2020
Chronic head injury promotes tau and amyloid‐beta pathology and accelerates cognitive decline in a humanized knock‐in model of Alzheimer's disease
Chiasseu M, Fesharaki A, Saito T, Saido T, Strittmatter S. Chronic head injury promotes tau and amyloid‐beta pathology and accelerates cognitive decline in a humanized knock‐in model of Alzheimer's disease. Alzheimer's & Dementia 2020, 16 DOI: 10.1002/alz.047623.Peer-Reviewed Original ResearchMild traumatic brain injuryChronic head injuryHead injuryMorris water maze testAmyloid-beta pathologyAccumulation of amyloidAge-matched miceWater maze testTraumatic brain injuryNovel object recognitionProtein gene mutationsEnvironmental risk factorsAlzheimer's disease symptomsIba1 expressionCortical AβAlzheimer pathologyPhospho-tauClinical manifestationsAD pathologyCortical impactorAD pathogenesisRisk factorsBrain injuryApp NLMaze test
2019
Prefrontal Cortical and Behavioral Adaptations to Surgical Delivery Mediated by Metabolic Principles
Taylor-Giorlando M, Scheinost D, Ment L, Rothman D, Horvath TL. Prefrontal Cortical and Behavioral Adaptations to Surgical Delivery Mediated by Metabolic Principles. Cerebral Cortex 2019, 29: 5061-5071. PMID: 30877804, PMCID: PMC6918927, DOI: 10.1093/cercor/bhz046.Peer-Reviewed Original ResearchConceptsMode of deliverySurgical deliveryLayer 3 pyramidal neuronsAlters mitochondrial dynamicsValues of miceMurine findingsCerebral cortexPyramidal neuronsAdult behaviorHuman neonatesMaze testPrepulse inhibitionSpine synapsesPsychiatric illnessAdult miceNeuronal circuitryAnimal modelsClinical relevanceHuman clinical relevanceUCP-2Prefrontal cortexMitochondrial adaptationsImpaired performanceMitochondrial mechanismsBehavioral phenotypes
2018
Pluripotent stem cell-derived interneuron progenitors mature and restore memory deficits but do not suppress seizures in the epileptic mouse brain
Anderson NC, Van Zandt MA, Shrestha S, Lawrence DB, Gupta J, Chen CY, Harrsch FA, Boyi T, Dundes CE, Aaron G, Naegele JR, Grabel L. Pluripotent stem cell-derived interneuron progenitors mature and restore memory deficits but do not suppress seizures in the epileptic mouse brain. Stem Cell Research 2018, 33: 83-94. PMID: 30340090, DOI: 10.1016/j.scr.2018.10.007.Peer-Reviewed Original ResearchConceptsTemporal lobe epilepsyInterneuron progenitorsHippocampal-dependent spatial memory deficitsMemory deficitsMorris water maze testEpileptic mouse brainMature firing patternMature GABAergic interneuronsWater maze testSpatial memory deficitsGABAergic interneuron dysfunctionHippocampus of rodentsInterneuron dysfunctionLobe epilepsySuppress seizuresGABAergic interneuronsMaze testSeizure suppressionMouse modelMouse brainFiring patternsSeizuresTransplantMiceStem cellsIntravenous infusion of mesenchymal stem cells reduces epileptogenesis in a rat model of status epilepticus
Fukumura S, Sasaki M, Kataoka-Sasaki Y, Oka S, Nakazaki M, Nagahama H, Morita T, Sakai T, Tsutsumi H, Kocsis JD, Honmou O. Intravenous infusion of mesenchymal stem cells reduces epileptogenesis in a rat model of status epilepticus. Epilepsy Research 2018, 141: 56-63. PMID: 29475054, DOI: 10.1016/j.eplepsyres.2018.02.008.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDisease Models, AnimalGlutamate DecarboxylaseGreen Fluorescent ProteinsHippocampusInfusions, IntravenousLithiumMagnetic Resonance ImagingMaleMaze LearningMesenchymal Stem Cell TransplantationMesenchymal Stem CellsMuscarinic AgonistsNeuronsPhosphopyruvate HydratasePilocarpineRatsRats, Sprague-DawleyRats, TransgenicStatus EpilepticusTime FactorsConceptsAberrant mossy fiber sproutingMossy fiber sproutingStatus epilepticusNeuronal cell deathMesenchymal stem cellsMSC infusionIntravenous infusionRat modelCognitive functionMorris water maze testCognitive function preservationNumber of GAD67Water maze testVehicle-infused ratsMagnetic resonance imagingCell deathStem cellsSeizure frequencyFiber sproutingFunction preservationTimm stainingMaze testHippocampal neuronsImmunohistochemical stainingCognitive deteriorationImpaired insulin signaling and spatial learning in middle-aged rats: The role of PTP1B
