2025
Identifying the epileptic network by linking interictal functional and structural connectivity
Boddeti U, Farooque P, McGrath H, Percy J, Chishti O, Duckrow R, Spencer D, Zaveri H, Ksendzovsky A. Identifying the epileptic network by linking interictal functional and structural connectivity. Scientific Reports 2025, 15: 9106. PMID: 40097693, PMCID: PMC11914057, DOI: 10.1038/s41598-025-93978-3.Peer-Reviewed Original ResearchConceptsStructural connectivityFunctional connectivity findingsWhite matter connectivityConnectivity findingsSeizure networkMesial temporal lobe epilepsyHigher functional connectivityPost-operative seizure freedomResective epilepsy surgeryNetwork disorderTemporal lobe epilepsyIntracranial electrode contacts
2024
Caudal and Thalamic Segregation in White Matter Brain Network Communities in Alzheimer's Disease Population
Xu F, Duong-Tran D, Zhao Y, Shen L. Caudal and Thalamic Segregation in White Matter Brain Network Communities in Alzheimer's Disease Population. 2024, 00: 1-8. DOI: 10.1109/bhi62660.2024.10913835.Peer-Reviewed Original ResearchStructural brain networksMild cognitive impairmentBrain networksDiffusion tensor imagingNeural correlates of cognitive deficitsCorrelates of cognitive deficitsConsensus communitiesAlzheimer's diseaseDecision-making regionsWhite matter connectivityHealthy controlsResolution parameterNeural correlatesCognitive deficitsNeuroimaging studiesBrain regionsDiagnosed AD subjectsDisconnection syndromeClinically diagnosed ADCognitive impairmentAD groupTensor imagingAD subjectsGray matterAD relationshipsMapping the structure-function relationship along macroscale gradients in the human brain
Collins E, Chishti O, Obaid S, McGrath H, King A, Shen X, Arora J, Papademetris X, Constable R, Spencer D, Zaveri H. Mapping the structure-function relationship along macroscale gradients in the human brain. Nature Communications 2024, 15: 7063. PMID: 39152127, PMCID: PMC11329792, DOI: 10.1038/s41467-024-51395-6.Peer-Reviewed Original ResearchConceptsStructure-function correspondenceBrain regionsMacroscale gradientWhite matter connectivityHuman brain regionsStructure-function couplingNeural network propertiesAssociation cortexCognitive functionBridging neuroscienceFunctional coactivationOrganizational axisCortical thicknessHuman brainMotor cortexLanguage processingBrainCortexMotor functionNatural language processingNetwork propertiesMotorNeuroscienceNatural languageData repositoriesEdge-centric network control on the human brain structural network
Sun H, Rosenblatt M, Dadashkarimi J, Rodriguez R, Tejavibulya L, Scheinost D. Edge-centric network control on the human brain structural network. Imaging Neuroscience 2024, 2: 1-15. DOI: 10.1162/imag_a_00191.Peer-Reviewed Original ResearchHuman brain structural networksNetwork control theoryEdge controlWhole-brain networksHuman Connectome ProjectDiffusion MRI dataWhite matter connectivityConnectome ProjectBrain dynamicsExecutive functionBrain structural networksBrain network connectivityBrain connectivityFunctional connectomeState transitionsTransitionEnergy patternsTheory modelBrain energy consumptionDynamic processStructural networkStateNetwork control mechanismsCognitive statesNetwork pairs
2023
Network controllability of structural connectomes in the neonatal brain
Sun H, Jiang R, Dai W, Dufford A, Noble S, Spann M, Gu S, Scheinost D. Network controllability of structural connectomes in the neonatal brain. Nature Communications 2023, 14: 5820. PMID: 37726267, PMCID: PMC10509217, DOI: 10.1038/s41467-023-41499-w.Peer-Reviewed Original Research
2022
Differential Developmental Associations of Material Hardship Exposure and Adolescent Amygdala–Prefrontal Cortex White Matter Connectivity
