2025
Multimodality imaging review of retroperitoneal fibrosis
Czerniak S, Mathur M. Multimodality imaging review of retroperitoneal fibrosis. Abdominal Radiology 2025, 1-19. PMID: 40035807, DOI: 10.1007/s00261-025-04847-6.Peer-Reviewed Original ResearchRetroperitoneal fibrosisSecondary causesEvaluation of retroperitoneal fibrosisAssociated with autoimmune diseasesNonspecific clinical presentationIgG4 related diseasePotential diagnostic pitfallsDiffusion weighted imagingMagnetic resonance imagingAdvanced imaging techniquesPET/CT imagingClinical presentationMultimodality imaging reviewVenous stenosisClinical featuresDiagnostic pitfallsFibroinflammatory diseaseImaging findingsAutoimmune diseasesImaging reviewInflammatory disordersIdiopathic diseaseTreatment approachesImaging appearanceImaging modalities
2024
Head and neck tumor segmentation from [18F]F-FDG PET/CT images based on 3D diffusion model
Dong Y, Gong K. Head and neck tumor segmentation from [18F]F-FDG PET/CT images based on 3D diffusion model. Physics In Medicine And Biology 2024, 69: 155001. PMID: 38959909, PMCID: PMC11302413, DOI: 10.1088/1361-6560/ad5ef2.Peer-Reviewed Original ResearchConceptsTumor segmentationNetwork inputState-of-the-art techniquesState-of-the-artAccurate segmentation resultsSingle-modal dataPET/CT imagingCancer managementChallenge datasetSegmentation masksCT volumesUNet structureSegmentation resultsU-NetCT imagesDiffusion modelCT dataReversal processPrevalent typeTumor maskQuantitative metricsTumorProposed diffusion modelCTNoise volume
2023
PET/CT May Assist in Avoiding Pointless Thyroidectomy in Indeterminate Thyroid Nodules: A Narrative Review
Karam G, Malhotra A. PET/CT May Assist in Avoiding Pointless Thyroidectomy in Indeterminate Thyroid Nodules: A Narrative Review. Cancers 2023, 15: 1547. PMID: 36900338, PMCID: PMC10000406, DOI: 10.3390/cancers15051547.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2022
Multimodal analysis suggests differential immuno-metabolic crosstalk in lung squamous cell carcinoma and adenocarcinoma
Leitner BP, Givechian KB, Ospanova S, Beisenbayeva A, Politi K, Perry RJ. Multimodal analysis suggests differential immuno-metabolic crosstalk in lung squamous cell carcinoma and adenocarcinoma. Npj Precision Oncology 2022, 6: 8. PMID: 35087143, PMCID: PMC8795406, DOI: 10.1038/s41698-021-00248-2.Peer-Reviewed Original ResearchNon-small cell lung cancerLung squamous cell carcinomaBody mass indexSquamous cell carcinomaLung adenocarcinomaHigher glucose uptakeVisceral adiposityVisceral fatCell carcinomaLung cancerGlucose uptakeTreatment of NSCLCHigher Body Mass IndexTumor-infiltrating T cellsImmune checkpoint inhibitionCell lung cancerHigh visceral fatPET/CT imagingTumors of patientsPrecision therapy approachesTumor glucose uptakePrecision medicine approachLUSC tumorsPrognostic gene expressionAdjunct therapy
2021
Phase II double blinded randomized placebo-controlled trial of minocycline to ameliorate chemotherapy-induced cognitive changes in breast cancer (BC) patients.
