2021
Impact of Sex on Sleep Disorders Across the Lifespan
Tobias L, Thapa S, Won CHJ. Impact of Sex on Sleep Disorders Across the Lifespan. Clinics In Chest Medicine 2021, 42: 427-442. PMID: 34353449, DOI: 10.1016/j.ccm.2021.04.005.ChaptersConceptsSleep disordersAdverse maternal outcomesSleep-disordered breathingQuality of lifeImpact of sexDevelopment of insomniaMaternal outcomesMedical comorbiditiesSex predominanceVasomotor symptomsSleep symptomsReproductive milestonesSleep disturbancesSleep architectureSleep disruptionHormonal changesWomen's livesDisordersMenopausePregnancySymptomsComorbiditiesDerangementInsomniaPrevalenceHepatocellular carcinoma: metastatic pathways and extra-hepatic findings
Arora S, Harmath C, Catania R, Mandler A, Fowler KJ, Borhani AA. Hepatocellular carcinoma: metastatic pathways and extra-hepatic findings. Abdominal Radiology 2021, 46: 3698-3707. PMID: 34091729, DOI: 10.1007/s00261-021-03151-3.Peer-Reviewed Original ResearchConceptsHepatocellular carcinomaExtrahepatic diseaseMetastatic diseaseManagement of patientsEarly metastatic diseaseCourse of treatmentExtrahepatic spreadDefinitive treatmentInitial presentationTreatment optionsPrecise stagingMetastatic pathwaysTumor biologySystemic spreadMolecular derangementsPatientsDiseasePotential roleDifferent pathwaysMolecular characteristicsTreatmentPathwayCarcinomaDerangementStagingBleeding in Critically Ill Children—Review of Literature, Knowledge Gaps, and Suggestions for Future Investigation
Aran AA, Karam O, Nellis ME. Bleeding in Critically Ill Children—Review of Literature, Knowledge Gaps, and Suggestions for Future Investigation. Frontiers In Pediatrics 2021, 9: 611680. PMID: 33585373, PMCID: PMC7873638, DOI: 10.3389/fped.2021.611680.Peer-Reviewed Original Research
2014
Low-copper diet as a preventive strategy for Alzheimer's disease
Squitti R, Siotto M, Polimanti R. Low-copper diet as a preventive strategy for Alzheimer's disease. Neurobiology Of Aging 2014, 35: s40-s50. PMID: 24913894, DOI: 10.1016/j.neurobiolaging.2014.02.031.Peer-Reviewed Original ResearchConceptsLow copper dietAlzheimer's diseasePreventive strategiesRisk of ADSporadic Alzheimer's diseaseCopper metabolismAdverse sequelaeDietary intakePathogenetic mechanismsGeneral populationAD riskPathogenic mechanismsDiseaseDietCopper deficiencyRecent studiesRiskMetabolismPhenotypeSequelaeDerangementIntakePathophysiology of Portal Hypertension
Iwakiri Y, Groszmann R. Pathophysiology of Portal Hypertension. 2014, 3-14. DOI: 10.1007/978-1-4939-0002-2_1.Peer-Reviewed Original ResearchPortal hypertensionLiver diseaseHyperdynamic splanchnic circulationHepatic vascular resistanceSerious liver diseaseExtrahepatic diseaseGastroesophageal varicesVascular resistanceHemodynamic abnormalitiesSplanchnic circulationLethal complicationCirculatory derangementsHypertensionDiseaseCurrent knowledgeVaricesAscitesComplicationsHemorrhageDerangementPathophysiologyRegulatory mechanismsAbnormalitiesFunctional aspects
2013
Abdominal distention and renal failure in a neonate
