2023
Internal capsule microstructure mediates the relationship between childhood maltreatment and PTSD following adulthood trauma exposure
Wong S, Lebois L, Ely T, van Rooij S, Bruce S, Murty V, Jovanovic T, House S, Beaudoin F, An X, Zeng D, Neylan T, Clifford G, Linnstaedt S, Germine L, Bollen K, Rauch S, Haran J, Storrow A, Lewandowski C, Musey P, Hendry P, Sheikh S, Jones C, Punches B, Kurz M, Swor R, Hudak L, Pascual J, Seamon M, Pearson C, Peak D, Merchant R, Domeier R, Rathlev N, O’Neil B, Sergot P, Sanchez L, Miller M, Pietrzak R, Joormann J, Barch D, Pizzagalli D, Harte S, Elliott J, Kessler R, Koenen K, McLean S, Ressler K, Stevens J, Harnett N. Internal capsule microstructure mediates the relationship between childhood maltreatment and PTSD following adulthood trauma exposure. Molecular Psychiatry 2023, 28: 5140-5149. PMID: 36932158, PMCID: PMC10505244, DOI: 10.1038/s41380-023-02012-3.Peer-Reviewed Original ResearchInternal capsuleDiffusion tensor imagingPosttraumatic dysfunctionWhite matter microstructureFractional anisotropyPTSD symptomsChildhood traumaRecent traumaChildhood maltreatmentTrauma exposureBilateral internal capsuleFuture PTSD symptomsAdulthood trauma exposureChildhood trauma exposureStress-related disordersWhite matter tractsPCL-5 scoresAssessment of PTSDSensory fibersEmergency departmentRisk factorsCorpus callosumNeural pathwaysCingulum bundleNeural circuits
2022
White matter alterations associated with lifetime and current depression in adolescents: Evidence for cingulum disruptions
Barch D, Hua X, Kandala S, Harms M, Sanders A, Brady R, Tillman R, Luby J. White matter alterations associated with lifetime and current depression in adolescents: Evidence for cingulum disruptions. Depression And Anxiety 2022, 39: 881-890. PMID: 36321433, PMCID: PMC10848013, DOI: 10.1002/da.23294.Peer-Reviewed Original ResearchConceptsDepression severityCingulum bundleReduced FAFractional anisotropyCurrent depression severityPreschool Depression StudyWhite matter microstructural differencesFunctional connectivity differencesDorsal cingulum bundleEstimates of fractional anisotropySuperior longitudinal fasciculusWhite matter differencesMean diffusivityAxial diffusivityAssociated with depressionIncreased RDRadial diffusivityWhite matter structuresEmotion dysregulationDepression StudyLifetime diagnosisConcurrent depressionCurrent depressionConnectivity differencesBrain regions
2020
Microstructure of the Dorsal Anterior Cingulum Bundle in Very Preterm Neonates Predicts the Preterm Behavioral Phenotype at 5 Years of Age
Brenner R, Smyser C, Lean R, Kenley J, Smyser T, Cyr P, Shimony J, Barch D, Rogers C. Microstructure of the Dorsal Anterior Cingulum Bundle in Very Preterm Neonates Predicts the Preterm Behavioral Phenotype at 5 Years of Age. Biological Psychiatry 2020, 89: 433-442. PMID: 32828528, PMCID: PMC8064762, DOI: 10.1016/j.biopsych.2020.06.015.Peer-Reviewed Original ResearchConceptsVery preterm neonatesPreterm behavioral phenotypeVery pretermVery preterm childrenFull-term neonatesYears of agePosterior CBPreterm neonatesCingulum bundleVery preterm infantsMean diffusivityDecreased mean diffusivityBehavioral phenotypesAnterior portionAnterior CBAnterior cingulum bundleIncreased fractional anisotropyNonsedated neonatesPhenotypic symptomsPretermNeonatesRight CBMagnetic resonance imaging dataWhite matter microstructureFractional anisotropyFixel-Based Diffusion Magnetic Resonance Imaging Reveals Novel Associations Between White Matter Microstructure and Childhood Aggressive Behavior
Grazioplene R, Tseng WL, Cimino K, Kalvin C, Ibrahim K, Pelphrey KA, Sukhodolsky DG. Fixel-Based Diffusion Magnetic Resonance Imaging Reveals Novel Associations Between White Matter Microstructure and Childhood Aggressive Behavior. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2020, 5: 490-498. PMID: 32144044, PMCID: PMC7214205, DOI: 10.1016/j.bpsc.2019.12.018.Peer-Reviewed Original ResearchConceptsWhite matter densityCorpus callosumFiber densityAggressive behaviorCingulum bundleAbnormal interhemispheric connectivityHealthy control childrenWhite matter abnormalitiesAttention-deficit/hyperactivity disorderMiddle cerebellar peduncleSuperior thalamic radiationMagnetic resonance imagingInferior fronto-occipital fasciculusWhole-brain analysisInferior longitudinal fasciculusFronto-occipital fasciculusPotential neural mechanismsWhite matter microstructureDiffusion magnetic resonance imagingInterhemispheric connectivityCortical pathwaysCerebellar peduncleChild Behavior ChecklistThalamic radiationFiber bundle density