Sharpe J, Schnell P, Knopp M, Binzel K, Magyer M, Cherian M, Gatti-Mays M, Pariser A, Wesolowski R, Sardesai S, VanDeusen J, Stover D, Ramaswamy B, Williams N, DeVries A, Shinde N, Orchard T, Lustberg M. Phase II double blinded randomized placebo-controlled trial of minocycline to ameliorate chemotherapy-induced cognitive changes in breast cancer (BC) patients. Journal Of Clinical Oncology 2021, 39: e12528-e12528. DOI: 10.1200/jco.2021.39.15_suppl.e12528.Peer-Reviewed Original ResearchPET/CT imagingPET/CTCytokine levelsMicroglial activationCT imagingF-fluorodeoxyglucoseDouble-blinded randomized placebo-controlled trialBlinded randomized placebo-controlled trialChemotherapy-induced cognitive changesRandomized placebo-controlled trialCognitive functionPlacebo-controlled trialInflammatory cytokine levelsBreast cancer patientsCognitive changesCT brain imagingAC therapyDaily minocyclinePotent mitigatorNeoadjuvant chemotherapyPlacebo groupInflammatory markersInflammatory changesMedian ageMinocycline groupFourteen-day PET/CT imaging to monitor drug combination activity in treated individuals with tuberculosis
Xie Y, de Jager V, Chen R, Dodd L, Paripati P, Via L, Follmann D, Wang J, Lumbard K, Lahouar S, Malherbe S, Andrews J, Yu X, Goldfeder L, Cai Y, Arora K, Loxton A, Vanker N, Duvenhage M, Winter J, Song T, Walzl G, Diacon A, Barry C. Fourteen-day PET/CT imaging to monitor drug combination activity in treated individuals with tuberculosis. Science Translational Medicine 2021, 13 PMID: 33536283, PMCID: PMC11135015, DOI: 10.1126/scitranslmed.abd7618.Peer-Reviewed Original ResearchConceptsPET/CT imagingPET/CTDrug treatmentCT imagingDrug combinationsD-glucose positron emission tomographyRecent phase 3 clinical trialsPhase 3 clinical trialsEarly bactericidal activity studyDrug combination activitySputum bacterial loadFirst-line chemotherapyPhase 3 trialHigh FDG uptakeLung lesion volumeActivity of pyrazinamideNew TB drugsPositron emission tomographyExperimental drug treatmentDrug regimensRadiological responseClinical outcomesFDG uptakeLung lesionsTB drugs18F-Fluciclovine Uptake in a Ureterocele.
Bitar R, Szklaruk J, Martiniova L, Zurita A, Chery L, Ravizzini G. 18F-Fluciclovine Uptake in a Ureterocele. Clinical Nuclear Medicine 2021, 46: e3-e5. PMID: 32956112, DOI: 10.1097/rlu.0000000000003272.Peer-Reviewed Original ResearchConceptsPET/CT imagingBilateral pelvic lymph node dissectionSerum prostate-specific antigen levelPelvic lymph node dissectionProstate-specific antigen levelF-fluciclovine PET/CTPost radical prostatectomyLymph node dissectionRight ureterovesical junctionF-fluciclovineRadical prostatectomyNode dissectionAntigen levelsUreterovesical junctionProximal thighPET/CTIV administrationUreteroceleProstatectomyProstateMBqAbnormalitiesDissectionSerumPelvis
2020
Incidental 18F-Fluciclovine Uptake in a Warthin Tumor of the Parotid Gland in a Patient Undergoing PET/CT Imaging for Biochemical Recurrent Prostate Cancer.
Bitar R, Martiniova L, Bell D, Ravizzini G. Incidental 18F-Fluciclovine Uptake in a Warthin Tumor of the Parotid Gland in a Patient Undergoing PET/CT Imaging for Biochemical Recurrent Prostate Cancer. Clinical Nuclear Medicine 2020, 45: e208-e210. PMID: 31977491, DOI: 10.1097/rlu.0000000000002938.Peer-Reviewed Original ResearchConceptsBiochemically recurrent prostate cancerRecurrent prostate cancerPET/CT imagingF-fluciclovineWarthin's tumorProstate cancerParotid glandUltrasound-guided fine-needle aspiration biopsyFine-needle aspiration biopsyBenign Warthin tumorF-fluciclovine PET/CTLeft parotid glandAspiration biopsyAsymptomatic menIntravenous administrationTreatment strategiesProximal thighPET/CTTumorCancerGlandRestagingWarthinBiopsyParotid
2019
Novel radioligands for imaging sigma-1 receptor in brain using positron emission tomography (PET)