Bedri B, Goodwin JE. Abdominal distention and renal failure in a neonate. BMJ Case Reports 2013, 2013: bcr2012007955. PMID: 23429016, PMCID: PMC3604299, DOI: 10.1136/bcr-2012-007955.Peer-Reviewed Original ResearchConceptsAbdominal distentionRenal failureSevere unilateral hydronephrosisSignificant abdominal distentionPosterior urethral valvesTerm male neonateHospital dischargeUnilateral hydronephrosisUrethral valvesMale neonatePrenatal careDefinitive diagnosisMetabolic acidosisEchogenic kidneysDistentionNeonatesCystourethrogramHydronephrosisFailureDerangementAcidosisPediatriciansKidneyLab testsDiagnosis
2012
Metabolism of the right ventricle and the response to hypertrophy and failure
Altin S, Schulze P. Metabolism of the right ventricle and the response to hypertrophy and failure. Progress In Cardiovascular Diseases 2012, 55: 229-233. PMID: 23009918, PMCID: PMC3766963, DOI: 10.1016/j.pcad.2012.07.010.Peer-Reviewed Original ResearchConceptsRight ventriclePositron emission tomographyRV metabolismRV hypertrophyVolume overloadMetabolic abnormalitiesNon-invasive imagingPharmacologic interventionsClinical trialsCardiac hypertrophyEmission tomographyPathophysiologic stressHypertrophyMolecular targetsEnergetic derangementsMolecular dysfunctionCurrent roleATP levelsVentricleFatty acidsATP generationFailureMetabolismSubsequent failureDerangement
2011
The Neonate After Cardiac Surgery: What do You Need to Worry About in the Emergency Department?
Aronson P, Chen J. The Neonate After Cardiac Surgery: What do You Need to Worry About in the Emergency Department? Clinical Pediatric Emergency Medicine 2011, 12: 313-322. DOI: 10.1016/j.cpem.2011.09.005.Peer-Reviewed Educational MaterialsCongenital heart diseaseEmergency departmentHeart diseaseLife-threatening complicationsPostoperative dysrhythmiasPostoperative complicationsCardiac surgeryCardiac lesionsAirway managementCommon surgeryPatient populationVascular accessProcedural sedationSurgical correctionNeonatesComplicationsSurgeryDiseaseDepartmentPalliationDysrhythmiasSedationDerangementLesionsEpidemiology and Natural History of Thoraco-Abdominal Aortic Aneurysms
Stein L, Elefteriades J. Epidemiology and Natural History of Thoraco-Abdominal Aortic Aneurysms. 2011, 25-32. DOI: 10.1007/978-88-470-1857-0_3.Peer-Reviewed Original ResearchThoracic aortic aneurysmAortic aneurysmThoraco-abdominal aortic aneurysmChronic obstructive pulmonary diseaseObstructive pulmonary diseaseSmooth muscle cellsTAAA rupturePulmonary diseaseTertiary centerAortic diameterTAAANatural historyAneurysm growthMuscle cellsOptimal timingAneurysmsPresent unique challengesRiskBetter identificationRupture increasesHypertensionSmokingPatientsDerangementUnique challenges
2007
δ‐, but not µ‐, opioid receptor stabilizes K+ homeostasis by reducing Ca2+ influx in the cortex during acute hypoxia
Chao D, Bazzy‐Asaad A, Balboni G, Xia Y. δ‐, but not µ‐, opioid receptor stabilizes K+ homeostasis by reducing Ca2+ influx in the cortex during acute hypoxia. Journal Of Cellular Physiology 2007, 212: 60-67. PMID: 17373650, DOI: 10.1002/jcp.21000.Peer-Reviewed Original ResearchConceptsMicro-opioid receptorOxygen-glucose deprivationOpioid receptorsDelta-opioid receptor activationHypoxic/ischemic stressPresence of paxillineHypoxia-induced increaseH-Dmt-TicDOR activityDOR antagonistDOR agonistsCortical slicesAcute hypoxiaMOR agonistsChannel blockersDOR effectsIschemic stressDerangementReceptor activationCortexDADLEReceptorsUnderlying mechanismChannel activityAgonists
2000
Implantation defect in endometriosis: endometrium or peritoneal fluid.
