The associations between duration of untreated psychosis, growth factors, and neurocognition in patients with drug-naïve schizophrenia
Su Q, Xuekelaiti Z, Ma H, Qiu Y, Sun X, Bi F, Li M, Li J. The associations between duration of untreated psychosis, growth factors, and neurocognition in patients with drug-naïve schizophrenia. Schizophrenia Research 2024, 274: 113-120. PMID: 39288474, DOI: 10.1016/j.schres.2024.09.011.Peer-Reviewed Original ResearchDuration of untreated psychosisBrain-derived neurotrophic factorMATRICS Consensus Cognitive BatterySpeed of processingVascular endothelial growth factorUntreated psychosisEpidermal growth factorAssociated with speed of processingDuration of untreated psychosis groupGrowth factorConsensus Cognitive BatteryDrug-naive schizophreniaPlasma concentrations of vascular endothelial growth factorPlasma concentrationsConcentrations of vascular endothelial growth factorCognitive batteryVerbal learningAssociated with speedEndothelial growth factorNeurocognitionVisual learningCognitive impairmentEnzyme-linked immunosorbent assayBiological mechanismsNeurotrophic factorStructural white matter abnormalities in Schizophrenia and associations with neurocognitive performance and symptom severity
Male A, Goudzwaard E, Nakahara S, Turner J, Calhoun V, Mueller B, Lim K, Bustillo J, Belger A, Voyvodic J, O'Leary D, Mathalon D, Ford J, Potkin S, Preda A, van Erp T. Structural white matter abnormalities in Schizophrenia and associations with neurocognitive performance and symptom severity. Psychiatry Research Neuroimaging 2024, 342: 111843. PMID: 38896909, DOI: 10.1016/j.pscychresns.2024.111843.Peer-Reviewed Original ResearchConceptsSymptom severityFractional anisotropyDiffusion tensor imagingNeurocognitive performanceCognitive performanceAssociated with speed of processingLeft inferior fronto-occipital fasciculusWM abnormalitiesAssociated with neurocognitive performancePathophysiology of schizophreniaCognitive performance deficitsInferior fronto-occipital fasciculusSpeed of processingStructural white matter abnormalitiesMean diffusivityAxial diffusivityFronto-occipital fasciculusHealthy controlsRadial diffusivityRegional WM abnormalitiesNegative symptomsPerformance deficitsWhite matterWhite matter abnormalitiesAssociated with speed
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