Lan Y, Bai P, Chen Z, Neelamegam R, Placzek M, Wang H, Fiedler S, Yang J, Yuan G, Qu X, Schmidt H, Song J, Normandin M, Ran C, Wang C. Novel radioligands for imaging sigma-1 receptor in brain using positron emission tomography (PET). Acta Pharmaceutica Sinica B 2019, 9: 1204-1215. PMID: 31867166, PMCID: PMC6900558, DOI: 10.1016/j.apsb.2019.07.002.Peer-Reviewed Original ResearchPositron emission tomographySigma-1 receptorCentral nervous systemPET/CT imagingEmission tomographyOrgans of micePositron emission tomography tracersNeuropsychiatric disordersNon-invasive quantificationBrain regionsNoninvasive toolSigma-1RadioligandDisease pathophysiologyNervous systemNovel radioligandMiceMouse brainPathological conditionsBrainReceptorsTomographyIntracellular proteinsTarget validationPET/CTFDG PET imaging of vascular inflammation in post-traumatic stress disorder: A pilot case–control study
Toczek J, Hillmer AT, Han J, Liu C, Peters D, Emami H, Wu J, Esterlis I, Cosgrove KP, Sadeghi MM. FDG PET imaging of vascular inflammation in post-traumatic stress disorder: A pilot case–control study. Journal Of Nuclear Cardiology 2019, 28: 688-694. PMID: 31073848, PMCID: PMC6842076, DOI: 10.1007/s12350-019-01724-w.Peer-Reviewed Original ResearchConceptsFDG-PET imagingPost-traumatic stress disorderFDG signalSystemic inflammationVascular inflammationCardiovascular diseaseBone marrowPET imagingFDG PET/CT imagingPilot case-control studyStress disorderCardiovascular risk factorsInflammatory biomarker levelsHealthy control subjectsPET/CT imagingCase-control studyPositron emission tomography (PET) imagingEmission Tomography ImagingInflammatory biomarkersControl subjectsBlood glucoseRisk factorsBiomarker levelsHealthy controlsProspective groupPD60-10 A PROSPECTIVE PHASE 2/3 MULTI-CENTER STUDY OF 18 F-DCFPYL PET/CT IMAGING IN PATIENTS WITH PROSTATE CANCER – EXAMINATION OF DIAGNOSTIC ACCURACY (OSPREY)
Gorin* M, Pienta K, Siegel B, Carroll P, Pouliot F, Probst S, Saperstein L, Preston M, Alva A, Patnaik A, Durack J, Rowe S, Nichols M, Lin T, Strack T, DiPippo V, Mahmood S, Jensen J, Wong V, Morris M. PD60-10 A PROSPECTIVE PHASE 2/3 MULTI-CENTER STUDY OF 18 F-DCFPYL PET/CT IMAGING IN PATIENTS WITH PROSTATE CANCER – EXAMINATION OF DIAGNOSTIC ACCURACY (OSPREY). Journal Of Urology 2019, 201 DOI: 10.1097/01.ju.0000557215.99831.87.Peer-Reviewed Original Research
2018
Significance of Negative Posttreatment 18-FDG PET/CT Imaging in Patients With p16/HPV-Positive Oropharyngeal Cancer
Ng S, Johnson J, Gunn G, Rosenthal D, Skinner H, Phan J, Frank S, Morrison W, Sturgis E, Mott F, Williams M, Fuller C, Garden A. Significance of Negative Posttreatment 18-FDG PET/CT Imaging in Patients With p16/HPV-Positive Oropharyngeal Cancer. International Journal Of Radiation Oncology • Biology • Physics 2018, 102: 1029-1035. PMID: 29960060, PMCID: PMC9620951, DOI: 10.1016/j.ijrobp.2018.06.031.Peer-Reviewed Original ResearchConceptsOropharyngeal squamous cell carcinomaComplete metabolic responseDisease-free survivalOverall survival rateSquamous cell carcinomaCell carcinomaTomography scanSurvival rateHPV-positive oropharyngeal cancerCommon primary siteHPV/p16Posttreatment PET imagingPosttreatment PET scansKaplan-Meier methodSubgroup of patientsBase of tongueGroup of patientsHuman papilloma virusDevelopment of recurrencePET/CT imagingMetabolic responseOptimal surveillance strategyPositron emission tomographyLonger life expectancyEleven patientsKinetics of human brown adipose tissue activation and deactivation
Leitner BP, Weiner LS, Desir M, Kahn PA, Selen DJ, Tsang C, Kolodny GM, Cypess AM. Kinetics of human brown adipose tissue activation and deactivation. International Journal Of Obesity 2018, 43: 633-637. PMID: 29795459, PMCID: PMC6252171, DOI: 10.1038/s41366-018-0104-3.Peer-Reviewed Original ResearchConceptsBrown adipose tissueBAT volumeMetabolic diseasesBrown adipose tissue activationActive brown adipose tissueCold exposureHuman BAT thermogenesisBAT glucose uptakePrevention of obesityPET/CT imagingBAT activationBAT thermogenesisClinical trialsAdipose tissueHealthy adultsCold stimulationTissue activationCT imagingGlucose uptakeDuration of stimuliPotential targetCessation of coolingObesityDiseaseActivation
2017