Selam B, Arici A. Implantation defect in endometriosis: endometrium or peritoneal fluid. Society Of Reproduction And Fertility 2000, 55: 121-8. PMID: 10889841.Peer-Reviewed Original ResearchConceptsEndometrial receptivityPeritoneal environmentRole of alterationsCytokine concentrationsPeritoneal fluidCell adhesion moleculeEndometriosisClinical observationsHormone analogueDirect actionAdhesion moleculesIron metabolismBiochemical factorsImplantation defectsImplantationWomenRecent studiesFluid microenvironmentPossible mechanismReceptivityEndometriumGonadotrophinDerangement
1999
Evaluation and Treatment of Heritable Forms of Rickets
Levine B, Carpenter T. Evaluation and Treatment of Heritable Forms of Rickets. The Endocrinologist 1999, 9: 358-365. DOI: 10.1097/00019616-199909000-00006.Peer-Reviewed Original ResearchHereditary ricketsOverall treatment strategySpecific therapeutic guidelinesTherapeutic guidelinesPrimary derangementRadiographic featuresTreatment strategiesCorrect diagnosisSkeletal diseaseRicketsRachitic diseaseHeritable formDiseaseChildrenDisorder resultsHypophosphatemiaMajor formDerangementDiagnosis
1998
Internal derangements of the knee: rates of occurrence at MR imaging in patients referred by orthopedic surgeons compared with rates in patients referred by physicians who are not orthopedic surgeons.
Uppal A, Disler D, Short W, McCauley T, Cooper J. Internal derangements of the knee: rates of occurrence at MR imaging in patients referred by orthopedic surgeons compared with rates in patients referred by physicians who are not orthopedic surgeons. Radiology 1998, 207: 633-6. PMID: 9609884, DOI: 10.1148/radiology.207.3.9609884.Peer-Reviewed Original ResearchConceptsOrthopaedic surgeonsInternal derangementLigament tearsProportion of patientsRate of occurrenceSignificant differencesMagnetic resonance imagingNumber of abnormalitiesMeniscus tearsPatientsArticular cartilage abnormalitiesMR imagesKnee abnormalitiesResonance imagingSurgeonsDerangementPhysiciansCartilage abnormalitiesTearsKnee MR imagesAbnormalitiesHyaline cartilage defectsCartilage defectsKneeCartilage tears
1992
Uremic Pancreopathy: Impaired Secretory Function In Vitro
Abu-Alfa A, Mujais S. Uremic Pancreopathy: Impaired Secretory Function In Vitro. American Journal Of Kidney Diseases 1992, 20: 585-588. PMID: 1462987, DOI: 10.1016/s0272-6386(12)70223-8.Peer-Reviewed Original ResearchConceptsSecretory responsePair-fed shamResult of derangementsExocrine pancreatic functionLeucine incorporationRenal failurePancreatic functionProtein synthesisProtein secretionSecretory functionPancreatic aciniExocrine pancreasAbnormalitiesCarbacholSecretionPresent studyAciniDNA contentUremiaDerangementShamPancreasRats
1980
Sleep Breathing Abnormalities in Kyphoscoliosis1–3
Mezon B, West P, Israels J, Kryger M. Sleep Breathing Abnormalities in Kyphoscoliosis1–3. American Journal Of Respiratory And Critical Care Medicine 1980, 122: 617-21. PMID: 7436128, DOI: 10.1164/arrd.1980.122.4.617.Peer-Reviewed Original ResearchConceptsBreathing abnormalitiesGreater oxygen desaturationPulmonary function testsArterial oxygen saturationCor pulmonaleChronic hypoxemiaOxygen desaturationCentral apneaFunction testsClinical evidencePhysiologic disturbancesSevere kyphoscoliosisMovement sleepSevere derangementThoracic deformityArterial PCO2Oxygen saturationSevere episodesChemical driveAbnormalitiesSleepPatientsDerangementPulmonaleHypoxemia
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