2023
2106. Desirability of Outcome Ranking (DOOR): Application to a Phase 3 Registrational Trial Evaluating Sulopenem for Patients with Complicated Intra-abdominal Infection (cIAI)
Aronin S, Dunne M, Gupta J, Puttagunta S. 2106. Desirability of Outcome Ranking (DOOR): Application to a Phase 3 Registrational Trial Evaluating Sulopenem for Patients with Complicated Intra-abdominal Infection (cIAI). Open Forum Infectious Diseases 2023, 10: ofad500.1730. PMCID: PMC10678622, DOI: 10.1093/ofid/ofad500.1730.Peer-Reviewed Original ResearchAn international, multispecialty, expert-based Delphi Consensus document on controversial issues in the management of patients with asymptomatic and symptomatic carotid stenosis
Paraskevas K, Mikhailidis D, Ringleb P, Brown M, Dardik A, Poredos P, Gray W, Nicolaides A, Lal B, Mansilha A, Antignani P, de Borst G, Cambria R, Loftus I, Lavie C, Blinc A, Lyden S, Matsumura J, Jezovnik M, Bacharach J, Meschia J, Clair D, Zeebregts C, Lanza G, Capoccia L, Spinelli F, Liapis C, Jawien A, Parikh S, Svetlikov A, Menyhei G, Davies A, Musialek P, Roubin G, Stilo F, Sultan S, Proczka R, Faggioli G, Geroulakos G, Fernandes E Fernandes J, Ricco J, Saba L, Secemsky E, Pini R, Myrcha P, Rundek T, Martinelli O, Kakkos S, Sachar R, Goudot G, Schlachetzki F, Lavenson G, Ricci S, Topakian R, Millon A, Di Lazzaro V, Silvestrini M, Chaturvedi S, Eckstein H, Gloviczki P, White C. An international, multispecialty, expert-based Delphi Consensus document on controversial issues in the management of patients with asymptomatic and symptomatic carotid stenosis. Journal Of Vascular Surgery 2023, 79: 420-435.e1. PMID: 37944771, DOI: 10.1016/j.jvs.2023.09.031.Peer-Reviewed Original ResearchSymptomatic carotid stenosisManagement of patientsConsensus documentCarotid stenosisHospital stroke/deathStroke/deathThree-round Delphi consensus processDelphi consensus processGrade of stenosisCarotid interventionHigh riskPatientsInternational guidelinesStenosisControversial evidenceRound 2Round 1Round 3Consensus processMonthsMost expertsCurrent definitionSpecific responsesGuidelinesParticipantsA framework for the definition and interpretation of the use of surrogate endpoints in interventional trials
Ciani O, Manyara A, Davies P, Stewart D, Weir C, Young A, Blazeby J, Butcher N, Bujkiewicz S, Chan A, Dawoud D, Offringa M, Ouwens M, Hróbjartssson A, Amstutz A, Bertolaccini L, Bruno V, Devane D, Faria C, Gilbert P, Harris R, Lassere M, Marinelli L, Markham S, Powers J, Rezaei Y, Richert L, Schwendicke F, Tereshchenko L, Thoma A, Turan A, Worrall A, Christensen R, Collins G, Ross J, Taylor R. A framework for the definition and interpretation of the use of surrogate endpoints in interventional trials. EClinicalMedicine 2023, 65: 102283. PMID: 37877001, PMCID: PMC10590868, DOI: 10.1016/j.eclinm.2023.102283.Peer-Reviewed Original ResearchSurrogate endpointsInterventional trialsIntermediate outcomesHealth technology assessment expertsPrimary outcome measureMeasures of functionTreatment effectsE-Delphi studyOutcome measuresConsensus meetingBetter HealthTarget outcomesTrialsEndpointLack of consensusOutcomesPatientsFuture reportingCurrent definitionUrgent needSymptomsCliniciansSettingBiomarkers
2021
Bleeding in Critically Ill Children—Review of Literature, Knowledge Gaps, and Suggestions for Future Investigation
Aran AA, Karam O, Nellis ME. Bleeding in Critically Ill Children—Review of Literature, Knowledge Gaps, and Suggestions for Future Investigation. Frontiers In Pediatrics 2021, 9: 611680. PMID: 33585373, PMCID: PMC7873638, DOI: 10.3389/fped.2021.611680.Peer-Reviewed Original ResearchPulmonary Hypertension in Obstructive Sleep Apnea
Mohsenin V. Pulmonary Hypertension in Obstructive Sleep Apnea. 2021, 69-76. DOI: 10.1007/978-3-030-57942-5_6.Peer-Reviewed Original ResearchMean pulmonary artery pressurePulmonary hypertensionChronic obstructive pulmonary diseaseMild pulmonary arterial hypertensionPulmonary artery pressurePulmonary arterial hypertensionThird of patientsChronic lung diseaseObstructive pulmonary diseaseObstructive sleep apneaTreatment of OSADaytime hypoxemiaArterial hypertensionArtery pressureObesity hypoventilationHeart failurePulmonary diseaseSleep apneaLung diseaseHypertensionOSAPatientsDiseaseCurrent definitionHypoxemia
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