2018
Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals
Jacobs H, Hedden T, Schultz A, Sepulcre J, Perea R, Amariglio R, Papp K, Rentz D, Sperling R, Johnson K. Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals. Nature Neuroscience 2018, 21: 424-431. PMID: 29403032, PMCID: PMC5857215, DOI: 10.1038/s41593-018-0070-z.Peer-Reviewed Original ResearchConceptsPosterior cingulate cortexMemory declineCingulate cortexHippocampal volumeTau accumulationAssociated with increased mean diffusivityCognitively healthy older individualsBaseline hippocampal volumeAmyloid-positive individualsWhite matter connectivityAmyloid-negative individualsPreclinical Alzheimer's diseaseAmyloid pathologyAnimal models of Alzheimer's diseaseHealthy older individualsTau pathology propagationModel of Alzheimer's diseaseAlzheimer's diseaseTau positron emission tomographyMemory performanceNeural vulnerabilityCingulum bundleOlder individualsPositron emission tomographyMean diffusivity
2012
White Matter Abnormalities in Pediatric Obsessive-Compulsive Disorder
Gruner P, Vo A, Ikuta T, Mahon K, Peters BD, Malhotra AK, Uluğ AM, Szeszko PR. White Matter Abnormalities in Pediatric Obsessive-Compulsive Disorder. Neuropsychopharmacology 2012, 37: 2730-2739. PMID: 22871914, PMCID: PMC3473339, DOI: 10.1038/npp.2012.138.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderDorsal cingulum bundleFractional anisotropyYale-Brown ObsessiveCingulum bundleGreater fractional anisotropyT GE systemDrug-naïve patientsCourse of illnessNeurobiology of OCDPatients' symptom severityWhite matter abnormalitiesPediatric OCD patientsRight corticospinal tractWhite matter deficitsPediatric obsessive-compulsive disorderInferior fronto-occipital fasciculusLower fractional anisotropyWhite matter tractsChildren's Yale-Brown ObsessiveFronto-occipital fasciculusResponse inhibition functionHigher fractional anisotropyPediatric patientsCorticospinal tract
2011
Diffusion Tensor Imaging of Incentive Effects in Prospective Memory after Pediatric Traumatic Brain Injury
McCauley S, Wilde E, Bigler E, Chu Z, Yallampalli R, Oni M, Wu T, Ramos M, Pedroza C, Vásquez A, Hunter J, Levin H. Diffusion Tensor Imaging of Incentive Effects in Prospective Memory after Pediatric Traumatic Brain Injury. Journal Of Neurotrauma 2011, 28: 503-516. PMID: 21250917, PMCID: PMC3070141, DOI: 10.1089/neu.2010.1555.Peer-Reviewed Original ResearchConceptsSevere traumatic brain injuryTraumatic brain injuryMotivation conditionOrbitofrontal white matterUncinate fasciculusProspective memory impairmentHigh-motivation conditionLow-motivation conditionCingulum bundleBrain-behavior relationsPediatric traumatic brain injurySignificant group differencesBrain injuryProspective memoryLeft cingulum bundleTBI groupMemory impairmentWM structuresGroup differencesFractional anisotropyEnhancement conditionsDiffusion tensor imagingChildrenFasciculusOrthopedic injuries
2010
Diffusion Tensor Imaging of the Cingulum Bundle in Children After Traumatic Brain Injury
Wilde E, Ramos M, Yallampalli R, Bigler E, McCauley S, Chu Z, Wu T, Hanten G, Scheibel R, Li X, Vásquez A, Hunter J, Levin H. Diffusion Tensor Imaging of the Cingulum Bundle in Children After Traumatic Brain Injury. Developmental Neuropsychology 2010, 35: 333-351. PMID: 20446136, PMCID: PMC3229222, DOI: 10.1080/87565641003696940.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnisotropyBrain InjuriesBrain MappingChildCognition DisordersDiffusion Tensor ImagingFemaleFunctional LateralityGyrus CinguliHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleNerve FibersNeuropsychological TestsRecognition, PsychologyReproducibility of ResultsSocioeconomic FactorsStatistics as TopicConceptsTraumatic brain injuryDiffusion tensor imagingBrain injuryCingulum bundleFractional anisotropyTensor imagingSevere traumatic brain injuryPrefrontal-cingulate networkApparent diffusion coefficient (ADC) valuesFrontal lesion volumeExtracranial injuriesNeurobehavioral deficitsLesion volumeInjury mechanismInjury severityTBI groupInjuryDTI parametersChildrenDiffusion coefficient valuesControl measuresImaging
2009
Neuregulin 1 genetic variation and anterior cingulum integrity in patients with schizophrenia and healthy controls