Scatter Correction with Combined Single-Scatter Simulation and Monte Carlo Simulation Scaling Improved the Visual Artifacts and Quantification in 3-Dimensional Brain PET/CT Imaging with 15O-Gas Inhalation
Magota K, Shiga T, Asano Y, Shinyama D, Ye J, Perkins AE, Maniawski PJ, Toyonaga T, Kobayashi K, Hirata K, Katoh C, Hattori N, Tamaki N. Scatter Correction with Combined Single-Scatter Simulation and Monte Carlo Simulation Scaling Improved the Visual Artifacts and Quantification in 3-Dimensional Brain PET/CT Imaging with 15O-Gas Inhalation. Journal Of Nuclear Medicine 2017, 58: 2020-2025. PMID: 28646012, DOI: 10.2967/jnumed.117.193060.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsArtifactsBrainComputer SimulationFluorodeoxyglucose F18HumansImage Processing, Computer-AssistedImaging, Three-DimensionalMonte Carlo MethodOxygen RadioisotopesPhantoms, ImagingPositron Emission Tomography Computed TomographyRadiopharmaceuticalsReproducibility of ResultsScattering, Radiation
2015
SVM Based Lung Cancer Diagnosis Using Multiple Image Features in PET/CT
Guo N, Yen R, Fakhri G, Li Q. SVM Based Lung Cancer Diagnosis Using Multiple Image Features in PET/CT. 2015, 1-4. DOI: 10.1109/nssmic.2015.7582234.Peer-Reviewed Original ResearchIntra-tumor heterogeneityLung cancer diagnosisF-FLTCT textureStage malignancyLung cancerStaging of lung cancerCT texture featuresAdvanced stage malignanciesEarly stage malignancyImprove tumor stagingCancer diagnosisImage featuresPET/CT scansPET/CT imagingTumor stageTumor heterogeneityCancer stageDiagnostic accuracyPatient groupClinical valuePET/CTGold standardLung nodulesPET imaging
2014
55P PET/CT Imaging of 64CU-Labelled HER2 Liposomal Doxorubicin (64CU-MM-302) Quantifies Variability of Liposomal Drug Delivery to Diverse Tumor Lesions in HER2-Positive Breast Cancer Patients
Hendriks B, Shields A, Siegel B, Miller K, Munster P, Ma C, Campbell K, Moyo V, Wickham T, LoRusso P. 55P PET/CT Imaging of 64CU-Labelled HER2 Liposomal Doxorubicin (64CU-MM-302) Quantifies Variability of Liposomal Drug Delivery to Diverse Tumor Lesions in HER2-Positive Breast Cancer Patients. Annals Of Oncology 2014, 25: i19. DOI: 10.1093/annonc/mdu068.1.Peer-Reviewed Original Research
2009
SU‐FF‐J‐129: In‐Room Proton Range Verification Using Mobile NeuroPET ‐ Feasibility Study
Knopf A, Zhu X, Parodi K, Paganetti H, Bortfeld T, Fakhri G. SU‐FF‐J‐129: In‐Room Proton Range Verification Using Mobile NeuroPET ‐ Feasibility Study. Medical Physics 2009, 36: 2506-2506. DOI: 10.1118/1.3181421.Peer-Reviewed Original ResearchProton range verificationRange verificationPET/CT scannerCommercial PET/CT scannersWater equivalent rangePositron emission tomographyBiological washoutPMMA phantomProton fieldsProton beamActivity depth profilesProton treatmentPhantom studyTreatment roomIn-roomPositron emission tomography scanPositron emission tomography dataPatient repositioningPhantomPositron emission tomography imagingProtonDepth profilesPET/CT imagingRadiation treatmentTotal doseQuantitative relationship between coronary calcium content and coronary flow reserve as assessed by integrated PET/CT imaging
Curillova Z, Yaman B, Dorbala S, Kwong R, Sitek A, El Fakhri G, Anagnostopoulos C, Di Carli M. Quantitative relationship between coronary calcium content and coronary flow reserve as assessed by integrated PET/CT imaging. European Journal Of Nuclear Medicine And Molecular Imaging 2009, 36: 1603-1610. PMID: 19387640, PMCID: PMC3117296, DOI: 10.1007/s00259-009-1121-1.Peer-Reviewed Original ResearchConceptsCoronary artery calcium scoreCoronary artery calciumCoronary vasodilator functionCoronary flow reserveCoronary artery diseaseHyperemic myocardial blood flowMyocardial blood flowVasodilator functionWeak inverse correlationCAC scoreCoronary artery calcium contentFlow reserveIncreasing CAC scorePer-vessel basisPer-patient basisInverse correlationBody mass indexCoronary calcium contentCoronary risk factorsCoronary vascular resistancePET/CT imagingConclusionIn patientsArtery calciumVascular resistanceMass index
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