2025
Learn-As-you-GO (LAGO) trials: optimizing treatments and preventing trial failure through ongoing learning
Bing A, Spiegelman D, Nevo D, Lok J. Learn-As-you-GO (LAGO) trials: optimizing treatments and preventing trial failure through ongoing learning. Biometrics 2025, 81: ujaf061. PMID: 40407021, PMCID: PMC12099308, DOI: 10.1093/biomtc/ujaf061.Peer-Reviewed Original ResearchConceptsIntervention packageBinary outcomesIntervention effectsConditional mean modelsOptimal intervention packagesOverall intervention effectContinuous outcomesComplex intervention packagesConfidence bandsInterval estimationImplementation trialLarge-scale intervention trialsMean modelIntervention trialsHypothesis testingInterventionStandard statistical methodsOutcomesTrialsConfidenceTheoryPower and Sample Size Calculations for Cluster Randomized Hybrid Type 2 Effectiveness‐Implementation Studies
Owen M, Curran G, Smith J, Tedla Y, Cheng C, Spiegelman D. Power and Sample Size Calculations for Cluster Randomized Hybrid Type 2 Effectiveness‐Implementation Studies. Statistics In Medicine 2025, 44: e70015. PMID: 39930740, DOI: 10.1002/sim.70015.Peer-Reviewed Original ResearchConceptsHybrid type 2 effectiveness-implementation studySample size calculationCluster randomized trialCluster randomized designSize calculationImplementation research outcomesReduce cardiovascular diseaseIssue of multiple testingEffective outcomesImplementation outcomesCommunity interventionsControl blood pressureBinary outcomesOutcomes approachLiterature searchMultiple testingCardiovascular diseaseInterventionRandomized trialsStandard statistical methodsBlood pressureOutcomesType 2 studies
2007
Maternal, Birth, and Early-Life Influences on Adult Body Size in Women
Terry MB, Wei Y, Esserman D. Maternal, Birth, and Early-Life Influences on Adult Body Size in Women. American Journal Of Epidemiology 2007, 166: 5-13. PMID: 17470452, DOI: 10.1093/aje/kwm094.Peer-Reviewed Original ResearchConceptsAge 20 yearsInfant factorsAdult BMIChildhood growthRapid childhood growthMaternal weight gainAge 40 yearsChildhood growth measuresEarly life influencesImportant predictorPersistence of effectsMaternal BMIBirth measuresBirth weightAge 40BMIEarly infancyMaternal factorsAge 20Weight gainWomenLife influencesLarger womenAge 1Standard statistical methods
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