral compression fracturesOsteogenesis imperfectaNovel homozygous mutationRare formMultiple vertebral compression fracturesBilateral tibial fracturesNormal serum calciumHigh-resolution peripheral quantitative CTHomozygous mutationLumbar spine BMDTotal hip BMDVertebral height lossEffectiveness of bisphosphonatesFemoral neck BMDProtein 1Age 6 yearsAge 2.5 yearsPeripheral quantitative CTGross motor delayAutosomal recessive osteogenesis imperfectaBroad phenotypic spectrumBP therapySpinal osteopeniaSubtle facial dysmorphismSymptomatic relief
2019
Optical Coherence Tomography Angiography in Amblyopia.
Kaur S, Singh S, Katoch D, Dogra M, Sukhija J. Optical Coherence Tomography Angiography in Amblyopia. Ophthalmic Surgery Lasers And Imaging Retina 2019, 50: e294-e299. PMID: 31755981, DOI: 10.3928/23258160-20191031-17.Peer-Reviewed Original ResearchConceptsPathogenesis of amblyopiaOptical coherence tomography angiographyChoriocapillaris vessel densityAmblyopic eyeCoherence tomography angiographyVessel densityFellow eyesVisual acuityBest-corrected visual acuityAge 6 yearsAmblyopiaContralateral eyeSource of blood supplyChoriocapillarisPosterior segmentProspective studyBlood supplyPatientsAcuityAngiographyEyesPathogenesisYearsFellowAbnormalities
2018
Early Prophylaxis Provides Continued Joint Protection in Severe Hemophilia A: Results of the Joint Outcome Continuation Study
Warren B, Thornhill D, Stein J, Fadell M, Funk S, Lane H, Bennett C, Shapiro A, Recht M, Manco-Johnson M. Early Prophylaxis Provides Continued Joint Protection in Severe Hemophilia A: Results of the Joint Outcome Continuation Study. Blood 2018, 132: 382. DOI: 10.1182/blood-2018-99-117413.Peer-Reviewed Original ResearchEntity's Board of DirectorsSevere hemophilia AHemophilia AEarly prophylaxisPhysical exam scoresEpisodic treatmentDelayed prophylaxisProphylaxis armJoint damageFactor VIIIIndex jointMagnetic resonance imaging scalesPrevent joint diseaseOsteochondral damageFactor VIII prophylaxisJoint bleeding episodesSoft tissue changesRisk of joint damageRisk of soft tissue damageInitial treatment groupAdvisory CommitteeProphylactic factor VIIIAge 6 yearsTiter inhibitorsRandomized Controlled Trials
2015
Marital Hostility, Hostile Parenting, and Child Aggression: Associations From Toddlerhood to School Age
Stover CS, Zhou Y, Kiselica A, Leve LD, Neiderhiser JM, Shaw DS, Natsuaki MN, Scaramella LV, Reiss D. Marital Hostility, Hostile Parenting, and Child Aggression: Associations From Toddlerhood to School Age. Journal Of The American Academy Of Child & Adolescent Psychiatry 2015, 55: 235-242. PMID: 26903257, PMCID: PMC4764800, DOI: 10.1016/j.jaac.2015.12.008.Peer-Reviewed Original ResearchConceptsChild aggressionMarital hostilityHostile parentingParental hostilityAntisocial traitsSpillover hypothesisFinancial strainAggressive child behaviorParent-child dyadsAge 6 yearsStructural equation modelingChildren age 18Sets of childrenInterparental conflictToddler periodMarital conflictChildren ages 9 monthsChild behaviorPoor parentingAdoption designAge 4.5 yearsAge 4.5ParentingAdoptive parentsEquation modeling
2013
Long-Term Orthopedic Effects Of Delaying Prophylaxis In Severe Hemophilia A Until Age 6 Years: Results Of The Joint Outcome Study Continuation (JOSc)
Manco-Johnson M, Manco-Johnson M, Blades T, Funk S, Lane H, McRedmond K, Dunn A, Recht M, Shapiro A, Valentino L, Brown D. Long-Term Orthopedic Effects Of Delaying Prophylaxis In Severe Hemophilia A Until Age 6 Years: Results Of The Joint Outcome Study Continuation (JOSc). Blood 2013, 122: 210. DOI: 10.1182/blood.v122.21.210.210.Peer-Reviewed Original ResearchAge 6 yearsMagnetic resonance imagingInitiation of prophylaxisIndex jointEpisodic therapyCSL BehringPhysical examinationSevere factor VIII deficiencySevere hemophilia AFactor VIII deficiencyRandomized controlled clinical trialResponse to bleedingAdvisory CommitteeMonths of ageProphylaxis therapyEarly prophylaxisProphylaxis initiationHemophilia AProphylaxis adherenceProphylaxisClinical trialsFactor VIIIDelayed initiationAffected boneQuality of life
2006
Facial Emotion Recognition after Curative Nondominant Temporal Lobectomy in Patients with Mesial Temporal Sclerosis
McClelland S, Garcia RE, Peraza DM, Shih TT, Hirsch LJ, Hirsch J, Goodman RR. Facial Emotion Recognition after Curative Nondominant Temporal Lobectomy in Patients with Mesial Temporal Sclerosis. Epilepsia 2006, 47: 1337-1342. PMID: 16922878, DOI: 10.1111/j.1528-1167.2006.00557.x.Peer-Reviewed Original ResearchConceptsMesial temporal sclerosisAnteromedial temporal lobectomyTemporal lobe epilepsyTLE onsetTemporal sclerosisTemporal lobectomyRight amygdalaEarly-onset patientsLate-onset patientsEarly-onset groupLate-onset groupAmygdalar damageAge 6 yearsFER impairmentPostsurgical populationLobe epilepsyLeft-hemisphere language dominancePreoperative MRIPatientsFrightened expressionImpaired facial emotion recognitionLobectomySclerosisAmygdalaOnset
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