Hardi F, Goetschius L, Peckins M, Brooks-Gunn J, McLanahan S, McLoyd V, Lopez-Duran N, Mitchell C, Hyde L, Monk C. Differential Developmental Associations of Material Hardship Exposure and Adolescent Amygdala–Prefrontal Cortex White Matter Connectivity. Journal Of Cognitive Neuroscience 2022, 34: 1866-1891. PMID: 34942644, PMCID: PMC9651170, DOI: 10.1162/jocn_a_01801.Peer-Reviewed Original ResearchConceptsWhite matter connectivityAssociated with greater connectivityDevelopmental timing of exposureLow-income sampleGrowth curve analysisWindow of plasticityFrontolimbic structuresDorsomedial PFCAmygdala-prefrontalACC connectivityHippocampus-amygdalaPrefrontal regionsEmotional processingNeural regionsNeuroimaging studiesMiddle childhoodGreater connectivityDepressive symptomsBrain structuresDiffusion imaging dataDevelopmental associationDevelopmental periodStructural connectivityMaterial hardshipAdolescents
2018
Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals
Jacobs H, Hedden T, Schultz A, Sepulcre J, Perea R, Amariglio R, Papp K, Rentz D, Sperling R, Johnson K. Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals. Nature Neuroscience 2018, 21: 424-431. PMID: 29403032, PMCID: PMC5857215, DOI: 10.1038/s41593-018-0070-z.Peer-Reviewed Original ResearchConceptsPosterior cingulate cortexMemory declineCingulate cortexHippocampal volumeTau accumulationAssociated with increased mean diffusivityCognitively healthy older individualsBaseline hippocampal volumeAmyloid-positive individualsWhite matter connectivityAmyloid-negative individualsPreclinical Alzheimer's diseaseAmyloid pathologyAnimal models of Alzheimer's diseaseHealthy older individualsTau pathology propagationModel of Alzheimer's diseaseAlzheimer's diseaseTau positron emission tomographyMemory performanceNeural vulnerabilityCingulum bundleOlder individualsPositron emission tomographyMean diffusivity
2016
Changes in functional organization and white matter integrity in the connectome in Parkinson's disease
Tinaz S, Lauro PM, Ghosh P, Lungu C, Horovitz SG. Changes in functional organization and white matter integrity in the connectome in Parkinson's disease. NeuroImage Clinical 2016, 13: 395-404. PMID: 28116232, PMCID: PMC5226806, DOI: 10.1016/j.nicl.2016.12.019.Peer-Reviewed Original ResearchConceptsParkinson's diseaseWhite matter integrityPD patientsPD groupWhite matter connectivity changesResting-state functional MRINon-demented PD patientsEarly disease stagesCortico-striatal circuitsWhite matter connectivityDopaminergic medicationDorsal attention networkDisease stageFunctional organizationSensorimotor networkWhole-brain connectomeFunctional modular organizationWhite matterFunctional MRIConnectivity changesDiseasePatientsDiffusion tensorDefault modeBrain connectomeIC‐P‐185: The Effect of Tract‐Specific Loss of White Matter Connectivity on Cognitive Decline in Healthy Older Individuals Depends on Entorhinal T807 Binding
Jacobs H, Schultz A, Amariglio R, Hedden T, Papp K, Perea R, Rentz D, Sepulcre J, Sperling R, Johnson K. IC‐P‐185: The Effect of Tract‐Specific Loss of White Matter Connectivity on Cognitive Decline in Healthy Older Individuals Depends on Entorhinal T807 Binding. Alzheimer's & Dementia 2016, 12: p135-p135. DOI: 10.1016/j.jalz.2016.06.216.Peer-Reviewed Original ResearchLoss of white matter connectivityWhite matter connectivityHealthy older individualsCognitive declineO3‐08‐03: The Effect of Tract‐Specific Loss of White Matter Connectivity on Cognitive Decline in Healthy Older Individuals Depends on Entorhinal T807 Binding
Jacobs H, Schultz A, Amariglio R, Hedden T, Papp K, Perea R, Rentz D, Sepulcre J, Sperling R, Johnson K. O3‐08‐03: The Effect of Tract‐Specific Loss of White Matter Connectivity on Cognitive Decline in Healthy Older Individuals Depends on Entorhinal T807 Binding. Alzheimer's & Dementia 2016, 12: p304-p305. DOI: 10.1016/j.jalz.2016.06.551.Peer-Reviewed Original ResearchLoss of white matter connectivityWhite matter connectivityHealthy older individualsCognitive decline
2015
Primary and secondary alterations of white matter connectivity in schizophrenia: A study on first-episode and chronic patients using whole-brain tractography-based analysis