Wang F, Jiang T, Sun Z, Teng S, Luo X, Zhu Z, Zang Y, Zhang H, Yue W, Qu M, Lu T, Hong N, Huang H, Blumberg H, Zhang D. Neuregulin 1 genetic variation and anterior cingulum integrity in patients with schizophrenia and healthy controls. Journal Of Psychiatry And Neuroscience 2009, 34: 181-186. DOI: 10.1139/jpn.0924.Peer-Reviewed Original ResearchAnterior cingulumFractional anisotropyBrain regionsDevelopment of white matter connectivityGenetic susceptibility to schizophreniaDiagnosis of schizophreniaSusceptibility to schizophreniaWhite matter connectivityHealthy controlsWhite matter structuresSchizophrenia groupDiffusion tensor imagingSchizophreniaCingulum bundleConsistent with previous reportsMatter structuresSignificant groupTensor imagingCingulumMyelin integrityTT subgroupT carriersAnterior componentNeuregulin1Previous reportsNeuregulin 1 genetic variation and anterior cingulum integrity in patients with schizophrenia and healthy controls
Wang F, Jiang T, Sun Z, Teng SL, Luo X, Zhu Z, Zang Y, Zhang H, Yue W, Qu M, Lu T, Hong N, Huang H, Blumberg HP, Zhang D. Neuregulin 1 genetic variation and anterior cingulum integrity in patients with schizophrenia and healthy controls. Journal Of Psychiatry And Neuroscience 2009, 34: 181-186. PMID: 19448847, PMCID: PMC2674970, DOI: 10.1503/jpn.0924.Peer-Reviewed Original ResearchConceptsAnterior cingulumFractional anisotropyHealthy controlsBrain regionsDiagnosis of schizophreniaDiffusion tensorWhite matter connectivityHealthy menWhite matter structuresT carriersMyelin integrityTT subgroupPatientsProminent involvementT alleleReciprocal connectionsAnterior componentC alleleCingulum bundleSchizophrenia groupGenetic susceptibilityCingulum fractional anisotropyNeuregulin1SchizophreniaSmall sample sizeAssociation between symptom severity and internal capsule volume in obsessive-compulsive disorder
de Souza Duran F, Hoexter M, Valente A, Miguel E, Busatto G. Association between symptom severity and internal capsule volume in obsessive-compulsive disorder. Neuroscience Letters 2009, 452: 68-71. PMID: 19150484, DOI: 10.1016/j.neulet.2009.01.007.Peer-Reviewed Original ResearchConceptsWhite matter volumeObsessive-compulsive disorderMagnetic resonance imagingMatter volumeCingulum bundleWhite matter volume deficitsPathophysiology of OCDOCD patientsAsymptomatic control subjectsWhite matter reductionThalamic-cortical circuitWhite matter alterationsVoxel-based morphometryWhite matter tractsRegional white matter volumeSymptom severity ratingsInternal capsuleNeurosurgical treatmentSeverity scoreControl subjectsAnterior limbConnectivity dysfunctionT MRI scannerOCD severity scoresVolume deficits
2004
Anterior Cingulum Abnormalities in Male Patients With Schizophrenia Determined Through Diffusion Tensor Imaging
Wang F, Sun Z, Cui L, Du X, Wang X, Zhang H, Cong Z, Hong N, Zhang D. Anterior Cingulum Abnormalities in Male Patients With Schizophrenia Determined Through Diffusion Tensor Imaging. American Journal Of Psychiatry 2004, 161: 573-575. PMID: 14992988, DOI: 10.1176/appi.ajp.161.3.573.Peer-Reviewed Original ResearchConceptsAnterior cingulumDiffusion tensor imagingLeft-greater-than-right asymmetryFractional anisotropyHealthy comparison menPosterior cingulum bundleTensor imagingSchizophrenia patientsComparison subjectsComparison menMale patientsCingulum bundleSchizophreniaStructural disconnectionCingulumPatientsAbnormalitiesDisconnectionFindings
1984
Dual pathways connecting the dorsolateral prefrontal cortex with the hippocampal formation and parahippocampal cortex in the rhesus monkey
Goldman-Rakic P, Selemon L, Schwartz M. Dual pathways connecting the dorsolateral prefrontal cortex with the hippocampal formation and parahippocampal cortex in the rhesus monkey. Neuroscience 1984, 12: 719-743. PMID: 6472617, DOI: 10.1016/0306-4522(84)90166-0.Peer-Reviewed Original ResearchConceptsDorsolateral prefrontal cortexPrefrontal cortexParahippocampal gyrusTransitional cortexReciprocal projectionsHippocampal formationHorseradish peroxidase histochemistryFronto-occipital fasciculusPrestriate areasNeurons projectRhinal sulcusAfferent inputPrefrontal projectionsPosterior subdivisionsCaudal partCaudomedial lobuleCytoarchitectonic areasPosterior cingulatePresubiculumCingulum bundleCortical regionsParahippocampal cortexRhesus monkeysCortexHippocampus
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