2021
Effects of microRNA-181b-5p on cognitive deficits in first-episode patients with schizophrenia: Mediated by BCL-2
Gou M, Pan S, Tong J, Zhou Y, Han J, Xie T, Yu T, Feng W, Li Y, Chen S, Cui Y, Tian B, Tan MDS, Wang Z, Luo X, Li CR, Zhang P, Huang J, Hong LE, Tan Y, Tian L. Effects of microRNA-181b-5p on cognitive deficits in first-episode patients with schizophrenia: Mediated by BCL-2. Journal Of Psychiatric Research 2021, 136: 358-365. PMID: 33636692, DOI: 10.1016/j.jpsychires.2021.02.003.Peer-Reviewed Original ResearchConceptsFirst-episode patientsBcl-2 mRNAEnzyme Linked Immunosorbent AssayMATRICS Consensus Cognitive BatteryQuantitative real-time PCRCognitive deficitsCognitive functionGender-matched healthy controlsBcl-2Pathogenesis of schizophreniaPeripheral whole bloodExpression levelsNegative Syndrome ScaleBcl-2 protein expressionLinked Immunosorbent AssayBcl-2 protein levelsPeripheral bloodHealthy controlsBcl-2 mRNA levelsReal-time PCRTarget genes Bcl-2Consensus Cognitive BatterySchizophrenia patientsSyndrome ScaleGene Bcl-2
2009
Goniothalamin-induced oxidative stress, DNA damage and apoptosis via caspase-2 independent and Bcl-2 independent pathways in Jurkat T-cells
Inayat-Hussain S, Chan K, Rajab N, Din L, Chow S, Kizilors A, Farzaneh F, Williams G. Goniothalamin-induced oxidative stress, DNA damage and apoptosis via caspase-2 independent and Bcl-2 independent pathways in Jurkat T-cells. Toxicology Letters 2009, 193: 108-114. PMID: 20026395, PMCID: PMC2828539, DOI: 10.1016/j.toxlet.2009.12.010.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic Agents, PhytogenicApoptosisBlotting, WesternCaspase 2Caspase InhibitorsComet AssayCytochromes cDNA DamageDNA Topoisomerases, Type IIEnzyme InhibitorsFlow CytometryGlutathioneGoniothalamusHumansJurkat CellsOligopeptidesOxidative StressProto-Oncogene Proteins c-bcl-2PyronesReactive Oxygen SpeciesSignal TransductionTetrazolium SaltsThiazolesConceptsCaspase-2 activityCaspase-2DNA damageZ-VDVAD-FMKBcl-2-independent pathwayJurkat T leukemia cellsOxidative stressCytochrome c releaseBcl-2Bcl-2 transfectantsJurkat T cellsCellular oxidative stressT leukemia cellsApoptosis upstreamBcl-2 protein expressionGoniothalamus spC releaseII-independent pathwayReactive oxygen speciesIndependent pathwaysJurkat cellsCancer cell linesApoptosisCell linesProtein expressionAssociation of expression of bcl-2 with outcome in non-small cell lung cancer
Anagnostou V, Lowery F, Syrigos K, Frangia K, Zolota V, Panagopoulos N, Dougenis D, Tanoue L, Detterbeck F, Homer R, Rimm D. Association of expression of bcl-2 with outcome in non-small cell lung cancer. Journal Of Clinical Oncology 2009, 27: e22039-e22039. DOI: 10.1200/jco.2009.27.15_suppl.e22039.Peer-Reviewed Original ResearchLung cancer patientsSquamous cell carcinomaBcl-2 expressionCancer patientsCell carcinomaBcl-2Non-small cell lung cancerYale-New Haven HospitalIndependent lower riskPatras University HospitalMedian overall survivalProtein expressionPotential prognostic parametersSubgroup of patientsCell lung cancerHigh Bcl-2 expressionNew Haven HospitalBcl-2 protein expressionAssociation of expressionBcl-2 protein levelsOverall survivalPatient survivalValidation cohortPathological characteristicsPrognostic parameters
2000
Primary cutaneous follicle center cell lymphoma with follicular growth pattern
Cerroni L, Arzberger E, Puütz B, Hoüfler G, Metze D, Sander C, Rose C, Wolf P, Ruütten A, McNiff J, Kerl H. Primary cutaneous follicle center cell lymphoma with follicular growth pattern. Blood 2000, 95: 3922-3928. PMID: 10845929, DOI: 10.1182/blood.v95.12.3922.Peer-Reviewed Original ResearchConceptsB-cell infiltratesFollicular growth patternGerminal centersPrimary cutaneous follicle center cell lymphomaCutaneous follicle center cell lymphomaPrimary cutaneous follicular lymphomaCutaneous B-cell lymphomaCutaneous follicular lymphomaSame monoclonal populationFollicle center cell lymphomaCutaneous B-cell infiltratesBone marrow biopsyReactive germinal centersB-cell lymphomaFollicle center cellsBcl-2 protein expressionExtracutaneous spreadStaging investigationsPolymerase chain reaction analysisMarrow biopsyImmunophenotypic criteriaNeoplastic folliclesFollicular patternMonoclonal rearrangementSkin lesionsPrimary cutaneous follicle center cell lymphoma with follicular growth pattern
Cerroni L, Arzberger E, Pütz B, Höfler G, Metze D, Sander C, Rose C, Wolf P, Rütten A, McNiff J, Kerl H. Primary cutaneous follicle center cell lymphoma with follicular growth pattern. Blood 2000, 95: 3922-3928. DOI: 10.1182/blood.v95.12.3922.012k08_3922_3928.Peer-Reviewed Original ResearchB-cell infiltratesFollicular growth patternGerminal centersPrimary cutaneous follicle center cell lymphomaCutaneous follicle center cell lymphomaPrimary cutaneous follicular lymphomaCutaneous B-cell lymphomaCutaneous follicular lymphomaSame monoclonal populationFollicle center cell lymphomaCutaneous B-cell infiltratesBone marrow biopsyReactive germinal centersB-cell lymphomaFollicle center cellsBcl-2 protein expressionExtracutaneous spreadStaging investigationsPolymerase chain reaction analysisMarrow biopsyImmunophenotypic criteriaNeoplastic folliclesFollicular patternMonoclonal rearrangementSkin lesions
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