Wu C, Hwang T, Chen Y, Hsu Y, Lo Y, Liu C, Hwu H, Liu C, Hsieh M, Chien Y, Chen C, Tseng W. Primary and secondary alterations of white matter connectivity in schizophrenia: A study on first-episode and chronic patients using whole-brain tractography-based analysis. Schizophrenia Research 2015, 169: 54-61. PMID: 26443482, DOI: 10.1016/j.schres.2015.09.023.Peer-Reviewed Original ResearchConceptsDorsolateral prefrontal cortexBilateral DLPFCFirst-episode patientsWhite matter connectivityFirst-episodeChronic patientsBilateral dorsolateral prefrontal cortexFirst-episode schizophreniaWidespread white matter abnormalitiesBilateral temporal polesDebilitating mental disorderReduced white matter connectivityRight arcuate fasciculusSuperior longitudinal fasciculus IDuration of illnessAssociated with clinical variablesCallosal fibersBetween-group analysisWhite matter tractsWhite matter abnormalitiesPrefrontal cortexImpaired connectivityTemporal poleArcuate fasciculusCerebral white matter
2009
Functional and Structural Connectivity Between the Perigenual Anterior Cingulate and Amygdala in Bipolar Disorder
Wang F, Kalmar JH, He Y, Jackowski M, Chepenik LG, Edmiston E, Tie K, Gong G, Shah MP, Jones M, Uderman J, Constable RT, Blumberg HP. Functional and Structural Connectivity Between the Perigenual Anterior Cingulate and Amygdala in Bipolar Disorder. Biological Psychiatry 2009, 66: 516-521. PMID: 19427632, PMCID: PMC2830492, DOI: 10.1016/j.biopsych.2009.03.023.Peer-Reviewed Original ResearchConceptsPerigenual anterior cingulate cortexHealthy comparison subjectsBipolar disorderFunctional magnetic resonance imagingDiffusion tensor imagingFunctional connectivityWhite matterFractional anisotropyHC groupPerigenual anterior cingulateAnterior cingulate cortexMagnetic resonance imagingGray matter structuresRegional fractional anisotropyWhite matter connectivityEmotional processingFunctional connectivity measuresSignificant positive associationBD groupComparison subjectsAnterior cingulateCingulate cortexResonance imagingSignificant associationBrain regionsNeuregulin 1 genetic variation and anterior cingulum integrity in patients with schizophrenia and healthy controls.
Wang F, Jiang T, Sun Z, Teng SL, Luo X, Zhu Z, Zang Y, Zhang H, Yue W, Qu M, Lu T, Hong N, Huang H, Blumberg HP, Zhang D. Neuregulin 1 genetic variation and anterior cingulum integrity in patients with schizophrenia and healthy controls. Journal Of Psychiatry And Neuroscience 2009, 34: 181-6. PMID: 19448847, PMCID: PMC2674970.Peer-Reviewed Original ResearchConceptsAnterior cingulumFractional anisotropyHealthy controlsBrain regionsDiagnosis of schizophreniaDiffusion tensorWhite matter connectivityHealthy menWhite matter structuresT carriersMyelin integrityTT subgroupPatientsProminent involvementT alleleReciprocal connectionsAnterior componentC alleleCingulum bundleSchizophrenia groupGenetic susceptibilityCingulum fractional anisotropyNeuregulin1SchizophreniaSmall sample sizeBrain pathways of verbal working memory A lesion–function correlation study
Sepulcre J, Masdeu J, Pastor M, Goñi J, Barbosa C, Bejarano B, Villoslada P. Brain pathways of verbal working memory A lesion–function correlation study. NeuroImage 2009, 47: 773-778. PMID: 19393745, DOI: 10.1016/j.neuroimage.2009.04.054.Peer-Reviewed Original ResearchConceptsVerbal Working MemoryWorking memoryWhite matter pathwaysWhite matter regionsMatter regionsVerbal Working Memory TaskDisrupted white matter pathwaysRight cerebellar white matterWorking Memory TaskWhite matter connectivityMemory taskGray matter regionsCognitive processesCognitive functionThalamo-cortical projectionsInformation processingHuman brainMagnetic resonance imagingMemoryCerebellar white matterWhite matterWhite matter lesionsLeft-sided predominanceBrainMultiple sclerosis patients
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