Kuga G, Muñoz V, Gaspar R, Nakandakari S, da Silva A, Botezelli J, Leme J, Gomes R, de Moura L, Cintra D, Ropelle E, Pauli J. Impaired insulin signaling and spatial learning in middle-aged rats: The role of PTP1B. Experimental Gerontology 2018, 104: 66-71. PMID: 29421605, DOI: 10.1016/j.exger.2018.02.005.Peer-Reviewed Original ResearchConceptsMiddle-aged ratsBrain-derived neurotrophic factorΒ-amyloid contentAlzheimer's diseaseInsulin resistanceTau phosphorylationMorris water maze testMiddle-aged Wistar ratsInsulin tolerance testMain risk factorsAge-related changesNeurotrophic factorTolerance testRisk factorsMaze testImpaired insulinWistar ratsNew therapiesHippocampus regionBody weightCognitive declineRole of PTP1BSynaptic plasticityRatsSpatial learning
2012
Gabra5-gene haplotype block associated with behavioral properties of the full agonist benzodiazepine chlordiazepoxide
Clément Y, Prut L, Saurini F, Mineur Y, Le Guisquet A, Védrine S, Andres C, Vodjdani G, Belzung C. Gabra5-gene haplotype block associated with behavioral properties of the full agonist benzodiazepine chlordiazepoxide. Behavioural Brain Research 2012, 233: 474-482. PMID: 22677273, DOI: 10.1016/j.bbr.2012.05.041.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PsychologicalAnimalsBehavior, AnimalBenzodiazepinesCarrier ProteinsCerebral CortexChlordiazepoxideDose-Response Relationship, DrugGene Expression RegulationHaplotypesHippocampusMaleMaze LearningMembrane ProteinsMiceMice, Inbred C57BLMice, Mutant StrainsMotor ActivityMutationReaction TimeReceptors, GABA-ARNA, MessengerRotarod Performance TestSpace Perception
2008
Trait impulsiveness and executive function in healthy young adults
Pietrzak R, Sprague A, Snyder P. Trait impulsiveness and executive function in healthy young adults. Journal Of Research In Personality 2008, 42: 1347-1351. DOI: 10.1016/j.jrp.2008.03.004.Peer-Reviewed Original ResearchHealthy young adultsTrait impulsivenessPerformance-based neuropsychological testsNon-planning impulsiveness scoreTotal BIS-11 scoreMeasures of planningBarratt Impulsiveness Scale-11Executive function testsYoung adultsBIS-11 scoresCognitive complexityExecutive functionNeuropsychological testsImpulsiveness scoresConvergent validityImpulsivenessSpecific dimensionsMaze testMeasuresAdultsScoresPerformanceDimensionsValidityTest
1998
Cerebral blood flow velocity decreases during cognitive stimulation in Huntington's disease
Deckel A, Cohen D, Duckrow R. Cerebral blood flow velocity decreases during cognitive stimulation in Huntington's disease. Neurology 1998, 51: 1576-1583. PMID: 9855504, DOI: 10.1212/wnl.51.6.1576.Peer-Reviewed Original ResearchConceptsAnterior cerebral arteryAnterior cerebral artery flow velocityCerebral artery flow velocityBlood flow velocity changesMiddle cerebral arteryCerebral arteryArtery flow velocityHD patientsTranscranial Doppler ultrasonographyFlow velocity changesControl subjectsMaze testHuntington's diseaseCerebral blood flow velocity changesBlood flow velocity decreasesLeft anterior cerebral arteryMiddle cerebral artery velocityCognitive test scoresCerebral blood flow velocityBlood flow velocity increasePorteus Maze TestRating ScaleCognitive testingTrails TestAsymptomatic HD patients
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